Clinical trials: Neuromuscular Blocking Agents
Neuromuscular Blockade, Arthroplasty, Replacement, Hip
Reversal of Neuromuscular Blockade With Sugammadex or Usual Care in Hip Fracture Surgery or Joint (Hip/Knee) Replacement (P07038)
This study will assess the effect of reversal of neuromuscular blockade with sugammadex compared with reversal according to usual care (neostigmine or spontaneous reversal) on the incidence of post-surgical bleeding events and on…
- Conditions
- Neuromuscular Blockade, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee, Blood Coagulation
- Trial name
- NCT01422304
- Testing
- Sugammadex, neostigmine and glycopyrrolate or atropine
- Volunteers
- 1,198 people
- Sponsor
- Merck Sharp & Dohme LLC
Thyroid, Neuromuscular Blockade
Anaesthesia With or Without Rocuronium in Intubation and Intraoperative Nerve-monitoring During Thyroid Surgery.
In this randomized controlled trial the investigators want to assess if, compared to controls, the administration of one single low-dose of rocuronium would increase the occurrence of absent or weak (i.e.
- Conditions
- Thyroid, Neuromuscular Blockade, Anesthesia Complication, Anesthesia Intubation Complication
- Trial name
- NCT03910504
- Testing
- Rocuronium 0.3 mg*kg, No Rocuronium
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Federico Longhini
Neuromuscular Blockade, Pulmonary Complication
Incidence of Residual Neuromuscular Blockade in Intra-abdominal Surgery: A Prospective, Observational Study
The aim of this prospective, observational study is to determine the incidence of post-operative residual neuromuscular blockade (PRNB) in patients undergoing intra-abdominal procedures compared to patients undergoing other…
- Trial name
- NCT02984839
- Testing
- Stimpod NMS450® Nerve Stimulator, by Xavant™ Technology
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- OhioHealth
Neuromuscular Blocking Agents, Residual Neuromuscular Block
Measuring of the Duration of Action of Different Doses of Rocuronium-induced Neuromuscular Block in Infants During Surgical Treatment of Craniosynostosis
The use of intravenous muscle relaxants during anaesthesia can significantly facilitate endotracheal intubation and reduce the chance of possible airway complications during intubation.
- Conditions
- Neuromuscular Blocking Agents, Residual Neuromuscular Block, Neuromuscular Blockade Monitoring
- Trial name
- NCT07080528
- Testing
- Sevofluorane, Propofol
- Where
- Hungary
- Volunteers
- 20 people
- Sponsor
- Tamas Vegh, MD
Out-of-hospital Cardiac Arrest
Continuous NMB in PCAS
The main purpose of this study is to test the hypothesis that continuous NMB could improve outcome in cardiac arrest patients treated with therapeutic hypothermia.
- Trial name
- NCT02790164
- Testing
- Esmeron, Saline
- Where
- South Korea
- Volunteers
- 81 people
- Sponsor
- Chun Song Youn
Airway Morbidity, Anesthesia
I-gel vs Ambu AuraGain in Laparoscopic Gynecological Surgery
To compare the effects of i-gel and Ambu AuraGain on ventilation parameters and surgical view during Trendelenburg position laparoscopic gynecological surgery in cases administered positive pressure ventilation without the use of…
- Trial name
- NCT03760692
- Testing
- i-gel, Ambu AuroGain
- Where
- 2 sites in Spain, Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Dokuz Eylul University
Disease of Respiratory System
Application of Low-dose Muscle Relaxants in Bronchoscopic Interventional Procedures
The purpose of this clinical trial is to observe the use of low-dose muscle relaxants in bronchoscopy intervention surgeries, compared with no muscle relaxants, in terms of the satisfaction of tracheal tube insertion after…
- Trial name
- NCT07035301
- Testing
- Lidocaine Intravenous Infusion, Remimazolam Tosilate, Remifentanil
- Where
- China
- Volunteers
- 153 people
- Sponsor
- Harbin Medical University
Neuromuscular Monitoring After Administration of Neuromuscular Blocking Agents in Different Types of Surgery
Observational Study to Evaluate the Current Neuromuscular Monitoring Practice Used After Different Types of Surgery, for Which Neuromuscular Blocking Agents Were Used, With or Without Blocking Reversal (P06556)
The intent of this observational study is to collect prospective data regarding neuromuscular monitoring practices and extubation standards (Train-Of-Four [TOF] value) during surgery, in countries of Central and Eastern Europe…
- Trial name
- NCT01213264
- Testing
- No neuromuscular blockade (NMB)-reversal agent used, Sugammadex, Other NMB-Reversal Agents Used in Routine Anesthesiology Practice
- Volunteers
- 659 people
- Sponsor
- Merck Sharp & Dohme LLC
ARDS, TTM
TwichView-guided Atricurium Dose Adjustment Trial
The goal of this clinical trial is to learn if using a monitor that measures muscle response can lower the amount of muscle relaxant medicine needed in adults who are treated in an intensive care unit (ICU) and need a continuous…
- Conditions
- ARDS, TTM, ECMO, Neuromuscular Blockade Monitoring
- Trial name
- NCT07807046
- Testing
- EMG-based quantitative TOF-guided atracurium titration
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Fu Jen Catholic University Hospital
Neuromuscular Blockade, Anesthetic Agents
Effects of Anesthetics on High-Dose Rocuronium
This study evaluates the effects of three different anesthetics on high dose rocuronium in laparoscopic cholecystectomy cases. Patients were randomly assigned to one of the propofol, desflurane, or sevoflurane groups.
