Clinical trials: Neurodevelopmental Outcome
Extra Corporeal Membrane Oxygenation
Acute Neurological Complications and Neurodevelopmental Outcome in Children Undergoing Extracorporeal Membrane Oxygenation.
The purpose of this retrospective study is to describe the different types of acute neurologic complications in children who underwent extracorporeal membrane oxygenation (ECMO), and their risk factors.
- Trial name
- NeurECMO (NCT04519528)
- Testing
- DENVER scale (under 2 years old) or Pediatric Cerebral Performance Category (PCPC) score (over 2 years old), Pediatric Quality of Life Inventory™ (PedsQL)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infant, Very Low Birth Weight, Growth Failure
Preterm Infants on Early Solid Foods
Introduction: Preterm infants with a birth weight less than 1500 grams have special nutritional needs in comparison to full-term neonates.
- Trial name
- PIES-Project (NCT01809548)
- Testing
- Early intervention group, Late intervention group
- Where
- Austria
- Volunteers
- 177 people
- Sponsor
- Medical University of Vienna
Alcoholism, Attention Deficit Disorder With Hyperactivity
ADHD: Gaps Between Patients With Alcohol-dependence and Impact on Relapse
Some recent studies have found that adult attention deficit - hyperactivity disorder (ADHD) was frequent among patients with alcohol-dependence.
- Trial name
- AGADIR (NCT02364817)
- Testing
- cognitive and psychiatric assessment
- Where
- 3 sites in France
- Volunteers
- 113 people
- Sponsor
- University Hospital, Lille
Neonatal Seizures
Prophylactic Phenobarbital After Neonatal Seizures
The treatment of infants with medications after their seizures have stopped is very variable. No one knows if continuing treatment with phenobarbital for up to several months is helpful or harmful.
- Trial name
- PROPHENO (NCT01089504)
- Testing
- phenobarbital
- Where
- 18 sites in United States
- Volunteers
- 13 people
- Sponsor
- University of Rochester
Attention Deficit Disorder With Hyperactivity (ADHD)
ADHD Medication and Predictors of Treatment Outcome
ADHD medication of children and adolescents is becoming increasingly common. Clinical experience and scientific studies have proven that approximately 30% of children/adolescents with ADHD do not benefit from this treatment.
- Trial name
- ADAPT (NCT02136147)
- Testing
- methylphenidate medication, atomoxetine medication, lisdexamphetamine medication
- Where
- Sweden
- Volunteers
- 632 people
- Sponsor
- Karolinska Institutet
White Matter Abnormalities, Nonspecific, ADHD
Predicting the Outcome of ADHD in White Matter Injure Neonates With Multi-modality MRI
The goal of this bidirectional observational cohort study is to investigate the longitudinal relationship between neonatal white matter injury (WMI) and the subsequent development of attention-deficit/hyperactivity disorder…
- Conditions
- White Matter Abnormalities, Nonspecific, ADHD, Neurodevelopment Outcome
- Trial name
- NCT07836244
- Where
- 9 sites in China
- Volunteers
- 348 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
ADHD, Conduct Disorder
Preventing Health Disparities in Hispanic Youth
This study seeks to investigate the efficacy and mechanisms of a highly promising "Culturally Informed Family Therapy for Adolescents" in preventing the emergence of two important health disparities in Hispanic youth, namely drug…
- Conditions
- ADHD, Conduct Disorder, Depression, Family Dysfunction
- Trial name
- CIFFTA-P (NCT02318745)
- Testing
- Culturally Informed Family Treatment for Adolescents, Individual Treatment
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Miami
Head and Neck Cancer, Radiotherapy Side Effect
DENTOFACIAL-PBT Stage 2 - Feasibility Study
What is the health problem? Proton beam therapy (PBT), a type of radiotherapy treatment, can be especially beneficial to children and teenagers with cancer.
- Conditions
- Head and Neck Cancer, Radiotherapy Side Effect, Adverse Effect of Radiation Therapy, Childhood Cancer
- Trial name
- NCT07057284
- Testing
- Orthopantomogram (or a set of Lateral Oblique Radiographs)
- Where
- 2 sites in United Kingdom
- Volunteers
- 255 people
- Sponsor
- Manchester University NHS Foundation Trust
ADHD
Cognitive Training in Children With Attention Deficit/ Hyperactivity Disorder (ADHD)
The purpose of this study is to determine the effect of computer program C8 on specific cognitive functions, symptoms and functional outcome compared to treatment as usual in children with ADHD.
- Trial name
- NCT01752530
- Testing
- Computer program C8, Treatment as usual
- Where
- 3 sites in Denmark
- Volunteers
- 70 people
- Sponsor
- Region Syddanmark
Iron Deficiency, Anemia of Prematurity
Neurodevelopment After Early Iron Supplementation
Background: Iron deficiency in early childhood may impair neurodevelopment. Aim: To examine whether early iron supplementation improved neurodevelopment in preterm infants.
- Conditions
- Iron Deficiency, Anemia of Prematurity, Neurodevelopmental Delay
- Trial name
- NCT00457990
- Testing
- Oral administration of ferrous sulphate
- Where
- Germany
- Volunteers
- 204 people
- Sponsor
- University of Ulm
Zika Virus, Congenital Zika Syndrome
Neurodevelopmental Outcomes in ZIKV-Exposed Children
In this study the investigators will follow the neurodevelopmental outcome of children with in utero ZIKV exposure who do not have microcephaly or severe abnormalities consistent with Congenital Zika Syndrome.
