Clinical trials: Neutropenia
Myeldysplastic Syndrome (MDS), MYELOPROLIFERATIVE DISORDER (P Vera, CMML, ET)
Evaluation of Antibiotic Prophylaxis in Myelodysplastic Syndromes and Acute Myeloid Leukemia (MYELO-CAN:ABX)
Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are serious, life-changing blood cancers. Patients with MDS and AML commonly experience complications related to infection, which affect patient quality-of-life and…
- Conditions
- Myeldysplastic Syndrome (MDS), MYELOPROLIFERATIVE DISORDER (P Vera, CMML, ET), Acute Myeloid Leukemia
- Trial name
- MYELO-CAN:ABX (NCT07528417)
- Testing
- Levofloxacin, Usual Care
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- University of Manitoba
Febrile Neutropenia
Pharmacokinetic/Pharmacodynamic Study of Doripenem in Febrile Neutropenic Patients
Primary: To determine the serum pharmacokinetics (PK) of doripenem in febrile neutropenic patients. Secondary: Monte Carlo Simulations Tested Against Various Gram-negative Isolates and Reported as Probability of Target Attainment…
- Trial name
- NCT01401010
- Testing
- Doripenem
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Gary E. Stein, Pharm.D.
Shwachman-Diamond Syndrome, Shwachman-Diamond Syndrome-Like
Shwachman Diamond Syndrome Registry and Study
Shwachman-Diamond syndrome (SDS) is a genetic condition characterized by bone marrow failure, medical co-morbidities, and leukemia predisposition.
- Trial name
- SDSR (NCT06056908)
- Where
- 4 sites in United States
- Volunteers
- 5,000 people
- Sponsor
- Boston Children's Hospital
Anemia, Aplastic, Amegakaryocytic Thrombocytopenia
Partially Matched Stem Cell Transplantation for Patients With Refractory Severe Aplastic Anemia or Refractory Cytopenias
Due to an overall and disease free survival of 85% to 100%, allogeneic blood or bone marrow stem cell transplantation using an HLA matched sibling donor is the therapy of choice for patients with severe aplastic anemia (SAA).
- Conditions
- Anemia, Aplastic, Amegakaryocytic Thrombocytopenia, Diamond-Blackfan Anemia, Kostmann Syndrome
- Trial name
- NCT00244010
- Testing
- Allogeneic stem cell transplant
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- St. Jude Children's Research Hospital
Breast Cancer Female
Trial to Compare the Efficacy and Safety Of MW05 and PEG-rhG-CSF
In the study, subjects will scheduled to undergo four 21-days cycles of chemotherapy treatment. Three group were treated with MW05 300 μg/kg or MW05 500 μg/kg or PEG-rhG-CSF 100 μg/kg on the 3th day of each cycle randomized 1:1:1…
- Trial name
- NCT04554056
- Testing
- MW05, PEG-rhG-CSF
- Where
- China
- Volunteers
- 586 people
- Sponsor
- Mabwell (Shanghai) Bioscience Co., Ltd.
Severe Congenital Neutropenia, GATA2 Deficiency
Total Lymphoid Irradiation Pre-HSCT in Severe Congenital Neutropenia
Severe congenital neutropenia (SCN) is a group of primary immunodeficiencies caused by distinct gene mutations and characterized by neutrophil maturation impairment, which leads to neutropenia, predisposition to severe bacterial…
- Trial name
- NCT04844177
- Testing
- conditioning with TLI
- Where
- Russia
- Volunteers
- 10 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Neutropenia, Healthy
Pharmacokinetics and Pharmacodynamics Comparison Study Between Two Pegfilgrastim Formulations
This study will evaluate the pharmacokinetics (relative bioavailability) and pharmacodynamics, after single subcutaneous application, in healthy volunteers of both sexes, between pegfilgrastim formulation, produced by Eurofarma…
- Trial name
- NCT02589301
- Testing
- Pegfilgrastim
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Eurofarma Laboratorios S.A.
Glycogen Storage Disease Type IB
Prospective Cohort Study of Children With GSD1b Receiving Empagliflozin
This is a prospective cohort study of children with GSD1b to evaluate their outcome after using empagliflozin for neutrophil defects.
- Trial name
- NCT04986735
- Testing
- Empagliflozin
- Where
- Hong Kong
- Volunteers
- 11 people
- Sponsor
- Hong Kong Children's Hospital
Unresectable Pancreatic Cancer, Unresectable Bile Duct Carcinoma
Tripegfilgrastim Trial to Reduce the Risk of Severe Neutropenia in Patients With Unresectable Pancreaticobiliary Cancers
Clinical trial phase: Phase 2 Intervention model: Control group Group allocation: Randomized controlled trial Research perspective: Prospective study Participating centers: Multicenter study Definition of the intervention period…
- Conditions
- Unresectable Pancreatic Cancer, Unresectable Bile Duct Carcinoma, Unresectable Biliary Tract Carcinoma
- Trial name
- Dulastin (NCT06135896)
- Testing
- Tripegfilgrastim
- Where
- South Korea
- Volunteers
- 98 people
- Sponsor
- National Cancer Center, Korea
Breast Cancer
REaCT Integrated Consent Model to Compare Two Standard of Care Regimens
The Integrated Consent Model is being increasingly used internationally to improve patient care. In this feasibility study we will explore whether the model is feasible in practice; and whether it can be used to increase the…
- Trial name
- OTT14-03 (NCT02173262)
- Testing
- G-CSF, Ciprofloxacin
- Where
- Canada
- Volunteers
- 142 people
- Sponsor
- Ottawa Hospital Research Institute
Fever, Sweats, and Hot Flashes, Infection
Recombinant Human Mannose-Binding Lectin (MBL) in Treating Young Patients With MBL Deficiency and Fever and Neutropenia
RATIONALE: Recombinant human mannose-binding lectin (MBL) may be effective in preventing infection in young patients with fever and neutropenia receiving chemotherapy for blood disease or cancer.
