Clinical trials: Neurology
Mild Cognitive Impairment, Alzheimer's Disease
Enhancing Spatial Navigation Using Non-Invasive Brain Stimulation
Remembering how to travel from one location to another is critical in everyday life, yet this vital ability declines with normal aging and can be further affected by conditions that disproportionately affect the elderly, such as…
- Trial name
- NCT01958437
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- 2 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Human Immunodeficiency Virus (HIV), HIV Associated Neurocognitive Disorders (HAND)
A Study of the Neurological Effects of Adding Raltegravir to HAART Regimen in Patients With HIV
HIV related cognitive impairment still occurs despite highly active antiretroviral therapy (HAART). HIV disease affects the brain in 20-40% of patients with advancing HIV disease leading to varying degrees of cognitive…
- Trial name
- HANDral (NCT01448486)
- Testing
- Raltegravir
- Where
- 2 sites in Australia
- Volunteers
- 6 people
- Sponsor
- St Vincent's Hospital, Sydney
Narcolepsy Without Cataplexy, Idiopathic Hypersomnia
Clarithromycin Mechanisms in Hypersomnia Syndromes
The purpose of this study is to evaluate a medication called clarithromycin for treating sleepiness in narcolepsy and idiopathic hypersomnia.
- Conditions
- Narcolepsy Without Cataplexy, Idiopathic Hypersomnia, Narcolepsy With Cataplexy
- Trial name
- NCT04026958
- Testing
- Clarithromycin
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Emory University
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Efficacy and Safety Study of I10E in the Maintenance Treatment of Patients With CIDP: Extension of PRISM Study I10E-1302
Primary objective: To assess the efficacy of I10E administered at a reduced maintenance dose in sustaining CIDP response after an initial 6-month treatment in PRISM study. (I10E-1302).
- Trial name
- PRISM2 (NCT02317562)
- Testing
- I10E
- Where
- 30 sites in France, Italy and 4 more
- Volunteers
- 19 people
- Sponsor
- Laboratoire français de Fractionnement et de Biotechnologies
Epilepsy
Bridging the Childhood Epilepsy Treatment Gap in Africa
About half of the world's children with epilepsy do not receive treatment - known as the epilepsy treatment gap - with significantly higher rates (67%-90%) in low- and middle-income countries (LMICs).
- Trial name
- BRIDGE (NCT04290975)
- Testing
- Task-shifting epilepsy care to epilepsy-trained community health workers (CHWs), Enhanced usual care for epilepsy (EUC)
- Where
- 3 sites in Nigeria
- Volunteers
- 1,672 people
- Sponsor
- Vanderbilt University Medical Center
Research With Clinical Staff in Stroke Rehabilitation
Usability Study of OnTrack Tools
Aims: Assess the usability of OnTrack Tools, a clinician facing interface to manage stroke survivors using the OnTrack rehabilitation system.
- Trial name
- NCT05330234
- Testing
- OnTrack Tools
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Mild Cognitive Impairment
Evaluation of Cognitive State in Senior Subjects Using Neurosteer EEG System
This is an observational study. Patients who fulfill all inclusion criteria and none of the exclusion criteria will be enrolled in the study, be neurologically evaluated and will go through EEG recordings while listening to an…
- Trial name
- NCT04683835
- Testing
- Neurosteer Aurora system
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Neurosteer Ltd.
Cognitive Decline
Evaluation of Cognitive State Using Neurosteer EEG System
This is an observational study. Patients who fulfill all inclusion criteria and none of the exclusion criteria will be enrolled in the study, be neurologically evaluated and will go through EEG recordings while listening to an…
- Trial name
- NCT04386902
- Testing
- Neurosteer Aurora system
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Neurosteer Ltd.
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Efficacy and Safety Study of I10E in Treatment of Patients With CIDP
Primary objective: To assess the efficacy of I10E in improving the disability of patients with CIDP. Secondary objective: To assess the safety of I10E in patients with CIDP.
- Trial name
- PRISM (NCT02293460)
- Testing
- I10E
- Where
- 33 sites in France, Italy and 4 more
- Volunteers
- 44 people
- Sponsor
- Laboratoire français de Fractionnement et de Biotechnologies
Type 2 Diabetes Mellitus, Cognitive Impairment
Intensive Aerobic and Resistance Exercise Program (IAREP)
A 12-week Intensive Aerobic and Resistance Exercise Program (IAREP) intervention was implemented on high-risk and low-risk subjects with cognitive impairment in type 2 Diabetes Mellitus.
