Clinical trials: Nicotine Addiction
Tobacco Use Disorder
Safety of Combining Modafinil and Nicotine Replacement Therapy in Treating Nicotine Dependent Adolescents
Nicotine is one of the most widely abused substances in the United States. Nicotine replacement therapy (NRT) is currently an effective treatment for nicotine dependence; however, even with NRT most people fail at quitting…
- Trial name
- NCT00258479
- Testing
- ModafinilNicotine Replacement Therapy, Modafinil
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Catherine Martin, MD
Tobacco Dependence
Measuring Neuroadaptations in Response to Very Low Nicotine Content Cigarettes
The overall goal of this study is to determine if switching to very low nicotine content cigarettes changes the function of brain circuitry involved in incentive salience and executive control among dependent smokers.
- Trial name
- NCT03612960
- Testing
- Very low nicotine content cigarettes, Normal nicotine content cigarettes
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Milton S. Hershey Medical Center
HIV Infections, AIDS
HIV Infection and Tobacco Use Among Injection Drug Users in Baltimore, Maryland: A Pilot Study of Biomarkers
Background: The incidence of lung cancer is quite high among people with the human immunodeficiency (HIV) virus. Frequent smoking may explain that cancer increase, given that 50% to 70% of HIV-infected people are current smokers.
- Conditions
- HIV Infections, AIDS, Lung Cancer, Tobacco Addiction
- Trial name
- NCT00491335
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Nicotine Dependence
Do Flavors Increase the Addiction Potential of Nicotine?
The FDA has concluded that flavors (e.g. menthol) are associated with greater addiction potential in tobacco cigarettes (Gottlieb March 13, 2019).
- Trial name
- NCT04696380
- Testing
- Nicotine, JUUL e-cigarette
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Vermont