Clinical trials: Neuropathy
Diabetic Foot Ulcers
A Prospective, Randomized Clinical Trial of PRP Concepts Fibrin Bio-Matrix in Non-Healing Diabetic Foot Ulcers
A prospective, randomized, controlled, clinical study to establish clinical based evidence of PRP Concepts Fibrin Bio-Matrix and compare its performance with the usual and customary practice for the treatment of Wagner 1 or 2…
- Trial name
- NCT02312596
- Testing
- PRP Concepts Fibrin Bio-Matrix, Usual and Customary Practice
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- PRP Concepts, LLC
Bier Block, Dexmedetomidine
A Sequential Allocation Study to Determine the ED50 of Dexmetedomidine as an Adjuvant to Lidocaine Intravenous Regional Anesthesia
Intravenous Regional Anesthesia (IVRA) is an easy and reliable anesthetic technique for hand and forearm surgery. Its use is however limited by the presence of tourniquet pain during the surgery and the absence of postoperative…
- Conditions
- Bier Block, Dexmedetomidine, Tourniquet Pain, Carpal Tunnel
- Trial name
- NCT05342870
- Testing
- Dexmedetomidine
- Volunteers
- 23 people
- Sponsor
- American University of Beirut Medical Center
Carpal Tunnel Syndrome
Ultrasound-guided Dextrose Injection Versus Dextrose With Methylprednisolone in Carpal Tunnel Syndrome
The goal of this prospective, randomized, double-blinded, head-to-head comparative study is to compare the efficacy of ultrasound-guided 4 ml 5% dextrose perineural injection versus 3 ml 5% dextrose with 1 ml 40 mg/ml…
- Trial name
- NCT06045013
- Testing
- 5% dextrose injection, 5% dextrose injections with methylprednisolone acetate 40 mg/ml
- Where
- Croatia
- Volunteers
- 70 people
- Sponsor
- General and Veteran Hospital Croatian Pride Knin
Diabetic Neuropathy
Vitamin D Treatment for Painful Diabetic Neuropathy
The main objective of the study is to assess the effect of vitamin D treatment on painful diabetic neuropathy in Pakistan. This is a prospective study of diabetic patients with a DN score ≥ 4, administered a single dose of…
- Trial name
- NCT02737423
- Testing
- cholecalciferol
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Baqai Institute of Diabetology and Endocrinology
Breast Cancer, Gynecologic Cancer
Evaluation of Hydroxychloroquine to Prevent CIPN
The study is being done to research if hydroxychloroquine can prevent chemotherapy induced peripheral neuropathy. Certain chemotherapy drugs, like paclitaxel, are known to cause neuropathy which can impact quality of life.
- Conditions
- Breast Cancer, Gynecologic Cancer, Early-stage Breast Cancer, Peripheral Neuropathy
- Trial name
- NCT05689359
- Testing
- Hydroxychloroquine
- Sponsor
- University of Arizona
Fabry Disease
An Open-Label Maintenance Study of the Enzyme Replacement Therapy Replagal in Patients With Fabry Disease
This study will continue to evaluate the safety of using intravenous doses of Replagal for two patients with Fabry disease. Fabry disease is a genetic disorder inherited as an X-linked recessive trait.
- Trial name
- NCT00357786
- Testing
- Replagal agalsidase alfa, Replagal
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Glaucoma
Repetitive Transcranial Alternating Current Stimulation (rtACS) for the Treatment of Optic Neuropathies
The goal of this study is to see whether repeated transcranial alternating current stimulation can activate impaired retinal ganglion cells and improve both structural and functional outcomes in patients with glaucoma.
- Trial name
- NCT07145073
- Testing
- DC-Stimulator MC
- Where
- Taiwan
- Volunteers
- 188 people
- Sponsor
- National Taiwan University Hospital
Amyloidosis
Impact of a Cardiac Rehabilitation Program on Patients With Cardiac Amyloidosis
The goal of this clinical trial is to learn if a structured cardiac rehabilitation program can help people with cardiac amyloidosis improve their ability to exercise and their quality of life.
- Trial name
- RECARDA (NCT07494942)
- Testing
- Cardiac Rehabilitation Program
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Montpellier
Carpal Tunnel Syndrome
Efficacy of Steroid Injection in Patients With Bifid Median Nerve Diagnosed Carpal Tunnel Syndrome
Various median nerve anatomical variations have been reported in the literature.One of these is the bifid median nerve.Due to its relatively higher cross-sectional area, it can facilitate compression of the median nerve in the…
- Trial name
- NCT06599086
- Testing
- 2 cc:(1 cc betamethasone dipropionate+1cc physiological saline)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Yunus Burak Bayır
Diabetic Foot Ulcer
Noraxon myoRESEARCH™ Software Gait Analysis Evaluation and Orthotic Gait Correction in Reducing Diabetic Foot Ulceration Or Subsequent Amputation in Patients With a History of a Diabetic Foot Ulceration
Determining whether the utilization of Noraxon myoRESEARCH Software gait analysis Evaluation and orthotic gait Correction can reduce diabetic foot ulceration Or subsequent amputation in patients with a history of a diabetic foot…
- Trial name
- NECRO (NCT04164641)
- Testing
- Noraxon myoRESEARCH™ Software Gait Analysis Evaluation and Orthotic
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Johns Hopkins University
Venous Hypertension Ulcers, Venous Stasis Ulcer
Cooling Leg and Foot Ulcer Skin Post Healing to Prevent Ulcer Recurrence
The goal of this study is to test MUSTCOOL, a home-based self-monitoring and self-management ulcer prevention intervention for patients with newly healed chronic venous leg and diabetic foot ulcers.
