Clinical trials: Neuromuscular Blockade, open to volunteers
Spinal Stenosis Lumbar
The Effect of Progressive Muscle Relaxation Exercises on Pain and Disability After Spinal Surgery
This study was planned as a randomized controlled experimental study to determine the effect of progressive muscle relaxation exercises on pain and disability in patients undergoing spinal surgery.
- Trial name
- NCT05253326
- Testing
- Progressive Muscle Relaxation Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Istanbul Medeniyet University
Laparoscopic Surgery, Neuromuscular Blocking Agents
Study of the Relationship Between Curarization and Pneumoperitoneum in Laparoscopic Surgery
The number of surgical procedures is increasing worldwide (1). Laparoscopic surgery is one of the surgical techniques that has become indispensable. Laparoscopic surgery is less invasive than laparotomy.
- Conditions
- Laparoscopic Surgery, Neuromuscular Blocking Agents, Pneumoperitoneum
- Trial name
- PneumandTOF (NCT07005518)
- Testing
- No Intervention: Observational Cohort
- Volunteers
- 200 people
- Sponsor
- Poitiers University Hospital
Neuromuscular Blockade, Statin-Associated Myopathy
Evaluation of Neuromuscular Blockade Responses in Statin-Using and Non-Using Patients
This study aims to compare the neuromuscular blockade responses in patients undergoing elective surgery under general anesthesia, with a focus on the use of statins.
- Conditions
- Neuromuscular Blockade, Statin-Associated Myopathy, Neuromuscular Monitoring
- Trial name
- NCT06834776
- Testing
- TOF (Train-of-Four) monitoring for depth of neuromuscular blockade.
- Volunteers
- 104 people
- Sponsor
- Ankara City Hospital Bilkent
Nerve Block, Neuromuscular Blockade
LIA vs. LIA + ACB-iPACK Block for Total Knee Arthroplasty
LIA is the mainstay of postoperative analgesia in patients having knee arthroplasty. The combination of ACB-iPACK blocks has also been proposed as an effective analgesic modality for total knee arthroplasty.
- Trial name
- NCT04808947
- Testing
- Local infiltration analgesia, Ultrasound-guided adductor canal block
- Volunteers
- 60 people
- Sponsor
- Women's College Hospital
Chronic Post-thoracotomy Pain, Neuropathic Pain
SPS Block vs. Surgical Intercostal Block for Chronic Pain After Thoracoscopic Surgery
This study aims to evaluate the efficacy of ultrasound-guided Serratus Posterior Superior (SPS) block compared to surgeon-administered intercostal blockade in preventing chronic pain at 3, 6, and 12 months following…
- Conditions
- Chronic Post-thoracotomy Pain, Neuropathic Pain, Postoperative Pain, Acute
- Trial name
- NCT07436806
- Testing
- SPS block, Surgical Intercostal Blockade.
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Medipol University
End Stage Renal Disease on Dialysis
Fight Fatigue: A Progressive Muscle Relaxation and Walking Intervention to Reduce Fatigue in Adults With ESKD
Fight Fatigue is evaluating the feasibility and acceptability of a combined progressive muscle relaxation and walking intervention to reduce fatigue for adults with end-stage kidney disease receiving in-center hemodialysis.
- Trial name
- NCT07014111
- Testing
- Fight Fatigue, Attention Control
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Illinois Chicago
Muscle Relaxation
Effect of Magnesium Sulphate Pretreatment in Pediatric Abdominal Surgery
In this study, the investigators will compare the effect of magnesium sulphate pretreatment on the onset and duration of intense and deep neuromuscular Block of rocuronium versus Cis-Atracurium and on the period of no response to…
- Trial name
- MgSO4/MR (NCT05736744)
- Testing
- MgSO4, Cis-Atracurium
- Where
- 2 sites in Egypt
- Volunteers
- 58 people
- Sponsor
- Assiut University
Levator Scapulae Syndrome
Upper Cervical Mobilization Versus Integrated Neuromuscular Inhibition Technique in Patients With Levator Scapulae Syndrome
the study will be conducted to answer the following research question: is there a difference between the effect of upper cervical mobilization and integrated neuromuscular inhibition technique of levator scapulae muscle in…
- Trial name
- LSS (NCT07208396)
- Testing
- Upper cervical mobilization, Integrated neuromuscular inhibition technique, Conventional treatment
- Volunteers
- 60 people
- Sponsor
- Cairo University
Pain, Postoperative, Muscle Weakness
Low-Volume Pericapsular Nerve Group (PENG) Block With Dexamethasone vs Standard-Volume PENG Block After Total Hip Arthroplasty
The goal of this clinical trial is to compare two regimens of the pericapsular nerve group (PENG) block, an ultrasound-guided injection of local anaesthetic targeting the nerves supplying the front of the hip joint, for…
- Conditions
- Pain, Postoperative, Muscle Weakness, Arthroplasty, Replacement, Hip
- Trial name
- NCT07855341
- Testing
- Pericapsular nerve group (PENG) block, Bupivacaine, Dexamethasone
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Postoperative Pulmonary Complications
Postoperative Pulmonary Complications After Use of Supraglottic Airway Devices and Neuromuscular Blockade
SupAIR is an international, multicenter, randomized controlled trial investigating whether airway management and neuromuscular blockade during general anesthesia influence postoperative pulmonary complications.
