Clinical trials: Neurological Impairment
Development, Infant, Development, Language
Early Neurophysiological Markers of Language Impairments
The present project aims at identifying very early electrophysiological risk markers for language impairments. The long-term goals of the study include the characterization of learning developmental trajectories in children at…
- Conditions
- Development, Infant, Development, Language, Developmental Language Disorder, Learning Disabilities
- Trial name
- NCT05767242
- Testing
- Electrophysiological recording, Behavioral assessment
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Cognition Disorder, Nervous System Diseases
A Follow-up Study to Assess Safety and Tolerability of Galantamine Treatment in Individuals With Mild Cognitive Impairment
The purpose of this follow-up study is to assess the long-term safety and tolerability of galantamine in individuals with mild cognitive impairment who participated in a previous study with galantamine
- Conditions
- Cognition Disorder, Nervous System Diseases, Mental Disorders, Brain Diseases
- Trial name
- NCT00240695
- Testing
- galantamine hydrobromide
- Volunteers
- 724 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Nature, Human, Microbial Colonization
Biodiversity Interventions for Assisted Living Centers
Biodiversity is essential for nature and human well-being. Land use has reduced biodiversity in cities, which weakens the functionality of the urban ecosystems and the well-being of citizens.
- Conditions
- Nature, Human, Microbial Colonization, Well-Being, Psychological, Immune System and Related Disorders
- Trial name
- BIWE (NCT06390683)
- Testing
- Rewilding
- Where
- Finland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Natural Resources Institute Finland
Hearing Loss, Cognitive Impairment, Mild
ENACT Program on Auditory Perception and Function, Cognitive Function and Health-related Quality of Life
Although previous studies indicated that tackling hearing loss may have a secondary benefit in improving cognitive function and delaying the onset of dementia, a more integrated care approach to optimize both hearing and…
- Trial name
- NCT06955494
- Testing
- Empowerment Network for Auditory-Cognitive Training (ENACT) Program, Usual Care
- Where
- Hong Kong
- Volunteers
- 62 people
- Sponsor
- The University of Hong Kong
Neuropsychological Tests, Memory
Adaptation and Normalization of a Verbal Episodic Memory Test in French Sign Language
To date, neuropsychological assessment of deaf signing persons is complicated by a lack of resources, especially the absence of tools available in French Sign Language (LSF).
- Conditions
- Neuropsychological Tests, Memory, Alzheimer Disease, Deafness
- Trial name
- RL-RI-LSF (NCT06902753)
- Testing
- Questionnaire and Physical Exam
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Dementia, Memory Impairment
Cultural and Linguistic Adaptation and Normative Study of the Turkish Version of the Free and Cued Selective Reminding Test: 16-Word Version (FCSRT-T)
An Adaptation Study of Free and Cued Selective Reminding Test in Turkish
- Trial name
- FCSRT-T (NCT05756231)
- Testing
- SIHT-16
- Where
- Turkey (Türkiye)
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Parkinson Disease, Freezing of Gait
Use of CereGate Therapy for Freezing of Gait in PD
A Multi-Center, Controlled Study to Evaluate Use of CereGate Therapy to Reduce Freezing of Gait in Participants Diagnosed with Parkinson's Disease.
- Conditions
- Parkinson Disease, Freezing of Gait, Deep Brain Stimulation
- Trial name
- NCT05292794
- Testing
- CereGate Software; BSN cDBS Programmer; BSN Burst Programmer
- Where
- 7 sites in United States
- Volunteers
- 41 people
- Sponsor
- CereGate Inc.
Neurological Diseases or Conditions, Dementia of Alzheimer Type
An Observational Study of Patients Living With Chronic Neurological Diseases
TARGET-NEURO is an observational research study to conduct a comprehensive review of outcomes for patients living with chronic neurological diseases: Alzheimer's disease and related dementia (ADRD), mild cognitive impairment…
- Conditions
- Neurological Diseases or Conditions, Dementia of Alzheimer Type, Alzheimer Disease, Mild Cognitive Impairment
- Trial name
- NCT05796037
- Volunteers
- 1,500,000 people
- Sponsor
- Target PharmaSolutions, Inc.
Pain, Terminal Illness
Neurotoxic Adverse Effects of Morphine and Oxycodone for Pain in Terminal Patients With Diminished Renal Function
Significant pain is a common condition in dying patients. Continuous subcutaneous infusion (CSCI) of opioids is the cornerstone in treatment of pain in this last phase of life.
- Conditions
- Pain, Terminal Illness, Renal Impairment
- Trial name
- MOSART (NCT03616639)
- Testing
- Oxycodone, Morphine
- Where
- 15 sites in Netherlands
- Volunteers
- 8 people
- Sponsor
- Maastricht University Medical Center
Migraine Disorders, Aphasia
Stroke-like Migraine Attacks After Radiation Treatment (SMART) Syndrome Language Intervention
Stroke-like migraine attacks after radiation therapy-also known as SMART syndrome-constitute a rare condition typically characterized by headache, seizures, vision abnormalities, hemiparesis, and aphasia.
