Clinical trials: Noninvasive Ventilation
Respiratory Disease
Does NIV-NAVA Improve Diaphragmatic Function in Preterm Infants
Non-Invasive Positive Pressure Ventilation (NIPPV) provides un-synchronized positive pressure and considered to be superior to nCPAP in preventing extubation failure.
- Trial name
- NCT05079412
- Testing
- Chest ultrasound
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Mount Sinai Hospital, Canada
Brain Injuries, Traumatic
Noninvasive Neuromodulation for Treatment of Symptoms Due to Mild or Moderate Traumatic Brain Injury
The investigators hypothesis is that electrical stimulation to the tongue that directly stimulates two cranial nerve nuclei (Trigeminal and Facial Nerve Nuclei), will excite neural impulses to the brainstem and cerebellum.
- Trial name
- NCT02158494
- Testing
- Balance and Gait Training using neurostimulation modulation.
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Wisconsin, Madison
Rox Index
ROX Index in Acute Respiratory Failure
evaluation of ROX index among ICU patients to evaluate the success of non invasive ventilation or the need for intubation
- Trial name
- NCT05309239
- Testing
- ROX index
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Amyotrophic Lateral Sclerosis, Respiratory Insufficiency
Early Stage Amyotrophic Lateral Sclerosis Phrenic Stimulation
ALS is is characterized by a progressive degeneration of motor neurons, leading to progressive weakness of muscles, including respiratory muscles, the diaphragm.
- Trial name
- RespiStimALS (NCT01583088)
- Testing
- phenique nerve stimulation NeurX™ (Synapse Biomedical)
- Where
- France
- Volunteers
- 74 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Apnea Syndrome, Obstructive Sleep Apnea
Analysis of Mandibular Movements in Ventilated Children With Sleep Apnea Syndrome
Obstructive Sleep Apnea is a common medical condition in children. Diagnosis is based on polysomnography . We conducted an open prospective non randomised clinical trial to assess the efficacy of a new medical device called…
- Trial name
- AMANDA (NCT05908188)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Grenoble
Early Acute Respiratory Failure
Early Non-invasive Ventilation Outside the Intensive Care Unit
A large multicentre, randomized, controlled trial to demonstrate that non invasive ventilation given at an early stage of acute respiratory failure (ARF) outside the intensive care unit (ICU) can prevent the deterioration of ARF…
- Trial name
- NAVIGATE (NCT01572337)
- Testing
- Non-invasive ventilation, Standard care
- Where
- 14 sites in Greece, Italy and 1 more
- Volunteers
- 520 people
- Sponsor
- Università Vita-Salute San Raffaele
Surgery, Trauma to the Abdomen
Non Invasive Ventilation in Abdominal Postoperative Period
Acute respiratory failure may occur early in the postoperative course, requiring endotracheal intubation and mechanical ventilation in selected patients, thus increasing morbidity and mortality and prolonging intensive care unit…
- Conditions
- Surgery, Trauma to the Abdomen, Acute Respiratory Failure
- Trial name
- NIVAS (NCT01971892)
- Testing
- Non Invasive ventilation (facial mask and NIV ventilator), Standard oxygen therapy with facial mask
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Montpellier
Care, Palliative, Respiratory Failure
RENOVATE Palliative: HFNC vs. Standard Respiratory Support in Patients With Do-Not-Intubate Order and ARF
Randomized clinical trial in which the main objective is to compare High Flow Nasal Cannula (HFNC) versus the standard respiratory care in the alleviation of dyspnea perception in patients with do-not-intubate (DNI) order.
- Trial name
- NCT04269681
- Testing
- High Flow Nasal Cannula, Standard respiratory support
- Where
- Brazil
- Volunteers
- 3 people
- Sponsor
- Hospital do Coracao
Neuromuscular Diseases, Alveolar Hypoventilation
Impact of the Type of Interface in Neuromuscular Patients Treated With Nocturnal Noninvasive Ventilation
Nocturnal Non Invasive Ventilation (NIV) is the reference treatment for chronic alveolar hypoventilation in patients with neuro-muscular diseases.
- Trial name
- InterfaceNMD (NCT03458507)
- Testing
- Switch of nocturnal NIV interface
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Grenoble
Cystic Fibrosis
Non-invasive Ventilation and Oxygen Therapy in Cystic Fibrosis Patients With Nocturnal Oxygen Desaturation
The purpose of this study is to determine whether correction of low nighttime oxygen (O2) levels and/ or high carbon dioxide levels in patients with cystic fibrosis improves their quality of life.
