Clinical trials: Neural Degeneration
Alzheimer Disease, Alzheimer Dementia
Multimodal Ocular Imaging in Neurodegeneration
Alzheimer's disease (AD) and frontotemporal dementia (FTD) are two of the most common types of age-related neurodegenerative disorders.
- Conditions
- Alzheimer Disease, Alzheimer Dementia, Frontotemporal Dementia
- Trial name
- NCT03699644
- Testing
- Spectral-Domain Optical Coherence Tomography (SD-OCT), Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Parkinson's, Parkinson Disease
Longitudinal Investigation of I2BS in PD
In this study, the researchers aim to find a biomarker of PD. Using imaging scans called Positron Emission tomography (PET), Single Photon Emission Computed Tomography (SPECT), and Magnetic Resonance Imaging (MRI).
- Conditions
- Parkinson's, Parkinson Disease, Parkinson's Disease, Neurodegenerative Diseases
- Trial name
- FOX_2 (NCT05516719)
- Testing
- Positron Emission Tomography (PET) scan using BU99008 tracer, FP-CIT Single-photon Emission Computed Tomography (SPECT) scan, Magnetic Resonance Imaging (MRI) Scan
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Multiple Sclerosis
Prognosis Value of the Neuronal Damage in Early Multiple Sclerosis
In this study the investigators will use PET and 11C-Flumazenil to visualize and quantify neuronal injury in the cortex and the deep gray matter of Multiple Sclerosis patients at an early stage.
- Trial name
- Flumatep_2 (NCT01651520)
- Testing
- PET with 11C-Flumazenil
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cognitive Dysfunction, Alzheimer Disease
ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults
This randomized, double-blind, placebo-controlled pilot trial will evaluate the effects of alpha-linolenic acid (ALA) supplementation on cognitive function, blood-brain barrier integrity, and brain vascular health in older adults…
- Conditions
- Cognitive Dysfunction, Alzheimer Disease, Blood-Brain Barrier, Apolipoprotein E, Deficiency or Defect of
- Trial name
- NCT07392723
- Testing
- Alpha-Linolenic Acid (2.6 g/day)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Michal Schnaider Beeri, Ph.D.
Cognition Disorders
Longitudinal Evaluation of Amyloid Risk and Neurodegeneration - the LEARN Study
The LEARN study a multicenter, observational study will that will evaluate the rate of cognitive change in approximately 500 clinically normal older individuals who "screen-fail" for the A4 trial on the basis of their screening…
- Trial name
- LEARN (NCT02488720)
- Where
- 40 sites in United States
- Volunteers
- 538 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Personality Disorder, Depression
EEG Objectification in Neuropsychiatry
The main objective of the study is to evaluate the use of EEG in the management and follow-up of neuropsychiatric disorders. Secondary objectives are therefore better understanding of the pathological activations in neural…
- Conditions
- Personality Disorder, Depression, Neurodegeneration, Alzheimer's Disease
- Trial name
- NCT01476228
- Testing
- EEG recording
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Cerebral Small Vessel Disease
Biomarkers, Risk Assessment, Imaging, and Neurodegeneration in Cerebral Small Vessel Disease (BRAIN-CSVD)
The BRAIN-CSVD study is a single-center prospective cohort study focusing on cerebral small vessel disease (CSVD).Patients enrolled in this research will undergo assessments for vascular risk factors, cognitive and other…
- Trial name
- BRAIN-CSVD (NCT07093515)
- Testing
- No intervention
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Zhejiang Hospital
Non-arteritic Ischemic Optic Neuropathy
Citicoline in Non-Arteritic Ischemic Optic Neuropathy
The investigators tested the hypothesis whether the treatment with Citicoline in oral solution (OS-Citicoline) would increase or stabilize visual acuity, retinal ganglion cells (RGCs) function and neural conduction along the…
- Trial name
- NCT03758118
- Testing
- Citicoline
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fondazione G.B. Bietti, IRCCS
Multiple Sclerosis
BrainAgeMS - a Comparative Study of Brain Aging in Healthy and Patients With Multiple Sclerosis
The purpose of this study is to investigate new quantitative MRI-sequences for assessment of age-specific data for the prediction of brain aging.
- Trial name
- BrainAgeMS (NCT06221631)
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Sporadic Dystonia, Dystonia, Familial
Imaging Neuromelanin and Iron in Dystonia/Parkinsonism
To generate pilot data to investigate the potential to use in vivo iron- and neuromelanin-quantification as imaging tools for the diagnostic evaluation of movement disorders with predominant dystonia / parkinsonism.
