Clinical trials: Non-invasive Ventilation Support
Noninvasive Ventilation
NHFOV Vs NIPPV Post-extubation in Preterm Neonates
comparison between Noninvasive Intermittent Positive Pressure Ventilation (NIPPV) and Noninvasive High Frequency Oscillation Ventilation (NHFOV) post-extubation in preterm neonates as regards the efficacy and their possible…
- Trial name
- NCT06620107
- Testing
- noninvasive high frequency oscillation ventilation, noninvasive positive pressure ventilation
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Kafrelsheikh University
Chronic Obstructive Pulmonary Disease
Effect of Provision of Information and Supportive Nursing Care: A Randomised Controlled Trial
Background: Informative and supportive nursing care is essential to reduce complications and improve outcomes in Chronic Obstructive Pulmonary Disease (COPD) patients treated with Non-Invasive Ventilation (NIV).
- Trial name
- NCT04834037
- Testing
- Behavioral
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ondokuz Mayıs University
Ventilatory Failure, Hypoxemic Respiratory Failure
PREdicting Failure of Non-inVasIve Ventilatory Support Using Non-invaSIve mONitoring in Non-intubated Patients With Acute Hypoxemic Respiratory Failure or Post-extubation Failure. The PREVISION Study
The goal of this observational study is to assess the potential non-invasive tools (e.g. regional ventilation, respiratory muscle response, lung mechanic's parameters) to identify the risk of failure when using high flow nasal…
- Conditions
- Ventilatory Failure, Hypoxemic Respiratory Failure, Weaning Failure, Respiratory
- Trial name
- PREVISION (NCT06716463)
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Unity Health Toronto
COVID-19, Hypoxemic Respiratory Failure
The Effect of Non-invasive Respiratory Support on Outcome and Its Risks in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2)-Related Hypoxemic Respiratory Failure
Coronavirus disease (COVID-19) can result in severe hypoxemic respiratory failure that ultimately may require invasive mechanical ventilation in the Intensive Care Unit (ICU).
- Trial name
- NORMO2 (NCT06033560)
- Testing
- High flow nasal oxygen (HFNO, more than 15 L/min)
- Where
- Netherlands
- Volunteers
- 6,000 people
- Sponsor
- Amsterdam UMC, location VUmc
Chronic Obstructive Pulmonary Disease, Invasive Mechanical Ventilation
Trial to Study Intubation Rates of Non-invasive Ventilation Using Pressure Support Ventilation (PSV) Versus Adaptive Support Ventilation (ASV) Mode in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The clinical course of chronic obstructive pulmonary disease (COPD) is associated with recurrent episodes of exacerbation that results in respiratory failure.
- Conditions
- Chronic Obstructive Pulmonary Disease, Invasive Mechanical Ventilation, Adaptive Support Ventilation
- Trial name
- PSV vs ASV for (NCT02877524)
- Testing
- Adaptive support ventilation, Pressure support ventilation
- Where
- India
- Volunteers
- 74 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Non-invasive Ventilation, High-frequency Ventilation
Evaluation of Prolonged Apnea Supported by High Frequency Non-invasive Ventilation.
The purpose of the study is to assess the efficacy of high-frequency non-invasive ventilation on apnea duration, carbon dioxide clearance and oxygen delivery in healthy subjets and patients with lung disease.
- Conditions
- Non-invasive Ventilation, High-frequency Ventilation, Healthy Volunteer, Lung Diseases
- Trial name
- ANIV (NCT02712190)
- Testing
- High-frequency non-invasive ventilation
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
COVID-19 Pneumonia, COVID-19
Predictive Factors for Failure of Non-invasive Support Ventilation in Patients With COVID-19: A Retrospective Study.
During the progression of COVID-19, some patients may require noninvasive ventilation (NIV) or high-flow nasal catheter (CNAF) oxygen therapy.
- Trial name
- NCT05579080
- Testing
- noninvasive ventilation
- Where
- 2 sites in Brazil
- Volunteers
- 1,319 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Sleep, Cerebral Oxygenation
Respiratory Support and Brain Health in Preterm Infants
Premature babies often require breathing support during their neonatal intensive care unit stay. This is because their lungs are not fully developed to perform the work of breathing on their own.
- Trial name
- NCT05589831
- Testing
- Non-invasive Neurally Adjusted Ventilatory Assist
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Mount Sinai Hospital, Canada
Type II Respiratory Failure, Hypercapnic Respiratory Failure
Post-Extubation High-Flow Nasal Cannula Versus Non-Invasive Ventilation in Type II Respiratory Failure
Acute hypercapnic respiratory failure is characterized by elevated arterial carbon dioxide levels and commonly occurs in patients with chronic respiratory diseases.
- Trial name
- NCT06918288
- Testing
- High-Flow Nasal Cannula (HFNC), Non-Invasive Ventilation (NIV)
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Benha University
Covid19
Pronation in COVID-19 Patients Undergoing Non Invasive Respiratory Support
Pronation seems feasible and effective in improving blood oxygenation in patients with COVID-19 pneumonia. Data are lacking on the effects of pronation on clinical outcome in this subset of patients.
