Clinical trials: Neurosurgical Patients
Mechanical Ventilation Complication, Neurological Complication
The Cerebral-Respiratory Interaction During Spontaneous Breathing Ventilation in Neurosurgical Patients (CeRes-SB)
Mechanical ventilation (MV) is a life-saving supportive therapy and one of the most common interventions implemented in intensive care.
- Conditions
- Mechanical Ventilation Complication, Neurological Complication, Respiratory Complication
- Trial name
- CeRes-SB (NCT05363098)
- Testing
- Mechanically ventilated neurosurgical patients
- Volunteers
- 30 people
- Sponsor
- Uppsala University
Neurosurgical Procedures, Neurosurgical Patients
Prolonged Mechanical Ventilation in Neurosurgical Patients:
The study was carried out at the neurosurgical operating theater and neurosurgical intensive care unit, Maharaj Nakorn Chiang Mai University-Hospital.
- Conditions
- Neurosurgical Procedures, Neurosurgical Patients, Prolonged Mechanical Ventilation
- Trial name
- NCT06591624
- Testing
- Prolonged Mechanical Ventilation, remain intubation after surgery
- Where
- Thailand
- Volunteers
- 340 people
- Sponsor
- Chiang Mai University
Hypotension
Vasopressor Impact on Brain Circulation, Organ Blood Flow and Tissue Oxygenation During Anesthesia
The optimal vasopressor for ensuring organ blood flow and tissue oxygen delivery during surgery remains undetermined. This study aim to compare the effects of noradrenaline vs.
- Trial name
- IMPACT (NCT06083948)
- Testing
- Noradrenalin, Phenylephrine
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- University of Aarhus
Hypnotic; Withdrawal State With Delirium, Neurological Disorder
Efficacy of BIS Monitoring in Deep Hypnotic State
Determining the efficacy of the BIS monitor in monitoring deep hypnotic states as well as intra- and post-operative outcomes in neurosurgery patients
- Conditions
- Hypnotic; Withdrawal State With Delirium, Neurological Disorder, Postoperative Delirium, Postoperative Confusion
- Trial name
- NCT06177847
- Testing
- BIS
- Volunteers
- 50 people
- Sponsor
- Universitas Indonesia
Muscle Weakness, Critical Illness
Critical Illness Neuromuscular Abnormalities in Neurocritical Care Patients
The aim of this research is to investigate critical illness neuromuscular abnormalities in neurocritical care patients.
- Trial name
- NCT00893633
- Where
- Russia
- Volunteers
- 135 people
- Sponsor
- Clinical Institute of the Brain, Russia
Laryngoscopy, Intubation
Effect of Lidocaine Sprayed for Attenuating Hemodynamic Response During Laryngoscopy and Intubation
The goal of this clinical trial is to to evaluate the efficacy of lidocaine sprayed at the laryngeal inlet combined with the endotracheal tube cuff compare with intravenous lidocaine on the hemodynamic response to laryngoscopy…
- Conditions
- Laryngoscopy, Intubation, Hemodynamics, Neurosurgery
- Trial name
- NCT06226532
- Testing
- lidocaine spray, Intravenous Lidocaine
- Where
- Thailand
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Stress, Pain
A Randomized Controlled Trial to Assess the Impact of Live and Recorded Music-Based Interventions on Pre-operative Stress, Mood, Pain and Biomarkers, in Neurosurgical Patients (Music-STAR Trial)
The study plans to enroll a total of 132 patients. The goal of this study is to measure pre-and post-music intervention changes in patients' vital signs, serum- and plasma-level biomarkers by broad-spectrum proteomics analysis…
- Trial name
- NCT06536504
- Testing
- Steinway Spirio M recording/player piano
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- M.D. Anderson Cancer Center
Cerebral Hemodynamics
Perioperative Cerebrovascular Autoregulation Monitoring in Neurosurgical Patients
One of the challenges in pediatric anesthesiology is to ensure adequate cerebral perfusion pressure to prevent cerebral ischemia or hyperemia from pressure-passive perfusion.
- Trial name
- NCT04174001
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Boston Children's Hospital
Posterior Fossa Tumor, Brain Tumor Adult
Fluid Responsiveness in Posterior Fossa Tumor Resection: PPV and CVP Guidance
To answer the question: What are the differences in intraoperative fluid administration volumes between PPV and CVP-guided strategies during posterior fossa tumor resection in the park bench position?
- Trial name
- NCT06595667
- Testing
- Pulse pressure variation, Central venous pressure
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- Chiang Mai University
Cognitive Dysfunction, Patient Positioning
Near Infrared Spectroscopy for Detection of Cerebral Desaturation After Positioning for Neurosurgical Procedures
The occurrence of postoperative cognitive dysfunction (POCD) might be related to intraoperative cerebral desaturation. Positioning for neurosurgical procedures are associated with head rotation, elevation, flexion or extention…
- Trial name
- NCT03093311
- Testing
- NIRS based protocol
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital Hradec Kralove
Ventilator-Associated Pneumonia (VAP), Intensive Care Unit (ICU) Patients
Pulmonary Microbiota Changes and Clinical Outcomes in Neurosurgical ICU Patients With Artificial Airways
After neurosurgery, many patients need to stay in the intensive care unit (ICU) and use a breathing machine (mechanical ventilation) because of issues like decreased consciousness, weak breathing, or poor airway protection.
