Clinical trials: New Onset
Atrial Fibrillation
Predicting Patient-level New Onset Atrial Fibrillation
Atrial fibrillation (AF) is a major cardiovascular health problem: it is common, chronic and incurs substantial health-care expenditure as a result of stroke, sudden death, heart failure and unplanned hospitalisation.
- Trial name
- NCT04657900
- Testing
- Observational
- Where
- United Kingdom
- Volunteers
- 140,000 people
- Sponsor
- University of Leeds
Epilepsy
A Study to Investigate the Safety of the Drugs Topiramate and Levetiracetam in Treating Children Recently Diagnosed With Epilepsy
The purpose of this study is to evaluate the safety of topiramate monotherapy compared with levetiracetam another standard antiepileptic drug (AED), as monotherapy for new-onset or recent-onset epilepsy (seizure disorder) on…
- Trial name
- NCT02201251
- Testing
- Topiramate, Levetiracetam
- Where
- 41 sites in United States, Argentina and 12 more
- Volunteers
- 63 people
- Sponsor
- Janssen Research & Development, LLC
Type 1 Diabetes Mellitus, New-onset Type 1 Diabetes Mellitus
Tocilizumab (TCZ) in New-onset Type 1 Diabetes
Type 1 diabetes mellitus (T1DM) is an autoimmune disease. Based on previous research, study doctors think that giving medicines to affect the immune system soon after diabetes is diagnosed may stop, delay or decrease the…
- Conditions
- Type 1 Diabetes Mellitus, New-onset Type 1 Diabetes Mellitus, T1DM, T1D
- Trial name
- EXTEND (NCT02293837)
- Testing
- Tocilizumab (TCZ), Standard of Care
- Where
- 19 sites in United States, Australia
- Volunteers
- 136 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type 1 Diabetes
Atorvastatin in New Onset Type 1 Diabetes Mellitus (T1DM)
The goal of this application is to evaluate the safety and efficacy of atorvastatin as a potential treatment to preserve beta cell function in children and young adults with newly diagnosed type 1 diabetes (T1DM).
- Trial name
- TIDM (NCT00529191)
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Hospital of Philadelphia
Crohn Disease
Thalidomide Versus Infliximab in New Onset Crohn's Disease With Poor Prognostic Factors
Crohn's disease (CD) is a life-long inflammatory bowel disease disease with an unknown pathogenesis. The ultimate goal of therapy is to modify the natural history of CD thus reducing complications.
- Trial name
- NCT03221166
- Testing
- Thalidomide, Infliximab
- Where
- 6 sites in Italy
- Volunteers
- 9 people
- Sponsor
- IRCCS Burlo Garofolo
Hyperglycemia
Insulin Therapy for the Prevention of New Onset Diabetes After Transplantation Prospective Study in Non-Diabetic De Novo Kidney Transplant Recipients
This study aims to assess the effects of early basal insulin therapy in previously non-diabetic de novo kidney transplant patients in reducing the incidence of new onset diabetes in particular and abnormal glucose metabolism in…
- Trial name
- ITP-NODAT (NCT03507829)
- Testing
- Human insulin isophane, Humulin N (Eli Lilly), Standard of care, Insulin lispro, Humalog (Eli Lilly) in insulin pump
- Volunteers
- 263 people
- Sponsor
- Medical University of Vienna
Atrial Fibrillation New Onset
High Sensitivity Estimate of the Incidence of Atrial Fibrillation Occurring Transiently With Stress (AFOTS Incidence Study)
BACKGROUND: Atrial fibrillation (AF) is the most common serious heart rhythm disorder and is associated with a 4 to 5-fold increase in the risk of ischemic stroke.
- Trial name
- NCT03552588
- Testing
- Continuous Electrocardiogram
- Where
- Canada
- Volunteers
- 249 people
- Sponsor
- Population Health Research Institute
Aortic Valve Disease, Conduction Disturbances
Ambulatory Electrocardiographic Monitoring for the Detection of High-Degree Atrio-Ventricular Block in Patients With New-onset PeRsistent LEft Bundle Branch Block After Transcatheter Aortic Valve Implantation. The "MARE" Study
The purpose of this study is to determine the incidence and predictors of high degree or complete atrioventricular block (AVB) (paroxysmal or persistent) in patients with new-onset persistent left bundle branch block (NOP-LBBB)…
- Trial name
- MARE (NCT02153307)
- Testing
- Implantable loop recorders system Reveal ICM LINQ®,
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
New Onset Atrial Fibrillation, Sepsis
Rapid Atrial Fibrillation Treatment Strategy
Prospective, randomized, open-label clinical trial studying the treatment of new onset atrial fibrillation in critically ill patients with septic shock.
- Conditions
- New Onset Atrial Fibrillation, Sepsis, Respiratory Failure
- Trial name
- RAFTS (NCT04092621)
- Testing
- Amiodarone in Parenteral Dosage Form, Amiodarone Pill, Direct Current Cardioversion (DCC)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Our Lady of the Lake Hospital
Tourette Syndrome, Tourette's Disorder
Assessment of Children With Tic Onset in the Past 6 Months
The purpose of this research is to study why most children who have tics never develop Tourette syndrome but some do. In other words, we aim to find features that may predict whose tics will go away and whose tics will continue…
- Conditions
- Tourette Syndrome, Tourette's Disorder, Chronic Motor or Vocal Tic Disorder, Transient Tic Disorder
- Trial name
- NewTics (NCT01177774)
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Washington University School of Medicine
New Onset Diabetes After Transplant, Diabetes Mellitus
"Outcome of Diabetes Education Among Renal Transplant Recipients With New Onset Diabetes After Transplantation (NODAT)"
Introduction: Diabetes is a chronic disease that requires lifelong self care behavior. Successful treatment of chronic diseases is closely associated with the education of both patients and their relatives.
