Clinical trials: Neuromodulation
Writer's Cramp, Dystonias
VTS Sensorimotor Neuromodulation in WC
Writer's cramps (WC) is a focal task-specific upper limb dystonia that significantly impairs handwriting and other manual skills, affecting functionality.
- Trial name
- VTS in WC (NCT07894198)
- Testing
- Vibro-tactile stimulation
- Volunteers
- 10 people
- Sponsor
- Ottawa Hospital Research Institute
Epilepsy, Chronic Pain
fMRI in Deep Brain Stimulation
With fMRI, we want to understand the mechanisms of brain neuromodulation in (dys)functional brain circuits, to obtain knowledge on involved brain networks in DBS.
- Trial name
- NCT03819738
- Testing
- fMRI
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Spinal Cord Injuries
Finding the Best Combination of Brain and Spinal Cord Stimulation With Hand Training After Spinal Cord Injury
While physical exercise remains the foundation for any rehabilitation therapy, the team seeks to improve the benefits of exercise by combining it with the concept of "Fire Together, Wire Together" - when brain stimulation is…
- Trial name
- NCT06104735
- Testing
- Synaptic Pairing Interval, Frequency, Bouts
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Bronx VA Medical Center
Stroke, Cerebrovascular Accident
Optimizing Transcranial Direct Current Stimulation for Motor Recovery From Hemiparesis
This study will compare the effectiveness of different polarities of transcranial direct current stimulation paired with intensive motor training in recovery of upper extremity function in individuals with severe post-stroke…
- Trial name
- NCT03124147
- Testing
- Neuroconn Eldith stimulator by Magstim
- Volunteers
- 38 people
- Sponsor
- Lumy Sawaki
Opioid-use Disorder, Substance Use Disorders
Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Use Disorders (SUDs)
The purpose of this clinical trial is to investigate Low Intensity Focused Ultrasound (LIFU) using the Exablate® Model 4000 Type 2.0/2.1 as an adjunctive neuromodulatory treatment for OUD (Opioid Use Disorder) and/or other…
- Trial name
- NCT04197921
- Testing
- Exablate Model 4000 Type 2.0/2.1
- Where
- 4 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- InSightec
Rheumatoid Arthritis (RA)
At-home Ultrasound Localized Therapy for Rheumatoid Arthritis Study [At-home ULTRA Study]
The At-Home ULTRA Study will evaluate performance of the MINI system as indicated for the treatment of adults with active, moderate to severe rheumatoid arthritis who are inadequate responders or are intolerant to conventional…
- Trial name
- At-home ULTRA (NCT07163221)
- Testing
- Non-invasive ultrasound stimulation of the spleen - Treatment Setting 1, Non-invasive ultrasound stimulation of the spleen - Treatment Setting 2, Conventional Synthetic DMARD
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- SecondWave Systems Inc.
Non-invasive Neuromodulation in Healthy Subjects
Mechanisms of Non-Invasive Neuromodulation Interventions: Influence on Human Neurochemistry and Functional Connectivity
The aim of this project is to increase our understanding of how two different protocols of repetitive transcranial magnetic stimulation (rTMS), inhibitory (1 Hz) and excitatory (5 Hz), applied over the primary motor cortex of the…
- Trial name
- NCT02677740
- Testing
- Inhibitory rTMS (1 Hz), Excitatory rTMS (5 Hz)
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Shoulder Pain
Percutaneous Electrical Nerve Stimulation and Exercise for Shoulder Pain
Based on the available literature, application of percutaneous electrical nerve stimulation interventions targeting peripheral nerves (also called percutaneous neuromodulation) has shown positive effects for improving…
- Trial name
- NCT06158568
- Testing
- Percutaneous Electrical Nerve Stimulation, Exercise
- Where
- Spain
- Volunteers
- 59 people
- Sponsor
- César Fernández-de-las-Peñas
Obsessive-Compulsive Disorder
Improving Obsessive-compulsive Disorder Treatments: From Lesions to Neuromodulation Targets
While in most cases of obsessive-compulsive disorder (OCD) a cause cannot be identified, this syndrome may develop as a consequence of focal brain lesions.