- Conditions
- Sporadic Dystonia, Dystonia, Familial, Parkinson Disease, Juvenile, Neurodegeneration With Brain Iron Accumulation 5
- Trial name
- NCT03572114
- Testing
- 3Tesla MRI, Burke-Fahn-Marsden Dystonia Rating scale, MDS-United Parkinsons Disease Rating Scale, Part III
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University College, London
Glaucoma Associated With Other Ocular Disorders, Retina Disorder
AOSLO Imaging for the Study of Cellular Alterations in Retinal Neurodegeneration
Primary objective: Acquisition and analysis of images for non-medical purposes using the MONA IV system, an adaptive-optics-corrected scanning ophthalmoscope.
- Trial name
- RETION (NCT07725055)
- Testing
- MONA Imaging System
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Lewy Body Disease, Alzheimer Disease
A Study of Neurodegeneration and Neuronal Fluctuations in Lewy Body Disease and Alzheimer's Disease
The purpose of this research study is to investigate how the brain, memory, thinking, and motor behavior change both in individuals with movement and/or cognitive disorders, as well as healthy individuals.
- Conditions
- Lewy Body Disease, Alzheimer Disease, Healthy
- Trial name
- NCT06057909
- Testing
- Magnetic Resonance Imaging, Electroencephalography, Electromyography
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Neuron Degeneration
Mental Practice (MP) Combined With Transcranial Direct Current Stimulation (tDCS) on Motor Learning in the Elderly
Scientific background and rationale: Motor sequence learning (MSL) is composed of three phases: initial acquisition or rapid learning occurs during the first practice session, characterized by a rapid increase in motor…
- Trial name
- VIASTIM (NCT04605367)
- Testing
- Transcranial stimulation
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Parkinson Disease
The Differential Diagnosis and Prognosis of Idiopathic and Atypical Parkinson Disease by Using Diffusion MRI
The hypothesis is that the differential extent of microstructural damages in the affected brain regions can be specific to the disease of interest and could reflect the clinical severity.
- Trial name
- NCT04472325
- Where
- Taiwan
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Mental Health Issue, Cognitive Symptom
PrimeCog: Primary Care Cognitive Testing
The PrimeCog study aims to describe the symptomatology and pathophysiology of stress-induced exhaustion disorder (SED) and major depressive disorder (MDD) compared to healthy controls (HC).
- Conditions
- Mental Health Issue, Cognitive Symptom, Primary Health Care
- Trial name
- PrimeCog (NCT06346535)
- Testing
- Cognitive Testing
- Where
- Sweden
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Region Östergötland
CADASIL
Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Study
This is an observational study to better understand the risk factors and progression of CADASIL, a leading cause of vascular cognitive impairment and dementia (VCID).
- Trial name
- NCT05677880
- Testing
- Study Procedures
- Where
- 12 sites in United States
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Neuroinflammatory Response, Nerve Injury
Assessment of Nerve Damage Biomarkers in Acute and Chronic Organophosphate Toxicity
The aim of this observational study is to answer the following questions in individuals with acute and chronic exposure to organophosphates. The main questions to be addressed are 1.
- Conditions
- Neuroinflammatory Response, Nerve Injury, Nerve Damage, Neurotoxicity
- Trial name
- NCT06021262
- Testing
- exposure to organophosphates
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Alexandria University
CANVAS Syndrome
Pathogenic Insights and Search for Biomarkers in RFC1-ataxia/CANVAS
CANVAS (Cerebellar Ataxia, Neuropathy, Vestibular Areflexia Syndrome), also referred to as RFC1-ataxia, is a recently molecularly characterized neurodegenerative disorder caused by a biallelic expansion of an AAGGG…
- Trial name
- INSIDE-CANVAS (NCT07156214)
- Testing
- Assessment of markers of oxidative stress in peripheral blood samples
- Where
- 2 sites in Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Glymphatic System, Neurodegeneration
Acute Effects of Vigorous-intensity Aerobic Exercise on Glymphatic Flow in Healthy Adults
This study investigates changes in glymphatic flow in the brain acutely after vigorous-intensity steady-state aerobic exercise. Twenty subjects (10 male and 10 female) perform 25 minute submaximal cycle ergometry exercise and the…
- Trial name
- GLYMREG (NCT04255758)
- Testing
- Cycle Ergometer Exercise
- Where
- Finland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Anxiety, Microbiome
Microbiome, Anxiety and Cognitive Orientation Study
Mounting evidence shows that the gut microbiome plays an important role in communication within the gut-brain axis. However, the relationship between gut microbiota and their influence on anxiety is still not fully understood.
- Conditions
- Anxiety, Microbiome, Mood Disorders, Neurodegeneration
- Trial name
- MACO (NCT05388630)
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Endominance