Clinical trials: Neurocognitive Function
Nonamnestic Mild Cognitive Impairment, Cognitive Dysfunction
Online Cognitive Rehabilitation of Executive Dysfunction in Nonamnestic MCI
Nonamnestic mild cognitive impairment (naMCI) is a prodromal state characterized by deficits in executive functioning, a collection of higher-order abilities involved in organization, planning, inhibition, and complex reasoning.
- Conditions
- Nonamnestic Mild Cognitive Impairment, Cognitive Dysfunction, Cognitive Disorder, Neurocognitive Disorders
- Trial name
- NCT04503798
- Testing
- Online Goal Management Training
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Baycrest
Accidental Falls, Aging
Evaluation of the Effects of a Cognitive-Motor Fall Prevention Program on Fall Risk Factors
The goal of this interventional study is to compare in community dwelling elderly people the effects of two physical activity programs to prevent accident falls : "SILVER XIII EQUILIBRE" program and "VIVIFRAIL" program, on…
- Conditions
- Accidental Falls, Aging, Mild Cognitive Impairment
- Trial name
- 13EVAL (NCT05625828)
- Testing
- Cognitive-motor Physical Activity, Multifactorial Physical Activity
- Where
- France
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- EZUS-LYON 1
Alzheimer Disease, Sarcopenia
Silkworm Pupa Powder Improves Alzheimer's Disease
The goal of this clinical trial is to learn if silkworm pupa powder works to treat Alzheimer's disease in patients. It will also learn about the safety of silkworm pupa powder, and its effect on patients' nutritional and frailty…
- Conditions
- Alzheimer Disease, Sarcopenia, Asthenia, Frailty
- Trial name
- NCT07638449
- Testing
- Silkworm pupa powder
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhejiang Provincial Tongde Hospital
Parkinson's Disease, Mild Cognitive Impairment
Effect of Transcranial Magnetic Stimulation on Cognition and Neural Changes in Parkinson's Disease
Parkinson's disease (PD) affects more than 100,000 Canadians and results in symptoms affecting both motor and cognitive (thinking and memory) functions.
- Trial name
- PD-MCI-TMS (NCT03243214)
- Testing
- TMS
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- University of Calgary
Mild Cognitive Impairment, TTM
Non-pharmacological Interventions on Cognitive Functions in Older People With Mild Cognitive Impairment
This project is proposed to be a three-year project. The purposes of this project are to develop and examine physical activity program, cognitive rehabilitation training, and new life-style (combination of exercise and cognitive)…
- Conditions
- Mild Cognitive Impairment, TTM, Physical Activity, Cognitive Rehabilitation
- Trial name
- NCT03545152
- Testing
- Exercise, Cognitive training, New life-style
- Volunteers
- 192 people
- Sponsor
- Tzu-Ting Huang
Dementia, Lewy Body
ANeED Joint Effort 21: eHealth and a PPI Program in Dementia With Lewybodies (DLB)
The goal of the study is to develop predictive algorithms and digital biomarkers to capture disease fluctuations in (prodromal) dementia with lewybodies (DLB) patients and to improve treatment, diagnosis and prognosis of the…
- Trial name
- JointEffort21 (NCT05773443)
- Testing
- Digital biomarkers
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- University of Bergen
Mild Cognitive Impairment
Effect of Perch Essence on Cognitive Function Status in Subjects With Mild Cognitive Impairment
With global population aging, cognitive impairment and dementia have become major public health issues worldwide. According to the 2019 World Alzheimer Report by the Alzheimer's Disease International, there are more than 50…
- Trial name
- NCT07239635
- Testing
- Perch essence, Fish stock
- Where
- Taiwan
- Volunteers
- 54 people
- Sponsor
- Taipei Medical University
Schizophrenia
The Effects of Prebiotics on Cognitive Functioning and Weight Gain in Psychosis
The investigators propose a maltodextrin-controlled cross over experimental medicine study that aims to examine the role of the immune system in cognitive processes and weight gain in 40 adult patients with psychosis, stable on…
- Trial name
- Prepsy (NCT03153046)
- Testing
- prebiotics, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 39 people
- Sponsor
- University of Oxford
Hearing Loss, Cognitive Impairment, Mild
ENACT Program on Auditory Perception and Function, Cognitive Function and Health-related Quality of Life
Although previous studies indicated that tackling hearing loss may have a secondary benefit in improving cognitive function and delaying the onset of dementia, a more integrated care approach to optimize both hearing and…
- Trial name
- NCT06955494
- Testing
- Empowerment Network for Auditory-Cognitive Training (ENACT) Program, Usual Care
- Where
- Hong Kong
- Volunteers
- 62 people
- Sponsor
- The University of Hong Kong
Mild Cognitive Impairment (MCI), Cognitive Dysfunction, Cognitive Disorder
A Study of Sabroxy™ (Oroxylum Indicum Extract) for Improving Cognitive Function in Adults With Mild Memory Concerns
This study is testing whether Sabroxy™ (Oroxylum indicum extract) can improve memory and thinking in older adults who report mild problems with their cognition.
