Clinical trials: Neurodegenerative Diseases, open to volunteers
Parkinson Disease
Parkinson Progression Marker Initiative Online (PPMI Online)
Parkinson Progression Marker Initiative Online (PPMI Online) is an observational study collecting participant reported information from people with and without Parkinson's disease (PD), for the goal of better understanding risk…
- Trial name
- NCT05065060
- Testing
- Observation
- Where
- United States
- Volunteers
- 500,000 people, healthy volunteers welcome
- Sponsor
- Michael J. Fox Foundation for Parkinson's Research
Tauopathies, Neurodegenerative Diseases
Tau PET/CT in Various Tau-Related Disease Patients
To evaluate the potential usefulness of 18F-S16/T807 positron emission tomography/computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various Tau-related disease patients.
- Conditions
- Tauopathies, Neurodegenerative Diseases, Neurodegeneration
- Trial name
- NCT06690983
- Testing
- 18F-S16/T807
- Where
- 3 sites in China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University
Amyloid, Beta-Amyloid
Beta Amyloid PET/CT in Various Aβ-Related Disease
To evaluate the potential usefulness of 18F-92/AV45, 11C-PIB positron emission tomography/computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various Tau-related disease patients.
- Conditions
- Amyloid, Beta-Amyloid, Neurodegenerative Diseases
- Trial name
- NCT06725706
- Testing
- 18F-92/AV45, 11C-PIB
- Where
- 4 sites in China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University
Neuroinflammation, Stroke
Translocator Protein PET/CT in Various TSPO-Related Disease
To evaluate the potential usefulness of 18F-DPA714/FDPA positron emission tomography/computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various TSPO-related disease patients.
- Conditions
- Neuroinflammation, Stroke, Neurodegenerative Diseases
- Trial name
- NCT06725719
- Testing
- 18F-DPA714/FDPA
- Where
- 3 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University
Neurodegenerative Disease, Alzheimer s Disease
[18F]NIDF PET Imaging in Tau-related Diseases
In the field of diagnosing brain neurodegenerative diseases, it is now a well-established practice to inject positron-emitting tracers into the human body.
- Conditions
- Neurodegenerative Disease, Alzheimer s Disease, Tauopathies
- Trial name
- NCT07306598
- Where
- 3 sites in China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University
Aging, Mortality
Human Observatory Study
The Human Observatory Study is a prospective observational and ecological surveillance study building a continuously-updating world model for human health, disease, and death at the individual and population level.
- Conditions
- Aging, Mortality, All-cause Mortality, Life Expectancy
- Trial name
- HOS (NCT07646782)
- Testing
- Multi-Domain Ecological and Clinical Data Linkage
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Longevity Metrics, Inc.
Neurodegenerative Diseases, Parkinson Disease
Neurodegenerative Diseases Progression Markers (MARKERS-NDD)
MARKERS-NDD is a prospective, observational, longitudinal study, which aims to collect data from patients affected by neurodegenerative diseases (NDD) followed longitudinally for routine examinations performed as part of normal…
- Conditions
- Neurodegenerative Diseases, Parkinson Disease, Synucleinopathies, Lewy Body Disease
- Trial name
- MARKERS-NDD (NCT06596746)
- Testing
- Observation
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Casa di Cura San Raffaele Cassino
Friedreich Ataxia
Friedreich Ataxia Global Clinical Consortium UNIFIED Natural History Study
This project is a global, multicenter, prospective, longitudinal, observational natural history study that can be used to understand the disease progression and support the development of safe and effective drugs and biological…
- Trial name
- UNIFAI (NCT06016946)
- Where
- 34 sites in United States, Australia and 15 more
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Friedreich's Ataxia Research Alliance
Frontotemporal Degeneration (FTD), ALS (Amyotrophic Lateral Sclerosis)
Biofluid Research on Age-Related or Inherited Neurodegeneration
The aim of this study is to contribute to and continue to sustain a repository of blood samples, nucleic acid (DNA and/or RNA) samples, family history information, and other demographic information from individuals with…
- Conditions
- Frontotemporal Degeneration (FTD), ALS (Amyotrophic Lateral Sclerosis), Primary Progressive Aphasia (PPA), Familial Frontotemporal Lobar Degeneration (fFTLD)
- Trial name
- BRAIN (NCT07798700)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Parkinson Disease, Prodromal Stage
Slow-SPEED-NL: Slowing Parkinson's Early Through Exercise Dosage-Netherlands
The goal of this clinical trial is to investigate the feasibility if a remotely administered smartphone app can increase the volume and intensity of physical activity in daily life in patients with isolated Rapid Eye Movement…
- Conditions
- Parkinson Disease, Prodromal Stage, Neurodegenerative Diseases, Parkinsonian Disorders
- Trial name
- Slow-SPEED-NL (NCT06193252)
- Testing
- Increase of physical activity volume and intensity with the use of a motivational smartphone application
- Where
- Netherlands
- Volunteers
- 110 people
- Sponsor
- Radboud University Medical Center
Dyskinesia, Drug-Induced, Parkinson Disease
rTMS as an Intervention for Levodopa-induced Dyskinesia
The proposed study investigates the use of repetitive transcranial magnetic stimulation (rTMS) as a treatment for levodopa-induced dyskinesia (LID) in Parkinson's Disease (PD).
