Clinical trials: Neuropathy (Disorder)
Carpal Tunnel
Short- to Medium-term Outcome of Minimally Invasive Carpal Tunnel Release
The aim of the study is to determine whether minimally invasive, ultrasound-guided thread carpal tunnel release leads to faster functional recovery compared to standard open and endoscopic techniques in patients with carpal…
- Trial name
- NCT06997172
- Testing
- TCTR (thread carpal tunnel release), Standard-of-care
- Where
- Switzerland
- Volunteers
- 61 people
- Sponsor
- University Hospital, Basel, Switzerland
Paclitaxel Adverse Reaction, Neuropathy;Peripheral
ABCB1 SNPs as Predictors of PIPN
The study aim is to determine the allele frequencies of 1236 G>A and 3435 G>A in ABCB1 and study their association with the incidence and severity of paclitaxel-induced peripheral neuropathy while adjusting for other baseline…
- Conditions
- Paclitaxel Adverse Reaction, Neuropathy;Peripheral, Breast Cancer
- Trial name
- NCT05093023
- Testing
- Real-Time PCR
- Where
- Egypt
- Volunteers
- 92 people
- Sponsor
- Ain Shams University
Optic Pathway Glioma
Safety and Efficacy of the PAINLESS Nerve Growth Factor CHF6467 in Optic Pathway Glioma (OPG)
Infantile optic pathway glioma (OPG) is generally benign and slow-growing, but due to infiltration and compression of sensitive neuronal structures in the optical pathways, progressive visual loss is a frequent and highly…
- Trial name
- NGF-OPG (NCT05733572)
- Testing
- CHF6467
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- Benedetto Falsini
Pain, Diabetic Neuropathy
Study to Evaluate the Analgesic Efficacy of 28 Days' Oral Administration of AZD2066 Compared With Placebo in Patients With Painful Diabetic Neuropathy
The purpose of this study is to investigate if AZD2066 can relieve the pain arising from painful diabetic neuropathy compared to placebo.
- Trial name
- NCT00857623
- Testing
- AZD2066
- Where
- 19 sites in United States
- Volunteers
- 127 people
- Sponsor
- AstraZeneca
Chemotherapy Induced Peripheral Neuropathy (CIPN), Paresthesia
Gut Microbiome Profiles in Patients With Chemotherapy-induced Neuropathy in the RCT OzoParQT (NCT06706544).
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating side effect of chemotherapy (CT), often requiring dose reductions or treatment interruptions, which can compromise efficacy of the planned CT…
- Conditions
- Chemotherapy Induced Peripheral Neuropathy (CIPN), Paresthesia, Numbness, Tingling
- Trial name
- OzoParQTmicrob (NCT06799351)
- Testing
- Ozone therapy
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Bernardino Clavo, MD, PhD
Peripheral Neuropathy, Diabetic Neuropathies
Efficacy of Moxibustion in Diabetes Peripheral Neuropathy
This pragmatic randomized controlled study aimed to evaluate the effectiveness and safety of moxibustion therapy on diabetes peripheral neuropathy.
- Trial name
- NCT04894461
- Testing
- Moxibustion
- Volunteers
- 40 people
- Sponsor
- Xiamen University
Chemotherapy-induced Peripheral Neuropathy
A Study of Topical Pirenzepine or Placebo in Oncology Patients With Chemotherapy Induced Peripheral Neuropathy
This is a randomized, double-blind, placebo-controlled adaptive study of the safety, tolerability, and exploratory efficacy of once-daily topical WST-057 administered for up to 19 weeks (or up to 24 weeks for subjects who…
- Trial name
- NCT05488873
- Testing
- WST-057 Active
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- WinSanTor, Inc
Chemotherapy-induced Peripheral Neuropathy (CIPN), Gynecologic Cancers
Glove Compression for Chemotherapy-Induced Neuropathy
This study investigates whether wearing tight-fitting surgical gloves on the non-dominant hand could help prevent chemotherapy-induced peripheral neuropathy (CIPN) in women with gynecologic cancers treated with paclitaxel.
- Conditions
- Chemotherapy-induced Peripheral Neuropathy (CIPN), Gynecologic Cancers, Ovarian Cancer (OvCa), Endometrial Cancer
- Trial name
- NEURO-GLOVE (NCT07105553)
- Testing
- Surgical Glove Compression
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Ankara Etlik City Hospital
Diabetic Foot Ulcer (DFU), Venous Leg Ulcer (VLU)
Evaluation of the Safety and Efficacy of Dehydrated Human Placenta Tissue (dHPT) for Wound Healing
The retrospective trial is observational, intended to stand alone, complement and integrate data collected in ongoing clinical studies to aid in establishing payor coverage in the United States (U.S.) for Cellution Biologics…
- Conditions
- Diabetic Foot Ulcer (DFU), Venous Leg Ulcer (VLU), Pressure Ulcer (PU)
- Trial name
- RETRO-PLAST (NCT07375160)
- Testing
- dHPT, AIC
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Cellution Biologics
Carpal Tunnel Syndrome
Ultrasound Guided Median Nerve Hydrodissection Using Dextrose
to compare the efficacy of dextrose 5% with steroid hydrodissection in patients with carpal tunnel syndrome
- Trial name
- NCT05725460
- Testing
- dextrose 5% median nerve hydrodissection
- Where
- Iraq
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Iraqi Board of medical specialties
Head Neck Cancer, Radiation Neuropathy
Study of Efficacy and Safety of Gabapentin to Reduce the Need for Strong Opioid Use in Head and Neck Cancer Patients.