- Conditions
- Ventilator-Associated Pneumonia (VAP), Intensive Care Unit (ICU) Patients, Microbiome Dysbiosis
- Trial name
- NCT07129174
- Where
- 3 sites in China
- Volunteers
- 220 people
- Sponsor
- Jian-Xin Zhou
Hyperglycemia, Postoperative Infection
Hyperglycemia in Neurosurgery
Poor glycemic control is recognized as a risk factor for postoperative infection. For the neurosurgical patient, postoperative infection can lead to devastating complications such as meningitis, encephalitis and death.
- Trial name
- NCT05236751
- Where
- 3 sites in United States, Italy and 1 more
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Glioma, Coagulopathy
Hemostasis Alterations in Neurosurgical Patients
Prospective, observational study aimed to investigate the specific hemostatic alterations in patients undergoing glial tumor resection.
- Conditions
- Glioma, Coagulopathy, Acquired Platelet Function Disorder, Thromboelastometry
- Trial name
- ABCD (NCT02652897)
- Testing
- Exposure to glioma resection surgery, Exposure to colon resection surgery
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Santiago R. Leal-Noval
Brain Tumors
Frailty as a Predictor of Neurosurgical Outcomes in Brain Tumor Patients
Frailty as an adjunct to preoperative assessment of neurosurgical patients has never been evaluated. This study aims to determine if frailty predicts neurosurgical complications in brain tumor patients and enhances current…
- Trial name
- NCT02530749
- Where
- United States
- Volunteers
- 265 people
- Sponsor
- University of Colorado, Denver
Central Nervous System Infections
Economic Impact of mNGS on Diagnosis of Post-neurosurgical Central Nervous System Infection
The aim of the current study was to assess the economic impact of using metagenomic next-generation sequencing (mNGS) versus traditional bacterial culture directed CNSIs diagnosis and therapy in post-neurosurgical patients from…
- Trial name
- mNGS (NCT05887037)
- Testing
- mNGS, The traditional microbiological cultures
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Jian-Xin Zhou
Brain Injuries, Brain Trauma
Evaluation of qSOFA in Neurosurgical Patients
The aim of the study is to look if Quick Sequential Organ Failure Assessment Score score in detecting a eary Sepsis is afflicted by neurosurgical disorders
- Conditions
- Brain Injuries, Brain Trauma, Subarachnoid Hemorrhage
- Trial name
- NCT04265404
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Goethe University
Agitation, Craniotomy
Agitation in Post Operative Neurosurgical Patients
Agitation is a significant clinical issue in anesthesiology and critical care medicine. Several studies have carried out to survey the epidemics of agitation in post-anesthesia care unit and intensive care unit, and results…
- Trial name
- NCT00590499
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Capital Medical University
Glioblastoma (GBM)
Efficacy of Zoster Vaccination in Glioblastoma Patients
In modern practice a trimodality treatment has emerged as standard of care for histologically confirmed glioblastoma. We hypothesize that the additional vaccination against herpes zoster, after surgical resection followed by…
- Trial name
- STARGATE (NCT07546669)
- Testing
- Additional vaccination against shingles (herpes zoster), Standard of care treatment without additional vaccination
- Volunteers
- 230 people
- Sponsor
- University Hospital, Essen
Pressure Injuries
Effect of Positioning Protocol on Skin Pressure Injury and Shoulder Traction Pain in Neurosurgical Patients
This study evaluates a modified lateral decubitus positioning method designed to prevent pressure injuries and reduce shoulder traction pain in patients undergoing neurosurgical procedures under general anesthesia.
- Trial name
- NCT07791056
- Testing
- Modified Lateral Decubitus Positioning Protocol, Conventional Lateral Decubitus Positioning
- Where
- China
- Volunteers
- 80 people
- Sponsor
- General Hospital of Ningxia Medical University
Neurocognitive Disorders, Postoperative Period
Pre-operative Neurocognitive Disorder and Low Near-infrared Spectrometry is Associated With Postoperative Delirium
The main goal of the investigation is to identify the incidence of cognitive dysfunction and POD in patients older than 65 years of age undergoing neurosurgical elective surgery and determine if an association between cognitive…
- Conditions
- Neurocognitive Disorders, Postoperative Period, Postoperative Complications
- Trial name
- NCT03171766
- Testing
- Mini-Mental State Examination (MMSE), Visual Analog Scale (VAS), Mini Cog test
- Where
- Portugal
- Volunteers
- 100 people
- Sponsor
- Centro Hospitalar do Porto