Clinical trials: Non-operative Treatment
Necrotic Pulp
Incidence of Post-Operative Pain After Single Visit Root Canal Treatment in Necrotic Teeth Using Two Different Rotary Systems (Protaper Nex t& Neolix File)
this prospective in vivo randomized clinical is to evaluate the post operative pain (incidence ,degree and duration) with multiple full rotation file (protaper next ®) and single full rotation file (Neolix®) in treating maxillary…
- Trial name
- NCT03059290
- Testing
- neolix file
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Radius Fracture Distal
Overnight and In-house 3D-printed Patient-specific Casts for Non-operative Treatment of Distal Radius Fractures
The aim of this prospective randomized trial is the acquisition and evaluation of data to assess the relevance, feasibility and safety of forearm casts based on 3D-printing technology in the nonoperative treatment of distal…
- Trial name
- 3D-cast (NCT05346926)
- Testing
- 3D-printed cast, Conventional cast
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Alissa Gubeli
Lipoma
RFA for Superficial Lipomas
Lipomas are non-cancerous growths of fatty tissue that develop under the skin in approximately 1 in 1000 people, though this number may be higher.
- Trial name
- NCT06903208
- Testing
- STARMed VIVA Combo RF System
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Columbia University
Metastatic Cancer to the Hip
Fully Constrained Acetabular Liner vs. Dual Mobility Hip Joint in the Surgical Treatment of Metastatic Bone Disease of the Hip
The purpose of the current study is to investigate whether dual mobility liners are non-inferior til constrained liners regarding the post-operative hip joint dislocation risk following total hip replacement in patients with…
- Trial name
- NCT05461313
- Testing
- Constrained Liner, Dual Mobility
- Where
- Denmark
- Volunteers
- 146 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Ankle Fracture, Ankle Arthrodesis
Compression Therapy for Swelling Management Following Ankle Injury
After an injury or undergoing foot/ankle surgery, patients often experience swelling in the injured area. Under current standard of care, plaster casts are removed at six weeks and patients are put in a walking boot.
- Trial name
- NCT06772649
- Testing
- Compression sleeve
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Nova Scotia Health Authority
Degenerative Lumbar Spinal Stenosis
Efficacy and Tolerance Study of B-DYN Versus Conventional Fusion in the Treatment of Lumbar Stenosis on the Degree of Post-operative Functional Incapacity (BDYNCLIN)
Degenerative Lumbar Spinal Stenosis (LSS) is an extremely common condition affecting more than 102 million people each year. It is a narrowing of the spinal canal in the lower back.
- Trial name
- BDYNCLIN (NCT04407338)
- Testing
- B-DYN, Conventional Bolted fusion (with or without cage)
- Where
- 2 sites in France
- Volunteers
- 216 people
- Sponsor
- Quanta Medical
Lung Cancer
Surgery With or Without Preoperative Chemotherapy in Treating Patients With Resectable Non-small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known if surgery is more effective with or without preoperative chemotherapy in treating…
- Trial name
- NCT00003159
- Testing
- carboplatin, cisplatin, docetaxel
- Where
- 2 sites in United Kingdom
- Volunteers
- 600 people
- Sponsor
- Medical Research Council
Lung Non-Small Cell Carcinoma
A Study of Targeted Post-Surgery Radiation Therapy for Non-Small Cell Lung Cancer With Remaining Lymph Node Cancer After Treatment
This phase II trial compares the effect of intensity-modulated post-operative radiation therapy (I²-PORT) followed by standard of care therapy (chemotherapy or immunotherapy) to standard of care therapy alone in treating patients…
- Trial name
- NCT07293247
- Testing
- Chemotherapy, Immunotherapy, Intensity-Modulated Radiation Therapy
- Where
- 125 sites in United States
- Volunteers
- 164 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Ankle Fracture, Malleolus Fracture
Surgical Versus Nonsurgical Treatment of Fibular Fractures: A Prospective Randomized Study
Isolated surgical repair of the inside portion of the tibia may be enough to stabilize an ankle fracture in which both the tibia and the fibula are broken.
- Conditions
- Ankle Fracture, Malleolus Fracture, Medial Malleolus Fracture, Bimalleolar Fracture
- Trial name
- NCT02032966
- Testing
- Nonsurgical, Surgical
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Tennessee
High Energy Midshaft Clavicle Fractures
Non-Operative Versus Operative Treatment for High-Energy Midshaft Clavicle Fractures
Clavicle (collar bone) fractures account for about 33% of all fractures around the shoulder. Some surgeons suggest that surgical treatment is the best option, while others suggest that nonoperative care is the best treatment.
- Trial name
- NCT00590850
- Testing
- ORIF with Plate and Screws, Pin Fixation
- Where
- United States
- Volunteers
- 412 people
- Sponsor
- Prisma Health-Upstate
Head and Neck Neoplasms
HFHS-1801-A Pilot Study of Immunotherapy As Consolidation Therapy for Patients with Recurrent Head and Neck Cancer
The study is a pilot study to explore the feasibility and efficacy of immunotherapy following salvage surgery for recurrent head and neck cancer.
