Clinical trials: Nicotine Use Disorder, open to volunteers
Tobacco Use Disorder
Effect of Orexin System on Nicotine Addiction and Its Neural Mechanism
The goal of this clinical trial is to reveal the role and mechanism of orexin in nicotine addicts, compared to healthy control. The main questions it aims to answer are: Whether nicotine addiction-related behaviors, including…
- Trial name
- NCT05947162
- Testing
- extinction training (nicotine cues), extinction training (neutral cues), Time-restricted smoking cessation
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Shenzhen Kangning Hospital
Nicotine Use Disorder
Identify the Optimal TMS Target to Modulate Reward Activity
Our primary goal will be to identify the optimal prefrontal-cingulate target by systematically measuring the efficacy of various image-based targeting techniques to increase the reward positivity using the 10-Hz TMS protocol in…
- Trial name
- NCT05766254
- Testing
- Active 10-Hz TMS to the DLPFC
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Rutgers, The State University of New Jersey
Nicotine Dependence, Nicotine Vaping
Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine
In a crossover study, experienced electronic cigarette users will vape 3 different forms of nicotine: natural (derived from tobacco), synthetic, or a 50:50 mixture of both natural and synthetic.
- Trial name
- NCT05962229
- Testing
- (S)-Nicotine, (R)- nicotine, Racemic nicotine
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pregnancy in Adolescence
Teen motHers' ReproductIve and behaVioral Health intErvention in Barbados
The goal of this clinical trial is to learn if an integrated care program can help improve overall health and prevent repeat pregnancy in teen mothers in Barbados.
- Trial name
- THRIVE (NCT07149948)
- Testing
- THRIVE Integrated Care Program
- Where
- Barbados
- Volunteers
- 50 people
- Sponsor
- Hada Fongha Ieong, PhD
Smoking
Implementation of Transcranial Magnetic Stimulation for Smoking Cessation
Repetitive transcranial magnetic stimulation (rTMS) is an alternative non-invasive treatment to help people quit smoking. rTMS uses a magnetic field to stimulate regions of the brain that are involved in addiction.
- Trial name
- NCT06346028
- Testing
- Brainsway H4 deep rTMS coil and Brainsway stimulator system
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Substance Use Disorder, Alcohol Use Disorder
Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRP
Background: People who will participate in research studies need to undergo proper screening, evaluation, and assessment (SEA). SEA helps keep those who participate in studies safe. It also helps ensure accurate study results.
- Trial name
- NCT06552741
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Dependence
Orexin s Role in the Neurobiology of Substance Use Disorder
Study Description: Despite the availability of pharmacotherapy for some substance use disorders, relapse vulnerability is still a significant issue.
- Trial name
- NCT05630781
- Testing
- Belsomra, Methylphenidate
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Periodontitis, Smoking Cessation
Effect of Nicotine Gingival Fibroblast Intoxication on the Response of Periodontal Treatment
Impact of nicotine gingival intoxication on the clinical outcomes after periodontitis non surgical treatment
- Conditions
- Periodontitis, Smoking Cessation, Tobacco Dependence
- Trial name
- ENIPT's (NCT07491627)
- Testing
- periodontal non-surgical treatment
- Where
- Belgium
- Volunteers
- 56 people
- Sponsor
- University of Liege
Nicotine Dependence, Transcranial Magnetic Stimulation
Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study)
The goal of this clinical trial is to learn if a combination of varenicline and enhanced accelerated Transcranial Magnetic Stimulation (aTMS) works to help adults quit using nicotine products.
- Conditions
- Nicotine Dependence, Transcranial Magnetic Stimulation, Vaping, Smoking Cessation
- Trial name
- V-TMS (NCT07145866)
- Testing
- Varenicline, Transcranial Magnetic Stimulation, Nicotine Cessation Counseling
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Nicotine Dependence, Thoracic Diseases
Effect of Perioperative High-dose Transdermal Nicotine Patch on Pain Sensitivity Among Male Abstinent Tobacco Smokers Undergoing Thoracic Surgery: A Randomized Controlled Pilot Study
Globally, approximately 230 million adults undergo surgical procedures each year, with around 30% of patients maintaining smoking habits prior to surgery.
- Conditions
- Nicotine Dependence, Thoracic Diseases, Analgesia
- Trial name
- NCT07250230
- Testing
- Nicotine patch
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Henan Provincial People's Hospital
Nicotine Dependence
Effects of Psilocybin on Craving in Nicotine Dependence
This pilot study will examine how a single 25 mg dose of psilocybin affects nicotine craving in people with nicotine dependence.