- Trial name
- NCT03662295
- Testing
- Language treatment
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Quality Living, Inc.
Chronic Rhinosinusitis, Sleep Disorders
Sleep Disturbance and Daytime Fatigue as Predictors of Cognitive Decline and Functional Decline in Chronic Rhinosinusitis
FOCUS-CRS is a cross-sectional observational study examining the relationship between sleep disturbance, daytime fatigue, and cognitive and functional health in patients with chronic rhinosinusitis (CRS).
- Conditions
- Chronic Rhinosinusitis, Sleep Disorders, Fatigue, Cognitive Dysfunction
- Trial name
- SNOOZE-CRS (NCT07242040)
- Testing
- Self-Reported Questionnaires for Sleep, Fatigue, and Quality of Life
- Where
- Egypt
- Volunteers
- 134 people
- Sponsor
- Sinai University
Mild Cognitive Impairment, Dementia
A 3 Year Study to Evaluate the Safety and Efficacy of Low Dose Ladostigil in Patients With Mild Cognitive Impairment
The purpose of this study is to determine whether treatment with the investigational drug ladostigil will delay the onset of Alzheimer's disease(AD) in patients with Mild Cognitive Impairment (MCI).
- Trial name
- NCT01429623
- Testing
- ladostigil hemitartrate
- Where
- 12 sites in Austria, Germany and 1 more
- Volunteers
- 210 people
- Sponsor
- Avraham Pharmaceuticals Ltd
Age-related Macular Degeneration, Dementia
Words on the Brain: Can Reading Rehabilitation for Age-Related Vision Impairment Improve Cognitive Functioning?
Age-related vision impairment and dementia both become more prevalent with increasing age. Research into the mechanisms of these conditions has proposed that some of their causes (e.g., macular degeneration/glaucoma and…
- Conditions
- Age-related Macular Degeneration, Dementia, Low Vision, Low Vision Aids
- Trial name
- WOTB (NCT04276610)
- Testing
- Low Vision Reading Rehabilitation
- Where
- 2 sites in Canada
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Université de Montréal
Vision Disability
Assessment of an Augmented Reality Low Visual Aid in Children and Young People With Visual Impairment
Approximately 24,500 children and young people (CYP) in England have a visual impairment (VI). VI refers to a loss of vision that cannot be corrected with glasses or contact lenses. Low vision aids (e.g.
- Trial name
- NCT05201482
- Testing
- SightPlus
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Sheffield Children's NHS Foundation Trust
Accidental Fall, Visual Impairment
Falls Prevention for Visually Impaired Older People
This study aims to examine the effectiveness of an intensive five day falls prevention training programme with a home evaluation and a home exercise programme, compared with a home evaluation and exercise programme alone for…
- Conditions
- Accidental Fall, Visual Impairment, Fall
- Trial name
- NCT04078529
- Testing
- 5 day falls prevention training, Home exercise programme, Environmental Assessment
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Blind Veterans UK
Trauma, Neurologic Deficits
CT Change Management in Trauma Patients
In high-volume trauma centers, multi-slice CT scanners have become the routine imaging modality for screening trauma patients due to their speed and accuracy.
- Trial name
- NCT05138536
- Testing
- Pan-Computer Tomography
- Where
- United States
- Volunteers
- 510 people
- Sponsor
- Methodist Health System
Sensorineural Hearing Loss
Phase I/IIa Study Evaluating Safety and Efficacy of an Intratympanic Dose of PIPE-505 in Subjects With Hearing Loss
This is a randomized, double-blind study of PIPE-505, or placebo, in subjects with hearing loss associated with speech-in-noise impairment.
- Trial name
- NCT04462198
- Testing
- PIPE-505
- Where
- 8 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Contineum Therapeutics
Aging, Mild Cognitive Impairment
A Study of Characterizing Cognitive Decline and Functional Cardiac Senescence in Healthy Korean Volunteers
Although aging process appears to be generally characterized, investigators have been paid much attention to the specific target molecules, which leads to discover the clinical markers of the senescence.
- Conditions
- Aging, Mild Cognitive Impairment, Angina Pectoris
- Trial name
- NCT01590706
- Where
- South Korea
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Korea Institute of Oriental Medicine
Parkinson's Disease
Menthol for Improving Movement and Sleep in Parkinson's Disease Patients
Parkinson's disease (PD) is a progressive neurological disorder characterized by both motor and non-motor symptoms due to the degeneration of dopamine-producing neurons. There is currently no cure.
- Trial name
- NCT07294469
- Testing
- Menthol gloves and socks
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taipei Medical University Hospital
Eye Diseases
iSCREEN-study: Online Nurse-assisted Eye-screening in Home Healthcare
The aim of this study is to investigate the cost-effectiveness of a nurse-assisted online eye-screening in home healthcare in reducing eye complaints.
- Trial name
- NCT06058637
- Testing
- Eye screening
- Where
- Netherlands
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc