Clinical trials: Neurological Disorder
Episodic Cluster Headache, Chronic Cluster Headache
A Study of LY2951742 (Galcanezumab) in Participants With Cluster Headache
The main purpose of this study is to assess the long-term safety and tolerability of galcanezumab administered up to once monthly in participants with episodic or chronic cluster headache who have completed study I5Q-MC-CGAL…
- Trial name
- NCT02797951
- Testing
- Galcanezumab
- Where
- 40 sites in United States, Belgium and 10 more
- Volunteers
- 165 people
- Sponsor
- Eli Lilly and Company
Coronary Artery Bypass Graft Redo, Heart Valve Diseases
SONOlysis in Risk REduction of Symptomatic and Silent Brain infarCtions dUring Cardiac surgEry
The aim of the project is to demonstrate a fibrinolytic effect of sonothrombolysis (continual transcranial Doppler monitoring) using 2 MHz diagnostic probe on the reduction of risk of brain infarctions due to the activation of…
- Trial name
- SONORESCUE (NCT01591018)
- Testing
- sonolysis, cardiac surgery
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- University Hospital Ostrava
Stroke
Ventilation Strategies, Anesthetic Techniques and Cerebral Oxygenation in the Beach Chair Position
The seated or "beach chair" position during surgery and general anesthesia decreases brain oxygen levels and can result in stroke. As such, poor neurological outcome following beach chair positioning is a growing concern.
- Trial name
- NCT01535274
- Testing
- Inspired oxygen fraction / end tidal carbon dioxide
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- University of Michigan
Alzheimer Disease
Dapagliflozin In Alzheimer's Disease
This is a pilot randomized controlled trial in individuals with probable Alzheimer's disease testing the effects of 10 mg dapagliflozin, taken daily for 12 weeks, on cerebral n-acetyl aspartate (NAA) levels using magnetic…
- Trial name
- NCT03801642
- Testing
- Dapagliflozin
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Jeff Burns, MD
Accidental Falls/Prevention and Control
Nursing Home Prevention of Injury in Dementia (NH PRIDE)
The purpose of this study is to develop a consistent approach to prevent falls with injury in nursing home (NH) residents. A centralized Injury Liaison Service (ILS) will be developed and tested in four nursing home facilities…
- Trial name
- NH PRIDE (NCT04242186)
- Testing
- Injury Liaison Service
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Hebrew SeniorLife
Pain Management
Pudendal Enhancement of Enhanced Recovery After Surgery (ERAS) for Reconstructive Surgery (PEERS)
Patients will undergo their vaginal reconstructive surgery in the usual manner, but will also be randomly assigned on the day of surgery to either receive the extra injection of numbing medication at the onset of surgery or not.
- Trial name
- NCT04171050
- Testing
- Local anaesthetic, Pudendal Nerve Block plus anesthesia
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of California, Los Angeles
Multiple Sclerosis, Relapsing-Remitting
Acthar Gel for Multiple Sclerosis That Keeps Getting Better and Worse (RRMS)
This study will enroll about 66 participants who experienced a relapse of RRMS that steroids did not help. The doctor will put participants into a treatment group.
- Trial name
- OPTIONS (NCT03126760)
- Testing
- Acthar Gel
- Where
- 22 sites in United States
- Volunteers
- 35 people
- Sponsor
- Mallinckrodt ARD LLC
Parkinson's Disease
Effects of Cholinergic Augmentation on Measures of Balance and Gait
This study will compare the effects of placebo and donepezil, a drug that helps conserve concentrations of the neurotransmitter, acetylcholine, on measures of balance and gait in subjects with Parkinson's disease (PD).
- Trial name
- NCT02206620
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Oregon Health and Science University
Epilepsy, Tumor
High-density EEG in Neurological Disorders
The purpose of the study is to use a new method of high-density electroencephalogram (HD-EEG) recording to map brain areas important for movement, sensation, language, emotion, and cognition.
- Conditions
- Epilepsy, Tumor, Healthy
- Trial name
- NCT04266041
- Testing
- High-density electroencephalogram (HD-EEG)
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Acromegaly
Acromegaly Combination Treatment Study
In this study the investigators will evaluate whether combination low dose somatostatin receptor ligand (SRL) and weekly or daily pegvisomant will attain equivalent control of serum insulin-like growth factor (IGF)-1 levels at a…
- Trial name
- NCT01538966
- Testing
- Pegvisomant, Octreotide LAR, Lanreotide
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Cedars-Sinai Medical Center
Respiratory Depression
Long-term Extension Study of BEMA™ Fentanyl
This study is designed to provide continued access to BEMA Fentanyl for those subjects who previously participated in FEN-202 and who wish to continue using BEMA Fentanyl for the treatment of their breakthrough cancer pain.
