Clinical trials: Neuropathy
Safety, Peripheral Neuropathy
Xanamem™ in Healthy Elderly Subjects
Xanamem™ is being developed as a potential drug for Alzheimer's disease. This study drug has been designed to change the cortisol levels in the brain. Cortisol is a naturally occurring hormone in the body.
- Conditions
- Safety, Peripheral Neuropathy, Cortisol, Central Nervous System
- Trial name
- XanaHES (NCT03830762)
- Testing
- Xanamem
- Where
- Australia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Actinogen Medical
Toxic Optic Neuropathy, Treatment
Effect of Intravenous Methylprednisolone and Intravenous Erythropoietin in Toxic Optic Neuropathies: Randomized Clinical Trial.
The goal of this double-blind prospective randomized clinical trial is to determine if the effect of intravenous erythropoietin is superior to the effect of intravenous methylprednisolone in cases of toxic optic neuropathy 4…
- Conditions
- Toxic Optic Neuropathy, Treatment, Methylprednisolone, Erythropoietin
- Trial name
- NCT05748561
- Testing
- Recombinant human erythropoietin 4,000 UI and 2,000 UI, Methylprednisolone succinate 500 mg
- Where
- Mexico
- Volunteers
- 18 people
- Sponsor
- Asociación para Evitar la Ceguera en México
Diabetic Foot Ulcer
Transcutaneous Raman Spectroscope (TRS) Analyses of Diabetic Foot Ulcers
The primary translational research objective of the study is to demonstrate feasibility of using the Transcutaneous Raman Spectroscopy technology in a point-of-care environment.
- Trial name
- NCT02202668
- Testing
- TRS
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Michigan
Breast Cancer
Randomized Study Versus Placebo for the Prevention of Neurotoxicity Induced by Weekly PACLITAXEL
This study recommends the use of OnLife dietary supplement, which will be followed by a few day before the initiation of PACLITAXEL, for the prevention of PACLITAXEL induced neuropathy.
- Trial name
- NEUROTAX (NCT05695313)
- Testing
- OnLife®
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Georges Francois Leclerc
Lymphoma
Revlimid® Capsules Drug Use-results Surveillance (Relapsed or Refractory ATLL)
To understand the safety and efficacy of Revlimid® Capsules 2.5 mg and 5 mg (hereinafter referred to as Revlimid) under actual conditions of use in patients with relapsed or refractory adult T-cell leukemia lymphoma (hereinafter…
- Trial name
- NCT03098589
- Testing
- Revlimid
- Where
- Japan
- Volunteers
- 1,149 people
- Sponsor
- Celgene
Diabetic Foot
A Randomized Trial on Platelet Rich Plasma Versus Saline Dressing of Diabetic Foot Ulcers
New treatments for persistent DFU have emerged, among which are the bioengineered skin substitutes, extracellular matrix proteins products, matrix metalloproteinases modulators, and growth factor therapy.
- Trial name
- NCT04090008
- Testing
- PRP gel, Saline dressing
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Mansoura University
Low Back Pain, Nerve Entrapment Syndrome
The Frequency of Superior Cluneal Nerve Entrapment Diagnosed With Ultrasound Guided Nerve Block
Cluneal nerves are a group of pure sensory nerves that provide direct cutaneous innervation to the buttocks. Superior cluneal nerve(SCN) originates from the T11-L5 nerve roots and has at least 3 branches from medial to lateral…
- Conditions
- Low Back Pain, Nerve Entrapment Syndrome, Radiating Pain
- Trial name
- NCT05303597
- Testing
- ultrasound-guided diagnostic nerve block with lidocaine
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Istanbul University - Cerrahpasa
Chemotherapy-induced Peripheral Neuropathy, Cancer
A Mind-Body Intervention for Chemotherapy-Induced Peripheral Neuropathy
This pilot study will include up to 25 patients with cancer experiencing chemotherapy-induced peripheral neuropathy. Patients enrolled in the study will participate in a 10-week QiGong for Chemotherapy-Induced Neuropathy program.
- Trial name
- QiGong (NCT04185610)
- Testing
- Qi Gong
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Arash Asher, MD
Lower Extremity Chronic Ulcers in Diabetics
Evaluation of CureXcell® in Treating Lower Extremity Chronic Ulcers in Adults With Diabetes
Chronic foot ulcers are particularly prevalent in patients with underlying diabetes mellitus. These ulcers are reported to be the leading cause of hospitalization among people with diabetes.
- Trial name
- NCT01421966
- Testing
- CureXcell®
- Where
- 37 sites in United States, Canada and 1 more
- Volunteers
- 285 people
- Sponsor
- Macrocure Ltd.
Type 1 Diabetes, Sleep Apnea Syndrome
Sleep Apnea in Type 1 Diabetes
Sleep apnea syndrome is strongly associated to type 2 diabet, partly and this is partly due to obesity. Treatment of sleep apnea may improve hypertension, cardiovascular risk and in some studies diabetes status.