- Trial name
- NODAT-ES (NCT04030013)
- Testing
- group education
- Where
- Kuwait
- Volunteers
- 210 people
- Sponsor
- Dasman Diabetes Institute
Atrial Fibrillation New Onset
Combined Use of Dexmedetomidine and Hydrocortisone to Prevent New Onset AF After CABG Surgery
Atrial fibrillation (AF) occurs in 20% to 40% of patients after Coronary artery bypass grafting (CABG) and is associated with numerous detrimental sequelae.
- Trial name
- NCT05674253
- Testing
- Dexmedetomidine + Hydrocortisone
- Where
- Egypt
- Volunteers
- 248 people
- Sponsor
- Ain Shams University
Diabetes Mellitus, Type I
Effect of Advanced Hybrid Closed Loop System, MiniMed 780G in Newly Diagnosed Children and Adolescents With Type 1 Diabetes on Glycemic Control and Patient Reported Outcomes Compared to Standard Insulin Therapy Historical Data (AHCL in New Onset T1D Children Study)
The objective of this study is to evaluate glycemic control of users of the AHCL system MiniMed 780G with GS4 calibration-free sensor in children and adolescents with newly diagnosed T1D implemented directly upon T1D diagnosis in…
- Trial name
- NCT06919029
- Testing
- Advanced Hybrid Closed Loop from onset of type 1 diabetes in children
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- National and Kapodistrian University of Athens
New Onset, Atrial Fibrillation
Role of Dexmedatomidine Drug in Prevention of Atrial Fibrillations Post Mitral Valve Surgery
Recently, dexmedetomidine has been suggested as an alternative agent for sedation in tachyarrhythmias due to its antiarrhythmic properties through decreased catecholamine release, prolonged refractory period, and increased vagal…
- Trial name
- NCT07482540
- Testing
- Dexmedetomidine, Saline
- Volunteers
- 140 people
- Sponsor
- Ain Shams University
Acute Kidney Injury
Amino Acid Therapy Evaluating the Incidence of New-Onset AKI
The goal of this clinical trial is to learn whether giving amino acids through an IV during and after heart surgery can protect the kidneys of children with congenital heart disease.
- Trial name
- PROTEIN (NCT07880951)
- Testing
- Amino Acid infusion, Lactated Ringer Solution
- Volunteers
- 270 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Dyspepsia, Gastrointestinal Diseases
Comparison of a "Step-Up" Versus a "Step-Down" Treatment Strategy for Patients With New Onset Dyspepsia in General Practice (The DIAMOND-Study)
The purpose of this study was to determine which treatment strategy, the step-up or the step-down treatment strategy, is the most cost-effective treatment for patients with new onset dyspepsia in primary care.
- Trial name
- NCT00247715
- Testing
- algeldrate/magnesium oxide, ranitidine, pantoprazole
- Where
- 3 sites in Netherlands
- Volunteers
- 664 people
- Sponsor
- Radboud University Medical Center
Atrial Fibrillation New Onset
Peri-Operative Magnesium Infusion to Prevent Atrial Fibrillation Evaluated.
Post-operative atrial fibrillation (POAF) is commonly observed in patients post cardiac surgery without a previous history of atrial fibrillation (AF) or other arrythmias.
- Trial name
- POMPAE (NCT05669417)
- Testing
- Magnesium sulfate
- Where
- Netherlands
- Volunteers
- 265 people
- Sponsor
- HagaZiekenhuis
Headache, Migraine
New-onset Severe Headache After Covid-19 Vaccine
Hypotheses: 1. Severe new-onset headache after Covid-19 vaccine occur in a minor subset of vaccinated individuals. 2. Immunological reactivity with activation of trigeminal nociceptors can be among the mechanisms in severe…
- Conditions
- Headache, Migraine, COVID-19
- Trial name
- CovaxHEAD (NCT05235776)
- Testing
- observation
- Where
- 10 sites in Norway
- Volunteers
- 63 people
- Sponsor
- Oslo University Hospital
Atrial Fibrillation New Onset
Cost-effectiveness Analysis Between Two Anticoagulation Strategies for Atrial Fibrillation in the Postoperative Period of Coronary Artery Bypass Graft Surgery
Coronary artery bypass graft (CABG) surgery is a common intervention in patients with coronary artery disease (CAD). The presence of new postoperative atrial fibrillation / atrial flutter (POAF) occurs in 15-40% of patients…
- Trial name
- TASK-POAF (NCT05300555)
- Testing
- Rivaroxaban 20 MG Oral Tablet, Warfarin
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo General Hospital
Pre Diabetes, ASCVD
Comparison of Low-Intensity Statin Plus Ezetimibe Versus High-Intensity Statin Therapy on Risk of New-Onset Diabetes Mellitus (PROVE-DM)
This study is to evaluating the impact of low-intensity statin plus ezetimibe versus high-intensity statin therapy on risk of new-onset diabetes mellitus in patients with atherosclerotic cardiovascular disease who have…
- Trial name
- NCT05579626
- Testing
- high-intensity statin arm, low-intensity statin plus ezetimibe
- Where
- 31 sites in South Korea
- Volunteers
- 4,000 people
- Sponsor
- Seung-Whan Lee, M.D., Ph.D.