- Trial name
- NCT00696137
- Testing
- BEMA Fentanyl
- Volunteers
- 5 people
- Sponsor
- BioDelivery Sciences International
Spinal Muscular Atrophy (SMA)
Spinal Muscular Atrophy (SMA) Biomarkers Study in the Immediate Postnatal Period of Development
Spinal muscular atrophy (SMA) is the leading genetic cause of death of infants. Strong preclinical evidence suggests that effective therapy must be delivered as early as possible to prevent progression of the disease.
- Trial name
- NCT01736553
- Where
- 15 sites in United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Auditory Hallucinations
Auditory Control Enhancement (ACE) in Schizophrenia
The purpose of this clinical trial is to investigate neural markers of target engagement to further develop auditory control enhancement (ACE) as a novel, inexpensive, and noninvasive intervention to address treatment-refractory…
- Trial name
- ACES (NCT06155695)
- Testing
- Transcranial Direct Current Stimulation (tDCS), Auditory Cognitive Control Training (ACCT)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Brian A Coffman, PhD
Sleep Apnea, Obstructive
Effect of Dalfampridine (4-AP) on Genioglossus Muscle Activity in Healthy Adults
In this protocol the investigators will test the effect of dalfampridine (a potassium channel blocker) on genioglossus muscle activity (EMG GG) during wakefulness and sleep in healthy control subjects.
- Trial name
- APIGLOSS (NCT02656160)
- Testing
- Dalfampridine
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Chronic Pain, Psychiatric Disorders
Adjunctive Transcranial Direct Current Stimulation
Transcranial direct current stimulation (tDCS) is an investigational device that has not been approved for the treatment of any medical condition by the FDA but is allowed to be used for research purposes.
- Trial name
- tDCS (NCT02665988)
- Testing
- tDCS
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Baylor College of Medicine
Breast Cancer, Cognitive/Functional Effects
Stereotactic Radiation Therapy With or Without Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases
RATIONALE: Stereotactic radiation therapy can send x-rays directly to the tumor and cause less damage to normal tissue. Radiation therapy uses high-energy x-rays to kill tumor cells.
- Conditions
- Breast Cancer, Cognitive/Functional Effects, Lung Cancer, Metastatic Cancer
- Trial name
- NCT00377156
- Testing
- radiation therapy, stereotactic radiosurgery
- Where
- 64 sites in United States, Canada
- Volunteers
- 213 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Obstructive Sleep Apnea
Pediatric Nasal Mask Usability Study
The purpose of the study is to demonstrate the effectiveness of a pediatric mask in treating obstructive sleep apnea (OSA) in a pediatric population.
- Trial name
- NCT01154322
- Testing
- Pixi pediatric mask
- Where
- 3 sites in United States
- Volunteers
- 16 people
- Sponsor
- ResMed
Alzheimer Disease
Simufilam 50 mg or 100 mg for Mild-to-Moderate Alzheimer's Disease
A 76-week safety and efficacy study of simufilam (PTI-125) given twice daily to participants with mild-to-moderate Alzheimer's disease (AD) for 76 weeks.
- Trial name
- REFOCUS-ALZ (NCT05026177)
- Testing
- Simufilam
- Where
- 89 sites in United States, Canada and 2 more
- Volunteers
- 1,125 people
- Sponsor
- Cassava Sciences, Inc.
Fever, Brain Hemorrhage
Temperature Control in Central Fever in the Neuro-ICU
There are few treatments for central fever (fever that is due to the central nervous system, as opposed to an infectious source).
- Trial name
- NCT00751634
- Testing
- Gaymar Rapr-Round (external cooling blanket)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Northwestern University
Multiple Sclerosis, Fatigue
Cubii for Exercise in People With MS
The goals of this observational study are to evaluate (1) the feasibility, usability, and satisfaction with the Cubii elliptical and (2) the preliminary efficacy of the Cubii elliptical for increasing activity (primary outcome)…
- Conditions
- Multiple Sclerosis, Fatigue, Activity, Motor, Quality of Life
- Trial name
- Cubii (NCT05826431)
- Testing
- Cubii elliptical
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Washington
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