Clinical trials: Neuroinflammation
Frontotemporal Dementia
Molecular Neuroimaging of Neuroinflammation in Neurodegenerative Dementias
Neuroinflammation is increasingly implicated as a potential critical pathogenic mechanism in a variety of neurologic and psychiatric disorders.
- Trial name
- NCT02945774
- Testing
- (18F)-FEPPA
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Mild, Moderate, or Severe Alzheimer's Disease
A Phase 2 Study to Assess the Safety of EI-1071 and the Effects of EI-1071 on Neuroinflammation in Alzheimer's Disease Patients
An open-label, exploratory, phase II, proof-of concept, clinical study to assess the safety and tolerability of EI-1071 and the effects of EI-1071 on neuroinflammation in patients with mild, moderate, or severe Alzheimer's disease
- Trial name
- NCT06745583
- Testing
- EI-1071 tablet, oral
- Where
- 2 sites in Taiwan
- Volunteers
- 7 people
- Sponsor
- Elixiron Immunotherapeutics Inc.
HIV Infections, Central Nervous System Diseases
Central Nervous System Disease in HIV-infected Children on HAART
This study will examine how HIV affects the brain and nervous system, learning, and behavior in children on highly active antiretroviral therapy (HAART).
- Trial name
- NCT00110331
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
Postoperative Cognitive Dysfunction, Delirium, Postoperative
Evaluation of the Predictive Impact of Serum S100B and S100B Polymorphisms on Postoperative Cognitive Dysfunction and Delirium
Postoperative cognitive disorders, including postoperative cognitive dysfunction (POCD) and postoperative delirium (POD), are common complications following surgery and anesthesia, particularly in vulnerable patient populations.
- Trial name
- NCT07509372
- Testing
- Perioperative Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 137 people
- Sponsor
- Ankara University
Gulf War Syndrome
Clinical Evaluation of Montelukast in Veterans With Gulf War Illness
The study addresses the pre-clinical promise of Montelukast (MLK) for improving brain function in veterans with Gulf War Illness (GWI).
- Trial name
- (GWI) (NCT05992311)
- Testing
- Montelukast
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Baylor College of Medicine
Parkinson Disease (PD)
Outlining Biological Effects of Subthalamic Deep Brain Stimulation in Parkinson's Disease Patients.
The aim of the study is to characterize the neuroinflammatory effects of subthalamic deep brain stimulation in patients with Parkinson's disease, by analyzing changes in blood neuroinflammatory and neurodegenerative biomarkers…
- Trial name
- BRAIN-DBS-GAIN (NCT07673783)
- Testing
- Deep brain stimulation surgery
- Volunteers
- 90 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Covid19, Delirium
Neurotropism and Neuroinflammation in COVID-19 Patients With Delirium.
Emerging evidence indicates that SARS-CoV-2, the etiologic agent of COVID-19, can cause neurological, neuropsychological and psychiatric complications.
- Conditions
- Covid19, Delirium, Post-traumatic Stress Disorder
- Trial name
- BRAINSTORM (NCT04785157)
- Testing
- serology testing profiles description, immune response characterization, in vivo brain PET-TSPO acquisitions
- Where
- 2 sites in France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Toulouse
ALS (Amyotrophic Lateral Sclerosis), ALS - Amyotrophic Lateral Sclerosis
The BANYAN Trial, an ALS MyMatch Trial Evaluating Safety, Biomarker Activity, and Microglial Activation of Nasal Foralumab
The goal of this clinical trial is to learn whether a nasal spray medicine called foralumab is safe and easy to tolerate in adults with amyotrophic lateral sclerosis (ALS).
- Conditions
- ALS (Amyotrophic Lateral Sclerosis), ALS - Amyotrophic Lateral Sclerosis, ALS
- Trial name
- BANYAN (NCT07688239)
- Testing
- Foralumab Nasal
- Where
- 4 sites in United States
- Volunteers
- 44 people
- Sponsor
- Tiziana Life Sciences LTD
Parkinson Disease
CS1P1 PET Studies of Neuroinflammation in Parkinson Disease
Parkinson disease (PD) is a progressive neurological disorder strongly linked to advancing age that results in decline in mobility and thinking.
- Trial name
- NCT06084533
- Testing
- [11C]-CS1P1
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Autism Spectrum Disorder
Intestinal Dysbiosis and BBB Integrity in Autism
Autism Spectrum Disorder (ASD) is characterised by an impairment of social interactions and communication, associated with repetitive behaviour and restrictive interests.
- Trial name
- LEDA (NCT04321915)
- Testing
- Analysis of intestinal microbiota in autism spectrum desorder, Analysis of neuroinflammation markers in autism spectrum desorder
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Autism Spectrum Disorder, Autism Spectrum Disorders
Prednisone in Adults With an Immune-Mediated Subtype of Autism Spectrum Disorder
The goal of this clinical trial is to learn how prednisone affects adults with autism spectrum disorder (ASD). It will also learn about the safety of prednisone.
