Clinical trials: Neurocritical Care
Coma
Using EEG to Study Coma in the Neurocritical Care Unit
Despite its clinical significance, the pathophysiology of coma is still under investigation and the physiology of emergence from coma remains a mystery.
- Trial name
- NCT01897194
- Volunteers
- 1 people
- Sponsor
- University of Utah
Severe Traumatic Brain Injury
Brain Tissue Oxygen Monitoring in Traumatic Brain Injury (TBI)
Traumatic brain injury (TBI) is a major cause of death and disability, with an estimated cost of 45 billion dollars a year in the United States alone.
- Trial name
- BOOST 2 (NCT00974259)
- Testing
- Management protocol based on pBrO2 and ICP values., Management protocol based on ICP values only.
- Where
- 10 sites in United States
- Volunteers
- 122 people
- Sponsor
- University of Pennsylvania
Myocardial Injury, Lung Injury
Neurogenic Myocardial and Lung Injury in SAH Patients
Up to this day, little is known whether the extent of brain damage in patients with SAH correlates with the degree neurogenic myocardial injury and neurogenic lung injury.
- Conditions
- Myocardial Injury, Lung Injury, Subarachnoid Hemorrhage
- Trial name
- NCT05408988
- Testing
- hs-TnT (high-sensitive cardiac troponin T) plasma concentration, CK-MB (creatine kinase myocardial band) plasma concentration, CPK (creatine phosphokinase) plasma concentration
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Medical University of Silesia
Intracerebral Haemorrhage, Intracerebral Haemorrhage, Intraventricular
Prehospital and Acute Phase Characteristics of Severe Spontaneous ICH
Spontaneous intracerebral hemorrhage (ICH) represents 10-15% of all strokes and is associated with high mortality and morbidity. Rapid identification and interventions, e.g.
- Conditions
- Intracerebral Haemorrhage, Intracerebral Haemorrhage, Intraventricular, ICH - Intracerebral Hemorrhage, Spontaneous Intracerebral Hemorrhage
- Trial name
- NCT07739030
- Where
- Denmark
- Volunteers
- 678 people
- Sponsor
- Kirsten Moller
Neurocritical Conditions, Traumatic Brain Injury
Protein Intake Dosage on the Prognosis of Neurocritical Patients
This study investigates the effect of different early protein supplementation levels (1.0-2.0g/kg/d, divided into three groups) on the prognosis of neurocritical patients, focusing on the 28-day Glasgow Coma Scale (GCS) score…
- Conditions
- Neurocritical Conditions, Traumatic Brain Injury, Ischemic Stroke
- Trial name
- NCT07295301
- Testing
- Low-Dose Enteral Protein Supplementation (Enteral Nutrition Formulas + Whey Protein Powder), Moderate-Dose Enteral Protein Supplementation (Enteral Nutrition Formulas + Whey Protein Powder), High-Dose Enteral Protein Supplementation (Enteral Nutrition Formulas + Whey Protein Powder)
- Volunteers
- 216 people
- Sponsor
- Wenshan City People's Hospital
Traumatic Brain Injury, Severe Traumatic Brain Injury
Feasibility and Safety of Targeting Neutral vs Liberal Fluid Balance in Traumatic Brain Injured Patients- LIMIT-TBI Trial
The LIMIT-TBI trial is a multicenter, international, randomized, phase II clinical trial designed to evaluate the feasibility and safety of targeting a neutral fluid balance compared to standard care in critically ill adult…
- Conditions
- Traumatic Brain Injury, Severe Traumatic Brain Injury, Acute Brain Injury, Neurocritical Care
- Trial name
- LIMIT-TBI (NCT07625995)
- Testing
- Neutral Fluid Balance Strategy
- Where
- 3 sites in Belgium, Italy
- Volunteers
- 88 people
- Sponsor
- Erasme University Hospital
Comatose, Prognosis
NEURO - Prognostication Using Late Somatosensory Evoked - Potentials
The main aim of this study is to develop a new technique for the passive diagnosis of cognitive-motor dissociation, with the detection of motor intention in a comatose patient by analysing the EEG signal and in particular the…
- Conditions
- Comatose, Prognosis, Critical Care
- Trial name
- NEURO-PULSE (NCT07506928)
- Testing
- EEGs
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
Acute Brain Injury, Hypoxia, Brain
Portable MRI for Pediatric Hypoxic Ischemic Brain Injury
This study will evaluate the sensitivity and specificity of low field portable MRI (pMRI) for detection of hypoxic ischemic brain injuries in pediatric patients compared to clinically obtained neuroimaging to define pediatric…
- Conditions
- Acute Brain Injury, Hypoxia, Brain, Ischemia, Brain, Brain Injuries
- Trial name
- pMRI for HIBI (NCT07577336)
- Testing
- Portable MRI, Scavenged Sample Collection
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Mercy Hospital Kansas City
Severe Traumatic Brain Injury, Severe Brain Injury
The Örebro Severe Traumatic Brain Injury Registry
Traumatic brain injury and other severe brain injuries requiring neurointensive care are associated with high mortality, long-term disability and substantial societal burden.
