Clinical trials: Neuromuscular Blockade Monitoring
Acute Respiratory Distress Syndrome
Monitoring in Intensive Care Unit of Neuromuscular Blocking Agents Used for Acute Respiratory Distress Syndrome After Cardiothoracic Surgery
Mortality in Acute Respiratory Distress Syndrome (ARDS) is high (40 to 60 %). Protective mechanical ventilation is the cornerstone of the ARDS therapeutic strategies.
- Trial name
- CURAREA (NCT02546947)
- Testing
- Train of four monitoring
- Where
- France
- Volunteers
- 82 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Mechanomyography, Neuromuscular Blockade Monitoring
The TOF3D Mechanomyograph. Evaluation of a New Device for Assessment of the Neuromuscular Block.
In clinical anesthesiologic practice, most institutions use acceleromyography in order to assess the degree of a neuromuscular block. The aim of the present study is to assess a new device using mechanomyography.
- Trial name
- MMG versus AMG (NCT07371377)
- Testing
- measurement of the time course of a neuromuscular block
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Klinikum Hersfeld-Rotenburg
Critical Illness
Comparison of Neuromuscular Blockade's Monitoring and Clinical Assessment During Cisatracurium Paralysis in Critically Ill Patients
The main objectives of the prolonged resuscitation paralysis are usually adaptation to mechanical ventilation, lower insufflation pressures and cough suppression.
- Trial name
- NCT03198637
- Testing
- Cisatracurium's monitoring by TOF (train-of-four) WATCH device., clinical assessment
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Poitiers University Hospital
Postoperative Residual Curarization, Neuromuscular Block Prolonged
Postoperative Residual Neuromuscular Block and Passive Smoke Exposure in Pediatric Dental Patients
Postoperative residual neuromuscular block (PRNB) may persist despite apparent clinical recovery from neuromuscular blockade and may increase the risk of postoperative respiratory complications.
- Trial name
- NCT07831434
- Testing
- Passive Smoke Exposure
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Istanbul University - Cerrahpasa
Neuromuscular Block
Efficacy of Sugammadex in Magnesium Pretreated Patients
Sugammadex is a new reversal agent for neuromuscular blockers (curare). It encapsulates the curare molecule and terminates immediately its action.
- Trial name
- MagSug (NCT01440933)
- Testing
- Magnesium Sulfate
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- University Hospital, Geneva
Observation of Neuromuscular Block, Flexor Hallucis
Evaluation of Monitoring Neuromuscular Blockade the Flexor Hallucis Compared to the Adductor Pollicis
Current guidelines recommend monitoring of neuromuscular blockade at the adductor pollicis by stimulation of the ulnar nerve at the wrist.
- Conditions
- Observation of Neuromuscular Block, Flexor Hallucis, Adductor Pollicis
- Trial name
- CurHaTOF (NCT02825121)
- Testing
- Monitoring Neuromuscular Blockade the Flexor Hallucis, Monitoring Neuromuscular Blockade adductor of the thumb.
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Poitiers University Hospital
Coronary Artery Disease, Valvular Heart Disease
Sugammadex Titration in Cardiac Surgery Patients
Sugammadex is frequently used to reverse the effects of neuromuscular blocking drugs. The recommended doses are 2 mg/kg or 4 mg/kg depending upon the depth of neuromuscular blockade.
- Conditions
- Coronary Artery Disease, Valvular Heart Disease, Aorta Disease, Heart Failure
- Trial name
- NCT05246397
- Testing
- Sugammadex administration
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Washington
Neuromuscular Blockade
Neuromuscular Monitoring in Children (6 Months - 2 Years) With Electromyography and Acceleromyography
The aim of this study is to compare AMG and EMG (Philips IntelliVue NMT module and Senzime TetraGraph) in the objective monitoring of neuromuscular blocking in children between the age of 6 months and 2 years.The monitoring will…
- Trial name
- NCT06409260
- Testing
- Acceleromyography (AMG), Electromyography (EMG)
- Where
- Denmark
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Matias Vested
Neuromuscular Blockade, Cholecystectomy
Acceleromyography Versus Electromyography for Neuromuscular Recovery Assessment at the End of Surgery
This prospective observational study aims to evaluate the agreement between acceleromyography and electromyography for measuring train-of-four (TOF) ratio at the end of surgery before reversal of neuromuscular blockade.
