Clinical trials: Nicotine
Psychology, Social, Smoking Cessation
Mindset Intervention for Nicotine Dependence
This study evaluates a new digitally delivered mindset based intervention in addition to a smartphone application (app) for smoking cessation.
- Conditions
- Psychology, Social, Smoking Cessation, Smoking (Tobacco) Addiction
- Trial name
- MIND (NCT03174730)
- Testing
- Growth Mindset, SmartQuit
- Where
- United States
- Volunteers
- 398 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Tobacco Use Disorder
Low Nicotine Content Cigarettes in Vulnerable Populations: Opioid Use Disorder
Prevalence of smoking among individuals with opioid use disorder (OUD) is six-fold that of the general US adult population. The mortality rate of opioid-dependent smokers is four times that of opioid-dependent nonsmokers, and…
- Trial name
- NCT04092101
- Testing
- Cigarettes with varying nicotine content, E-Cigarettes
- Where
- 2 sites in United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Smoking
CSD1602: A Crossover Study to Evaluate the Exposure to "Tar" and Nicotine From Two King Size Menthol Cigarette Products
This study will evaluate exposure to "tar" and nicotine from two menthol cigarette products and provide a basis for comparing mouth-level exposure when smokers smoke the two cigarette products.
- Trial name
- NCT03063034
- Testing
- PD21864AA, PD21864AB
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Nicotine Dependence
Trial on the Effectiveness of Mindfulness Training for Smokers
The Mindfulness Training for Smokers study follows a randomized controlled design with 240 total participants. Both the study group and the control group will be enrolled in the Wisconsin Tobacco Quit Line and will receive four…
- Trial name
- MTS (NCT01093599)
- Testing
- Quit Line plus MTS, Quit Line Only
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- University of Wisconsin, Madison
Tobacco Use Disorder, Cannabis Use Disorder
Varenicline for the Treatment of Cannabis and Tobacco Use Disorders in Veterans
After initial eligibility screening, Veterans who use both cannabis and tobacco will be randomly assigned to receive either varenicline (Chantix) or placebo for 12 weeks.
- Trial name
- Vet Cat (NCT05294263)
- Testing
- Varenicline
- Where
- United States
- Sponsor
- VA Office of Research and Development
Smoking
Ginglival Health Among Smokers Visiting Dental Hospital
The effect of different forms of nicotine intake on the gingival health of dental patients that visited a public sector in Islamabad.
- Trial name
- NCT06424600
- Testing
- Gingival Index
- Where
- Pakistan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Medical Sciences
Down Syndrome, Mild Cognitive Impairment
Nicotine Treatment of Cognitive Decline in Down Syndrome
This study will ascertain whether nicotine is safe and tolerable in DS patients, help with dose-ranging of nicotine in DS, look for evidence of enhancements in cognitive functioning, and establish evidence for biological and…
- Trial name
- NCT01778946
- Testing
- Low Dose Nicotine (7mg), Moderate Dose Nicotine (14mg)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Vanderbilt University Medical Center
Smoking, Smoking Cessation
Wisconsin Tobacco Quit Line Medicaid Incentive Evaluation
The study is designed to test the hypotheses that financial incentives can increase both participation in smoking cessation treatment and resulting cessation rates, when they are offered to BadgerCare Plus (Medicaid) smokers as…
- Conditions
- Smoking, Smoking Cessation, Nicotine Dependence
- Trial name
- NCT02713594
- Testing
- Counseling from WTQL, Financial incentive to participate
- Volunteers
- 1,900 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Tobacco Use
Oral Nicotine Pouch Marketing Features Influence on Perceptions
This study tests the effects of three oral nicotine marketing features on product perceptions.
- Trial name
- NCT06605924
- Testing
- Tobacco-free, Discrete, Convenient
- Where
- United States
- Volunteers
- 5,133 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Tobacco Use Disorder
Nicotine Lozenge to Reduce Smokeless Tobacco Use
Smokeless tobacco (ST), which includes both chewing tobacco and snuff, has as many health risks associated with its use as cigarettes.