- Trial name
- NCT04188951
- Testing
- Pembrolizumab 25 MG/1 ML Intravenous Solution [KEYTRUDA]
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Henry Ford Health System
Clavicle, Fracture
Study Comparing Plate Stabilization to Conservative Treatment in Midshaft Clavicle Fractures
The purpose of this study is to find whether to operate or treat conservatively dislocated midshaft clavicle fractures.
- Trial name
- NCT01199653
- Testing
- Operative treatment, Non-operative treatment with arm immobilised to a sling
- Where
- Finland
- Volunteers
- 60 people
- Sponsor
- Helsinki University Central Hospital
Locally Advanced Rectal Adenocarcinoma
Study Evaluating Two Treatment Strategies for Rectal Cancer in Patients ≥75 Years Old
The primary objective of the NACRE-2 trial is to assess whether the addition of chemotherapy after short-course radiotherapy is more effective than short-course radiotherapy alone in elderly patients with locally advanced rectal…
- Trial name
- NACRE-2 (NCT07118800)
- Testing
- FOLFOX4s, Short Course Radiotherapy
- Volunteers
- 160 people
- Sponsor
- UNICANCER
Ankle Fracture, Rehabilitation
Early Weightbearing Versus Non-weightbearing After Operative Treatment of an Ankle Fracture
Unstable ankle fractures are commonly treated operatively. After operative reduction and fixation of the fractures, there are varying rehabilitation regimes that include non-weightbearing for 6 weeks with active range of motion…
- Trial name
- NCT02029170
- Testing
- Early weightbearing, Non-weightbearing
- Where
- 4 sites in South Korea
- Volunteers
- 192 people
- Sponsor
- Hallym University Medical Center
Tendinopathy, Achilles Tendon
Plantaris Release for Non-insertional Achilles Tendinopathy
The plantaris tendon is recognised as an important factor in non-insertional Achilles tendinopathy (NIAT). A biomechanical study found the plantaris tendon is stiffer and stronger than the Achilles tendon (AT), thus reducing its…
- Trial name
- NCT02775201
- Testing
- Plantaris release under ultrasound guidance, Plantaris excision surgically
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- Fortius Clinic
Postoperative Pain
Pain After PRP Revascularization and Endodontic Treatment of Non-vital Mandibular Molars With Apical Periodontitis
randomized clinical trial which Evaluate thr Post-operative Pain Following Platelet Rich Plasma (PRP) Revascularization versus Conventional Endodontic Treatment of Non-vital Mature Mandibular Molars with Chronic Peri-apical…
- Trial name
- NCT03350841
- Testing
- Platelet rich plasma PRP, root canal treatment
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
Achilles Tendon Rupture
Operative Versus Non-operative Treatment of Achilles Tendon Rupture
This study is intended to determine whether the optimal treatment of acute Achilles tendon ruptures is surgical repair or functional bracing.
- Trial name
- NCT00284648
- Testing
- Surgical repair Achilles tendon rupture, Non-surgical repair Achilles tendon rupture
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Fowler Kennedy Sport Medicine Clinic
Proven or Suspected Gram-negative Bacterial Infection, Peri-operative Prophylaxis
Pharmacokinetic and Safety Study of Ceftolozane/Tazobactam in Pediatric Participants Receiving Antibiotic Therapy for Proven or Suspected Gram-negative Infection or for Peri-operative Prophylaxis (MK-7625A-010)
The purpose of this study was to assess the pharmacokinetics, safety, and tolerability of a single intravenous dose of ceftolozane/tazobactam (MK-7625A) in pediatric participants.
- Trial name
- NCT02266706
- Testing
- Ceftolozane/Tazobactam 1000/500 mg, Ceftolozane/Tazobactam 30/15 mg/kg, Ceftolozane/Tazobactam 20/10 mg/kg
- Volunteers
- 43 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Scapula Fracture, Clavicle Fracture
Operative Versus Nonoperative Treatment for Scapula Fractures
The purpose of this study is to contrast and evaluate the functional outcome of patients with operative vs. nonoperative treatment of scapula fractures.
- Trial name
- NCT00849771
- Where
- United States
- Sponsor
- Vanderbilt University
Heart Failure，Congestive
Evaluation of Post-operative, Nurse-based Heart Failure Care in Non-cardiac Surgery
Patients with heart failure NYHA >= II receiving non-emergent non-cardiac in-patient surgery will be randomized to receive either standard post-operative care (surgeon has to ask actively for specialist cardiological support) or…
- Trial name
- NCT03202329
- Testing
- standard care, Nurse-based care
- Where
- 2 sites in Germany
- Volunteers
- 525 people
- Sponsor
- Birgit Assmus