- Conditions
- Mild Cognitive Impairment (MCI), Cognitive Dysfunction, Cognitive Disorder, Memory Problems
- Trial name
- NCT07189754
- Testing
- Sabroxy™ (Oroxylum indicum extract)
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- SF Research Institute, Inc.
Cognitive Impairment, Stroke
Dance Intervention on Cognitive Functions and Quality of Life in Chronic Stroke
To examine the effect of dance interventions on cognitive functions and quality of life in patients with chronic stroke.
- Conditions
- Cognitive Impairment, Stroke, Quality of Life
- Trial name
- NCT06145503
- Testing
- Dance Intervention Group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Karadeniz Technical University
Dementia, Alzheimer Type
Photobiomodulation for Improving Brain Function in Dementia (PBM Dementia)
A recent study (Saltmarche et al., 21017) examined the effects of photobiomodulation (PBM), a kind of light therapy that uses red or near-infrared light to heal and protect tissue that has either been injured, is degenerating, or…
- Trial name
- PBM Dementia (NCT03160027)
- Testing
- Vielight Neuro Gamma
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Cognition, Fatigue
Cognitive Function and Fatigue in Colorectal Cancer (CRC) Patients After Chemotherapy
This is a prospective, longitudinal cohort study to evaluate fatigue and cognitive function in patients with colorectal cancer (CRC) treated with chemotherapy, and in patients with the same malignancy, that do not receive…
- Conditions
- Cognition, Fatigue, Colorectal Neoplasm
- Trial name
- NCT00188331
- Testing
- Neuropsychological Testing
- Where
- 2 sites in Australia, Canada
- Volunteers
- 441 people
- Sponsor
- University Health Network, Toronto
Caregivers, Alzheimer's Disease
Meditation or Education for Alzheimer Caregivers
The goal is to determine how 6-week stress reduction techniques may decrease stress in primary caregivers of people with Alzheimer's disease. The 3 intervention programs are meditation, education, and respite care.
- Trial name
- NCT00558402
- Testing
- Meditation, Education, Respite only
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Oregon Health and Science University
Mild Cognitive Impairment
Efficacy of a Multicomponent Intervention on Cognitive Function for the Caregiver-patient Dyad
With the aging of the population, an increase in neurocognitive diseases such as dementia is projected. Mild cognitive impairment is considered a precursor stage to dementia, with opportunities for intervention to prevent its…
- Trial name
- INTERCOG (NCT06408103)
- Testing
- Multi-component, transdisciplinary and multifocal intervention for the cognition
- Where
- Colombia
- Volunteers
- 102 people
- Sponsor
- Universidad de Santander
Critical Illness
Cortisol Levels as a Measure of Accumulated Physiological Stress in ICU Patients Undergoing Mechanical Ventilation
Critical illness is a situation of severe and prolonged stress for patients with mechanical ventilation (MV). Between 40-80% of these patients present the Post-ICU syndrome, a set of physical, cognitive, psychological alterations…
- Trial name
- Corti-COG (NCT03736135)
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Corporacion Parc Tauli
Alzheimer Disease 2 Due to Apoe4 Isoform
Acute Exercise on Neurocognitive Function Among Adults With/Without Generic Risk of AD
This study explores the acute exercise effect on neurocognitive function and also its potential moderators in an exercise setting and Apolipoprotein E (APOE) genetic risk.
- Trial name
- NCT05591313
- Testing
- LI-40, MI-30, HI-16
- Where
- Taiwan
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Hydrocephalus, Alzheimer Disease
MR Evaluation of Cerebrospinal Fluid (CSF) Dynamics
The Researchers are trying to test a MR imaging method for detection of Cerebral Spinal Fluid (CSF) flow in the brain to help diagnosis and better understand diseases that affect brain function.
- Trial name
- NCT04099823
- Testing
- MRI screening form, Urine pregnancy test, MR brain
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Cognitive Impairment, Dementia
Predicting MRI Abnormalities With Longitudinal Data of the Whitehall II Substudy
Follow-up study within the Whitehall II study, selecting 800 participants for further neuropsychological, clinical and imaging (MRI) examinations to examine brain structure and function in relation to age-related diseases and the…
- Conditions
- Cognitive Impairment, Dementia, Affective Disorders
- Trial name
- NCT03335696
- Where
- United Kingdom
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Alzheimer Disease
Huperzine A in Alzheimer's Disease
The present study will evaluate the safety and efficacy of the Chinese herb huperzine A in the treatment of Alzheimer's disease (AD) in a randomized controlled trial of its effect on cognitive function.
- Trial name
- NCT00083590
- Testing
- Huperzine A
- Where
- 29 sites in United States
- Volunteers
- 150 people
- Sponsor
- National Institute on Aging (NIA)