Clinical trials: Neurocognitive Disorders
Sleep Disturbance, Cognitive Change
Integrating Systematic Data of Medicine to Explore the Solution for Healthy Aging (ISDHA) Phase 4
This project aims to build up the comprehensive health database of geriatric medicine for middle-aged and elderly people in Taiwan.
- Conditions
- Sleep Disturbance, Cognitive Change, Aging
- Trial name
- NCT07414680
- Where
- 2 sites in Taiwan
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Healthy
Pharmacokinetics of BPDO-1603 or BPDO-16031 and BPDO-16033 Administration in Healthy Adults
Pharmacokinetics and safety of BPDO-1603 or BPDO-16031 and BPDO-16033 administration in healthy adults. Randomized, open-label, single-dose, cross-over, Phase 1 study
- Trial name
- NCT05804279
- Testing
- BPDO-1603
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hyundai Pharm
Alzheimer Disease
The Effect of High Fat Diet on the Pharmacokinetics of AD16 Tablets in Healthy Chinese Adult Subjects
The study was a single-center, randomized, open-access, two-crossover, single-dose study design with 16 subjects to evaluate the pharmacokinetics of a high-fat diet on a single dose of oral AD16 tablets in healthy Chinese adults…
- Trial name
- NCT05787041
- Testing
- high-fat diet group（AD16 20mg）, fasted group（AD16 20mg）
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- South China Center For Innovative Pharmaceuticals
Alzheimers Disease, Dementia
Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001
The purpose of this study is to assess the safety, tolerability, biomarker, cognitive and clinical efficacy of investigational products in participants with an Alzheimer's disease-causing mutation by determining if treatment with…
- Conditions
- Alzheimers Disease, Dementia, Alzheimers Disease, Familial
- Trial name
- DIAN-TU (NCT01760005)
- Testing
- Gantenerumab, Solanezumab, E2814
- Where
- 38 sites in United States, Argentina and 13 more
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Behavioral and Psychological Symptoms of Dementia, Dementia
Validation and Reliability of the Turkish Version of the Montreal Cognitive Assessment-Basic (MoCA-B) in Individuals With Low Educational Level
This study aimed to evaluate the validity, reliability, and diagnostic accuracy of the Turkish version of MoCA-B in distinguishing healthy controls, mild cognitive impairment (MCI), and dementia patients within a low-education…
- Conditions
- Behavioral and Psychological Symptoms of Dementia, Dementia, Dementia (Diagnosis), Dementia Alzheimer Type
- Trial name
- MoCA-B Turkish (NCT07630688)
- Where
- Turkey (Türkiye)
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Antalya Training and Research Hospital
Dementia
Copy Number Variations, Inflammatory Cytokines and the Risk of Dementia
Assess the association of copy number variation (CNV) and inflammatory cytokine with the risk of dementia.
- Trial name
- NCT00878280
- Where
- Taiwan
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Alzheimer
Telerehabilitation in Alzheimer's Disease
Telemedicine has developed rapidly during the COVID-19 pandemic and is now integrated into the clinical practice of many hospitals.
- Trial name
- VRTAD (NCT07722169)
- Testing
- Online cognitive telerehabilitation, VRRS tablet
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Alzheimer's Disease
Study of ITI-007 in Healthy Geriatric Volunteers and in Geriatric Patients With Dementia
A Phase 1b/2, Randomized, Double-blind, Placebo-Controlled, Multiple Oral Dose Escalation Study to Assess Safety, Tolerability and Pharmacokinetics of ITI-007 in Healthy Geriatric Volunteers and in Geriatric Patients with Dementia
- Trial name
- NCT02078310
- Testing
- ITI-007
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Intra-Cellular Therapies, Inc.
Delirium
Dexmedetomidine Versus Propofol for Prolonged Sedation in Critically Ill Trauma and Surgical Patients
The purpose of this study is to assess the efficacy of dexmedetomidine versus propofol for prolonged sedation in trauma and surgical patients.
- Trial name
- NCT02548923
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Tennessee Graduate School of Medicine
Alzheimer's Disease
Project ACT: Advancing Caregiving Techniques
The specific aims of this study are to: 1. Test the immediate effectiveness of the intervention to reduce caregiver upset with targeted disruptive behaviors (primary outcome).
