Clinical trials: Nicotine Vaping
Tobacco Use Disorder, Nicotine Dependence
TUBSIS 2.0 - Tobacco Use Behavioral Support and Intervention System
Background: Tobacco smoking and vaping remains public health concern, with many adults continuing to experience difficulties accessing appropriate support for smoking cessation in Switzerland and Türkiye.
- Conditions
- Tobacco Use Disorder, Nicotine Dependence, Vaping, Smoking Tobacco
- Trial name
- TUBSIS_2_0 (NCT07568483)
- Testing
- TUBSIS 2.0
- Where
- Switzerland
- Volunteers
- 406 people
- Sponsor
- University of Zurich
Tobacco Use, Nicotine Pouch Self-Administration
Comparison of Demand and Substitution for Nicotine Pouches as a Function of Nicotine Dosage
Smoking is a prominent public health issue. Traditional nicotine replacement therapy suffers from being a poor substitute for cigarettes.
- Trial name
- NCT07213947
- Testing
- Nicotine Pouch Dosage
- Where
- United States
- Volunteers
- 1,360 people
- Sponsor
- William Middleton
Electronic Nicotine Delivery Systems, Tobacco Products
Development of a Mobile Health Intervention for Electronic Cigarette Use Among Young Adults
Electronic Nicotine Delivery Systems (ENDS) use remains prevalent among young adults, and many have high interest in quitting, yet research on effective intervention is lacking.
- Conditions
- Electronic Nicotine Delivery Systems, Tobacco Products, Cigarette Smoking
- Trial name
- EQUIP (NCT06395415)
- Testing
- EQUIP, Standard Care
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Electronic Nicotine Delivery System Flavors
Potential Effects of Electronic Nicotine Delivery System Flavor Regulations on African American Menthol Smokers
This study aims to better understand how the availability of electronic nicotine delivery system (aka electronic cigarettes) flavors (e.g., menthol, tobacco) impacts tobacco use behaviors, toxicant exposure, and abuse liability…
- Trial name
- RVA Flavors (NCT05023096)
- Testing
- Tobacco product administration and assessment
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cigarette Smoking, Nicotine Vaping
Examining the Generality of Laboratory-based Findings and Their Moderators in the ITC Study
This study will investigate the relative appeal (abuse liability) of novel tobacco products, how the appeal is modulated by relative price, user type, and how novel products may substitute for one another.
- Trial name
- MUSC-R 3a (NCT06456671)
- Testing
- All nicotine/ tobacco products at market price, Nicotine vaping products at 1/2 market price, Heated tobacco products at 1/2 market price.
- Where
- United States
- Volunteers
- 440 people
- Sponsor
- Virginia Polytechnic Institute and State University
Nicotine Dependence, Tobacco Toxicity
Pharmacokinetics and Pharmacodynamics of Nicotine With Use of Standardized Research Electronic Cigarette (SREC)
This is a crossover study that will examine use behaviors, chemical exposures, and biological effects of Standardized Research Electronic Cigarette (SREC) compared to usual brand e-cigarette use in natural or synthetic nicotine…
- Conditions
- Nicotine Dependence, Tobacco Toxicity, Cardiovascular Risk Factors
- Trial name
- SREC22 (NCT05658471)
- Testing
- Standardized Research E-Cigarette (SREC), Over the Counter E-Cigarette (EC), Biological Samples
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Tobacco Smoking, Harm Reduction
Smoking Harm Reduction Using E-cigarettes and Cytisine
Smoking remains the leading cause of preventable death globally, with high prevalence in disadvantaged populations despite access to free nicotine replacement therapy (NRT) and counseling through Ontario's STOP Program.
- Conditions
- Tobacco Smoking, Harm Reduction, Nicotine
- Trial name
- SHRECC (NCT07274475)
- Testing
- E-cigarette e-liquid, Cytisine
- Volunteers
- 6,000 people
- Sponsor
- Centre for Addiction and Mental Health
E-cigarette Use/Vaping Prevention, Nicotine Dependence Prevention
A Virtual Reality E-cigarette Prevention and Emotion Regulation Intervention for Adolescents
This study will examine E-Invite Only VR, a novel school-based universal e-cigarette prevention intervention that uses virtual reality (VR) to deliver prevention and emotion regulation skills-building content to middle school…
- Conditions
- E-cigarette Use/Vaping Prevention, Nicotine Dependence Prevention, Adolescent Mental Health
- Trial name
- NCT07460622
- Testing
- Virtual Reality E-Cigarette Prevention Program
- Where
- United States
- Volunteers
- 1,251 people, healthy volunteers welcome
- Sponsor
- Yale University
Cigarette Smoking, Nicotine Vaping
Promotion and Mitigation Factors Leading to Illegal Tobacco Purchases
This study will investigate the effects of promotion factors and mitigation strategies on legal and illegal tobacco purchases for different tobacco-user types.
- Trial name
- NCT06001840
- Testing
- Promotion factors, Mitigation strategies
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Virginia Polytechnic Institute and State University
Electronic Cigarette Use, Smoking, Cigarette
Assessing E-Cigarettes for Tobacco Harm Reduction in the Context of Lung Cancer Screening
This study investigates the feasibility, acceptability, and short-term effects of providing 4 weeks of complimentary electronic cigarettes (ECs) to 30 individuals who did not quit after smoking cessation treatment provided in the…
- Conditions
- Electronic Cigarette Use, Smoking, Cigarette, Nicotine Dependence
- Trial name
- NCT06472869
- Testing
- NJOY ACE e-cigarette
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Massachusetts General Hospital
Nicotine Addiction
Developing Evidence to Inform Regulatory Policy on Nicotine Content in E-Liquids
The goal of this observational study is to learn if electronic cigarette users who currently choose to use lower nicotine eliquids have reduced harm compared those who choose higher nicotine eliquids.
- Trial name
- NCT06619964
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Rochester Institute of Technology
Addiction Nicotine
The CONQUER Trial - Cessation Of Nicotine, QUitting With E-cigarette Reduction
This clinical trial evaluates the VapeAway system, a novel, multi-modal intervention designed to address the multifaceted nature of vaping addiction.
- Trial name
- CONQUER (NCT07322432)
- Testing
- VapeAway filter system
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- VapeAway
E-cigarette Use, Vaping
A Trial of Varenicline for E-cigarette Cessation
This is randomized, placebo-controlled clinical trial in treatment-seeking adults who report regular e-cigarette use to test the hypothesis that varenicline is efficacious for quitting e-cigarettes.
- Conditions
- E-cigarette Use, Vaping, Nicotine Dependence
- Trial name
- NCT07040566
- Testing
- Varenicline 1mg BID
- Where
- 2 sites in United States
- Volunteers
- 326 people
- Sponsor
- Yale University
Nicotine Vaping
Nicotine Flux, a Potentially Powerful Tool for Regulating Nicotine Delivery From Electronic Cigarettes
The investigators will examine the relationship between nicotine flux, nicotine form, and the rate and dose of nicotine delivery.
- Trial name
- NCT05706701
- Testing
- Nicotine vaping visit 1 (free-base nicotine), Nicotine vaping visit 1 (protonated nicotine), Nicotine vaping visit 2 (free-base nicotine)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Yale University
Nicotine Administration & Dosage, E-cigarettes
Evaluating the Comparative Pharmacokinetics of Nicotine After Administration Via JUUL or Tobacco Cigarettes
This is an observational, crossover design that will examine the pharmacokinetics and pharmacodynamics of impact of smoking tobacco cigarettes or vaping the JUUL electronic cigarette.
- Conditions
- Nicotine Administration & Dosage, E-cigarettes, Vaping, E-Liquid
- Trial name
- NCT04053868
- Testing
- JUUL, Tobacco
- Where
- 2 sites in United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Smoking Electronic Cigarettes (Vaping), With Moderate and High Dependence for Nicotine
EFFECT OF WIM HOF BREATHING EXERCISE ON VENTILATORY FUNCTIONS IN SMOKERS
Cigarette smoking is the most common form of tobacco use worldwide, but other tobacco products, such as e-cigarettes, cigars, cigarillos, roll-your-own, pipes, and various smokeless tobacco products are also damaging.
- Trial name
- NCT07153640
- Testing
- 1 ) Wim Hof Breathing Exercise, 2) Aerobic exercises
- Where
- Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- October 6 University
E-cigarette, Vaping
Understanding Vape Marketing Study
The purpose of this study is to develop an electronic cigarette (e-cigarette) counter-marketing lesson for adolescents. The lesson will involve short videos designed to improve adolescents' cognition of e-cigarette marketing in…
- Conditions
- E-cigarette, Vaping, Tobacco, Nicotine
- Trial name
- NCT07129265
- Testing
- Working group, Focus group
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Cardiovascular Risk Factor, Nicotine Dependence
Short-Term Cardiovascular Effects of E-Cigarettes: Influence of E-Liquid pH
This study will examine the short-term cardiovascular (CV) effects of e-liquid pH in a randomized, crossover clinical and behavioral pharmacology study of experienced adult e-cigarette users (N=21).
- Trial name
- TCORS-2 (NCT04449510)
- Testing
- Electronic Cigarette
- Where
- 2 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Nicotine Vaping
Pilot Study of the YES-CAN! Program to Prevent Youth Nicotine Vaping
The goal of this pilot study is to determine the feasibility of a randomized trial of the YES-CAN! (Youth Engaged Strategies to Change Adolescent Norms) program to prevent nicotine vaping among adolescents.
- Trial name
- YES-CAN! (NCT07009509)
- Testing
- YES-CAN! program
- Where
- United States
- Volunteers
- 1,166 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Nicotine Dependence, Nicotine Addiction
A Smartphone Application (ACT on Vaping) for Vaping Cessation in Young Adults
Almost one in ten young adults report current e-cigarette use, putting them at risk of developing nicotine addiction and long-term health effects of exposure to inhaled toxicants.
- Conditions
- Nicotine Dependence, Nicotine Addiction, Nicotine Use Disorder, Nicotine Vaping
- Trial name
- NCT05897242
- Testing
- Smartphone app, Text Message, Survey Administration
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center