- Trial name
- SupAIR (NCT07829094)
- Testing
- Airway management strategy, Initiation of neuromuscular blockade (NMB), Deep versus moderate neuromuscular blockade (NMB)
- Volunteers
- 6,800 people
- Sponsor
- University Hospital Ulm
Surgery, Neuromuscular Blockade
TetraGraph to Evaluate Onset and Recovery Times of Rocuronium
In most clinical instances, direct laryngoscopy and endotracheal intubation is performed after a set time (generally 60 seconds) following the administration of a neuromuscular (NM) blocking agent, rocuronium.
- Trial name
- NCT07435792
- Testing
- TetraGraph
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Nationwide Children's Hospital
ARDS (Acute Respiratory Distress Syndrome)
Continuous vs Bolus Neuromuscular Blockade Regimens in Moderate to Severe Hypoxemic Respiratory Failure and ARDS (COBRA)
Current clinical guidelines, such as those from the Surviving Sepsis Campaign and ARDSNet, recommend short-term NMBA use for patients with moderate to severe ARDS who exhibit persistent ventilator dyssynchrony or high plateau…
- Trial name
- COBRA (NCT07567768)
- Testing
- Neuromuscular Blocking Agent - Bolus Dosing, Neuromuscular Blocking Agent - Continuous Infusion
- Volunteers
- 100 people
- Sponsor
- University of Calgary
Surgery
EMG ss AMG In Robotic/Laparoscopic Surgery
The purpose of this study is to compare the mean cumulative weight-based/time-corrected rocuronium dose administered in patients undergoing robotic- or laparoscopic- assisted surgery using either acceleromyography or…
- Trial name
- PEARL (NCT07525323)
- Testing
- AMG device, EMG
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Mayo Clinic
Hypersensitivity, Drug
GERAP's Epidemiological Survey on Perioperative Hypersensitivity Reactions
Perioperative hypersensitivity reactions are still associated with significant morbidity and mortality despite early recognition and use of epinephrine.
- Trial name
- SERAP (NCT04654923)
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- University Hospital, Strasbourg, France
ARDS, TTM
TwichView-guided Atricurium Dose Adjustment Trial
The goal of this clinical trial is to learn if using a monitor that measures muscle response can lower the amount of muscle relaxant medicine needed in adults who are treated in an intensive care unit (ICU) and need a continuous…
- Conditions
- ARDS, TTM, ECMO, Neuromuscular Blockade Monitoring
- Trial name
- NCT07807046
- Testing
- EMG-based quantitative TOF-guided atracurium titration
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Fu Jen Catholic University Hospital
Bruxism, Stress (Psychology)
Influence Of Different Relaxation Techniques On Stress Level For Patients With Bruxism Using Salivary Biomarkers.
This study will compare the effect of three different physical therapy techniques on stress level on patients with bruxism by assessment of morning salivary biomarkers.
- Trial name
- NCT07868341
- Testing
- The Rocabado Program, Jacobson Progressive Muscle Relaxation Technique, Surface electromyography biofeedback
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Misr University for Science and Technology
Neuropathic Pain, Neuropathic Pain Diagnostic Questionnaire (DN4) ≥ 4
Hematological Indices and Sympathetic Block Response in Neuropathic Pain
This prospective observational study aims to evaluate the relationship between hematological inflammatory indices and clinical treatment response in patients with neuropathic pain undergoing sympathetic nerve block procedures as…
- Trial name
- HINSPAIN (NCT07596823)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ankara City Hospital Bilkent
Pudendal Neuralgia, Chronic Pelvic Pain Syndrome
Transvaginal Versus Fluoroscopy-guided Trans Gluteal Pudendal Nerve Block for Pudendal Neuralgia
Chronic pain affecting the pelvic and urogenital area is a major clinical problem and can have a profound impact on quality of life and health care costs.
- Trial name
- NCT06644261
- Testing
- Bupivacaine injection
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Generalized Anxiety Disorder (GAD)
Inspiratory Muscle Training and Diaphragmatic Breathing in GAD
This study will compare inspiratory muscle training and diaphragmatic breathing exercises in individuals with generalized anxiety disorder (GAD).
- Trial name
- NCT07913503
- Testing
- Inspiratory Muscle Training, Diaphragmatic Breathing Exercises, Progressive Muscle Relaxation
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Saglik Bilimleri Universitesi
Residual Paralysis
Residual Paralysis in the Post Anesthesia Care Unit: the Association Beetween Residual Neuromuscular Block Risk Prediction Score and the Train-of-Four Ratio. a Prospective Single-Center Open-Label Cohort Study
The reported incidence of rNMB varies between 16% to more than 70 depending on the used definition (train-of-four [TOF] ratio 0.7 or 0.9), type of NMBA, type of reversal agent, and timing of measurements The degree of residual…
- Trial name
- NCT06796777
- Volunteers
- 91 people
- Sponsor
- Assiut University