- Trial name
- SCANS-PSIL (NCT07852832)
- Testing
- Psilocybin (drug)
- Volunteers
- 3 people
- Sponsor
- University of British Columbia
Tobacco Use
Cardiovascular Effects of Very Low Nicotine Content Cigarettes
The study is measuring Cardiovascular effects of very low nicotine content cigarettes on daily and non-daily smokers
- Trial name
- CEV (NCT05707871)
- Testing
- SPECTRUM cigarettes, usual brand of Cigarettes
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Behavioral Intervention, Nicotine Addiction
Impact of Appointment Reminder Strategies on Smoking Cessation Clinic Attendance
The goal of this clinical trial is to learn whether different appointment reminder methods can improve attendance at an anti-smoking (smoking cessation) clinic among adult smokers.
- Trial name
- NO-SHOW-NCC (NCT07779161)
- Testing
- Standard phone call, phone call with MINDSPACE elements
- Where
- Poland
- Volunteers
- 300 people
- Sponsor
- Medical University of Gdansk
Smoking Cessation, Nicotine Addiction
Circuitry-Guided Smoking Cessation in Schizophrenia (UH3)
Patients with schizophrenia spectrum disorder (SSD) will be exposed to active repetitive transcranial magnetic stimulation (rTMS) from F8 coil or active rTMS from H coil for smoking cessation.
- Conditions
- Smoking Cessation, Nicotine Addiction, Schizophrenia
- Trial name
- NCT05276050
- Testing
- active F8-coil delivered rTMS, active H-coil delivered rTMS
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The University of Texas Health Science Center, Houston
Community Health Services, Respiratory Disease
INSPIRE Respiratory Health Program in Botucatu, São Paulo, Brazil
The goal of this observational study is to evaluate the implementation of the INSPIRE program and to plan actions for the preparation, coordination, monitoring, diagnosis, and treatment of respiratory diseases in the municipality…
- Conditions
- Community Health Services, Respiratory Disease, Tobacco Smoking
- Trial name
- NCT06673225
- Testing
- Analysis of results
- Where
- Brazil
- Volunteers
- 2,000 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Vaping, Vaping Cessation
Social Media Support Groups for Adolescent Vaping Cessation
The purpose of this study is to pilot test feasibility and acceptability of the Quit the Hit Toolkit, a social media-based nicotine vaping cessation program for adolescents and young adults, adapted for use in community settings.
- Conditions
- Vaping, Vaping Cessation, Nicotine Dependence
- Trial name
- NCT07540780
- Testing
- Social Media Intervention
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Nicotine Dependence, Tobacco Smoking
Smoking Cessation and Menstrual Cycle Phase
Tobacco use is a risk factor for at least 20 types of cancer and remains the leading preventable cause of cancer in Canada. Smoking cessation is an important cancer prevention strategy for the close to 2 million Canadian women…
- Conditions
- Nicotine Dependence, Tobacco Smoking, Smoking Cessation, Nicotine Use Disorder
- Trial name
- MC-NRT (NCT05515354)
- Testing
- Timing of nicotine replacement therapy start date, Nicotine Replacement Therapy Agent
- Where
- Canada
- Volunteers
- 1,200 people
- Sponsor
- Centre for Addiction and Mental Health
Tobacco Use Disorder
Increasing Smoking Cessation Success Through Sleep-amplified Memory Consolidation
The goal of this subproject is to examine the hypothesized improvement of treatment with chess-based training and sleep enhancement, both together and on their own, in smokers.
- Trial name
- NCT05726045
- Testing
- Standard smoking cessation program (SCP), Cognitive remediation treatment (CRT), High-intensity interval training (HIIT evening)
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Nicotine Addiction
Non-Invasive Deep Brain Neuromodulation for Smoking Cessation
This study will develop novel low intensity focused ultrasound (LIFU) therapy to help people to quit cigarette smoking. Smoking is associated with cancers of the lung. Available smoking cessation methods help many to quit.
- Trial name
- NCT07298902
- Testing
- Low intensity focused ultrasound with active stimulations
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
E-cigarette Use/Vaping Prevention, Nicotine Dependence Prevention
A Virtual Reality E-cigarette Prevention and Emotion Regulation Intervention for Adolescents
This study will examine E-Invite Only VR, a novel school-based universal e-cigarette prevention intervention that uses virtual reality (VR) to deliver prevention and emotion regulation skills-building content to middle school…
- Conditions
- E-cigarette Use/Vaping Prevention, Nicotine Dependence Prevention, Adolescent Mental Health
- Trial name
- NCT07460622
- Testing
- Virtual Reality E-Cigarette Prevention Program
- Where
- United States
- Volunteers
- 1,251 people, healthy volunteers welcome
- Sponsor
- Yale University