- Conditions
- Severe Traumatic Brain Injury, Severe Brain Injury, Ischemic Stroke, Intracerebral Hemorrhage
- Trial name
- ÖrSBID (NCT07398274)
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- András Zoltán Buki
Subarachnoid Hemorrhage
Observational Study of Patients With Subarachnoid Hemorrhage
This prospective, observational study aim to identify : Prognostic factor of patients with subarachnoid haemorrhage in neuro intensive care unit The impact of standard therapeutic used (surgery, embolization ; medical treatment…
- Trial name
- ProReSHA (NCT02890004)
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Hospices Civils de Lyon
Brain Injury, Hyponatremia
Pharmacokinetics and Clinical Response of Tolvaptan in Neurocritical Care Patients
To assess the pharmacokinetic profile of tolvaptan in critically ill acute brain injury patients and to secondarily evaluate the clinical response and safety of tolvaptan in acute brain injured patients
- Trial name
- NCT02215148
- Testing
- Tolvaptan
- Where
- 3 sites in United States
- Volunteers
- 1 people
- Sponsor
- University of North Carolina, Chapel Hill
Clinical Competence, Self-Confidence
Neurocritical Care Video Training in Palestine: RCT on Nursing Students' EVD Knowledge, Attitude, Skills, Confidence
This randomized controlled trial aims to evaluate the effect of a video-based educational program on nursing students' knowledge, attitude, self-reported practice, and confidence related to external ventricular drainage (EVD)…
- Conditions
- Clinical Competence, Self-Confidence, Knowledge Level
- Trial name
- NCT07284537
- Testing
- video based education, Flashcard
- Where
- Palestinian Territories
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Modern University College
Neuro-intensive Care Unit Patients, Subarachnoid Hemorrhage, Aneurysmal
Risk Factors and Outcomes in Patients Treated in Neurocritical Care
The overall purpose of this epidemiologic research project is to provide a comprehensive exploration and analysis of critical elements within the neuro-intensive care process in Sweden.
- Conditions
- Neuro-intensive Care Unit Patients, Subarachnoid Hemorrhage, Aneurysmal, Ischemic Stroke, Intracerebral Hemorrhage
- Trial name
- EpiNIC (NCT07052656)
- Testing
- Observational study, participants are not assigned an intervention as part of the study., Transport modality
- Where
- Sweden
- Volunteers
- 70,000 people
- Sponsor
- Karolinska Institutet
Ultrasound, Optic Nerve Sheath Diameter
Ultrasound Measurement of Optic Nerve Sheath Diameter as Non-Invasive Detector of Raised Intracranial Pressure in Adult Traumatic and Non-Traumatic Neurocritical Patients in ICU
This study aimed to assess the role of ultrasound as a non-invasive method (bedside) to measure the rise of intracranial pressure by measuring the optic nerve sheath diameter in traumatic and nontraumatic neurocritical patients.
- Conditions
- Ultrasound, Optic Nerve Sheath Diameter, Non-Invasive, Intracranial Pressure
- Trial name
- NCT06993961
- Testing
- Ultrasound
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Hemorrhagic Stroke, Intracerebral, Acute Ischemic Stroke
Feasibility of a Digital Goals-of-Care Decision Aid for Clinicians and Families of Patients With SABI
The goal is to pilot test a highly accessible, web-based, pragmatic, scalable intervention to overcome ongoing problems with high stakes decision-making by surrogate decision-makers of patients in ICUs with severe acute brain…
- Conditions
- Hemorrhagic Stroke, Intracerebral, Acute Ischemic Stroke, Traumatic Brain Injury
- Trial name
- NCT05671874
- Testing
- Web/mobile/tablet-based digital decision aid + communication (DA+C) tool
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Subarachnoid Hemorrhage, Aneurysmal, Brain Injuries, Traumatic
Prospective Observational Multimodal Neuromonitoring in Adult NSICU Patients
This is a prospective observational cohort study of adult patients admitted to the Neurosciences Intensive Care Unit (NSICU) at UT Southwestern Medical Center.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Brain Injuries, Traumatic, Cerebral Hemorrhage, Ischemic Stroke
- Trial name
- NCT07577713
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Stroke
Guideline-recommended Basic Parameter Adherence in Neurocritical Care Patients
The aim of the planned study project is to assess the current situation regarding the treatment of patients with severe stroke at the neuro-critical care unit.
- Trial name
- NORMONICU (NCT06367543)
- Testing
- Time in therapeutic range of vital parameters
- Where
- Germany
- Volunteers
- 474 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Traumatic Brain Injury, Ischemic Stroke
Shared Decision Making to Improve Goals-of-Care Decisions for Families of Severe Acute Brain Injury Patients
Severe acute brain injury (SABI), including large artery acute ischemic stroke, intracerebral hemorrhage, and severe traumatic brain injury continue to be the leading cause of death and disability in adults in the U.S.
- Conditions
- Traumatic Brain Injury, Ischemic Stroke, Intracerebral Hemorrhage
- Trial name
- NCT03833375
- Testing
- Decision Aid
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- University of Massachusetts, Worcester
Traumatic Brain Injury, Transfusion
HEMOglobin Transfusion Threshold in Traumatic Brain Injury OptimizatioN: The HEMOTION Trial
Most trauma deaths are related to traumatic brain injury (TBI). Although the management of patients has improved, mortality remains unacceptably high, and half of survivors of moderate and severe TBI are left with major…
- Trial name
- HEMOTION (NCT03260478)
- Testing
- Red Blood Cells Transfusion
- Where
- 33 sites in Brazil, Canada and 2 more
- Volunteers
- 742 people
- Sponsor
- CHU de Quebec-Universite Laval