- Trial name
- NCT00157183
- Testing
- Nocturnal oxygen , nocturnal bi-level positive pressure ventilation
- Where
- Australia
- Volunteers
- 59 people
- Sponsor
- Bayside Health
Respiratory Failure
Non Invasive Ventilation After Cardiac Surgery
Patients with respiratory failure following cardiac surgery are randomized to receive standard therapy versus non invasive ventilation.
- Trial name
- CPAP-CCH (NCT01249794)
- Testing
- non invasive ventilation
- Where
- Italy
- Sponsor
- Università Vita-Salute San Raffaele
COPD, Non Invasive Ventilation
Prospective Cohort of Respiratory Insufficiency Outcome
The Respiratory Insufficiency Outcome (RIO) project consists in a french multicenter prospective cohort of patients with chronic obstructive pulmonary disease (COPD) undergoing domiciliary noninvasive positive pressure…
- Trial name
- RIO (NCT01192451)
- Where
- 4 sites in France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Transient Tachypnea of the Newborn
nHFOV Versus nCPAP in Transient Tachypnea of the Newborn
In this prospective, randomised clinical trial the investigators aim to assess if nasal high frequency oscillatory ventilation (nHFOV) could be used as the primary modality of respiratory support in late preterm and term infants…
- Trial name
- NCT03006354
- Testing
- nHFOV, nCPAP
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- The Hospital for Sick Children
Acute Respiratory Distress Syndrome
Noninvasive Positive Pressure Ventilation in Moderate Acute Respiratory Distress Syndrome
In order to identify the effect of noninvasive positive pressure ventilation (NPPV) on decreasing inflammatory response, improving the pathophysiological manifestation and reducing the morbidity and mortality in the moderate…
- Trial name
- NCT01585922
- Testing
- noninvasive positive pressure ventilation (NPPV), invasive mechanical ventilation
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Beijing Hospital
COPD
COPD AND ASSESSMENT OF RADIOLABELED AEROSOL DURING NONINVASIVE VENTILATION
Background: Beneficial effects from noninvasive ventilation (NIV) in acute COPD are well-established, but couple to nebulization is still challenging.
- Trial name
- NCT02247856
- Testing
- Noninvasive ventilation, Jet Nebulizer, Vibrating Mesh Nebulizer (VMN)
- Where
- Brazil
- Volunteers
- 9 people
- Sponsor
- Daniella Cunha Brandao
Failing Fontan Physiology, Pediatric Congenital Heart Disease
Noninvasive Negative Pressure Ventilation to Support Failing Fontan Physiology
The purpose of this study is to assess for acute hemodynamic changes after implementation of noninvasive negative pressure ventilation (as compared with spontaneous respiration) in pediatric patients with Fontan failure using…
- Trial name
- NCT03223168
- Testing
- Hayek RTX ventilator
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Michigan
Ventilator Associated Events, Asynchrony, Patient-Ventilator
Synchrony-Optimized Non-Invasive Ventilation Education Program and ICU Patients
The aim of this clinical trial is to find out whether a synchrony-optimized education program for non-invasive ventilation (NIV) can help ICU patients use their ventilator more effectively and improve their comfort, symptoms, and…
- Conditions
- Ventilator Associated Events, Asynchrony, Patient-Ventilator, Intensive Care (ICU), Noninvasive Ventilation
- Trial name
- NCT07291622
- Testing
- SYNC-NIV
- Volunteers
- 92 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Pediatric Respiratory Diseases
Asynchronies in Pediatric Noninvasive Ventilation
The term ''Non-invasive ventilation'' (NIV) refers to various methods of respiratory assistance, in the absence of an indwelling endotracheal tube.
- Trial name
- Asyn-Vent (NCT04017780)
- Testing
- Single-Limb Turbine-Driven Ventilator, Double-Limb Intensive Care Unit ventilator, Double-Limb Turbine-Driven Ventilator
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Chronic Obstructive Pulmonary Disease Severe, Dyspnea
Study of the Cytokine Response During Exercise Dyspnea in Patients With Chronic Obstructive Pulmonary Disease (COPD). Effect of Body Composition
Dyspnea, more commonly known as breathlessness, is a symptom found in the majority of patients with chronic obstructive pulmonary disease (COPD), with a major impact on quality of life and mortality.
- Trial name
- CYTODINE (NCT06229509)
- Testing
- Effective noninvasive ventilation
- Where
- France
- Volunteers
- 26 people
- Sponsor
- University Hospital, Clermont-Ferrand
Acute Respiratory Failure
NIV NAVA Versus NIV-PS in Pediatric Patients - Pilot Study
This pilot study will be an observational no randomize study in which the NiNAVAped protocol will be applied solely to the NIV NAVA arm.
- Trial name
- NINAVAPed (NCT01873261)
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Universitario La Paz