- Trial name
- NCT00218283
- Testing
- Nicotine Lozenge, Behavioral Counseling
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence, Nicotine Dependence
Efficacy of Varenicline in Methadone-Stabilized Cocaine Users
Cocaine addiction continues to be an important public health problem in the US with a significant cost to the individual and society.
- Trial name
- NCT00567320
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Yale University
Cigarette Smoker, Tobacco Use Disorder
Behavioral Activation Therapy and Nicotine Replacement Therapy in Increasing Smoking Cessation
This randomized clinical trial studies how well behavioral activation therapy and nicotine replacement therapy work in increasing smoking cessation.
- Trial name
- NCT02697227
- Testing
- Behavioral Intervention, Laboratory Biomarker Analysis, Nicotine Patch
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Smoking
Pilot Study: Preoperative Nicotine Lozenges
The goal of this pilot study is to determine the feasibility and potential effect size of nicotine lozenges as an adjunct to maintain brief preoperative abstinence, defined as not smoking the day of surgery.
- Trial name
- NCT00586482
- Testing
- Nicotine Lozenge, Abstinence Advisement
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Mayo Clinic
NIRS, Tissue Oxygenation
CHECK-NIRS2D-Study
The study investigates how external, physiological, and behavioral factors influence the measurement of regional tissue oxygenation using two-dimensional near-infrared spectroscopy (NIRS) imaging in healthy volunteers.
- Conditions
- NIRS, Tissue Oxygenation, Microvascular Perfusion, Vascular Occlusion Test
- Trial name
- NCT07854431
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Nicotine Dependence
Evaluation of Learning-Theory-Based Smoking Cessation Strategies
This clinical trial tested whether a new treatment designed to help smokers prepare to quit smoking by practicing quitting several times helped more smokers quit and stay quit than standard treatment with nicotine patch and…
- Trial name
- NCT01368653
- Testing
- Standard treatment, Standard treatment+practice quitting, Very low nicotine cigarettes
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Rutgers University
Stress Disorders, Posttraumatic, Tobacco Use Disorder
Nicotine Patch Pretreatment for Smoking Cessation in PTSD
This study seeks to evaluate the relationship between PTSD, abstinence, and factors associated with relapse in the context of a randomized, clinical smoking cessation trial.
- Trial name
- NCT00625131
- Testing
- Nicotine, Cognitive Behavioral Therapy for Smoking Cessation, Bupropion Sustained Release (SR)
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Pedophilia
Prevent It 2.0/PRIORITY - An iCBT to Reduce the Risk of Committing Child Sexual Abuse
Child sexual exploitation and abuse is a large-scale global issue that has been drastically rising since the advent of the internet that has brought about communication technologies enabling new ways to sexually abuse children.
- Trial name
- NCT05831657
- Testing
- Prevent It 2.0, Waitlist
- Where
- 3 sites in Germany, Portugal and 1 more
- Volunteers
- 205 people
- Sponsor
- Karolinska Institutet
Tinnitus, Chronic Subjective Tinnitus
Acute Nicotine Gum and Auditory Brain Responses in Adults With Chronic Tinnitus
This study tests whether a single dose of nicotine gum changes brain responses to sounds and the ability to detect target sounds in non-smoking adults with chronic tinnitus.
- Trial name
- NCT07877701
- Testing
- Nicotine polacrilex gum 4 mg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Xianhui Wang
Depressive Disorder
Effect of Nicotine on Brain Reward Pathways
The investigators will determine whether an acute dose of nicotine, in the form of the nicotine lozenge, impacts brain and behavioral measures of mood and reward responsiveness in individuals with major depressive disorder.
- Trial name
- NCT02346539
- Testing
- Nicotine polacrilex
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Cigarette Smoking Toxicity, Nicotine
The Acute Cardiovascular Effects of Nicotine in E-cigarettes (ACE) Study
The goal of this project is to evaluate the nicotine induced acute cardiovascular changes in E-Cigarette users and also study the mechanism involved particularly with vascular impairment.
- Conditions
- Cigarette Smoking Toxicity, Nicotine, Acute Cardiovascular Disease
- Trial name
- ACE (NCT03010995)
- Testing
- Prazosin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Louisville