Clinical trials: Neuroinflammation
Somatic Symptom Disorder (DSM-V)
Effect of Venlafaxine Versus Dosulepin in Pain Predominant Somatic Symptom Disorder
Somatic symptom disorder (SSD) is marked by persistent physical complaints, often involving pain, alongside excessive thoughts or behaviors related to health, which substantially disrupt daily functioning.
- Trial name
- NCT06803485
- Testing
- Venlafaxine, Dosulepin
- Where
- India
- Volunteers
- 84 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Carotid Artery Diseases, Carotid Artery Stenosis
A Lithium-Based Medication to Improve Neurological Outcomes After Surgical Carotid Reconstruction
There are 10.3 million cases of stroke registered in the world every year; 63% of them lead to death. According to World Health Organization, stroke is one of the most important risk factors of death and early disability.
- Trial name
- NCT05126238
- Testing
- Lithium Carbonate
- Where
- Russia
- Volunteers
- 107 people
- Sponsor
- Negovsky Reanimatology Research Institute
Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease
Longitudinal Profiling of Plasma-Derived Glial Extracellular Vesicles in Alzheimer's Disease
This project aims to longitudinally profile plasma-derived GDEVs and plasma biomarkers of neuroinflammation across three stages of the AD continuum (Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer's…
- Conditions
- Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease, Alzheimer's Disease Dementia, Alzheimer's Disease (AD)
- Trial name
- GLEVAD (NCT07803055)
- Testing
- blood sampling
- Where
- Italy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Idiopathic Pulmonary Fibrosis (IPF), Idiopathic Pulmonary Fibrosis
PET Study of PIPE-791 in Healthy Volunteers and Volunteers With PrMS and IPF
This is a study of PIPE-791, an investigational study drug to treat progressive multiple sclerosis (MS) and idiopathic pulmonary fibrosis (IPF).
- Conditions
- Idiopathic Pulmonary Fibrosis (IPF), Idiopathic Pulmonary Fibrosis, Multiple Sclerosis, Multiple Sclerosis, MS
- Trial name
- NCT06683612
- Testing
- PIPE-791
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Contineum Therapeutics
Obstructive Sleep Apnoea, Inflammation
Investigating the Neuropathology of Obstructive Sleep Apnoea
Our multi-disciplinary research group works closely with people who have obstructive sleep apnoea. This is a life-long illness that causes breathing to stop during sleep, which leads to low-oxygen in the blood.
- Trial name
- INcOSA (NCT02967536)
- Where
- United Kingdom
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- King's College London
Perinatal Depression, Chronic Pain
CSF/Serum Biomarkers in Predicting PND/Persistent Pain After Cesarean
The aim is to investigate if inflammatory biomarkers in the blood and cerebrospinal fluid (CSF) are associated with the development of perinatal depression and/or persistent pain after cesarean delivery.
- Trial name
- NCT04271072
- Testing
- No intervention
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Duke University
Parkinson Disease
CS1P1 PET Studies of Neuroinflammation in Parkinson Disease
Parkinson disease (PD) is a progressive neurological disorder strongly linked to advancing age that results in decline in mobility and thinking.
- Trial name
- NCT06084533
- Testing
- [11C]-CS1P1
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Neuroinflammation, Stroke
Translocator Protein PET/CT in Various TSPO-Related Disease
To evaluate the potential usefulness of 18F-DPA714/FDPA positron emission tomography/computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various TSPO-related disease patients.
- Conditions
- Neuroinflammation, Stroke, Neurodegenerative Diseases
- Trial name
- NCT06725719
- Testing
- 18F-DPA714/FDPA
- Where
- 3 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University
Postoperative Cognitive Dysfunction, Alzheimer Disease
Tau Pathology in the Brain After Hip or Knee Replacement Surgery
The goal of this observational study is to study whether major surgery is linked to changes in the brain that are typical of Alzheimer's disease.
- Conditions
- Postoperative Cognitive Dysfunction, Alzheimer Disease, Tauopathies, Neuroinflammation
- Trial name
- TAU-PET (NCT07871487)
- Testing
- Hip or Knee Arthroplasty Under Spinal Anesthesia
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Uppsala University Hospital
Traumatic Brain Injury
Long-term Recovery and Microbiota-Gut-Brain Axis Disruption After Traumatic Brain Injury
The OVERCOME-TBI project aims to collect multimodal data approximately 1-4 and 11-14 years after an earlier well-documented traumatic brain injury (TBI) and examine factors that influence disease progression in order to gain new…
- Trial name
- OVERCOME-TBI (NCT06927063)
- Testing
- blood-based protein biomarker assessments, blood-based metabolomic/lipidomic biomarker assessments, Diffusion-weighted magnetic resonance imaging (brain)
- Volunteers
- 160 people
- Sponsor
- Turku University Hospital
Epilepsy, Post-Traumatic
Imaging of Neuro-Inflammation and the Risk for Post-Traumatic Epilepsy
This study plans to evaluate the time course of inflammation in the brain after a moderate to severe traumatic brain injury using positron emission tomography (PET) brain imaging.