A multi-centre, double-blind, randomized-controlled trial to study the efficacy and safety of gabapentin to reduce the need for strong opioid use in the treatment of radiation-induced pain in head and neck cancer (HNCA) patients…
- Conditions
- Head Neck Cancer, Radiation Neuropathy, Pain, Neuropathic
- Trial name
- stREnGTH (NCT03747562)
- Testing
- Gabapentin
- Where
- 2 sites in Belgium
- Sponsor
- University Hospital, Ghent
Diabetic Foot Ulcer, Venous Leg Ulcer
DETEC® Esterase for Screening Wound Infection at Point of Care
This non-interventional, single-blinded, prospective, observational study assesses the planar distribution of leukocyte esterase in wounds by placing wound exudates soaked wound dressings in the DETEC® Esterase device during…
- Conditions
- Diabetic Foot Ulcer, Venous Leg Ulcer, Pressure Ulcer
- Trial name
- NCT04614870
- Testing
- DETEC® Esterase
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Progenitec Inc.
Carpal Tunnel Syndrome (CTS)
The Application of Multimodal Ultrasound Imaging in Carpal Tunnel Syndrome
The aim of this study is to explore the application value of multimodal ultrasound parameters in the diagnosis and treatment follow-up of Carpal Tunnel Syndrome.
- Trial name
- NCT06766370
- Testing
- Ultrasound-guided nerve hydrodissection treatment
- Volunteers
- 40 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Cisplatin Adverse Reaction, Cisplatin Nephrotoxicity
Evaluation of the Effect of N-acetylcysteine in Preventing Cisplatin-Induced Toxicities in Cancer Patients
Evaluation of the Effect of N-acetylcysteine in Preventing Cisplatin-Induced Toxicities in Cancer Patients
- Conditions
- Cisplatin Adverse Reaction, Cisplatin Nephrotoxicity, Cisplatin Induced Peripheral Neuropathy, Cancer Patients
- Trial name
- NCT06297369
- Testing
- N acetyl cysteine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Carpal Tunnel Syndrome, Incision
Comparing a Modified Mini-incision Approach Versus the Conventional Approach for Carpal Tunnel Release
Carpal tunnel syndrome (CTS) is the commonest nerve compression syndrome in the upper limbs, and carpal tunnel decompression is one of the most prevalent upper limb surgical interventions.
- Trial name
- NCT06114823
- Testing
- carpal tunnel release mini-incision, carpal tunnel release conventional incision
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Mansoura University
Peripheral Neuropathy
Effect of Transcranial Direct Current Stimulation on Peripheral Neuropathy
This study will be performed in patients with peripheral neuropathy who are walking independently, but have complains of balance problems such as recent falls or difficulty walking and show reduced vibratory and proprioceptive…
- Trial name
- NCT03073759
- Testing
- dTCS
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Johns Hopkins University
Carpal Tunnel Syndrome, Anesthesia, Local
Efficacy of Local Direct Median Nerve Block
Carpal tunnel syndrome is the most common compressive neuropathy. Carpal tunnel release is indicated when failed conservative treatment.
- Trial name
- NCT04453462
- Testing
- Endoscopic carpal tunnel release under local direct median nerve block, Endoscopic carpal tunnel release under brachial plexus block
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- Thammasat University
PolG, Primary Mitochondrial Myopathy
Prospective Natural History Study of POLG Disease
The PIONEER study is a prospective, natural history study dedicated to characterizing the clinical progression of POLG-related disorders.
- Trial name
- PIONEER (NCT07775872)
- Where
- 21 sites in United States, Australia and 7 more
- Volunteers
- 300 people
- Sponsor
- The POLG Foundation
Painful Diabetic Neuropathy
Safety, Tolerability & Pharmacokinetics Study of CNTX-6016 in Healthy Subjects and Subjects With PDN
A Phase 1b study to evaluate the safety, tolerability and pharmacokinetics of multiple ascending doses of CNTX-6016 in healthy subjects and a single cohort to evaluate painful diabetic neuropathy.
- Trial name
- NCT04857957
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Centrexion Therapeutics
Carpal Tunnel Syndrome
Vitamin B12 and Dextrose for Median Nerve Hydrodissection
Carpal tunnel syndrome is the most common peripheral entrapment neuropathy of the upper limb. Previous experiments found that ultrasound-guided median nerve hydrodissection with 5% dextrose water could ameliorate the condition of…
- Trial name
- NCT05423028
- Testing
- Ultrasound-guided nerve hydrodissection
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Cheng-Kung University Hospital