Clinical trials: Normal Pressure Hydrocephalus
Idiopathic Normal Pressure Hydrocephalus (INPH)
Efficacy in iNPH Shunting (PENS) Trial
The Placebo-Controlled Efficacy in Idiopathic Normal Pressure Hydrocephalus (iNPH) Shunting (PENS) trial is a multi-center blinded, randomized, placebo-controlled design investigation of cerebrospinal fluid (CSF) shunt surgery to…
- Trial name
- PENS (NCT05081128)
- Testing
- programmable CSF shunt valve
- Where
- 17 sites in United States, Canada and 1 more
- Volunteers
- 99 people
- Sponsor
- Johns Hopkins University
Idiopathic Normal Pressure Hydrocephalus (INPH)
A Placebo-Controlled Effectiveness in INPH Shunting (PENS) Trial
The Placebo-Controlled Effectiveness in Idiopathic Normal Pressure Hydrocephalus (iNPH) Shunting (PENS) trial is a multi-center blinded, randomized, placebo-controlled design investigation of cerebrospinal fluid (CSF) shunt…
- Trial name
- PENS (NCT03350750)
- Testing
- programmable CSF shunt valve
- Where
- 7 sites in United States, Canada and 1 more
- Volunteers
- 18 people
- Sponsor
- Johns Hopkins University
Normal Pressure Hydrocephalus
Factors Predicting Response to Shunting in Normal Pressure Hydrocephalus
The research project is designed to determine which combination of tests will enable physicians to predict whether a patient with symptoms of normal pressure hydrocephalus (NPH) will improve with a shunt.
- Trial name
- NPH (NCT00613886)
- Testing
- Programmable Shunt Insertion (Codman, Medtronic), Assessments in physical therapy, occupational therapy, and speech therapy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, Irvine
Normal Pressure Hydrocephalus
A Randomized Cross-over Study for Normal Pressure Hydrocephalus
The goal of our study is to verify the effectiveness of the shunt and to identify the most sensitive criteria to select patients for surgery.
- Trial name
- ARCS NPH (NCT01798641)
- Testing
- MIETHKE proGAV® / MIETHKE proSA®
- Where
- 5 sites in United States
- Volunteers
- 48 people
- Sponsor
- Johns Hopkins University
Normal Pressure Hydrocephalus
Positron Emission Tomography Imaging of Brain Amyloid in Normal Pressure Hydrocephalus
To determine the level of association between the quantitative estimates of brain uptake of [18F]flutemetamol and the quantitative immunohistochemical and histochemistry estimates of amyloid levels in frontal lobe biopsy samples…
- Trial name
- NCT01092546
- Testing
- [18F]Flutemetamol
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- GE Healthcare
Normal Pressure Hydrocephalus
PET Imaging of Brain Amyloid in Normal Pressure Hydrocephalus
This study will determine the level of association between the quantitative estimates of brain uptake of [18F]flutemetamol and the quantitative immunohistochemical estimates of amyloid levels in biopsy samples previously obtained…
- Trial name
- NCT01053312
- Testing
- [18F] Flutemetamol
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- GE Healthcare
Hydrocephalus, Normal Pressure Hydrocephalus
A Precision and Accuracy Study of the Codman Valve Position Verification (VPV) System.
The purpose of this study is to determine the agreement rate between the CODMAN Valve Position Verification (VPV) adjustment outcome (reprogramming) and X-ray verification in order to support an alternative to X-ray confirmation…
- Trial name
- NCT00196196
- Testing
- Codman VPV System
- Where
- 8 sites in United States
- Volunteers
- 274 people
- Sponsor
- Codman & Shurtleff