Clinical trials: Normal Pressure Hydrocephalus
Hydrocephalus, Normal Pressure
A Study Comparing Shunt Placement Versus Endoscopic Third Ventriculostomy in the Treatment of Hydrocephalus
The main purpose of this study is to compare two types of treatment of hydrocephalus: placement of a ventriculoperitoneal (VP) shunt versus an endoscopic third ventriculostomy (ETV).
- Trial name
- NCT01115270
- Testing
- Non-invasive measures
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- University of California, Los Angeles
Fecal Incontinence with Fecal Urgency, Urine Incontinence
Idiopathic Normal Pressure Hydrocephalus: Focus on Imaging and Clinical Symptoms.
LiNPH is a prospective single center clinical and radiological study.
- Conditions
- Fecal Incontinence with Fecal Urgency, Urine Incontinence, Diffusion Tensor Imaging, Leukoencephalopathies
- Trial name
- LiNPH (NCT04808076)
- Testing
- Shunt surgery
- Where
- Sweden
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Linkoeping University
Idiopathic Normal Pressure Hydrocephalus
Integrated Multimodal Assessment to Optimize Diagnosis and Surgical Selection in Idiopathic Normal Pressure Hydrocephalus
Idiopathic normal pressure hydrocephalus (iNPH) is a neurological condition that can cause walking difficulties, cognitive impairment, and urinary incontinence.
- Trial name
- NPH-OPTIMIZE (NCT07427836)
- Where
- 2 sites in Italy
- Volunteers
- 116 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Idiopathic Normal Pressure Hydrocephalus
A Trial of High and Low Pressure Level Settings on a Programmable Ventriculoperitoneal Shunt Valve for Idiopathic Normal Pressure Hydrocephalus
In treating idiopathic normal pressure hydrocephalus with a shunt there is always a risk of underdrainage or overdrainage. The hypothesis is tested whether treatment of patients with an adjustable valve preset at the highest…
- Trial name
- NCT01570257
- Testing
- lowering of the performance level of an adjustable Strata valve in a ventriculoperitoneal (VP) shunt for treating idiopathic normal pressure hydrocephalus
- Where
- Netherlands
- Volunteers
- 58 people
- Sponsor
- Erasmus Medical Center
Idiopathic Normal Pressure Hydrocephalus (INPH), Brain Diseases
Ventriculomegaly and Gait Disturbance in the Senior Population in the Region of Västerbotten
Idiopathic normal pressure hydrocephalus (INPH) is a treatable disease of the elderly, typically causing gait impariment, dementia and urinary incontinence.
- Conditions
- Idiopathic Normal Pressure Hydrocephalus (INPH), Brain Diseases, Central Nervous System Diseases, Dementia
- Trial name
- VESPR (NCT05204745)
- Where
- Sweden
- Volunteers
- 6,500 people
- Sponsor
- Umeå University
Hydrocephalus, Normal Pressure
Assessment of ShuntCheck Performance Characteristics in Asymptomatic Patients With Normal Pressure Hydrocephalus
The purpose of the study is to determine if the ShuntCheck test can correctly identify flow or no flow in a ventriculoperitoneal shunt in patients with asymptomatic normal pressure hydrocephalus.
- Trial name
- NCT04011566
- Testing
- ShuntCheck
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of South Florida
Normal Pressure Hydrocephalus
Positron Emission Tomography Imaging of Brain Amyloid in Normal Pressure Hydrocephalus
To determine the level of association between the quantitative estimates of brain uptake of [18F]flutemetamol and the quantitative immunohistochemical and histochemistry estimates of amyloid levels in frontal lobe biopsy samples…
- Trial name
- NCT01092546
- Testing
- [18F]Flutemetamol
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- GE Healthcare
Motor Condition as Measured by Quantified Scale, Cognitive Investigation
Normal Pressure Hydrocephalus Treatment by Acetazolamide
Normal pressure hydrocephalus (NPH) is an uncommon cause of dementia possibly reversible with treatment. First described in 1965 it consists of a triad of gait disturbance, cognitive deterioration, and urinary incontinence…
- Trial name
- NCT02163330
- Testing
- Acetazolamide, sugar pill
- Where
- Israel
- Volunteers
- 2 people
- Sponsor
- Rabin Medical Center
Aneurysms, Arteriovenous Malformations
Neurosurgical Outcome Network
The evaluation of neurosurgical outcomes varies from center to center, and the predictive factors that determine these outcomes are not fully known or shared.
- Conditions
- Aneurysms, Arteriovenous Malformations, Cavernomas, Skull Base Tumors
- Trial name
- NEON (NCT06724029)
- Where
- 27 sites in Italy
- Volunteers
- 4,500 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Walking, Cognitive Function
Transcranial and Rapid Magnetic Stimulation for Gait Apraxia Due to Normal Pressure Hydrocephalus and Cerebral Ischemia
The investigator(neurologist) has published a study in International Congress Series, in the 15th International Conference of Biomagnetism Vancouver Proceedings 2006,and Science Direct website, of 15 patients with brain ischemia…
- Trial name
- NCT00494689
- Where
- 2 sites in Singapore
- Volunteers
- 30 people
- Sponsor
- Devathasan Neurology Practice Pte Ltd
Normal Pressure Hydrocephalus, Sleep Apnea
Normal Pressure Hydrocephalus and Sleep Apnea
Normal-pressure hydrocephalus is associated with increases in the intracranial pressure during the night sleep. Sleep apnea also increases the intracranial pressure during the apneic spells.