- Trial name
- NCT06045559
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Mustafa Kemal University
ICU Patients
A Prospective, Randomized, Blinded Study of BIS Analysis in ICU Patients Requiring Neuromuscular Blocking Agents
This is a prospective, randomized, blinded study in which patients will be enrolled into either treated(BIS group) or untreated (non-BIS) group employing bispectral analysis to measure the level of sedation/analgesia in patients…
- Trial name
- NCT00714974
- Testing
- BIS
- Volunteers
- 56 people
- Sponsor
- University of Utah
Neuromuscular Blocking Agents
Antagonism of Neostigmine in Continuous Infusion of Mivacurium
In this study, the antagonism of neostigmine, a cholinesterase inhibitor, on continuous infusion of mivacurium during foot and ankle surgery under general anesthesia was investigated, and the appropriate time point of antagonism…
- Trial name
- NCT07524959
- Testing
- Neostigmine
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Beijing Tongren Hospital
Muscle Relaxation
Study of Efficacy, Pharmacokinetics, and Safety of Bolus Maintenance Doses of Org 9426 (Study P05976)(COMPLETED)
The purpose of this study is to evaluate the efficacy, pharmacokinetics, and safety of Org 9426 in maintenance of muscle relaxation in adult subjects undergoing general elective surgery.
- Trial name
- NCT00984633
- Testing
- Rocuronium bromide (Org 9426), Sevoflurane, Propofol
- Volunteers
- 40 people
- Sponsor
- Merck Sharp & Dohme LLC
Paraspinal Muscle Relaxation in Spine Surgery
Paraspinal Muscle Relaxation in Spine Surgery
During anesthesia, neuromuscular blocking agents (NMBA) are routinely used for relaxation of muscles necessary for the conduction of the surgical procedure.
- Trial name
- TOF (NCT03318718)
- Testing
- Anesthesia with non-depolarizing NMBA Rocuronium, TOF measurement, MEP measurement
- Where
- Switzerland
- Volunteers
- 25 people
- Sponsor
- Balgrist University Hospital
Laparoscopic Surgery
Dose for Deep Neuromuscular Blockade Deciding Factor of Neuromuscular Blocker Dose for Deep Neuromuscular Blockade
Find out the deciding factor(total body weight, corrected body weight, ideal body weight, fat-free mass, body mass index, skeletal muscle mass, body fat) of neuromuscular blocker dose for deep neuromuscular blockade.
- Trial name
- NCT04688268
- Testing
- deep neuromuscular blockade
- Volunteers
- 90 people
- Sponsor
- Seoul National University Bundang Hospital
Anesthesia
Study of Efficacy, Pharmacokinetics and Safety of Continuous Intravenous Infusion of Org 9426 (Study P05977)
The purpose of this study is to compare the infusion rate of Org 9426 following intubating dose of Org 9426 0.6 mg/kg or 0.9 mg/kg in adult surgical patients.
- Trial name
- NCT00988520
- Testing
- Rocuronium bromide, Sevoflurane, Propofol
- Volunteers
- 38 people
- Sponsor
- Merck Sharp & Dohme LLC
Muscle Weakness
The Impact of Quantitative Neuromuscular Monitoring in the PACU on Residual Blockade and Postoperative Recovery
Neuromuscular blocking drugs (NMBDs) provide anesthesiologists with powerful intraoperative tools, but their use carries the potential risk of serious postoperative complications.
- Trial name
- NCT01933841
- Testing
- TOF-Watch SX, Notify the provider
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Vanderbilt University Medical Center
Postoperative Gastrointestinal Dysfunction (POGD), Postoperative Ileus
Neuromuscular Blocking Agents on Gastrointestinal Function Following Colorectal Surgery
This study is a clinical research project conducted at Xijing Hospital to compare the effects of two different neuromuscular blockade reversal strategies on the recovery of gastrointestinal (GI) function after colorectal surgery.
- Conditions
- Postoperative Gastrointestinal Dysfunction (POGD), Postoperative Ileus, Colorectal Surgery
- Trial name
- NCT07271875
- Testing
- Neostigmine + Atropine, Sugammadex
- Volunteers
- 560 people
- Sponsor
- Xijing Hospital
Neuromuscular Blocking Agents, Urinary Retention After Procedure
NMBA Reversal and Postoperative Urinary Retention
In this single-center retrospective cohort study of adult patients who underwent surgery under general anesthesia at Beth Israel Deaconess Medical Center between September 2016 and January 2024, the association between the choice…
- Conditions
- Neuromuscular Blocking Agents, Urinary Retention After Procedure, Urinary Retention Postoperative, Neuromuscular Blockade Reversal Agent
- Trial name
- NCT06948409
- Testing
- Choice of reversal agent (sugammadex or neostigmine [with muscaranic antagonist])
- Where
- United States
- Volunteers
- 70,000 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Neuromuscular Blockade
Abdominal Muscle Volume and a Neuromuscular Blocking Agent
With the recent development of image analysis and artificial intelligence, it has become possible to measure the muscle volume from preoperative computed tomography (CT) images.
- Trial name
- NCT06769932
- Testing
- preoperative computed tomography
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Seoul National University Bundang Hospital