- Conditions
- Type 2 Diabetes Mellitus, Cognitive Impairment, Non-insulin-dependent Diabetes Mellitus, Cognitive Dysfunction
- Trial name
- NCT06401733
- Testing
- Intensive Aerobic and Resistance Exercise Program (IAREP)
- Where
- Singapore
- Volunteers
- 58 people
- Sponsor
- National University of Singapore
HIV
Efficacy of Neuro-HAART in Patients With HIV
Patients infected with Human Immunodeficiency Virus (HIV) are at risk of brain related complications despite the use of highly active antiretroviral therapy (HAART).
- Trial name
- HANDobs (NCT01434654)
- Where
- 2 sites in Australia
- Volunteers
- 19 people
- Sponsor
- St Vincent's Hospital, Sydney
Stroke
Structurally Reorganizing Motor Cortex in Stroke Patients Through Hebbian-type Stimulation
Stroke is a leading cause of morbidity in the United States but identification of treatment strategies to improve outcome is limited by the incomplete understanding of the mechanisms of recovery.
- Trial name
- NCT01569607
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Cathrin Buetefisch
Communication, Patient Satisfaction
Effect of Clear Masks on Patient Satisfaction With Communication
The purpose of this research study is to evaluate participants' experience and satisfaction during the awake deep brain stimulation (DBS) procedure.
- Trial name
- NCT05088603
- Testing
- Clear Mask
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Wake Forest University Health Sciences
Ischemic Stroke, Transient Ischemic Attack
Adapting Tools to Implement Stroke Risk Management to Veterans
The purpose of this study is to develop and evaluate the local adaptation of existing stroke prevention tools into practice. A stroke prevention program is a collection of materials including written materials like pamphlets and…
- Trial name
- TOOLS (NCT00355147)
- Testing
- Physician stroke guideline adherence, Stroke Self Management, Attention Control Group
- Where
- 2 sites in United States
- Volunteers
- 174 people
- Sponsor
- VA Office of Research and Development
Friedreich Ataxia
Neurology Measures in FA Children
The purpose of this study is to identify ways to follow progression of Friedreich's Ataxia (FA) and be able to measure changes over time in children with FA.
- Trial name
- NCT03418740
- Where
- 3 sites in United States
- Volunteers
- 108 people
- Sponsor
- Children's Hospital of Philadelphia
Mild Cognitive Impairment, Alzheimer's Disease
Promoting Adaptive Neuroplasticity in Mild Cognitive Impairment
The aging US population threatens to overwhelm our healthcare infrastructure, especially since the rate of Alzheimer's disease (AD) alone is expected to triple in the coming decades.
- Trial name
- NCT02155946
- Testing
- Transcranial direct current stimulation (tDCS) Soterix Medical Inc. tDCS unit
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- VA Office of Research and Development
Intracranial Artery Occlusion With Infarction
Endovascular Recanalization and Standard Medical Management for Symptomatic Nonacute Intracranial Artery Occlusion Trial
Background The management of patients with symptomatic nonacute intracranial artery occlusion (sNA-ICAO), which is a special subset with high morbidity and a high probability of recurrent serious ischemic events despite standard…
- Trial name
- NCT04864691
- Testing
- endovascular recanalization
- Where
- 15 sites in China
- Volunteers
- 453 people
- Sponsor
- Feng Gao
Mental Health, Neurology
Implementing Evidence in the Detection and Treatment of Post Stroke Depression
Post Stroke Depression (PSD)is a high volume condition with negative impact on patient recovery after stroke. The primary aim of this study is to evaluate the effectiveness of a system intervention to improve the proportion of…
- Conditions
- Mental Health, Neurology, Health Services
- Trial name
- NCT00296140
- Testing
- self management of PSD symptoms, screening and treatment of PSD
- Where
- 2 sites in United States
- Volunteers
- 66 people
- Sponsor
- VA Office of Research and Development
Human Immunodeficiency Virus (HIV), HIV Associated Neurocognitive Disorders (HAND)
A Study of the Neurological Effects of Adding Maraviroc to HAART Regimen in Patients With HIV (HANDmac)
HIV related cognitive impairment still occurs despite highly active antiretroviral therapy (HAART). HIV disease affects the brain in 20-40% of patients with advancing HIV disease; leading to varying degrees of cognitive…
- Trial name
- HANDmac (NCT01449006)
- Testing
- Maraviroc
- Where
- 2 sites in Australia
- Volunteers
- 19 people
- Sponsor
- Bruce Brew
Parkinson Disease
Motor Training in PD
The purpose of this research study is to learn more about brain activity when individuals with and without Parkinson disease (PD) move their lower limbs.
- Trial name
- NCT02457832
- Testing
- Adapted Tango Dancing, Behavioral Control (BC) Condition
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development