- Trial name
- DIASOM (NCT01935765)
- Testing
- Polysomnography, Evaluation of the autonomous nervous system, Clinical examination of the sleep
- Where
- France
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Small Fiber Neuropathy
Autofluorescent Flavoprotein Imaging of Intraepidermal Nerve Fibers: a Pilot Study
Small fiber neuropathy (SFN) is a common disorder, which has a profound negative impact on quality of life because of severe neuropathic pain.
- Trial name
- NCT02537951
- Testing
- AFI microscope, negative control 1: lidocaine/prilocaine, negative control 2: 8% capsaicin
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Diabetes Type 1, Proteomics
Proteomic Analysis in Paediatric Diabetes Type 1 (PAPD)
The aim of the present study is to investigate a targeted proteomic analysis in plasma of children - of Greek origin- with type 1 diabetes (DT1) and its correlation with the electrophysiological findings that accompany diabetic…
- Conditions
- Diabetes Type 1, Proteomics, Diabetic Peripheral Neuropathy
- Trial name
- PAPD (NCT04257877)
- Testing
- Blood sampling
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Urothelial Cancer
Peripheral Neuropathy in Patients Receiving Enfortumab Vedotin and Pembrolizumab as First Line Treatment for Metastatic or Locally Advanced Urothelial Carcinoma
The P-EVOLUTION trial is a prospective, multicenter, non-interventional observational study aimed at investigating peripheral neuropathy in patients receiving first-line treatment for metastatic or locally advanced urothelial…
- Trial name
- P-EVOLUTION (NCT06657157)
- Where
- 4 sites in Germany
- Volunteers
- 80 people
- Sponsor
- Comprehensive Cancer Center Munich (CCCM)
Piriformis Syndrome
f-ESWT vs Steroid Injection for Piriformis Syndrome
This study aims to compare two treatment methods for piriformis syndrome, a condition that can cause pain in the buttock and leg. Adult patients with piriformis syndrome will take part in the trial.
- Trial name
- NCT07145554
- Testing
- Focal extracorporeal schock wave therapy, Steroid Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Gulhane Training and Research Hospital
Neonatal Brachial Plexus Palsy
Does Wearing Tetra-Grip Improve Arm Function in Children Diagnosed With Neonatal Brachial Plexus Palsy?
This study evaluates the effect of wearing a tetra-grip on the affected arm of children with neonatal brachial plexus palsy. Half of the participants will have tetra-grip applied to the arm, while the other half will not have it…
- Trial name
- NCT03647761
- Testing
- Tetra-grip
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Texas Southwestern Medical Center
Chemotherapy-induced Peripheral Neuropathy, Recurrent Ovarian Carcinoma
High Dose Inorganic Selenium for Preventing Chemotherapy Induced Peripheral Neuropathy
This study aims to evaluate the safety and efficacy of high dose inorganic selenium in preventing and relieving chemotherapy-induced peripheral neuropathy (CIPN) in platinum-sensitive recurrent ovarian, fallopian, or primary…
- Conditions
- Chemotherapy-induced Peripheral Neuropathy, Recurrent Ovarian Carcinoma, Ovarian Cancer, Fallopian Tube Cancer
- Trial name
- SELENIUM (NCT04201561)
- Testing
- sodium selenite pentahydrate, Normal saline, Chemotherapy
- Where
- South Korea
- Volunteers
- 68 people
- Sponsor
- Seoul National University Hospital
Diabetic Polyneuropathy, Magnetic Resonance Imaging
Diffusion Tensor Imaging of Median Nerve in Diabetic Peripheral Neuropathy
This study is a diagnostic accuracy study that aims to evaluate the role of DTI in evaluation of DPN in comparison to clinical scores and nerve conduction studies (NCS).
- Trial name
- NCT03934970
- Testing
- Diffusion tensor imaging of peripheral nerves
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cairo University
Diabetic Peripheral Neuropathic Pain
Slider Versus Tensioner Neural Mobilization in Diabetic Peripheral Neuropathy
Neurodynamics, i.e., the mobilization of the peripheral nervous system, is a physical approach to the treatment of pain; the method relies on influencing pain physiology via mechanical treatment of neural tissues and the…
- Trial name
- NCT05349357
- Testing
- Sliding Neural mobilization, Tensioner Neural mobilization, Stretching exercises
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Diabetic Neuropathy Peripheral
Effect of High Tone Power Therapy on Neurophysiological Measures and Function Outcome in Patients With Diabetic Neuropathy
The purpose of the study is to investigate the effect of high tone power therapy on neurophysiological measures and function outcome in patients with diabetic neuropathy.
- Trial name
- NCT03888872
- Testing
- High tone power therapy, Selected Physical Therapy Program
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- October 6 University
Optic Nerve Diseases, Optic Nerve Injuries
Paraorbital-Occipital Alternating Current Stimulation Therapy for Optic Neuropathy (MCT_optnerve)
Aim is to validate that non-invasive brain stimulation can increase cortical excitability in the visual system. The investigators assess if transcranial alternating current stimulation (tACS) can improve visual field size in…
- Conditions
- Optic Nerve Diseases, Optic Nerve Injuries, Optic Neuropathies
- Trial name
- NCT01280877
- Testing
- tACS
- Where
- 4 sites in Germany
- Volunteers
- 90 people
- Sponsor
- University of Magdeburg