Clinical trials: Non-communicable Disease
Neisseria Gonorrhoeae Infection, Asymptomatic Pharyngeal Carriage
Clearance of Asymptomatic Pharyngeal Carriage of Neisseria Gonorrhoeae With or Without Ceftriaxone Treatment: Randomized Non-inferiority Study
Since the use of antibiotics, Neisseria Gonorrhoeae (NG) has acquired progressive resistance to penicillins, sulfonamides, tetracyclines and quinolones.
- Trial name
- PORTAPHAR (NCT05971550)
- Testing
- Absence of antibiotic treatment, Ceftriaxone
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Non-Communicable Diseases, Stroke
Make my Day - Primary Prevention of Stroke
The purpose of this study is to evaluate the feasibility of a digital, person-centered stroke prevention program with a focus on primary prevention.
- Conditions
- Non-Communicable Diseases, Stroke, Cardiovascular Risk Factor
- Trial name
- NCT03730701
- Testing
- Prevention program for stroke
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Emelie Malstam
Carpal Tunnel Syndrome, Wound Infection
abSorbable vErsus Non-absorbable SuturEs for Wound Closure in Carpal Tunnel Release
Carpal Tunnel Syndrome is a prevalent condition, up to 9% in women and 0.6% in men. Surgical decompression in the most effective treatment. After surgery, approximately 1,8% of the patients develop a wound infection.
- Conditions
- Carpal Tunnel Syndrome, Wound Infection, Suture, Complication
- Trial name
- SENSE (NCT05431101)
- Testing
- Carpal Tunnel Release
- Where
- 2 sites in Netherlands
- Volunteers
- 2,604 people, healthy volunteers welcome
- Sponsor
- Gelre Hospitals
Acute Febrile Illness
Clinical Study of Transcriptome-based Diagnostic Biomarker for Acute Febrile Illness
Acute febrile illness is the main cause of outpatient visits，and bacterial and viral infections remains the most common cause. The diagnosis of infection is still based on symptoms and traditional techniques, resulting in overuse…
- Trial name
- NCT06552975
- Testing
- Infection
- Where
- China
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Human Immunodeficiency Virus
A Trial to Assess the Functionality of Female Condom With a Silicone Elastomer Vaginal Ring
A multi-center, open-label, randomized, two-period, crossover non-inferiority trial to assess the functionality of female condoms with a silicone elastomer vaginal ring.
- Trial name
- NCT01755754
- Testing
- Silicone Elastomer Vaginal Ring, Female Condom
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- International Partnership for Microbicides, Inc.
Stigma, Social, HIV/AIDS
Transgender Education for Affirmative and Competent HIV and Healthcare
Educational workshops are an efficacious strategy to increase healthcare providers' ability to provide gender-affirming care for transgender (trans) people.
- Conditions
- Stigma, Social, HIV/AIDS, Health Care Acceptability
- Trial name
- TEACHH (NCT04096053)
- Testing
- TEACHH
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Hepatitis B
Expression of Th9 Cells and Poor/Non-responsiveness to Hepatitis B Vaccination
An observational study will be performed in subjects aged 3-65 years old to describe the dynamic changes of cellular immunity after vaccination of hepatitis B vaccine, and to find out the expression levels of Th9 cells and IL9 in…
- Trial name
- NCT01441609
- Where
- China
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Beijing Municipal Science & Technology Commission
Diabetes Mellitus, Type 2, Hypertension
Scaling Up NCD Interventions in South East Asia
The SUNI-SEA study is an intervention study that measures effectiveness and cost-effectiveness of prevention and early diagnosis of diabetes and cardiovascular diseases in communities and primary healthcare (PHC) facilities in…
- Conditions
- Diabetes Mellitus, Type 2, Hypertension, Cardiovascular Diseases
- Trial name
- SUNI-SEA (NCT05239572)
- Testing
- screening, prevention and counselling
- Where
- Vietnam
- Volunteers
- 16,850 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
HIV Seroconversion, Stimulant Abuse
Biobehavioral Interventions for HIV-negative, Stimulant Using Men Who Have Sex With Men
This study seeks to evaluate the efficacy of a contingency management (CM) intervention compared to a yoked control condition for eliminating illicit stimulant use and for decreasing time to initiating post exposure prophylaxis…
- Trial name
- NCT01140880
- Testing
- Truvada
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Friends Research Institute, Inc.
Treponema Pallidum, Treponema Pallidum Infection
This Study Evaluates the ALPCO Syphilis-T and Syphilis-NT CLIA Kits for Detecting Syphilis Antibodies in Serum and Plasma. Samples From At-risk, HIV-positive, Pregnant, and Healthy Individuals Will Assess Assay Performance Versus Established Comparator Tests.
This study will evaluate the clinical performance of two investigational diagnostic kits developed by ALPCO: the Syphilis-T CLIA Kit and the Syphilis-NT CLIA Kit.
- Conditions
- Treponema Pallidum, Treponema Pallidum Infection, Syphilis Infection, Serum
- Trial name
- NCT07089836
- Testing
- ALPCO Syphilis-T, ALPCO Syphilis-NT CLIA Kits
- Where
- 6 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- American Laboratory Products Company
Hepatic Encephalopathy, Cirrhosis
Default Mode Network fMRI Maps as a Predictive Index of Hepatic Encephalopathy Outcome
Investigating the impact of hepatic encephalopathy on default mode networks within the brain to provide more clues with understanding the physiology of consciousness and predicting the reversibility of comatose states.
- Conditions
- Hepatic Encephalopathy, Cirrhosis, Nonalcoholic Steatohepatitis, Hepatitis C
- Trial name
- NCT02083367
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- OSF Healthcare System
Immune Defect
Immunological Responses in Bovine vs Mechanical Composite Grafts
In the first retrospective part of the study the investigators will conduct a data analysis of patients having received a bovine aortic graft.
- Trial name
- IRBOcomp (NCT04010396)
- Testing
- Blood sampling
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
AIDS, HIV Infections
Dose-ranging Study to Evaluate the Safety & Immunogenicity of a HIV Vaccine 732461 in Healthy HIV Seronegative Volunteers
GSK has constructed a new HIV immunogen comprised of conserved parts of the HIV virus (gag, pol and nef). The principal objectives of this study are to evaluate the reactogenicity and safety of this candidate vaccine with or…
- Trial name
- NCT00434512
- Testing
- HIV vaccine 732461
- Where
- Belgium
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Physicians' Perceptions on Physical Activity and Exercise for Health
Physicians' Perceptions on Physical Activity and Exercise in Non Communicable Diseases.
This descriptive, cross sectional study aims to investigate the knowledge, attitudes, intentions, abilities, and behavior of physicians who manage patients with chronic, non-communicable, diseases about physical activity and…
- Trial name
- NCT05176574
- Testing
- Questionnaire
- Where
- Greece
- Volunteers
- 546 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Non-communicable Diseases (NCD)
Enabling Environments for Non-communicable Disease Risk Reduction in Ethiopia
The ENABLE study focuses on pregnant women attending routine antenatal care (ANC) in urban primary health care facilities in four Ethiopian cities.
- Trial name
- ENABLE (NCT07442318)
- Testing
- Structured lifestyle counseling integrated into ANC, Standard routine ANC
- Where
- 4 sites in Ethiopia
- Volunteers
- 1,268 people, healthy volunteers welcome
- Sponsor
- Norwegian Institute of Public Health
Surveys and Questionnaires, Noncommunicable Diseases
Use of Airtime Timing to Improve Interactive Voice Response Surveys in Bangladesh and Uganda
This study evaluates the effect of two different airtime incentive timings on interactive voice response (IVR) survey cooperation, response, refusal and contact rates, as compared to a control group, in Bangladesh and Uganda.
- Trial name
- NCT04513236
- Testing
- Pre-survey incentive, Post-survey incentive
- Where
- 2 sites in Bangladesh, Uganda
- Volunteers
- 2,287 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Lung Cancer, Small Cell Lung Cancer
A Multicenter Clinical Trial of Sputum DNA Testing for Lung Cancer in China
The primary objective of this study is to assess the safety and effectiveness of Human Multigene Methylation Detection Kit (Fluorescent PCR Method) for help diagnose lung cancer by comparing with clinical standard method…
- Conditions
- Lung Cancer, Small Cell Lung Cancer, Non-Small Cell Lung Cancer, Squamous Cell Carcinoma
- Trial name
- NCT05337163
- Testing
- Diagnostic Test: Sputum DNA methylation analysis, chest CT or pathological examination
- Where
- China
- Volunteers
- 1,564 people, healthy volunteers welcome
- Sponsor
- Creative Biosciences (Guangzhou) Co., Ltd.
Salmonella Infections, Salmonella Typhimurium
Challenge Non-Typhoidal Salmonella (CHANTS) Study
This protocol describes the challenge non-typhoidal Salmonella (CHANTS) study. This is a first-in-human phase 1, double-blinded, randomised, dose-escalation human infection study, conducted in healthy volunteers aged 18 to 50…
- Conditions
- Salmonella Infections, Salmonella Typhimurium, Non-typhoidal Salmonella (NTS), Invasive Non-Typhoidal Salmonella Disease
- Trial name
- CHANTS (NCT05870150)
- Testing
- Salmonella Typhimurium
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Imperial College Healthcare NHS Trust
HIV Infections, Coronary Artery Disease
Coronary Artery Disease and Its Association With Liver Steatosis Among HIV-Infected Persons
The primary purpose of this study is to evaluate the association between nonalcoholic fatty liver disease (NAFLD) by computed tomography (CT) scan and coronary artery disease (CAD) measured by the calcium (CAC) score among…
- Conditions
- HIV Infections, Coronary Artery Disease, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT00889577
- Where
- United States
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Infectious Disease, Neoplasms
AnovaOS Network Powered Patient Registry
The objective of this study is the development, implementation and management of a registry of patient data that captures clinically meaningful, real-world, data on the diagnosis, nature, course of infection, treatment(s) and…
- Conditions
- Infectious Disease, Neoplasms, Diseases of the Blood and Blood-Forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89), Endocrine, Nutritional and Metabolic Diseases (E00-E89)
- Trial name
- NCT05013944
- Where
- United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Anova Enterprises, Inc