- Trial name
- NCT07739862
- Testing
- Simultaneous Acceleromyography and Electromyography Monitoring
- Where
- Chile
- Volunteers
- 70 people
- Sponsor
- Clínica Dávila
Neuromuscular Blockade
Neuromuscular Monitoring:TOFCuff Versus EMG
Mechanomyography (MMG) is considered the gold-standard for neuromuscular blockade (NMB) monitoring. However, it is quite bulky and difficult to use on a routine basis.
- Trial name
- NCT04282213
- Where
- Spain
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Servei Central d'Anestesiologia
Anesthesia
Clinical Evaluation of a Novel Neuromuscular Blockade Monitoring System
This study is designed to formally evaluate the performance of the QTOF, as compared with the newest commercially available NMB monitoring equipment, EMG (the TwitchView).
- Trial name
- NCT04406740
- Testing
- TwitchView EMG Unit, Novel QTOF Device
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Minnesota
Neuromuscular Blockade
Validation of the TOF Cuff Monitor® Which Measures Neuromuscular Block on the Upper Arm
Neuromuscular blocking agents (NMBAs) are frequently used in anesthesia and quantitative neuromuscular monitoring is standard care.
- Trial name
- NCT03256955
- Testing
- Tof cuff, Tof Watch SX
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Christoph Czarnetzki
Postoperative Residual Curarization
Postoperative Residual Curarization in 2018
The primary objective of this study is to evaluate the incidence of postoperative residual curarization, as defined by a train-of-four <90%, upon postanaesthesia care unit arrival.
- Trial name
- NCT03665805
- Testing
- neuromuscular transmission monitoring
- Where
- Belgium
- Volunteers
- 587 people
- Sponsor
- Onze Lieve Vrouw Hospital
Residual Neuromuscular Blockade
Thumb vs Great Toe Recovery
Researches are comparing the accuracy of measuring muscle relaxation in the thumb versus the great toe.
- Trial name
- NCT04312256
- Testing
- TetraGraph
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Mayo Clinic
Postoperative Residual Curarization, Neuromuscular Blockade
Infantile - Postoperative Residual Curarization - Study
The primary object of this study is, to investigate the current procedure of neuromuscular monitoring at a tertiary academic university medical center.
- Conditions
- Postoperative Residual Curarization, Neuromuscular Blockade, Neuromuscular Monitoring
- Trial name
- I-PORC (NCT03804346)
- Testing
- Acceleromyography
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Regensburg
Anesthesia
Efficacy and Safety of Optimal Muscle Tension Management During Laparoscopic Cholecystectomy
Our study is intended to compare optimal muscle tension management or conventional anesthetic management in laparoscopic cholecystectomy about surgical condition during the surgery and other conditions after surgery at POR.
- Trial name
- NCT04165057
- Testing
- Optimal muscle tension management
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- National Taiwan University Hospital Hsin-Chu Branch
Neuromuscular Blockade, Muscle Relaxation
Clinical Application of "Train of Four" Testing in the Intraoperative Monitoring Setting
The study examines the clinical application of TOF (train of four test) used by anesthesiologists and neurophysiologists during instrumented spine procedures, as well as certain associated parameters.
- Trial name
- NCT01932983
- Testing
- Train of four test
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- NYU Langone Health
Driving Pressure, Neuromuscular Blockade Monitoring
Effect of Neuromuscular Block Depth on Driving Pressure and Postoperative Respiratory Events in Abdominal Surgeries
This randomized controlled study aims to evaluate the effects of deep versus moderate neuromuscular blockade on intraoperative driving pressure and the development of postoperative critical respiratory events in patients…
- Conditions
- Driving Pressure, Neuromuscular Blockade Monitoring, Postoperative Respiratory Complications
- Trial name
- NCT07464288
- Testing
- Rocuronium
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Neuromuscular Blocking Agents
Antagonism of Neostigmine in Continuous Infusion of Mivacurium
In this study, the antagonism of neostigmine, a cholinesterase inhibitor, on continuous infusion of mivacurium during foot and ankle surgery under general anesthesia was investigated, and the appropriate time point of antagonism…
- Trial name
- NCT07524959
- Testing
- Neostigmine
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Beijing Tongren Hospital