- Trial name
- PRINCESS (NCT04649658)
- Testing
- Prone position
- Where
- Italy
- Volunteers
- 93 people
- Sponsor
- University of Modena and Reggio Emilia
Apnoea, Prematurity
Automated Apnoea Detection in Preterms on Non-invasive Ventilation
The aim of this study is to monitor the frequency of apnoeas (pauses in breathing) on various methods of non-invasive respiratory support that are detected by an automated machine-learning (ML) model based on diaphragmatic…
- Trial name
- NCT07794007
- Testing
- Diaphragmatic electromyography
- Volunteers
- 30 people
- Sponsor
- King's College Hospital NHS Trust
Infant, Premature, Diseases, Infant, Newborn, Disease
Noninvasive High Frequency Oscillatory Ventilation as a Post-extubation Respiratory Support in Neonates
A randomized controlled trial comparing Noninvasive high frequency oscillatory ventilation (NHFOV) and Noninvasive positive pressure ventilation (NIPPV) as post-extubation respiratory support in preterm neonates with respiratory…
- Conditions
- Infant, Premature, Diseases, Infant, Newborn, Disease, Respiratory Tract Diseases, RDS
- Trial name
- NCT05493527
- Testing
- noninvasive high frequency oscillatory ventilation, noninvasive positive pressure ventilation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Target Trial Emulation, Invasive Mechanical Ventilation
The Effect of NOn-invasive Respiratory Support on outcoMe and Its Risks in SARS-COV-2-related Hypoxemic Respiratory Failure
To determine whether early endotracheal intubation compared to late endotracheal intubation affects clinical outcome (duration of invasive mechanical ventilation, mortality).
- Trial name
- NORMO2 (NCT06757166)
- Testing
- endotracheal intubation
- Where
- Netherlands
- Volunteers
- 50,000 people
- Sponsor
- Erasmus Medical Center
Non Invasive Ventilation, Patient Ventilator Interaction
Neurally Adjusted Ventilatory Assist for Non Invasive Ventilation and Patient-ventilator Interaction
The present study aims to compare various parameters reflecting patient-ventilator synchrony during standard pressure support (PS) and Neurally Adjusted Ventilatory assist (NAVA) in a group of patients receiving non invasive…
- Trial name
- NCT01074866
- Testing
- Neurally Adjusted Ventilatory Assist
- Where
- 4 sites in Belgium, Switzerland
- Volunteers
- 13 people
- Sponsor
- University Hospital, Geneva
COPD Exacerbation Acute, COPD Exacerbation
PSV Versus ASV With Intellisync Mode for Delivery of NIV in AECOPD
Acute exacerbation of chronic obstructive pulmonary disease (COPD) is defined acute worsening of respiratory symptoms requiring additional therapy.
- Trial name
- PAINT-COPD (NCT06160687)
- Testing
- PSV mode during NIV, ASV intellisync
- Where
- India
- Volunteers
- 55 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Chronic Obstructive Pulmonary Disease (COPD)
Effect of Exercise Ventilatory Support Pressure on Endurance in Patients With Severe Chronic Obstructive Pulmonary Disease - AVE-BPCO
Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by progressive obstruction of the airways.
- Trial name
- AVE-BPCO (NCT07125989)
- Testing
- non-invasive ventilation
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Apnea, Hypoxia
Effects of Automated Adjustment of Inspired Oxygen With Combined Adaptive Mechanical Backup Ventilation as Compared to Automated Oxygen Adjustment Alone in Preterm Infants With Intermittent Hypoxemic Events During Non-invasive Ventilatory Support
In this 2-phase cross-over study the investigators test the hypothesis that automated adjustment of the inspired oxygen with the combined use of synchronized noninvasive SpO2-sensitive and apnea-sensitive backup-ventilation…
- Trial name
- NCT02774408
- Testing
- Saturation sensitive backup ventilation
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Acute Hypoxemic Respiratory Failure
Tidal Volume in Patients With "de Novo" Acute Hypoxemic Respiratory Failure
Protective ventilation can be difficult to achieve during noninvasive ventilation for "de novo"acute hypoxemic respiratory failure (i.e., not due to exacerbation of chronic lung disease or cardiac failure).Recent data suggest…
- Trial name
- DENOVT (NCT04741659)
- Testing
- Ventimask, High Flow Nasal cannula (HFNC), Helmet CPAP
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Respiratory Distress Syndrome in Premature Infant
nHFOV Versus Invasive Conventional Ventilation for Preterm Neonates With Respiratory Distress Syndrome
Preterm neonates usually develop respiratory distress syndrome (RDS) for which they need respiratory support, which may be invasive and non-invasive depend on the availability and individual need.
- Trial name
- nHFOV (NCT04914715)
- Testing
- Non-invasive High Frequency Oscillatory Ventilation, Conventional Invasive Ventilation
- Where
- Pakistan
- Sponsor
- Indus Hospital and Health Network
Covid19, Acute Respiratory Failure
Noninvasive Respiratory Support in COVID-19 (CATCOVID-AIR)
COVID-19 pneumonia can cause severe acute hypoxemic respiratory failure. The usefulness of noninvasive respiratory support (NIRS), by means of nasal high-flow oxygen (NHFO), continuous positive airway pressure (CPAP), or…
- Conditions
- Covid19, Acute Respiratory Failure, Corona Virus Infection
- Trial name
- CATCOVID-AIR (NCT04668196)
- Testing
- High-flow nasal cannula treatment, Continuous positive airway pressure (CPAP) treatment, Noninvasive ventilation treatment
- Where
- 10 sites in Spain
- Volunteers
- 367 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute