Clinical trials: OA
Restless Leg Syndrome With Knee OA, Sleep Disorder
Comparative Effectiveness of Myofacial Release vs Cupping Therapy on Quality of Life in Restless Leg Syndrome With Knee O.A.
The aim of this study is to determine effectiveness of Myofascial Release and Cupping Therapy on Quality of Life in Restless Leg Syndrome with knee Osteoarthritis.
- Trial name
- RCT (NCT06918847)
- Testing
- Myofacial release, Dynamic cupping therapy
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Dow University of Health Sciences
Pain, Osteoarthritis
Brain Morphometry in OA Patients Treated With Duloxetine
This is a two week,single-blind study evaluating pain response and changes in brain imaging upon treatment with placebo in people with knee OA.
- Trial name
- NCT02903238
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Northwestern University
Knee Osteoarthritis
An Open-label, 8-week Safety, Efficacy, and Assessment of Cooling Methods for Administration of CNTX-4975-05 for Knee OA
An Open-label, 8-Week Study to Compare the Comfort and Ease of Use of Five Different Treatment Regimens for CNTX 4975-05 Intra-articular Injection in Subjects with Chronic, Moderate-to-Severe Osteoarthritis Knee Pain.
- Trial name
- NCT03661996
- Testing
- CNTX-4975-05, Lidocaine without epinephrine, ElastoGel
- Where
- 28 sites in United States
- Volunteers
- 854 people
- Sponsor
- Centrexion Therapeutics
Major Depression
A Randomized Control Trial of Enhanced Cognitive Behavioural Group Therapy for Older Adults with Depression: Efficacy Across Older Age-Groups
This study is on a type of psychotherapy to treat depression in older adults called Cognitive Behavioural Therapy (CBT-OA). CBT is based on the idea that changing thoughts and behaviours can improve mood.
- Trial name
- NCT06894641
- Testing
- Cognitive Behavior Therapy for Older Adults (CBT-OA)
- Volunteers
- 50 people
- Sponsor
- Nova Scotia Health Authority
Osteoarthritis
To Study Generic Diclofenac Sodium Topical Gel 1% in the Treatment of Osteoarthritis of the Knee (Degenerative Joint Disease Presented as Joint Pain, Stiffness, Swelling and Restricted Motion).
This is a Randomized, Double-Blind, Placebo-Controlled, Parallel-Design, Multiple-Site Clinical Study to Evaluate the Therapeutic Equivalence of Diclofenac Sodium Gel, 1% (Glenmark Pharmaceuticals Ltd) to Voltaren® Gel…
- Trial name
- NCT02596451
- Testing
- Diclofenac Sodium gel, 1%, Voltaren® Gel
- Where
- 44 sites in United States
- Volunteers
- 1,164 people
- Sponsor
- Glenmark Pharmaceuticals Ltd. India
Osteoarthritis (OA) of the Knee
Knee Pain and Lumbar Proprioception in Knee Osteoarthritis Patients
Knee osteoarthritis (KOA), is a chronic degenerative joint pathology with a global prevalence of 22.9% in individuals aged 40 and over.
- Trial name
- NCT07436897
- Testing
- porprioception
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Cairo University
Osteoarthritis, Osteoarthritis (OA) of the Knee
Systemic Oral Glucocorticoids for the Treatment of Acute Osteoarthritis Pain in the Emergency Department
The purpose of this clinical trial is to compare the analgesic effects (relief of pain) of glucocorticoids (steroids) and pain medication versus pain medication alone in adult patients presenting to the emergency department with…
- Conditions
- Osteoarthritis, Osteoarthritis (OA) of the Knee, Osteoarthritis (OA) of the Shoulder, Osteoarthritis (OA) of the Hip
- Trial name
- NCT06603662
- Testing
- Prednisone, Dexamethasone
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- WellSpan Health
Osteoarthritis (OA) of the Knee, Neuromodulation
Percutaneous Neurostimulation in Knee Osteoarthritis
Peripheral nerve stimulation (PNS) is a drug-free pain management procedure that uses electrical impulses to target specific nerves and block pain signals.
- Trial name
- NCT07637682
- Testing
- nerve stimulation using a nerve stimulator to the genicular nerve, nerve stimulation using a nerve stimulator to the saphenous nerve
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Tanta University
Osteoarthritis of the Knee
Phase 2 Efficacy Trial of OLT1177 Gel in Subjects With Moderate to Severe Pain Associated With OA of the Knee
The purpose of this trial is to investigate the efficacy and safety of OLT1177 Gel in subjects with moderate to severe pain associated with osteoarthritis of the knee following cessation of pain therapy.
- Trial name
- NCT01768975
- Testing
- OLT1177 Gel
- Where
- 3 sites in United States
- Volunteers
- 79 people
- Sponsor
- Olatec Therapeutics, Inc.
Osteoarthritis, Knee
A Study Comparing Viscosupplementation and Corticosteroid Injections for Knee Osteoarthritis
Do differences exist between patients who receive a single intra-articular injection of corticosteroid versus patients who receive a single intra-articular injection of hyaluronic acid for the treatment of knee osteoarthritis at…
- Trial name
- NCT01132677
- Testing
- Hylan G-F 20 (Synvisc One), Methylprednisolone (Corticosteroid)
- Where
- Canada
- Volunteers
- 78 people
- Sponsor
- LifeMark Health
Myofascial Trigger Points, Chronic Musculoskeletal Pain
Clinical Study of Myofascial Trigger Points(MTrPs) Injection in the Treatment of Shoulder Osteoarthritis(OA)
Chronic musculoskeletal pain (CMP) is a common disease in China, with a high incidence among the elderly, and has a significant impact on patients' quality of life. Shoulder osteoarthritis is a common type of CMP.
