Clinical trials: Neuropathy
Transthyretin Amyloid Polyneuropathy (ATTR-PN)
The Effect Of Tafamidis Meglumine In Transthyretin Amyloid Polyneuropathy Patients
This is a single-arm, open-label, multicenter study designed to evaluate the efficacy, safety, tolerability as well as pharmacodynamics of tafamidis meglumine in ATTR-PN participants in China.
- Trial name
- NCT04828993
- Testing
- tafamidis meglumine
- Where
- 9 sites in China
- Volunteers
- 15 people
- Sponsor
- Pfizer
Foot Drop
Augmenting Gait in a Population Exhibiting Foot Drop With Adaptive Functional Electrical Stimulation
The objective of this study is to investigate the effects of personalized, adaptive, current-steering functional electrical stimulation (FES) of the lower leg to improve gait in people with foot drop.
- Trial name
- NCT05346640
- Testing
- Cionic Neural Sleeve
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Cionic, Inc.
Traumatic Optic Neuropathy
Traumatic Optic Neuropathy Treatment Trial 2
After introducing intravenous erythropoietin (EPO) as an option for treatment of patients with indirect traumatic optic neuropathy in 2011 and publishing non inferiority trial in Oct.2017), TONTT2 is aiming to find out the best…
- Trial name
- TONTT-2 (NCT03308448)
- Testing
- Recombinant human erythropoietin
- Where
- 3 sites in Iran
- Volunteers
- 93 people
- Sponsor
- Iran University of Medical Sciences
Breast Cancer, Gynecologic Cancer
Evaluation of Hydroxychloroquine to Prevent CIPN
The study is being done to research if hydroxychloroquine can prevent chemotherapy induced peripheral neuropathy. Certain chemotherapy drugs, like paclitaxel, are known to cause neuropathy which can impact quality of life.
- Conditions
- Breast Cancer, Gynecologic Cancer, Early-stage Breast Cancer, Peripheral Neuropathy
- Trial name
- NCT05689359
- Testing
- Hydroxychloroquine
- Sponsor
- University of Arizona
Cisplatin Adverse Reaction, Cisplatin Nephrotoxicity
Evaluation of the Effect of N-acetylcysteine in Preventing Cisplatin-Induced Toxicities in Cancer Patients
Evaluation of the Effect of N-acetylcysteine in Preventing Cisplatin-Induced Toxicities in Cancer Patients
- Conditions
- Cisplatin Adverse Reaction, Cisplatin Nephrotoxicity, Cisplatin Induced Peripheral Neuropathy, Cancer Patients
- Trial name
- NCT06297369
- Testing
- N acetyl cysteine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Diabetic Peripheral Neuropathy
Peripheral Nerve Responses to Focal Vibration and Implications in Pain and Mobility for Patients With Diabetic Peripheral Neuropathy
The purpose of this study is to characterize the changes in peripheral nerve functions (sensory and motor) in patients with diabetic peripheral neuropathy, and examine the relations between the changes in nerve functions and…
- Trial name
- NCT05041816
- Testing
- Focal vibration therapy
- Where
- United States
- Sponsor
- University of Oklahoma
Chemotherapy-induced Peripheral Neuropathy
Photobiomodulation Therapy in the Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy
This study aims to investigate the effectiveness of photobiomodulation therapy (PBM) in the management of chemotherapy-induced peripheral neuropathy (CIPN).
- Trial name
- NeuroLight (NCT05199389)
- Testing
- Multiwave Locked System® (M6 laser, ASA srl, Arcugnano (VI), Italy)
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Jessa Hospital
Diabetic Neuropathies
Plantar Cutaneous Sensory Stimulation in Patients With Diabetic Neuropathy
To determine the effects of plantar cutaneous sensory stimulation on foot tactile sensitivity, postural control, and spatiotemporal gait parameters in patients with diabetic neuropathy.
- Trial name
- NCT06292468
- Testing
- Traditional physical therapy, Plantar cutaneous sensory stimulation
- Where
- 2 sites in Pakistan
- Volunteers
- 50 people
- Sponsor
- Riphah International University
PI3K and P110delta Hyperactivation Syndrome
CVL237 Tablets for APDS/PASLI
This study was designed to evaluate the efficacy and safety of CVL237 tablets in patients with APDS/PASLI (activated phosphoinositol 3-kinase δ syndrome /p110 delta-activated mutation leading to senescent T cells…
- Trial name
- NCT06293716
- Testing
- CVL237 tablets
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Convalife (Shanghai) Co., Ltd.
Chemotherapy-induced Peripheral Neuropathy
Chemotherapy Induced Peripheral Neuropathy Natural History Study (EPIPHANY)
This is a prospective natural history study of CIPN in approximately 200 participants receiving taxanes (paclitaxel, docetaxel) for breast cancer, bortezomib for multiple myeloma, oxaliplatin-based regimens for colorectal cancer…
- Trial name
- EPIPHANY (NCT03997981)
- Where
- 10 sites in United States
- Volunteers
- 200 people
- Sponsor
- Disarm Therapeutics
Lower Limb Amputation Knee, Lower Limb Amputation Above Knee (Injury)
Enhancing Abilities in Amputees and Patients With Peripheral Neuropathy Through Restoration of Sensory Feedback
Many amputees suffer from Phantom Limb Pain (PLP), a condition where painful perceptions arise from the missing limb. Leg amputees wear prostheses that do not provide any sensory feedback, apart from the stump-socket interaction.