- Trial name
- ADAPT-LIDI (NCT06570824)
- Testing
- active TMS
- Where
- Denmark
- Volunteers
- 68 people
- Sponsor
- Danish Research Centre for Magnetic Resonance
Alzheimer Disease
A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease
The main purpose of this study is to evaluate the safety of LY3954068 in participants with early symptomatic Alzheimer's Disease (AD).
- Trial name
- NCT06297590
- Testing
- LY3954068, Flortaucipir F18
- Where
- 10 sites in United States, Japan and 1 more
- Volunteers
- 48 people
- Sponsor
- Eli Lilly and Company
PD - Parkinson's Disease
Transplantation of Human iPS Cell-derived Dopaminergic Progenitors (CT1-DAP001) for Parkinson's Disease (Phase I/II)
To evaluate the safety and efficacy of transplantation of human induced pluripotent stem cell-derived dopaminergic progenitors, CT1-DAP001, into the corpus striatum in patients with Parkinson's disease
- Trial name
- CT1-DAP001 (NCT06482268)
- Testing
- Human induced pluripotent stem cell-derived dopaminergic progenitors (CT1-DAP001)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of California, San Diego
Mild Cognitive Impairment, Alzheimer Disease, Late Onset
Multimodal Assesment of Alzheimer Patients
The goal of this study is to learn more about the changes in the brains of patients with cognitive impairment (MCI) and Alzheimer's Disease (AD). The main questions the study aims to answer are: 1.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Late Onset, Cognitive Impairment, Dementia
- Trial name
- MultiAD (NCT06448403)
- Testing
- MRI Scanning, 64-channel EEG, Polysomnography
- Where
- Norway
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Alzheimer Disease, Neurodegenerative Diseases
Memory Deterioration in Alzheimer Disease
Semantic AD
- Conditions
- Alzheimer Disease, Neurodegenerative Diseases, Magnetic Resonance Imaging, Memory Impairment
- Trial name
- MemAD (NCT07118137)
- Testing
- 7T MRI, EEG, Blood samples
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Neurodegenerative Diseases, Parkinson Disease
Characterization of the Serotonin 2A Receptor Selective PET Tracer [18F]MH.MZ in Patients With Neurodegenerative Diseases
It is hypothesize that patients with clinically diagnosed neurodegenerative diseases will have significantly different receptor occupancy of 5HT2A receptors compared to a healthy age/sex-matched control group.
- Conditions
- Neurodegenerative Diseases, Parkinson Disease, Parkinson Disease Psychosis
- Trial name
- NCT05357612
- Testing
- Pimavanserin
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Psychosis Associated With Alzheimer's Disease
An Open-Label Study of ML-007C-MA in Adults With Alzheimer's Disease Psychosis
ML-007C-MA-222 is a 52-week, flexible-dose, open-label extension study designed to evaluate the long-term safety, tolerability, and effectiveness of ML007C-MA in participants with ADP who have completed the antecedent study (ie…
- Trial name
- NCT07459660
- Testing
- ML-007C-MA
- Where
- 8 sites in United States, Bulgaria and 1 more
- Volunteers
- 210 people
- Sponsor
- MapLight Therapeutics
Parkinson Disease
PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort
The Parkinson Progression Marker Initiative (PPMI) is a longitudinal, observational, multi-center natural history study to assess progression of clinical features, digital outcomes, and imaging, biologic and genetic markers of…
- Trial name
- PPMI (NCT04477785)
- Where
- 50 sites in United States, Austria and 10 more
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- Michael J. Fox Foundation for Parkinson's Research
Spinal Cord Diseases, Spinal Cord Injuries
Optimization of Adaptive Rowing Seating
Adaptive sports programs are integral components to combating Veteran isolation, promoting wellbeing and seeking to build teams, networks, communities.
- Conditions
- Spinal Cord Diseases, Spinal Cord Injuries, Neurodegenerative Disorders, Cerebrovascular Accident With Associated Sequelae
- Trial name
- OARS (NCT07099625)
- Testing
- Adaptive Indoor Rowing Seat, Paddle Sport adaptive seating system
- Where
- 2 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Parkinson's Disease (PD), Parkinsonian Disorders
ZR001 Chemogenetics Gene Therapy Study in Patients With Parkinson's Disease
This study aims to evaluate the safety, tolerability, and preliminary efficacy of ZR001, a novel chemogenetic gene therapy product, in patients with moderately advanced Parkinson's disease (PD).
- Trial name
- NCT07718659
- Testing
- ZR001
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Qianfoshan Hospital