Clinical trials: Neuronal Plasticity
Aging, Music
Brain Imaging and Behavioural Changes Following Cued-movement Training of Finger Sequences in Healthy Older Adults
The goal of this study is to examine changes in the brain, behavior, and personal experience when music is used to guide learning of finger movement sequences (compared to visual stimuli alone) in healthy older adults.
- Conditions
- Aging, Music, Motor Activity, Magnetic Resonance Imaging
- Trial name
- NMSOA (NCT06174740)
- Testing
- Music-cued audiovisual motor training, Visually-cued motor training
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universiteit Leiden
Anxiety
Neuroplasticity in an Extended Amygdala Network as a Target Mechanism for Attention Bias Modification Outcome
Anxiety disorders are one of the most common psychological disorders. Underlying anxiety is an increased attentional bias to threat, which has been identified as a causal contributor in the development of anxiety.
- Trial name
- NCT03092609
- Testing
- Attention Bias Modification, Attention Control
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Northern Michigan University
Stroke
Robotic Pedaling Therapy for Targeted Neural Plasticity
The aim of this Pilot study is to determine whether robotically targeted lower-limb pedaling therapy can increase the extent of stroke recovery on behavioral measures and induce brain plasticity as measured by functional magnetic…
- Trial name
- NCT03300258
- Testing
- Robotic therapy, Aerobic therapy
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Prolonged Pain, Neuroplasticity
Modulatory Effects of Multichannel tDCS During Prolonged Experimental Pain
Corticomotor excitability, pain sensitivity, descending pain control and somatosensory evoked potentials (SEPs) is often altered in acute and chronic pain.
- Conditions
- Prolonged Pain, Neuroplasticity, Brain Modulation
- Trial name
- NCT04165980
- Testing
- transcranial direct current stimulation
- Where
- Denmark
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Aging
Gait Adaptation Study
This pilot study proposes a clinical trial to target treatment of sensorimotor and cognitive deficits in persons with Multiple Sclerosis (pwMS).
- Trial name
- NCT07660601
- Testing
- Gait Adaptation Training, Basic Physical Training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Anxiety Disorders
Biomarkers for Exercise
The overarching objective is to examine the brain-based biological mechanistic pathway by which exercise exerts anxiolytic effects.
- Trial name
- NCT07340281
- Testing
- Exercise Intervention
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
ACL Injury
Neuroplasticity Associated With Anterior Cruciate Ligament Injury
Activation of the brain for knee movement changes after anterior cruciate ligament (ACL) reconstruction. The brain activation profile after ACL reconstruction indicates a shift to a visual-motor control strategy, as opposed to a…
- Trial name
- NCT03654495
- Testing
- Exergame training, Usual Care Training
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Autism Spectrum Disorder, Intellectual Disability
TMS for the Investigation of Brain Plasticity in Autism Spectrum Disorders
The main purpose is to study brain plasticity (the changes that occur in the brain through experience) in individuals with autism spectrum disorder (ASD).
- Trial name
- NCT02836405
- Testing
- Transcranial Magnetic Stimulation
- Where
- 2 sites in United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Math Learning Disability, Child Development
Interventions in Mathematics and Cognitive Skills
The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning…
- Conditions
- Math Learning Disability, Child Development, Developmental Disability, Learning Disabilities
- Trial name
- NCT05201534
- Testing
- Interventions in Mathematics and Cognitive Skills - Experimental, Interventions in Mathematics and Cognitive Skills - Active Comparator
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Stanford University
Low Intensity Focussed Ultrasound
Pharmacological Mechanisms of Low-intensity Focused Ultrasound for Motor Cortex Neuroplasticity
Low-intensity focused ultrasound (LIFUS) has been shown to be an effective and safe non-invasive brain stimulation technique, capable of reaching greater brain depth and a greater spatial resolution than other brain stimulation…
- Trial name
- LIFUS-Pharma (NCT04923659)
- Testing
- Carbamazepine, Lorazepam, Dextromethorphan
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Upper Limb Ischemia, Stroke
Identification of Non-motor Brain Areas Involved in Upper Limb Motor Recovery After Stroke
Why: Upper-limb recovery post-stroke is challenging. Rehabilitation, aiming to induce plasticity takes an important place in patients' treatment.