- Trial name
- ON-TARGET (NCT06490965)
- Testing
- Repetitive Transcranial Magnetic Stimulation, Neuronavigation, Magnetic Resonance Imaging
- Where
- Portugal
- Volunteers
- 32 people
- Sponsor
- Fundacao Champalimaud
Female Sexual Dysfunction, Spinal Cord Injuries
Effect of Peripheral Neuromodulation on Vaginal Blood Flow
The researchers want to see if nerve stimulation interventions cause a change in vaginal blood flow. This intervention was performed in women who have neurogenic (spinal cord injury) or non-neurogenic sexual dysfunction and…
- Trial name
- NCT04384172
- Testing
- Transcutaneous electrical nerve stimulation - Tibial Nerve, Transcutaneous electrical nerve stimulation - Genital Nerve
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Pain Cancer
Effectiveness of NMP and TDCS vs Pharmacological Treatment in Cancer Patients With Lower Limb Pain
the goal of this clinical trial is to compare in cancer patients: Is ultrasound-guided percutaneous neuromodulation useful for lower limb pain relief in cancer patients? Is direct current transcranial stimulation useful for…
- Trial name
- NCT06240377
- Testing
- Transcranial direct current stimulation (tDCS), Ultrasound-guided percutaneous neuromodulation (NMP)
- Where
- Spain
- Sponsor
- Universidad Europea de Canarias
Healthy Volunteers, no Condition, Basic Science
Transcranial Ultrasonic Neuromodulation of Primary Visual Cortex and Primary Auditory Cortex in Humans
There are a number of disorders of the brain that have limited treatment options, such as chronic pain, addiction, and major depression.
- Trial name
- NCT07508722
- Testing
- Transcranial Focused Ultrasound Stimulation, Electroencephalography, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Massachusetts Institute of Technology
Major Depression Moderate, Feasibility Studies
rTMS for Youth Inpatients With Depression
Youth aged 15-24 are likelier to have depression than all age groups in Canada. One-third of depressed youth do not respond to psychotherapy and/or antidepressant medications.
- Trial name
- NCT07140575
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Sunnybrook Health Sciences Centre
Multiple Sclerosis
Reducing Symptoms of Multiple Sclerosis Using Non-invasive Neuromodulation
This study sought to examine the effect of targeted physical therapy with and without cranial nerve non-invasive neuromodulation (CN-NINM), on the walking ability of people with MS who exhibited a dysfunctional gait.
- Trial name
- NCT04498039
- Testing
- Portable Neuromodulation Stimulator
- Volunteers
- 20 people
- Sponsor
- University of Wisconsin, Madison
Brain Imaging
tFUS Imaging & LIFU
This study is investigating a new method of brain imaging - transcranial functional ultrasound (tFUS). We are comparing the imaging capabilities with functional magnetic resonance imaging (fMRI).
- Trial name
- NCT07222865
- Testing
- Feasibility of imaging using tFUS
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Fibromyalgia
Occipital Transcranial Direct Current Stimulation in Fibromyalgia
The aim of this study is to investigate whether transcranial direct current stimulation is effective in the treatment of fibromyalgia related pain. The study provides a placebo arm and the design is a cross-over design.
- Trial name
- NCT00947622
- Testing
- Transcranial direct current stimulation
- Where
- Belgium
- Volunteers
- 35 people
- Sponsor
- University Hospital, Antwerp
Migraine, Acute Treatment of Migraine
Treatment Patterns Among US Veterans Using Remote Electrical Neuromodulation (REN) for Migraine Treatment
Among US veterans, migraine is a prevalent and disabling neurological disorder, creating a clinical need for effective treatment options.
- Trial name
- NCT07336420
- Testing
- Nerivio REN device
- Where
- United States
- Volunteers
- 466 people
- Sponsor
- Theranica
Incontinence
CPT Testing for Sacral Neuromodulation Outcomes
This is a prospective study. Subjects will be recruited from the urology practices of Dr. Ken Peters and Dr. Ananias Diokno at William Beaumont Hospital.
- Trial name
- NCT00617786
- Testing
- Current Perception Threshold (CPT) Testing
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Corewell Health East
Parkinson Disease, Movement Disorders
Deep Brain Stimulation to Treat Symptoms of Parkinson's Disease
The purpose of this study is to evaluate the safety and efficacy of bilateral stimulation of the subthalamic nucleus (STN) of the brain when using the ANS Totally Implantable Deep Brain Stimulation System as an adjunctive…
- Trial name
- NCT00552474
- Testing
- Libra Deep Brain Stimulation System
- Where
- 15 sites in United States
- Volunteers
- 136 people
- Sponsor
- Abbott Medical Devices
Drug Resistant Epilepsy
Feasibility Study of the iVEAcare Neuromodulation System for the Treatment of Drug-Resistant Epilepsy
The purpose of this study is to assess the safety and performance of the iVEAcare Neuromodulation System for the treatment of drug-resistant epilepsy.
- Trial name
- iVEAcare-FS (NCT07640191)
- Testing
- iVEAcare Neuromodulation System
- Where
- 7 sites in Australia
- Volunteers
- 30 people
- Sponsor
- iVEAcare