- Conditions
- Lower Limb Amputation Knee, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury), Diabetic Peripheral Neuropathy
- Trial name
- NCT04217005
- Testing
- Sensory Feedback
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- ETH Zurich
Transthyretin Amyloidosis, Carpal Tunnel Syndrome
Transthyretin Cardiac Amyloidosis in Patients With Idiopathic Carpal Tunnel Syndrome Referred for Release Surgery
This study will determine the prevalence of transthyretin amyloidosis in pathology of the transverse carpal ligament and cardiac involvement using natriuretic peptides, electrocardiography and echocardiography in patients…
- Trial name
- PRATHYC (NCT04611204)
- Testing
- Descriptive cohort
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Toulouse
Breast Cancer, Neuropathy
Hand-Foot Exercises on Peripheral Neuropathy
This study will be conducted to compare the effects of hand and foot exercises on peripheral neuropathy and quality of life in breast cancer patients taking taxanes
- Trial name
- NCT06055088
- Testing
- Hand and foot exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 79 people
- Sponsor
- Amasya University
Amyloid, Cardiac Amyloidosis
Amyloidosis Incidence in High-Risk Cardiac Device Patients
This single-practice prospective cohort study aims to enhance the diagnosis of cardiac amyloidosis in high-risk patients undergoing standard cardiac device implantation.
- Conditions
- Amyloid, Cardiac Amyloidosis, Amyloidosis Cardiac, Systemic Amyloidosis
- Trial name
- NCT06186167
- Testing
- Chest Wall Fat Tissue Collection
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Midwest Heart & Vascular Specialists
Diabetes Mellitus, Type 2, Obesity, Morbid
Phenotypic and Genotypic Characterization of Patients With Dysmetabolism in Greenland
The goal of this clinical trial is to perform a detailed description of the feno- and genotype of people living with type 2 diabetes and severe obesity who are linked to care at Steno Diabetes Center Greenland.
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Morbid, Obstructive Sleep Apnea, MODY
- Trial name
- NCT06264427
- Testing
- Whole genome sequencing, VAGUS, NightOwl
- Where
- Greenland
- Volunteers
- 1,000 people
- Sponsor
- Steno Diabetes Center Greenland
Lichen Simplex Chronicus
Fractional Carbon Dioxide Laser: A Novel Therapeutic Option for Lichen Simplex Chronicus
The goal of this randomized control trial is to compare the use of fractional carbon dioxide (Co2) laser to topical corticosteroids to treat lichen simplex chronicus (LSC) patients presenting to Dermatology outpatient clinic…
- Trial name
- NCT06267066
- Testing
- Betamethasone Valerate 0.1% Cream, SmartXide® fractional carbon dioxide laser, Vaseline Topical Product
- Where
- 2 sites in Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Diabetic Peripheral Neuropathy
DEXINEURO® Tab on Blood Glucose Reduction in Patients With Type 2 Diabetes Accompanied by Diabetic Peripheral Neuropathy
This study is to evaluate the efficacy of DEXINEURO® tab on blood glucose reduction and assess the interaction with concomitantly administered insulin or oral antidiabetic agents in patients with type 2 diabetes accompanied by…
- Trial name
- NCT06191614
- Where
- South Korea
- Volunteers
- 528 people
- Sponsor
- Hanlim Pharm. Co., Ltd.
Diabetic Peripheral Neuropathy
Effect of Structured Training Program in Diabetic Patients
Diabetic neuropathy, a challenging condition resulting from poorly managed type-1 or type-2 diabetes mellitus, often proves resistant to conventional medications when it comes to alleviating the associated symptoms.
- Trial name
- NCT06262074
- Testing
- Structured Exercise Program, Non structured exercise program
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Maharishi Markendeswar University (Deemed to be University)
Diabetic Neuropathy, Painful
Efficacy of Noninvasive Radiofrequency in Attenuating Diabetic Neuropathic Pain
Peripheral neuropathy increases the prevalence of diabetic foot ulcers following a decrease in foot sensation. Therefore, the treatment of this disorder is very important.
- Trial name
- NCT05917249
- Testing
- Capacitive-Resistive Noninvasive Radiofrequency
- Where
- Egypt
- Volunteers
- 23 people
- Sponsor
- Cairo University
Meralgia Paresthetica
Efficacy of Ultrasound-guided Injection of 5% Dextrose for Meralgia Paresthesia
Meralgia paresthetica (MP) is one of the most common peripheral entrapment neuropathies of the lower limbs. It is characterized by paresthesia, pain, tingling, numbness, hypersensitivity, or other abnormal skin sensations on the…
- Trial name
- NCT06251882
- Testing
- injection
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University People's Hospital