- Conditions
- Fever, Sweats, and Hot Flashes, Infection, Leukemia, Lymphoma
- Trial name
- NCT00886496
- Testing
- recombinant human mannose-binding lectin
- Where
- 3 sites in United States
- Sponsor
- Enzon Pharmaceuticals, Inc.
Childhood Cancer, Infection
Host RNA Signature in Children With Cancer and Infection
The aim is to investigate if RNA expression signature can discriminate bacterial from viral infection or non-infectious inflammation in children with cancer.
- Conditions
- Childhood Cancer, Infection, Neutropenia, Febrile
- Trial name
- NCT04669418
- Testing
- RNA expression signature
- Where
- 5 sites in Denmark
- Volunteers
- 370 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Chemotherapy-induced Neutropenia
Recombinant Human Serum Albumin/Granulocyte Colony Stimulating Factor Fusion Protein for Breast Cancer Patients
Evaluation of the efficacy and safety of recombinant human serum albumin / granulocyte-stimulating factor fusion protein for injection to prevent chemotherapy-induced neutropenia
- Trial name
- NCT03251768
- Testing
- rHSA-GCSF 2.4mg, GCSF
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Tianjin SinoBiotech Ltd.
Hepatitis C
Low-Dose Peginterferon and Ribavirin to Treat Chronic Hepatitis C in Patients Infected With HCV Genotype 2 or 3
This study will examine the effectiveness of low-dose peginterferon and ribavirin therapy for certain patients with chronic hepatitis C-a liver disease that, in some patients, can progress to cirrhosis of the liver, liver cancer…
- Trial name
- NCT00056862
- Testing
- Peginterferon alfa-2a, Ribavirin
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Pediatric Acute Myeloid Leukemia
Home or Away From Home - Descriptive Interviews (Aim 2)
The primary objectives of this study are to identify what outcomes related to the management of neutropenia are most important to children with AML and their caregivers.
- Trial name
- NCT02794207
- Where
- 11 sites in United States
- Volunteers
- 86 people
- Sponsor
- Children's Hospital of Philadelphia
Ovarian Cancer
Evaluating Pegfilgrastim and a Multi-Day Topotecan Regimen in Subjects With Relapsed or Refractory Ovarian Cancer
This trial will provide data on the safety and efficacy of pegfilgrastim, in terms of duration of grade 4 neutropenia, when administered on the last day or the day after a multi-day, myelosuppressive chemotherapy regimen for…
- Trial name
- NCT00113789
- Testing
- PI Discretion
- Volunteers
- 21 people
- Sponsor
- Amgen
Solid Tumor Cancer
Impact of Duffy-null Associated Neutropenia on Chemotherapy Dosing
The goal of this clinical trial is to: In Phase 1 (observational) to develop an algorithm for treatment of Duffy-null positive patients for chemotherapy dosing In Phase 2 (interventional), use the algorithm created in phase 1 to…
- Trial name
- NCT07743086
- Testing
- Standard of Care chemotherapy Following an Algorithm, Standard of Care chemotherapy following CTCAE criteria
- Where
- United States
- Volunteers
- 886 people
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Severe Chronic Neutropenia
Immunogenicity, Safety, and Efficacy of Zarzio®/Filgrastim HEXAL® in Patients With Severe Chronic Neutropenia
Purpose of the study is to investigate the safety, immunogenicity and the efficacy of Zarzio®/Filgrastim HEXAL® under chronic administration for 12 months in patients diagnosed with severe chronic neutropenia.
- Trial name
- NCT01859637
- Testing
- Filgrastim
- Where
- 2 sites in Germany, Sweden
- Volunteers
- 6 people
- Sponsor
- Sandoz
Childhood Cancer, Neutropenia
Blood Draw Validation for Ciprofloxacin Pharmacokinetic Research in Pediatric Cancer Patients
To validate blood draws via a central venous catheter (Port A Cath ®) for pharmacokinetic studies of ciprofloxacin in patients under treatment for childhood cancer.
- Trial name
- NCT02967341
- Testing
- Ciprofloxacin administration
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Universitair Ziekenhuis Brussel
Chemotherapy-induced Neutropenia, Metastatic Tumors
Safety and Pharmacokinetic(PK) Study of GW003 to Metastatic Tumors
This study is designed to access the safety, tolerance and Pharmacokinetic/Pharmacodynamic(PK/PD) of single subcutaneous(SC) injection of GW003 in patients with metastatic tumors.
- Trial name
- NCT02156388
- Testing
- GW003
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Jiangsu T-Mab Biopharma Co.,Ltd