- Conditions
- Zika Virus, Congenital Zika Syndrome, Congenital Infection, Child Development
- Trial name
- NCT04398901
- Testing
- Neurodevelopmental assessments
- Where
- 2 sites in United States, Colombia
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Neurodevelpmental Delays, Neurodevelopment
Implementation Outcomes and Cost-effectiveness of Developmental Monitoring for Children Exposed to HIV
The goal of this study is to learn about how to best carry out neurodevelopmental screening methods (tests to see if a young child can use support with brain development) in routine clinic visits in Botswana and Kenya among…
- Conditions
- Neurodevelpmental Delays, Neurodevelopment, Neurodevelopment Outcome
- Trial name
- IMPLEMENT (NCT07457411)
- Testing
- Neurodevelopmental screening
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- University of Washington
Attention Deficit Hyperactivity Disorder (ADHD)
The Effectiveness of Aerobic Exercise in the Treatment of Adults With Attention Deficit Hyperactivity Disorder (ADHD)
The purpose of this project is to evaluate the effectiveness of a structured aerobic exercise intervention for adults with Attention-Deficit/Hyperactivity Disorder (ADHD) with and without medication and compare it to medication…
- Trial name
- NCT02788851
- Testing
- Methylphenidate compounds and /or Amphetamine compounds and/or Strattera or Guanfacine, Aerobic Exercise
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Severe Intra-uterine Growth Restriction, Preterm Birth
Impact of Early and Severe Fetal Growth Restriction on Neurodevelopmental Outcomes in Preterm Infants
Very early onset intra uterine growth restriction (IUGR) affects 5-10% of pregnancies and is the second leading cause of perinatal mortality.
- Conditions
- Severe Intra-uterine Growth Restriction, Preterm Birth, Neurodevelopmental Disorders, Placental Insufficiency
- Trial name
- NCT05381272
- Volunteers
- 20 people
- Sponsor
- Central Hospital, Nancy, France
Brain Activity, Neurodevelopmental Outcome
Analysis of Correlation of Amplitude-Integrated EEG and Neurodevelopmental Outcome in Preterm Infants
The study included analysis of longitudinal recordings of amplitude-integrated EEG (aEEG) tracings on a weekly basis in preterm infants and evaluation of their neurodevelopmental outcome at the age of three years.
- Trial name
- NCT00728234
- Testing
- aEEG recording
- Where
- Austria
- Volunteers
- 284 people
- Sponsor
- Medical University of Vienna
Anesthesia, Infant Development
General Anesthesia Exposure and Neurodevelopmental Outcome in Pediatrics
This study investigates the impact of different levels of anesthesia exposure on children's neurocognitive development and evaluates the concurrent validity of different methods that assess neurodevelopmental outcome.
- Conditions
- Anesthesia, Infant Development, Anesthesia; Adverse Effect
- Trial name
- GAP (NCT04604106)
- Testing
- Eyetracker, Ages & Stages questionnaire, Bayley Scale of Infant Development
- Where
- Netherlands
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Hyperbilirubinemia, Neonatal, Jaundice, Neonatal
Trial of Aggressive Versus Conservative Phototherapy in Infants <1,000 Grams Birth Weight
This multi-center, randomized clinical trial compared different bilirubin levels as thresholds for timing of phototherapy in extremely low birth weight infants.
- Conditions
- Hyperbilirubinemia, Neonatal, Jaundice, Neonatal, Infant, Newborn, Infant, Low Birth Weight
- Trial name
- Phototherapy (NCT00114543)
- Testing
- Aggressive Phototherapy 501-750g, Aggressive Phototherapy 751-1000g, Conservative Phototherapy 501-750g
- Where
- 17 sites in United States
- Volunteers
- 1,974 people
- Sponsor
- NICHD Neonatal Research Network
Attention Deficit Disorder With Hyperactivity
Genetic, Brain Structure, and Environmental Effects on ADHD
Background: Attention deficit hyperactivity disorder (ADHD) is one of the most common and inheritable of all neuropsychiatric disorders. It causes problems with attention and impulse control.
- Trial name
- NCT01721720
- Where
- United States
- Volunteers
- 1,091 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Attention Deficit Hyperactivity Disorder
Open-Label Trial of Atomoxetine to Evaluate Academic Outcome in Children Ages 8-11 Years With Attention Deficit/Hyperactivity Disorder
Open-label trial of Atomoxetine to Evaluate Academic Outcome in Children Ages 8-11 years with Attention- Deficit/Hyperactivity Disorder
- Trial name
- NCT00191880
- Testing
- atomoxetine
- Where
- 8 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Eli Lilly and Company
Developmental Delay (Disorder)
Creative Music Therapy for Premature Infants
This study investigates whether creative music therapy applied to premature infants will facilitate brain growth and development at term equivalent assessed by magnetic resonance imaging.
- Trial name
- NCT02434224
- Testing
- Music Therapy
- Where
- Switzerland
- Volunteers
- 81 people
- Sponsor
- University of Zurich