- Trial name
- NCT00259480
- Testing
- Home Based Intervention
- Where
- United States
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Alzheimer Disease
Neural Mechanisms of Clinically Designed Improvisatory Music for Alzheimer's Disease
Clinically Designed Improvisatory Music (CDIM) is a form of improvised music based on calm-inducing sound parameters which brought relief to our cohort of neurology patients.
- Trial name
- NCT05477862
- Testing
- Clinically Designed Improvisatory Music
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Alcohol Use Disorder, Inflammatory Response
An Inflammatory Challenge Using Endotoxin
The study design consists of a randomized, double-blind, placebo-controlled trial of low dose endotoxin. The low dose endotoxin challenge induces a transient systemic inflammatory response with normalization of cytokine levels…
- Conditions
- Alcohol Use Disorder, Inflammatory Response, Craving, Depressed Mood
- Trial name
- NCT04310423
- Testing
- Endotoxin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Inflammation, Immune System
Design and Development of a Functional Plant-based Beverage to Improve Nutritional Status and Immunity for the Early Elderly People to Get Well-healthy Ageing
In 2018, for the first time, the number of people aged 65 and over exceeded the number of children under the age of 5. A rise in ageing societies is coming, and new efforts are needed to ensure that this increase in life…
- Trial name
- Immugold (NCT07409480)
- Testing
- Functional plant-based beverage, Control Beverage
- Where
- Spain
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Exercise Environment and Cognitive Performance in Older Adults
Outdoor vs. Indoor Exercises and Cognitive Functions in Older Adults
This observational, cross-sectional study aims to comparatively investigate the effects of outdoor versus indoor exercise environments on overall cognitive performance and its specific sub-domains (attention, memory, and…
- Trial name
- NCT07728786
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Alzheimer's Disease
Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD0328 in Elderly Healthy Subjects
The primary purpose of this study is to investigate the safety and tolerability of AZD0328 following once-daily dosing for 13 days in elderly healthy volunteers and to define maximum tolerated dose.
- Trial name
- NCT00687141
- Testing
- AZD0328
- Where
- 4 sites in Sweden
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Cognitive Function Assessment, Mild Cognitive Impairment
Prediction of Cognitive Test Performance Using AI-Based Analysis of Narrative Speech
This study aims to evaluate a new artificial intelligence (AI)-based method for measuring cognitive function using speech recordings.
- Conditions
- Cognitive Function Assessment, Mild Cognitive Impairment, Subjective Cognitive Decline
- Trial name
- NCT07511270
- Testing
- AI-Based Storytelling Speech Assessment
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Dementia, Mild
Trial-based Effectiveness and Cost-effectiveness of the Partner in Balance Intervention
Rationale: Informal care is one of the most important sources of care for dependent elderly people. The Partner in Balance (PIB) intervention aims to prepare and support informal caregivers for their caregiving tasks.
- Trial name
- NCT05450146
- Testing
- Partner in Balance
- Where
- Netherlands
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Magnetic Resonance Imaging, Alzheimer's Disease
Posterior Cingulate Function in Persons With Risk Factors for Alzheimer's Disease
The purpose of this study is to use fMRI techniques to explore a certain part of the brain associated with Alzheimer's disease known as the posterior cingulate.
- Conditions
- Magnetic Resonance Imaging, Alzheimer's Disease, Dementia, Adult Children
- Trial name
- PC (NCT00478166)
- Where
- United States
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Quality of Life, Surgery
Determination of the Effect of Puzzle Use in Elderly Patients
The aim of this study is to determine the effects of the use of a simple, reliable and cost-effective puzzle on post-operative cognitive function changes, postoperative recovery, and quality of life using questionnaires and…
- Conditions
- Quality of Life, Surgery, Postoperative Confusion, Cognitive Dysfunction
- Trial name
- NCT05796830
- Testing
- Puzzle application
- Volunteers
- healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Intensive Care Unit Syndrome, Prediction
Machine Learning-based Longitudinal Study of Post-ICU Syndrome Development Trajectory in Critically Ill Patients and Construction of Clinical Early Warning Models: a Research Protocol for Longitudinal Study
This project intends to track and evaluate whether post-ICU syndrome will occur 7 days, 1 month, 3 months and 6 months after ICU patients are transferred out of the ICU through a longitudinal study, apply the latent category…
- Conditions
- Intensive Care Unit Syndrome, Prediction, Cognitive Impairment, Sleep Disorder
- Trial name
- NCT06427265
- Where
- China
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- The Affiliated Hospital Of Guizhou Medical University
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