Clinical trials: Nicotine Vaping
Former Smoker, Non-Smoker
Vaped Phenanthrene
Some people who used to smoke cigarettes continue to be at higher risk of developing lung cancer, even years after quitting. This study will look to see if a specific chemical, phenanthrene, is broken down in the lungs of former…
- Trial name
- NCT07134426
- Testing
- D10-phenanthrene
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Smoking, Cigarette, Electronic Cigarette Use
Dual Use of ENDS and Combustible Cigarettes
This study investigates the degree to which shared behavioral processes underlie combustible cigarette (CC) and electronic nicotine delivery system (ENDS) use in young adult dual users of these products in both the laboratory and…
- Trial name
- DUET (NCT05280535)
- Testing
- Cue Reactivity Task, Computerized Visual Dot Probe, Choice Task
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Brown University
Electronic Cigarette Use
Assessing the Effect of Nicotine Reduction on ENDS User's Addiction and Exposures
The rapid increase of electronic nicotine delivery systems (ENDS) use by young people in the US and their potential to harm health, cause addiction, and serve as a risk for cigarette smoking or dual-use is alarming.
- Trial name
- NCT05205382
- Testing
- 5% nicotine (Partial Nicotine Reduction), 3% or 2.4% nicotine (Partial Nicotine Reduction), 5% nicotine (Total Nicotine Reduction)
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Florida International University
Vaping
Social Media Influences on Perceptions of Alternative Nicotine and Nicotine-like Vaping Products Among Youth and Young Adults (AYA)
The purpose of this study is to present images featuring various alternative nicotine and nicotine-like vaping products to assess adolescents' and young adults' harm and appeal perceptions of, and susceptibility to use these…
- Trial name
- USC TCORS P4 (NCT07849790)
- Testing
- An image resembling a social media post
- Where
- United States
- Volunteers
- 2,829 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Cervical Dysplasia
Smoking Cessation in Women With Gynecological Conditions
This feasibility study will compare two smoking cessation methods, traditional nicotine replacement therapy and Electronic Nicotine Delivery Systems (electronic cigarettes) in patients with gynecological conditions.
- Trial name
- NCT01989923
- Testing
- Nicotine Replacement Therapy, Electronic Cigarettes
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Lung Inflammation, HIV Seropositivity
Effects of E-cigarettes (ECIGs) on Pulmonary Inflammation and Behavior in HIV Infected Smokers
The purpose of this study is to determine if using e-cigarettes (ECIG) rather than regular tobacco cigarettes alters lung inflammation in people with and without HIV.
- Trial name
- NCT02848586
- Testing
- ECIGS, mobile contingency management (mCM), Usual brand
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Duke University
Substance Withdrawal Syndrome
Does Abstinence From E-cigarettes Produce Withdrawal Symptoms?
The purpose of this study is to see whether adults who use e-cigarettes every day experience symptoms of nicotine withdrawal when they stop using e-cigarettes for 6 days.
- Trial name
- NCT02825459
- Testing
- Abstinence from e-cigarettes
- Where
- 2 sites in United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Tobacco Use Disorder, Nicotine Dependence
Young Adult Tobacco/Nicotine and Cannabis Co-use
The goal of this project is to better understand the relationship between tobacco/nicotine and cannabis using behavioral economics during a tobacco/nicotine quit attempt.
- Trial name
- YouthCAT (NCT06239350)
- Testing
- Counseling, Contingency management, Text-based support
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Electronic Cigarette Use
Understanding Factors That Influence Electronic Cigarette Nicotine Delivery Through PET Imaging of Beta-2 Nicotinic Acetylcholine Receptors
The goal of this proposal is to test the overall hypothesis that e-cigarettes (ECs) provide efficient nicotine delivery to the brain and arterial blood in non-EC-naïve smokers and e-cigarette users and that EC liquid…
- Trial name
- NCT04258852
- Testing
- Low strength nicotine e-liquid, High strength nicotine e-liquid
- Where
- United States
- Sponsor
- Yale University
Vaping, E Cig Use
A Hybrid Program to Prevent Substance Use Risk Among Upper Elementary School Students Using a Positive Youth Development Approach
The goal of this randomized controlled trial is to evaluate a psychosocial school-based hybrid intervention which includes traditional classroom sessions and online e-learning modules to reduce risk of vaping and prescription…
- Conditions
- Vaping, E Cig Use, Prescription Drug Misuse
- Trial name
- NCT07162155
- Testing
- School-based Hybrid Intervention to Prevent Vaping and Prescription Drug Misuse
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Christopher Williams
Tobacco Smoking, Harm Reduction
Smoking Harm Reduction Using E-cigarettes and Cytisine
Smoking remains the leading cause of preventable death globally, with high prevalence in disadvantaged populations despite access to free nicotine replacement therapy (NRT) and counseling through Ontario's STOP Program.
- Conditions
- Tobacco Smoking, Harm Reduction, Nicotine
- Trial name
- SHRECC (NCT07274475)
- Testing
- E-cigarette e-liquid, Cytisine
- Volunteers
- 6,000 people
- Sponsor
- Centre for Addiction and Mental Health
Smoking, Carcinogenesis of the Nicotine
Determination of Carcinogens Nicotine in Electronic Cigarettes Users
Multicenter, national study, non-randomized , controlled, comparative with 4 independent groups (20 participants in each group).
- Trial name
- CANICE (NCT02897401)
- Testing
- pregnancy test, urinary cotinine assesment, Urinary NNN assesement
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
E-cigarette Use
Evaluating E-Cigarette Nicotine Form, Concentration, and Flavors Among Youth
This clinical trial examines the influence of nicotine form, concentration, and e-liquid flavor on youth vaping behavior, as well as the heart and lung effects associated with this behavior.
- Trial name
- NCT05458895
- Testing
- ECIG lab session 1, ECIG lab session 2, ECIG lab session 3
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Tobacco Use Cessation, Tobacco Use
Development of UP2UTeacher for High School Youth
Tobacco use is increasing among youth in the U.S. However evidence for the long-term effectiveness of tobacco prevention and cessation programs for youth is limited.
- Conditions
- Tobacco Use Cessation, Tobacco Use, Electronic Cigarette Use
- Trial name
- UP2UTeacher (NCT05396911)
- Testing
- UP2UTeacher
- Where
- United States
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Cannabis Use, THC
Cannabis THC Potency, Metabolism, and Cognitive Impairment in Young Adults
The goal of this interventional study is to determine the impact of high potency THC product use on cognitive function of young adults aged 21-25.
- Conditions
- Cannabis Use, THC, Marijuana Use, Cognitive Impairment
- Trial name
- THC-YA (NCT06077292)
- Testing
- 15% THC Potency Reduction, 35% THC Potency Reduction
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cigarette Smoking, Addiction
Electronic Cigarettes as a Harm Reduction Strategy in Individuals With Substance Use Disorder
Patients in addiction treatment have exceptionally higher rate of cigarette smoking and very low quit rates compared to the general population.
- Conditions
- Cigarette Smoking, Addiction, E Cig Use
- Trial name
- NCT04063267
- Testing
- E cigarettes, Nicotine Replacement Therapy
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Healthy
Acute Cardiorespiratory Effects of E-cigarette Inhalation
According to the World Health Organization cigarette smoking is today one of the leading single causes of preventable death and morbidity.
- Trial name
- NCT02899234
- Testing
- E-cigarette
- Where
- Sweden
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Umeå University
Nicotine Dependence, Electronic Cigarette Use
E-cigarette Nicotine Study
This is a pilot randomized controlled trial (RCT) with the overarching aim of testing the influence of reducing electronic nicotine delivery system (ENDS) use or nicotine on addiction and combustible cigarette (CC) smoking among…
- Conditions
- Nicotine Dependence, Electronic Cigarette Use, Cigarette Smoking
- Trial name
- NCT04709471
- Testing
- Nicotine, Juul e-cigarette, Reduction
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Role of Tobacco Harm Reduction in Smoking Cessation, Efficiency and Efficacy of E-cigarettes and Nicotine Pouches
Electronic Cigarettes and Nicotine Pouches for Smoking Cessation
Pakistan is one of the most vulnerable low- and middle-income countries with 29 million adult active tobacco users. Smoking cessation services are lacking as the tobacco control initiatives have largely failed to address the…
- Conditions
- Role of Tobacco Harm Reduction in Smoking Cessation, Efficiency and Efficacy of E-cigarettes and Nicotine Pouches, Adverse Effect of E-cigarettes and Nicotine Pouches
- Trial name
- NCT05715164
- Testing
- E-cigarettes device plus liquid, Nicotine Pouches, Basic care counseling about smoking cessation
- Where
- Pakistan
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Alternative Research Initiative
Nicotine Dependence, Cigarettes
Epidemiology and Acute Oral Effects Electronic Cigarette
Electronic cigarettes are battery-powered vaporizers which have a similar feel to tobacco smoking. They do not produce cigarette smoke but rather an aerosol, which is frequently referred to as vapor.
- Trial name
- NCT03011710
- Testing
- ProVari v2.5 (E-cigarette), Marlboro Gold (Conventional cigarette), Cigarette tip
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Semmelweis University