- Conditions
- Myofascial Trigger Points, Chronic Musculoskeletal Pain, Shoulder Osteoarthritis
- Trial name
- NCT07347054
- Testing
- Joint Cavity Injection, MTrPs Injection
- Where
- China
- Volunteers
- 1,036 people
- Sponsor
- Beijing Tiantan Hospital
Knee Osteoarthritis (Knee OA)
Muscle Isometric Contraction for the Treatment of Knee Osteoarthritis
This study compares the effects of three different intensities of Muscle Isometric Contraction (MIC) on balance ability, proprioception, muscle strength, KOA symptoms, and inflammatory factors in synovial fluid among elderly…
- Trial name
- KOA (NCT06870656)
- Testing
- Low-intensity group, Medium-intensity group, High-intensity group
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chengdu Sport University
Ocular Albinism (OA), Oculocutaneous Albinism (OCA)
The Effects of Lutein and Zeaxanthin Supplementation on Vision in Patients With Albinism
The LUVIA study is a randomized placebo-controlled trial designed to investigate the effects of lutein and zeaxanthin supplementation on macular pigment and visual function in ocular or oculocutaneous albinism.
- Trial name
- LUVIA (NCT02200263)
- Testing
- Lutein plus Zeaxanthin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
Osteoarthritis, Pain
From Perception to Performance: A Comprehensive Evaluation in Knee Osteoarthritis.
Knee Osteoarthritis (KOA) is commonly characterized by joint pain, swelling, stiffness, and a reduction in range of motion. These symptoms significantly affect daily activities and overall quality of life.
- Conditions
- Osteoarthritis, Pain, Function, Knee Joint Arthritis
- Trial name
- NCT07417033
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Lokman Hekim University
Osteoarthritis (OA), Knee Injury
Investigating the Safety and Regenerative Potential of MSC-Derived Secretome Combined With PRGF in Knee Osteoarthritis
This Phase I/II randomized clinical trial investigates the safety, feasibility, and early regenerative potential of intra-articular administration of mesenchymal stem cell (MSC)-derived secretome combined with Plasma Rich in…
- Conditions
- Osteoarthritis (OA), Knee Injury, Cartilage Degeneration
- Trial name
- PRGFSECKOA (NCT07157891)
- Testing
- MSC-Derived Secretome, MSC-Derived Secretome + Autologous PRGF
- Volunteers
- 25 people
- Sponsor
- University of the Punjab
Femoracetabular Impingement
Identification of Predictors for Clinical Outcomes in Femoroacetabular Impingement Surgery
The overarching goal of the study is to improve the surgical treatment outcomes of FAI, which is affecting an increasing number of military personnel and young active individuals in the general population.
- Trial name
- DoD FAI-2 (NCT04243447)
- Where
- 13 sites in United States, Canada
- Volunteers
- 747 people
- Sponsor
- Washington University School of Medicine
Osteoarthritis, Knee, Self Stimulation
Exercise and Muscle Stimulation in Patients With Knee Osteoarthritis
Objective: To evaluate the effectiveness of neuromuscular electrical stimulation (NMES) combined with closed kinetic chain (CKC) exercises in patients with knee OA.
- Conditions
- Osteoarthritis, Knee, Self Stimulation, Exercise Addiction
- Trial name
- NCT01320904
- Testing
- NMES, Closed Kinetic Chain
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Universidade Luterana do Brasil
Osteoarthritis (OA) of the Knee
Native Alignment in the Setting of an Arthritic Knee in Total Knee Arthroplasty
The goal of this clinical trial is to learn if preparing the target alignment of the operative side in total knee arthroplasty (TKA) based on the non-arthritic side will give the patient better overall alignment, function, and…
- Trial name
- NCT06617338
- Testing
- CT scan unilateral knee, CT scan bilateral knee
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Louisville
Chronic Pain
A Study Comparing the Effectiveness and Safety of Extended Release Tramadol HCl at 100 mg, 200 mg and 300 mg Doses to Placebo for the Treatment of Moderate to Severe Pain Due to Osteoarthritis (OA)
The purpose of this study is to compare the analgesic efficacy and safety of tramadol HCl ER 100 mg, 200 mg and 300 mg once a day (QD), with placebo in patients with moderate to severe pain due to OA.
- Trial name
- NCT00348452
- Testing
- tramadol HCl ER; celecoxib
- Volunteers
- 1,000 people
- Sponsor
- Bausch Health Americas, Inc.
Osteoarthritis
Buprenorphine in the Treatment of Osteoarthritis (OA) in the Elderly
The primary objective is to compare buprenorphine transdermal delivery system (BTDS) with standard- treatment in subjects with osteoarthritis (OA).
- Trial name
- NCT00324038
- Testing
- Buprenorphine, Codeine paracetamol
- Where
- United Kingdom
- Volunteers
- 219 people
- Sponsor
- Napp Pharmaceuticals Limited