- Conditions
- Autism Spectrum Disorder, Autism Spectrum Disorders, Autistic Disorder, Autism
- Trial name
- PREDICT (NCT06934915)
- Testing
- Prednisone
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Christopher John McDougle, M.D.
Neuroinflammatory Response, Psychosis
Neuroinflammation Markers in Subjects With Psychotic Symptoms
The main objective of the study is to measure the plasma and intracellular levels of several neuroinflammation markers (including cytokines and chemokines) and the endocannabinoid system in subjects presenting psychotic symptoms…
- Trial name
- NEUROINPS17 (NCT05815225)
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Parkinson Disease, Parkinsonian Disorders
Study of Axial and Cognitive Symptoms and Biomarkers of Neurodegeneration in Brain-first and Body-first PD
This observational study aims to systematically characterize a cohort of patients with early-stage Parkinson's disease (PD) attending the Movement Disorders Center of AUSL-IRCCS Reggio Emilia, Italy.
- Conditions
- Parkinson Disease, Parkinsonian Disorders, Brain Disease, Basal Ganglia Diseases
- Trial name
- BRABOAXPD (NCT07187843)
- Testing
- Clinical assessments, Phenotypic classification
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Alzheimer's Disease (AD)
Radiolabeled TSPO Targeted Molecular Probe in Alzheimer's Disease.
Evaluate the clinical application value of the novel radiolabeled TSPO-targeted molecular probe Gallium [68Ga]-DOTA-HK-011 in neuroinflammation imaging of Alzheimer's disease.
- Trial name
- NCT07105956
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Corticobasal Syndrome(CBS), Primary Progressive Aphasia(PPA)
Neuroinflammation in FTLD
The goal of this observational study is to investigate the role of neuroinflammation in frontotemporal lobar degeneration (FTLD). The main aims of this study are: 1.
- Conditions
- Corticobasal Syndrome(CBS), Primary Progressive Aphasia(PPA), Progressive Supranuclear Palsy(PSP), Behavioral Variant Frontotemporal Dementia (bvFTD)
- Trial name
- NCT06870838
- Testing
- 7T MRI scan, CSF, Blood withdrawal
- Where
- 2 sites in Netherlands
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Alzheimer Disease, Healthy Volunteer
Neuroinflammation Imaging in AD
This research study is being done to learn more about inflammation in the brain using Positron Emission Tomography/Computed Tomography (PET/CT) imaging in people with Alzheimer's Disease/Mild Cognitive Impairment or healthy…
- Trial name
- NCT04274998
- Testing
- [18F]NOS, [11C]PBR28
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Idiopathic Pulmonary Fibrosis (IPF), Idiopathic Pulmonary Fibrosis
PET Study of PIPE-791 in Healthy Volunteers and Volunteers With PrMS and IPF
This is a study of PIPE-791, an investigational study drug to treat progressive multiple sclerosis (MS) and idiopathic pulmonary fibrosis (IPF).
- Conditions
- Idiopathic Pulmonary Fibrosis (IPF), Idiopathic Pulmonary Fibrosis, Multiple Sclerosis, Multiple Sclerosis, MS
- Trial name
- NCT06683612
- Testing
- PIPE-791
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Contineum Therapeutics
Central Nervous System Diseases
TSPO-PET/MRI in Surveillance of Neuroinflammation in the Central Nervous System
Central Nervous System (CNS) inflammation is an immune response activated in the brain and spinal cord by microglial cells and astrocytes, commonly occurring under conditions such as central nervous system ischemia, autoimmunity…
- Trial name
- NCT06467773
- Testing
- Radiation: PET-MRI with [18F]-DPA-714
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Parkinson Disease, Physical Inactivity
Physical Activity on Neuroinflammation in Parkinson's Disease
Parkinson's Disease (PD) is a chronic progressive neurodegenerative disorder clinically defined by the association of resting tremor, rigidity, bradykinesia, and postural instability.
- Conditions
- Parkinson Disease, Physical Inactivity, Physical Disability
- Trial name
- MOVE-ON_WP1 (NCT06977204)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Postoperative Cognitive Dysfunction, Coronary Artery Disease
Neuroinflammation in Cognitive Decline Post-cardiac Surgery
Major cardiovascular surgery is associated with postoperative cognitive decline (POCD), with a deterioration in memory, attention and speed of information processing.
- Conditions
- Postoperative Cognitive Dysfunction, Coronary Artery Disease, Pathophysiology
- Trial name
- FOCUS (NCT04520802)
- Testing
- 18F-DPA-714 PET/CT neuroimaging
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center