- Trial name
- NCT03999164
- Testing
- [18F]DPA-714 Positron Emission Tomography Scan
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Davis
COVID-19
C11 ER176 PET in Evaluating Neuroinflammation in Patients With Post-COVID Syndrome
The purpose of this research is to find out if Positron Emission Tomography (PET) imaging with an investigational drug called C-11 ER176 can help us learn more about Post-COVID Syndrome.
- Trial name
- NCT07527130
- Testing
- C11 ER176 Tracer
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Cortico Basal Degeneration, Corticobasal Syndrome
Imaging Studies in Corticobasal Syndrome
The primary goal of this study is to investigate inflammation and white matter damage in corticobasal syndrome and determine whether these processes are related to each other.
- Conditions
- Cortico Basal Degeneration, Corticobasal Syndrome, Corticobasal Syndrome(CBS), Corticobasal Degeneration
- Trial name
- I-CAN (NCT07000851)
- Testing
- C-11 ER176 Radiotracer, C-11 PiB, AV1451 Tau
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Jennifer Whitwell
Major Depression
Brain Inflammation in Major Depressive Disorder Background
Background: Studies have shown that inflammation plays an important role in depression. Brain inflammation may contribute to depression, and may make it more difficult to treat some kinds of depression with current therapies.
- Trial name
- NCT01851356
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Epilepsy
Intraoperative Brain Microdialysis to Assess Neuroinflammation in Epileptic Tissue Immediately Prior to Surgical Resection.
This research study will investigate the fluid from the area of the brain that is being removed during clinical epilepsy surgery.
- Trial name
- NCT04531722
- Testing
- Intraoperative brain microdialysis
- Where
- United States
- Sponsor
- Mayo Clinic
Overweight and/or Obesity, Perimenopausal Women
Effects of a 6-months Fiber- and Polyphenol-rich Diet on Brain Inflammatory Processes in Perimenopausal Women Living With Overweight or Obesity
People living with obesity have a higher risk of late-life cognitive decline and developing dementia. In women, the risk of cognitive decline may further raise during the menopausal transition, a period of substantial hormonal…
- Trial name
- INFLAME (NCT07501377)
- Testing
- Polybiotic dietary intervention
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Max Planck Institute for Human Cognitive and Brain Sciences
Glaucoma, Adipokines
Comparison of Aqueous Humor Adipokines in Glaucoma Patients and Healthy Controls
The purpose of this study is to observe whether there are differences in adipokines in the aqueous humor between patients with primary open-angle glaucoma (POAG) and healthy controls
- Trial name
- NCT06190119
- Testing
- none intervention
- Where
- China
- Volunteers
- 2 people
- Sponsor
- Peking University
Obsessive-Compulsive Disorder
Neuroinflammation in Patients With OCD
The goal of this study is to examine whether measurements of inflammation from brain scanning and blood tests can predict how much benefit patients with obsessive-compulsive disorder (OCD) will have from treatment with an…
- Trial name
- NCT04786548
- Testing
- Celecoxib
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- New York State Psychiatric Institute
ADHD
Black Seed Oil in ADHD
Attention-Deficit/Hyperactivity Disorder is one of the most prevalent neuropsychiatric disorders affecting children with known persistence into adulthood in about 60% of patients.
- Trial name
- NCT06542887
- Testing
- Atomoxetine, Black Seed Oil Cap/Tab
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Mild Cognitive Impairment
Observation of Inhalation of CXMCI-01 Essential Oil on Patients With Mild Cognitive Impairment
Memory declined and cognitive impairment are common complaints in neurology clinics. Before diagnosing as dementia, individuals will undergo a transition period, including mild cognitive impairment (MCI).
- Trial name
- CXMCI-01-MCI (NCT06902181)
- Testing
- Experimental Group - 100% CXMCI-01 Essential Oil
- Where
- 2 sites in Taiwan
- Volunteers
- 100 people
- Sponsor
- China Medical University Hospital