- Conditions
- Venous Hypertension Ulcers, Venous Stasis Ulcer, Venous Ulcer, Venous Insufficiency
- Trial name
- MUSTCOOL (NCT02626156)
- Testing
- Cooling gel pack, Cooling cotton pack
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Medical University of South Carolina
Diabetic Peripheral Neuropathy, Chronic Pain
Safety and Efficacy of AEG33773 Versus Placebo in Patients With Painful Diabetic Peripheral Neuropathy
Two Phase 1 studies have been conducted with AEG33773 and available safety and tolerability data from these studies support further clinical development of AEG33773.
- Trial name
- NCT00891683
- Testing
- AEG33773 oral dosing
- Where
- 20 sites in United States, Bulgaria and 2 more
- Volunteers
- 128 people
- Sponsor
- Aegera Therapeutics
Sciatica Due to Intervertebral Disc Disorder
Electroacupuncture for Sciatica Due to Intervertebral Disc Displacement
This multicenter randomized controlled trial (RCT) will evaluate the therapeutic effectiveness and health-economics of electroacupuncture for sciatica due to intervertebral disc displacement in 3 compared groups…
- Trial name
- NCT02087462
- Testing
- Electroacupuncture (EA), Traction, Voltaren
- Where
- China
- Volunteers
- 324 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Diabetic Foot Ulcer (DFU)
Multicentric RCT Comparing High Purity Type I Collagen-Skin Substitute vs dHACM in Treatment of Diabetic Foot Ulcers
This is a randomized controlled clinical investigation in patients suffering from diabetic foot ulcers at multiple centers. The study intends to compare patient outcome data using Standard of Care with Type-I Collagen-based Skin…
- Trial name
- NCT07046403
- Testing
- High Purity Type-I Collagen-based Skin Substitute and SOC, Dehydrated Human Amnion / Chorion Membrane and SOC
- Where
- 4 sites in India
- Volunteers
- 120 people
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
Erb's Palsy
Effects of Modified Constraint-induced Movement Therapy With and Without Electrical Stimulation in Erb's Palsy
ERB's palsy is an injury of upper section of the brachial plexus (C5-6) leading to an internally rotated and adducted shoulder and a pronated forearm.
- Trial name
- NCT06303427
- Testing
- Modified constraint-induced movement therapy, Electrical stimulation
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- Riphah International University
Meralgia Paresthetica
Comparing Ways to Freeze the Nerve That Provides Thigh Sensation
Background The sensation on the outside of portion of our thighs is provided by a nerve called the lateral femoral cutaneous nerve (LFCN).
- Trial name
- NCT02577510
- Testing
- Nerve Injection- Nerve Stimulator, Nerve Injection - Ultrasound
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Canadian Forces Health Services Centre Ottawa
Diabetic Peripheral Neuropathy
Diagnostic Accuracy of Quantitative Neuropad Test for Diabetic Peripheral Neuropathy
This study aimed to evaluate the diagnostic vaule of quantitative Neuropad for diabetic peripheral neuropathy
- Trial name
- NCT05347420
- Testing
- The visual Neuropad test and the quantitative Neuropad test
- Where
- China
- Volunteers
- 600 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Peripheral Neuropathy With Type 2 Diabetes
Frequency Rhythmic Electrical Modulated Stimulation Effect in Peripheral Neuropathy Patients Severity of Cases and Qol.
It's estimated that 50% of diabetic patients will have peripheral neuropathy as a complication within 3 years of the diabetes incidence [14], the goal of the study is to investigate this problem through the following objectives…
- Trial name
- FREMS (NCT07645482)
- Testing
- frequency rhythmic electrical modulated stimulation., Duloxetine - low dose
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Beni-Suef University
Diabetes Mellitus, Type 1, Diabetic Polyneuropathy
Effect of C-Peptide on Diabetic Peripheral Neuropathy
The aim of the study is to investigate the effect of C-peptide administration on nerve function in patients with type 1 diabetes and peripheral sensory neuropathy.
- Trial name
- NCT00278980
- Testing
- C-peptide
- Where
- Sweden
- Volunteers
- 180 people
- Sponsor
- Creative Peptides Sweden Inc.
Alcohol Abuse, Peripheral Neuropathy
Cutaneous Denervation in Alcoholic Neuropathy
Peripheral neuropathy is a frequent neurological complication of chronic alcoholism. Most studies evaluated large-fiber involvement by nerve conduction studies (NCS).
- Trial name
- NCT00190073
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital