Clinical trials: Neuromodulation
Chronic Low-back Pain
Transcutaneous Spinal Cord Stimulation for Chronic Low Back Pain
As a leading cause of disability worldwide, chronic low back pain (cLBP) represents a significant medical and socioeconomic problem with estimated health care spending of $87 billion/annually.
- Trial name
- NCT05265000
- Testing
- tSpinalStim
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Healthy
Neuromodulation and Language Acquisition (Project Stage Ia)
The purpose of this study is to determine whether levodopa, pergolid, rivastigmine, or modafinil are effective in boosting semantic language acquisition in healthy subjects.
- Trial name
- NCT00102284
- Testing
- levodopa, rivastigmine, pergolid
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Rheumatoid Arthritis
Sacral Nerve Stimulation for Mild-to-Moderate or Refractory Rheumatoid Arthritis
This pilot study will assess the efficacy of sacral never stimulation (SNS) for the treatment of adult patients with active, mild-to-moderate rheumatoid arthritis or those with refractory disease.
- Trial name
- NCT04821050
- Testing
- Sacral nerve stimulation
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Opioid-use Disorder, Substance Use Disorders
Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Use Disorders (SUDs)
The purpose of this clinical trial is to investigate Low Intensity Focused Ultrasound (LIFU) using the Exablate® Model 4000 Type 2.0/2.1 as an adjunctive neuromodulatory treatment for OUD (Opioid Use Disorder) and/or other…
- Trial name
- NCT04197921
- Testing
- Exablate Model 4000 Type 2.0/2.1
- Where
- 4 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- InSightec
Non-invasive Neuromodulation in Healthy Subjects
Mechanisms of Non-Invasive Neuromodulation Interventions: Influence on Human Neurochemistry and Functional Connectivity
The aim of this project is to increase our understanding of how two different protocols of repetitive transcranial magnetic stimulation (rTMS), inhibitory (1 Hz) and excitatory (5 Hz), applied over the primary motor cortex of the…
- Trial name
- NCT02677740
- Testing
- Inhibitory rTMS (1 Hz), Excitatory rTMS (5 Hz)
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Constipation
Effectiveness of Non-invasive Neuromodulation for Intestinal Transit in Healthy Subjects
Objectives Main objective: Assess the effectiveness of non-invasive neuromodulation treatment (NESA) for the management of constipation in patients without diagnosed pathology in Spain Secondary objectives: Evaluate the…
- Trial name
- NCT06294457
- Testing
- Non-Invasive Neuromodulation NESA
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Europea de Madrid
Nociceptive Pain
Cervical/Thoracic Neuromodulation and Nociceptive Processing
Several studies have demonstrated that direct currents delivered through the skin at the level of the low-thoracic spinal cord can influence spinal cord function.
- Trial name
- MICROVOLT2 (NCT06367777)
- Testing
- cervical a-tsDCS, thoracic a-tsDCS
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Healthy Participants
Ultrasound Effects on Human Motor Cortical Plasticity
The purpose of this study is to test the duration and effect of single element focused ultrasound to the primary motor cortex on healthy human participants with the use of transcranial focused ultrasound and transcranial magnetic…
- Trial name
- NCT04168762
- Testing
- Transcranial Ultrasound Magnetic Stimulation
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Healthy, Brain Stimulation
Effects of Transcranial Electrical Stimulation on Task Performance in Healthy Adults
The objective of this randomized, double-blind, sham-controlled, crossover study is to evaluate the effects of transcranial electrical stimulation (tES) on complex cognitive task performance in healthy adult volunteers.
- Conditions
- Healthy, Brain Stimulation, Transcranial Direct Current Stimulation (tDCS), Cognition
- Trial name
- BRAIN-STIM (NCT06995560)
- Testing
- Active Transcranial Electrical Stimulation
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Normal Physiology, Amnestic Mild Cognitive Impairment
MRI Guided Closed-loop TMS-EEG
The goal of this interventional study is to develop an individualized approach using transcranial magnetic stimulation (TMS) in a high-precision manner.
- Trial name
- NCT06050603
- Testing
- TMS
- Where
- Canada
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Pain, Back Pain
Pain Intervention With Needling: Pilot Of Integrated Neuromodulation Techniques
The study will be conducted on site in Galveston, Texas, United States. Study-related assessments and procedures will be performed at the designated clinical study site by qualified study personnel in accordance with the study…
- Conditions
- Pain, Back Pain, Lower Back Pain, Quality of Life
- Trial name
- PINPOINT (NCT07112404)
- Testing
- Dry Needling, Dry needling with high-rate PENS, Dry needling with low-rate PENS
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Healthy Subjects
Optimizing Ultrasound-induced Anti-inflammation in Human Subjects
This is a feasibility study to determine whether pulsed ultrasound stimulation targeting the splenic nerve or the cervical vagus nerve can elicit an anti-inflammatory immune response in healthy volunteers.
- Trial name
- NCT05685108
- Testing
- Ultrasound stimulation intensity, Ultrasound stimulation site
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Alcohol Dependence, PTSD
Neuromodulation of Trauma Memories in PTSD & Alcohol Dependence
The purpose of this study is to examine the effect of propranolol versus placebo on craving, distress and cue reactivity to trauma and alcohol cues.
- Trial name
- NCT01055171
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cancer-related Fatigue, Neuromodulation
tDCS for Cancer-Related Fatigue and Weakness
This pilot study investigates the effectiveness of non-invasive brain stimulation (tDCS) in alleviating cancer-related fatigue (CRF) and muscle weakness.
- Trial name
- NCT07159100
- Testing
- Active tDCS + elbow flexion exercise
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Visceral Pain, Pancreatitis
Neurophysiological Effects on tPCS and tDCS on Healthy Subjects and on Patients With Chronic Visceral Pain
This study investigates comparing the effects of transcranial Pulsed Current Stimulation and transcranial Direct Current Stimulation (tDCS) (Soterix ©) and their combination on neurophysiological outcomes on healthy subjects as…
- Conditions
- Visceral Pain, Pancreatitis, Pelvic Pain
- Trial name
- NCT02497196
- Testing
- Active tPCS, Active tDCS
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Major Depressive Disorder
Low Intensity Ultrasound Neuromodulation of Repetitive Negative Thinking In Depression
The investigators propose to use low-intensity transcranial focused ultrasound (LIFU), a novel neuromodulation method, to probe the causal involvement of individually defined components of an anteromedial brain circuit in the…
- Trial name
- NCT05697172
- Testing
- Low-intensity focused ultrasound
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Laureate Institute for Brain Research, Inc.
Healthy Adults
Decision Making Study in Young and Middle-Aged Adults: Part II
Financial decisions are made during pre-retirement age that can influence financial well-being for the rest of an individual's life.
- Trial name
- DND (NCT03512171)
- Testing
- Dextroamphetamine, [18F]Fallypride, [18F]-FE-PE2I
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Female Sexual Dysfunction, Female Sexual Dysfunction Due to Physical Condition
Effect of Peripheral Neuromodulation on Vaginal Blood Flow - Study 2
The overall purpose of this research is to improve sexual function in women with sexual dysfunction. The goal of this study is to see if either of two nerve stimulation interventions cause a short-term change in vaginal blood…
- Trial name
- NCT06999265
- Testing
- Transcutaneous electrical nerve stimulation - Tibial Nerve, Transcutaneous electrical nerve stimulation - Genital Nerve, Neutral and Erotic Film Clip Alternation
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Schizophrenia, Psychosis
Enhancement of Treatment of Delusions in Schizophrenia Through Neuromodulation
The proposed study aims to use a form of neuromodulation, known as transcranial alternating current stimulation (tACS), to improve the effectiveness of the metacognitive training (MCT) program for treatment of delusions in…
- Conditions
- Schizophrenia, Psychosis, Delusions
- Trial name
- tACS (NCT03062553)
- Testing
- Metacognitive Training (MCT), transcranial alternating current stimulation (tACS)
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of British Columbia
Brain Concussion, Mild Traumatic Brain Injury
Neuromodulation and Neuroimaging in Older Children With Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) often causes persistent motor and cognitive deficits in children resulting in functional limitations.
- Conditions
- Brain Concussion, Mild Traumatic Brain Injury, Motor Disorders, Cognitive Impairment
- Trial name
- CI-tDCS (NCT05762796)
- Testing
- tDCS in Youth with mild traumatic brain injury
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo