Clinical trials: Neurogenic Bowel
Autonomic Dysfunction, Spinal Cord Injured
Autonomic Dysreflexia in Spinal Cord Injury
Autonomic dysreflexia in high spinal cord-injured can be initiated by a full bladder or bowel, or when trying to empty either. This randomised study aims at evaluating whether irrigation procedure or digital stimulation or…
- Trial name
- NCT01059370
- Testing
- bowel emptying
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- University of Aarhus
Spinal Cord Injuries, Neurogenic Bladder
Below the Belt: Non-invasive Neuromodulation to Treat Bladder, Bowel, and Sexual Dysfunction Following Spinal Cord Injury
Recent findings have demonstrated that electrical stimulation to the spinal cord (i.e. implanted electrodes) can significantly recover bladder, bowel, and sexual function after injury.
- Conditions
- Spinal Cord Injuries, Neurogenic Bladder, Neurogenic Bowel, Spinal Cord Stimulation
- Trial name
- NCT04604951
- Testing
- Transcutaneous Spinal Cord Stimulation
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- University of British Columbia
Spinal Cord Injuries
Osteopathic Manipulative Treatments and Neurogenic Bowel Dysfunction in Patients With Spinal Cord Injuries.
Studies based on the relationship between Osteopathic Manipulative Treatment (OMT) and the gastrointestinal system have been conducted in patients with constipation with Irritable Bowel Syndrome (IBS), and in children with…
- Trial name
- NCT04367571
- Testing
- Osteopathic Manipulative treatment (OMT)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Spinal Cord Injury, Detrusor Overacitivity
Effects of Sacral and Tibial Stimulation on Bladder Function in Subacute Suprasacral Spinal Cord Injury
Suprasacral spinal cord injury (SCI) frequently leads to neurogenic detrusor overactivity (NDO), resulting in elevated bladder storage pressures, urinary incontinence, and an increased risk of upper urinary tract damage.
- Trial name
- NCT07343583
- Testing
- Transcutaneous Tibial Nerve Stimulation, Transcutaneous Sacral Nerve Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Ankara City Hospital Bilkent
Spinal Cord Injury, Autonomic Dysfunction
Non-invasive Spinal Cord Stimulation for Recovery of Autonomic Function After Spinal Cord Injury
This study is a pilot clinical trial to explore the efficacy of transcutaneous spinal cord stimulation (TCSCS) (proof-of-concept) in mitigating crucial autonomic dysfunctions that impact the health-related quality of life of…
- Conditions
- Spinal Cord Injury, Autonomic Dysfunction, Sexual Dysfunction, Neurogenic Bladder Dysfunction
- Trial name
- NCT05369520
- Testing
- TESCoN or SCONE device - Thoracic stimulation, TESCoN or SCONE device - Lumbosacral stimulation
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University of British Columbia
Neurogenic Bowel Dysfunction, Spinal Cord Injury
Kinesio Taping for Neurogenic Bowel Dysfunction in Spinal Cord Injury
Neurogenic bowel dysfunction is a common complication of spinal cord injury and may cause constipation, difficulty with defecation, prolonged bowel care, incomplete evacuation, fecal incontinence, and reduced quality of life.
- Trial name
- NCT07705984
- Testing
- Kinesio Taping, Routine Bowel Management Program
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Pamukkale University
Bladder Dysfunction, Bowel Dysfunction
Comparison of Transcutaneous Electrical Nerve Stimulation and Manual Therapy in Children With Cerebral Palsy
There are many studies in the literature on healthy children with lower urinary tract dysfunction (LUTD), but there are limited number of studies in children with cerebral palsy (CP) with LUTD.
- Conditions
- Bladder Dysfunction, Bowel Dysfunction, Cerebral Palsy, Neurogenic Bladder
- Trial name
- NCT05351138
- Testing
- TENS, Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Bahçeşehir University
Neurogenic Bowel
Improving Bowel Function and Quality of Life After Spinal Cord Injury
Bowel dysfunction is consistently rated as one of the most common complications affecting daily life for individuals with spinal cord injury.
- Trial name
- NCT03949660
- Testing
- Stimulation for blood pressure without stand, Stimulation for blood pressure with stand, Stimulation for trunk and core without stand
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- University of Louisville
Spinal Cord Injury
High Frequency SARS for Neurogenic Bladder and Bowel Emptying
The purpose of this study is to determine if bladder emptying can be achieved using stimulation of the sacral roots at certain frequencies. Neurogenic bladder dysfunction occurs after spinal cord injury (SCI).
- Trial name
- SARS600 (NCT05214378)
- Testing
- Finetech-Brindley Sacral Anterior Roots Stimulation System
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injury
At-Home Genital Nerve Stimulation for SCI Bowel
The purpose of this study is to test whether electrical stimulation of the skin in the pelvic area (near the genitals) can reduce the reflexes that cause bowel accidents in people with spinal cord injuries.
- Trial name
- NCT06836739
- Testing
- Genital nerve stimulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- MetroHealth Medical Center
Fecal Incontinence, Neurogenic Bowel
A Within Subjects Comparison of Two Antegrade Flushing Regimens in Children
There is a surgical procedure to help children with intractable fecal incontinence gain continence for stool through construction of a tube that connects the abdominal wall to the colon near or through the appendix.
- Trial name
- NCT02435069
- Testing
- Dose Response - NS and USP Glycerin - First Intervention, Effectiveness - NS and USP Glycerin - Second Intervention
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Nemours Children's Clinic
Spinal Cord Injury, Constipation
Utility of an Animated Bowel Biofeedback Training Routine to Improve Bowel Function in Individuals With SCI
An injury to the spinal cord results in a number of secondary medical problems, including the inability to voluntarily control the bowels.
- Conditions
- Spinal Cord Injury, Constipation, Fecal Incontinence, Neurogenic Bowel
- Trial name
- NCT02406859
- Testing
- Bowel Biofeedback, Anorectal Manometry
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
Microbial Colonization
Analysis of Urinary, Vaginal and Intestinal Microbiota in Patients With Neurogenic Bladder
The neurogenic bladder and bowel are two pathological conditions occurring when damaged innervation results in functional alteration of both the bladder and the bowel with a clinical presentation that can vary from retention to…
- Trial name
- NCT06093035
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Gastrointestinal Dysmotility
Enteric Neural Precursor Cells (ENPC) in the Human Gut
The study aim is to acquire human tissues to (a) understand the structure and organization of the human Enteric Nervous System; (b) perform a molecular transcriptomic profile of individual cells residing in the human gut; (c)…
- Trial name
- NCT04880538
- Testing
- Endoscopic procedure
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Neurogenic Bowel
Evaluation of a Novel Electronic Transanal Irrigation System - Navina™ Smart
This study is designed as an open, prospective, single arm, multicenter study in order to investigate patient satisfaction, perception and compliance for the novel Navina Smart, a transanal irrigation (TAI) system.
- Trial name
- NCT02709395
- Testing
- Navina Smart
- Where
- 2 sites in Sweden, United Kingdom
- Volunteers
- 28 people
- Sponsor
- Wellspect HealthCare
Chronic Spinal Cord Injury
Abdominal Electrical Stimulation for Bowel Dysfunction in SCI
Many people with spinal cord injury (SCI) have bowel problems resulting in constipation and need a long time to empty the bowel. Some people spend an hour or more to empty their bowel.
- Trial name
- NCT06948175
- Testing
- Abdominal transcutaneous electrical stimulation (TES)
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Alberta
Neurogenic Bladder, Neurogenic Bowel
Sacral Neuromodulation in Neurogenic Patients
The goal of this observational study is to evaluate efficacy and safety of sacral neuromodulation in neurogenic patients compared to non-neurogenic (idiopathic) patients. [.
- Conditions
- Neurogenic Bladder, Neurogenic Bowel, Urge Incontinence, Overactive Bladder
- Trial name
- NCT05688644
- Testing
- InterStim II
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Omri Schwarztuch Gildor
Spinal Cord Injuries, Constipation
Transdermal Administration by a Novel Wireless Iontophoresis Device
Persons with spinal cord injury (SCI) have neurogenic bowel disorders which is associated with significant morbidity. The negative impact of bowel complications is often at the top of the list of problems reported by persons with…
- Conditions
- Spinal Cord Injuries, Constipation, Fecal Incontinence, Neurogenic Bowel
- Trial name
- NCT06351852
- Testing
- Combination of Neostigmine and Glycopyrrolate, I-Box by Dynatronics
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Neurogenic Bowel
Electrical Stimulation of Abdominal Muscles for Bowel Management in People With Spinal Cord Injury
A well-managed bowel program is an essential part of daily life for many people with a SCI. Nevertheless, constipation is frequently reported (42-95%).
- Trial name
- BOWMAN (NCT04307303)
- Testing
- abdominal functional electrical stimulation
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Salisbury NHS Foundation Trust
Central Nervous System Injury, Neurogenic Bowel Dysfunction
Effects of Osteopathic Manipulative Treatment in People With Neurogenic Bowel Dysfunction
People affected central nervous system (CNS) diseases often suffer from neurogenic bowel dysfunction (NBD) that causes a reduction in the quality of life and participation in social life.
- Trial name
- NCT04127617
- Testing
- Osteopathic Manipulative Treatment, Nursing Educational Care
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- University of Turin, Italy