- Conditions
- Normal Pressure Hydrocephalus, Sleep Apnea, Cerebrospinal Fluid Shunt Occlusion
- Trial name
- NPH/OSA (NCT04471740)
- Testing
- CSF shunt diversion
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- University of Valencia
Idiopathic Normal Pressure Hydrocephalus (INPH)
Walking Pattern Characteristics in Normal Pressure Hydrocephalus
20 patients who are diagnosed with NPH receive a set of 5 wearable gyroscopes (IMUs, ZurichMove sensors) for a period of 3 days for measurement and characterization of their walking in an ambulatory setting.
- Trial name
- NPH wearables (NCT04702035)
- Testing
- Characterization of walking pattern characteristics in an ambulatory setting using wearable IMUs (ZurichMOVE sensors)
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Normal Pressure Hydrocephalus
Conservative Versus Surgical Management of Idiopathic Normal Pressure Hydrocephalus (INPH)
This study aims to provide class 1 evidence supporting or refuting the existence of normal pressure hydrocephalus.
- Trial name
- NCT00727142
- Testing
- Surgical treatment
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- University College London Hospitals
Hydrocephalus, Idiopathic Normal Pressure Hydrocephalus
Clinical Outcome in Patients With INPH
The aim of this study is to determine the clinical spectrum and natural progression of idiopathic normal pressure hydrocephalus （iNPH ) and related disorders in a prospective single center study, identify digital, imaging and…
- Conditions
- Hydrocephalus, Idiopathic Normal Pressure Hydrocephalus, CSF, Glympathic System
- Trial name
- NCT06428734
- Testing
- hydrocephalus group, normal group
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Parkinson Disease, Multiple System Atrophy
A Pilot Biomarker Study Assessing Alpha-synuclein Aggregates Across Biofluid Reservoirs in Patients With Synucleinopathies
This will be an observational study looking at clinical and biomarker characteristics in patients with Parkinson's Disease (PD), Multiple System Atrophy (MSA), Rapid Eye Movement Sleep Behavior Disorder (RBD), Normal Pressure…
- Conditions
- Parkinson Disease, Multiple System Atrophy, Rapid Eye Movement Sleep Behavior Disorder, Normal Pressure Hydrocephalus
- Trial name
- NCT04020198
- Testing
- Biomarker assay
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Normal Pressure Hydrocephalus
Computerised Testing of Cognitive Response to Cerebrospinal Fluid Shunting in Idiopathic Normal Pressure Hydrocephalus
A novel computerised neuropsychological test battery for normal pressure hydrocephalus (NPH) has been developed. The aim is to provide the clinician with a free of charge, standardized tool, assessing the cognitive decline or…
- Trial name
- NCT01618500
- Where
- 4 sites in Denmark, Sweden
- Volunteers
- 80 people
- Sponsor
- Umeå University
Idiopathic Normal Pressure Hydrocephalus (INPH)
Efficacy in iNPH Shunting (PENS) Trial
The Placebo-Controlled Efficacy in Idiopathic Normal Pressure Hydrocephalus (iNPH) Shunting (PENS) trial is a multi-center blinded, randomized, placebo-controlled design investigation of cerebrospinal fluid (CSF) shunt surgery to…
- Trial name
- PENS (NCT05081128)
- Testing
- programmable CSF shunt valve
- Where
- 17 sites in United States, Canada and 1 more
- Volunteers
- 99 people
- Sponsor
- Johns Hopkins University
Normal Pressure Hydrocephalus
Prognostic Value of Transforming Growth Factor-Beta 1 in Normal Pressure Hydrocephalus
Correlation of cerebrospinal fluid levels of transforming growth factor beta-1 with functional improvements after insertion of ventriculoperitoneal shunt for normal pressure hydrocephalus
- Trial name
- NCT00600795
- Testing
- CSF collection
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Vanderbilt University Medical Center
Intracranial Pressure
New Reference Values for Intracranial Pressure
Intracranial pressure is a cornerstone in neurosurgical care used in a variety of diseases. However currently, doubts regarding normal intracranial pressure exist.
- Trial name
- NCT03594136
- Testing
- Raumedic Neurovent-P-tel
- Where
- 3 sites in Czechia, Denmark
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hydrocephalus, NPH (Normal Pressure Hydrocephalus)
CERTAS Programmable Valve Registry
Post-Market Clinical Follow-up Registry of Patients with CODMAN CERTAS Plus Programmable Valves.
- Conditions
- Hydrocephalus, NPH (Normal Pressure Hydrocephalus), IIH - Idiopathic Intracranial Hypertension
- Trial name
- CERTAS (NCT04207229)
- Testing
- CODMAN CERTAS Programmable Valves
- Where
- 8 sites in Germany, Netherlands
- Volunteers
- 35 people
- Sponsor
- Integra LifeSciences Corporation