- Trial name
- NOMO-Stroke (NCT05313776)
- Testing
- Magnetic Resonance Imaging
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Schizophrenia
Effects of Varenicline on Plasticity in Schizophrenia
This laboratory pilot study will explore the effects of varenicline tartrate on long-term potentiation (LTP)-like mechanisms of (1) the motor cortex and (2) the dorsolateral prefrontal cortex (DLPFC) and working memory in…
- Trial name
- VAR-PAS (NCT01934023)
- Testing
- Varenicline
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Healthy Young Adults
Lifestyle, Fitness, and Plasma Biomarkers in Healthy Young Adults
Lifestyle play a key role in modulating brain health by directly influencing a number of key biological processes, such as neuroplasticity, neurogenesis, and regulation of biomarkers associated with cognitive decline.
- Trial name
- NEUROACTIVE (NCT07032168)
- Where
- Spain
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- European University Miguel de Cervantes
Cognitive Control
Measuring Plasticity in SFC/dACC Following Theta-Burst-Stimulation Using TMS
This is a study to determine whether particular forms of brain-stimulation, applied to superior frontal cortex/preSMA can affect cognition and associated frontal theta oscillations.
- Trial name
- BTMS (NCT03946059)
- Testing
- iTBS then cTBS, cTBS then iTBS
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Spinal Cord Injuries
NeuroSuitUp: Neurorehabilitation Through Synergistic Man-machine Interfaces
NeuroSuitUp is a multidisciplinary neurophysiological \& neural rehabilitation engineering project, developed by the Lab of Medical Physics \& Digital Innovation, School of Medicine, Faculty of Health Science Aristotle University…
- Trial name
- NeuroSuitUp (NCT05465486)
- Testing
- Brain-Computer Interface control of robotic arms with augmented reality, Serious game with augmented reality
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Old Age; Dementia, Aging
Compensatory Brain Activity in Older Adults.
There are two important aspects in which the present project will allow to enrich our understanding of compensatory brain activity in older adults.
- Conditions
- Old Age; Dementia, Aging, Cognitive Decline
- Trial name
- BrainAct (NCT06235840)
- Testing
- working memory adaptive training, multi-domain non-adaptive control training
- Where
- Poland
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Kazimierz Wielki University
Aging Hands
Neural Substrates Underlying Adaptations in Manual Dexterity of Older Adults
Age-related declines in motor function can compromise independence and quality of life. This project examines how practice and somatosensory stimulation reshape the neural control of hand muscles in older adults, leveraging…
- Trial name
- NCT07011160
- Testing
- Transcutaneous electrical nerve stimulation (TENS), Familiarization
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Multiple Sclerosis, Cognitive Decline
MS-NEUROPLAST: Neuroplasticity of Cortical Areas Induced by Cognitive Training in Patients With Multiple Sclerosis
This clinical study aims to identify MS related beneficial plasticity and by contrast maladaptive reorganization in combination with elements of daily functional status as a response to a cognitive training program
- Trial name
- MSNEUROPLAST (NCT04806568)
- Testing
- Cognitive Training, Monitoring of daily activity
- Where
- Greece
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Healthy Volunteer Study
A Multi-domain Intervention for Healthy Aging
This study aims to investigate the long-term impact of a non-pharmacological intervention including several activities (e.g., physical activity, choir, learning programs, horticulture, etc.) to prevent cognitive impairment in…
- Trial name
- MultiMusic (NCT06767410)
- Testing
- Multidomain Intervention, General activities
- Where
- 4 sites in Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Bari
Neuroplasticity in Motor Learning
Neuroplasticity in Motor Learning in Young Adults Under Variable and Constant Practice Conditions
The project aims at providing a better understanding of motor skill acquisition and learning processes. The primary objectives of the study are to determine how practice conditions, i.e., variable and constant practice…
- Trial name
- NMLPC (NCT04921072)
- Testing
- Constant practice conditions, Variable practice conditions
- Where
- Czechia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Masaryk University