Clinical trials: Nervous System Diseases
Lennox-Gastaut Syndrome
Transcranial Direct Current Stimulation, Treatment of Childhood Drug-Resistant Lennox-Gastaut Syndrome, A Pilot Study
Background: Lennox-Gastaut syndrome (LGS) is a severe childhood epileptic syndrome with high pharmacoresistance. The treatment outcomes are still unsatisfied.
- Trial name
- NCT02731300
- Testing
- tDCS
- Volunteers
- 22 people
- Sponsor
- Khon Kaen University
Hemiplegia, Spastic, Spastic
Wearable Robotic System and Robotic Mirror Therapy in Spastic Hemiplegia Post Botulinum Toxin Injection
The purpose of this project is to examine and compare the immediate and long-term effects of combined Botulinum toxin type A(BoNT-A) injection with wearable robotic hand system (RT) and Robotic mirror therapy (RMT) in patients…
- Trial name
- NCT04826900
- Testing
- BoNT-A injections, Robotic therapy (RT), Robotic mirror therapy (RMT)
- Where
- Taiwan
- Volunteers
- 31 people
- Sponsor
- Chang Gung Memorial Hospital
Blindness
Enhanced Tactile Memory in the Blind
This study will determine if the brain regions in blind people that would normally be involved in vision are used instead to remember touch.
- Trial name
- NCT00076700
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Multiple Sclerosis
VR and Orthoses for Rehabilitation in Multiple Sclerosis
This non-drug, non-medical device, interventional study explores the feasibility of integrating virtual reality (VR) with wearable sensors to support gait training using a passive orthosis in individuals with multiple sclerosis…
- Trial name
- VIRTUE (NCT07096700)
- Testing
- VR and walking brace-based gait rehabilitation
- Where
- 2 sites in Italy
- Volunteers
- 12 people
- Sponsor
- Azienda Usl di Bologna
Neuralgia
Botulinum Toxin Type A for Neuropathic Pain in Patients With Diabetic Peripheral Polyneuropathy
The purpose of this study is to determine whether botulinum toxin A is effective in the treatment of neuropathic pain in patients with diabetic peripheral polyneuropathy.
- Trial name
- BTXADMPPNP (NCT02460107)
- Testing
- Botulinum toxin type A, Normal saline
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- Catholic University of Korea Saint Paul's Hospital
Schizophrenia, Psychosis
To Rescue Cognition With Valaciclovir
This is a one-week, randomized, double blind add-on study of valaciclovir versus placebo in 24 clinical patients with Schizophrenia according to DSM IV, currently experiencing psychosis as is defined by the positive items of the…
- Trial name
- NCT01364792
- Testing
- Valaciclovir
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- University Medical Center Groningen
Myofacial Pain Syndrome
Dry Needling and Low-Level Laser Microcurrent Electrical Stimulation for Myofascial Pain Syndrome
This study aims to evaluate the effectiveness of dry needling and Low-Level Laser Microcurrent Electrical Stimulation (LL MCES) in patients with acute upper trapezius myofascial pain syndrome (MPS) by assessing both biological…
- Trial name
- NCT07750392
- Testing
- Dry Needle, Low-Level Laser Microcurrent Electrical Stimulation
- Where
- Indonesia
- Volunteers
- 80 people
- Sponsor
- Udayana University
Dream Disorder, Thrombotic Infarction
Biological Function of Dreaming in Dreaming and Non-Dreaming Patients With PCA Infarction
This study is a quasi-experimental between-group design. Using a prospective two-arm controlled exploratory study, data will be collected on an initial assessment of the effects of a specific neurological sample after thrombotic…
- Conditions
- Dream Disorder, Thrombotic Infarction, PCA Infarct
- Trial name
- BFD (NCT04749992)
- Testing
- Polysomnographic examination in sleep laboratory (PSG measurement)
- Where
- 2 sites in Germany
- Volunteers
- 142 people
- Sponsor
- International Psychoanalytic University Berlin
Craniectomy, Trephined Syndrome
External Post-Operative Skull Prosthesis to Prevent Sunken Flap Syndrome in Craniectomy Patients
Patients that undergo decompressive craniectomy are at risk of delayed changes in brain function known as "Sunken Flap Syndrome" or "Syndrome of the Trephined." The goal of this clinical trial is to see if placing a prosthetic…
- Conditions
- Craniectomy, Trephined Syndrome, Traumatic Brain Injury (TBI) Patients, Ischemic Stroke
- Trial name
- ExO-Skull (NCT06899711)
- Testing
- External Cranial Prosthesis
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- Johns Hopkins University
Mastectomy, Postoperative Pain
Comparison of Postoperative Analgesic Effectiveness of Superficial and Deep Serratus Plane Blocks for Mastectomy
Pain after breast surgery can be quite severe and can significantly affect quality of life. By successfully treating acute pain, it is aimed to prevent the formation of pain memory and to ensure that chronic pain never occurs.
- Conditions
- Mastectomy, Postoperative Pain, Analgesia
- Trial name
- NCT06438211
- Testing
- superficial or deep serratus anterior plane block for mastectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- TC Erciyes University
Child, Anesthesia Morbidity
A Study on the Effects of Midazolam on Delirium After Sevoflurane Anesthesia in Pediatric Strabismus Surgery
Sevoflurane with its rapid induction and emergence, hemodynamic stability, and nonirritating airway properties, has acquired widespread acceptance in children.
- Conditions
- Child, Anesthesia Morbidity, Delirium on Emergence
- Trial name
- NCT01680471
- Testing
- Midazolam 0.03mg/kg, Midazolam 0.05mg/kg
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Korea University Anam Hospital
Sleep Apnea, Obstructive
Study of Provent Treatment of Obstructive Sleep Apnea in Patients Who Are Non-compliant With CPAP
The primary objective of the proposed investigation is to evaluate the efficacy of the Provent device in a sample of OSA patients who have either refused or been non-adherent with PAP treatment.
- Trial name
- NCT00901771
- Testing
- Provent
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- St. Luke's Hospital, Chesterfield, Missouri
Neurodegenerative Diseases, Alzheimer Disease
[18F]MC225-PET in Neurodegenerative Disease
P-glycoprotein, an efflux transporter at the blood-brain barrier plays an important role in de development of neurodegenerative disease.
- Conditions
- Neurodegenerative Diseases, Alzheimer Disease, Parkinson Disease, Mild Cognitive Impairment
- Trial name
- NCT05853471
- Testing
- [18F]MC225
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- University Medical Center Groningen
Pulsed Radiofrequency, Shoulder Individual Nerves Brachial Plexus
Pulsed Radiofrequency of Shoulder Individual Nerves Versus Brachial Plexus in Management of Chronic Post Mastectomy Shoulder Pain
this study aims to assess the role of pulsed radiofrequency of the brachial plexus or pulsed radiofrequency of shoulder individual nerves in the management of post-mastectomy shoulder pain.
- Conditions
- Pulsed Radiofrequency, Shoulder Individual Nerves Brachial Plexus, Chronic, Post Mastectomy
- Trial name
- NCT07002944
- Testing
- Brachial plexus pulsed radiofrequency, Sholder individual nerves pulsed radiofrequency, Control
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Sensation Diminished, Pinprick, Pain
Tactile and Pain Sensory Thresholds and Hand Grip Strength
The aim of this study was to compare fingertip tactile sensation, hand and finger grip strength, and hand pain thresholds in children diagnosed with specific learning disorder with impairment in written expression and healthy…
- Conditions
- Sensation Diminished, Pinprick, Pain, Specific Learning Disorder, With Impairment in Written Expression
- Trial name
- NCT07533409
- Testing
- Treatment outcome
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Sultan 1. Murat State Hospital
Intracerebral Hemorrhage
TaVNS for Acute Intracerebral Hemorrhage
This study aims to evaluate the efficacy and safety of transcutaneous auricular vagus nerve stimulation (taVNS) in patients with acute intracerebral hemorrhage (ICH).
- Trial name
- TAVANS-ICH (NCT06918964)
- Testing
- transcutaneous auricular vagus nerve stimulation device
- Where
- China
- Volunteers
- 186 people
- Sponsor
- Beijing Tiantan Hospital
Parkinson Disease
Assessment of Three-dimensional Vision Alteration in Parkinson Disease
Parkinson's disease is characterized by motor deficits, improved by dopaminergic intakes. Besides motor symptoms, visual troubles are observed in patients with Parkinson's disease, in particular spatial orientation problems…
- Trial name
- 3Dparks (NCT01620164)
- Testing
- Psychophysical measurements of 3D perception
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Carotid Artery Stenosis, Carotid Atherosclerosis
Photon-Counting CT Versus Conventional CT for Carotid Plaque Assessment in Patients With Carotid Artery Stenosis
This prospective observational study aims to compare photon-counting detector computed tomography angiography (PCD-CTA) with conventional energy-integrating detector computed tomography angiography (EID-CTA) for the assessment of…
- Conditions
- Carotid Artery Stenosis, Carotid Atherosclerosis, Carotid Atherosclerotic Plaque
- Trial name
- NCT07762664
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Brain Metastasis, Bladder Cancer
Phase II Trial of Stereotactic Radiosurgery Boost Following Surgical Resection for Brain Metastases
For patients who have one or two metastases in the brain, the tumor(s) can often be removed with surgery to relieve symptoms from the tumor(s) and to improve survival.
- Conditions
- Brain Metastasis, Bladder Cancer, Breast Cancer, Cervical Cancer
- Trial name
- NCT00587964
- Testing
- Stereotactic Radiosurgery
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Bladder Cancer, Spinal Cord Injury
Novel mRNA-based Urine Test for Bladder Cancer in Spinal Cord Injury Individuals
Bladder cancer is a well-recognized complication in spinal cord injury (SCI) individuals. The observed incidence rates in SCI individuals are considerably higher compared to the general population.
- Trial name
- NCT02538809
- Testing
- measurement of tumor mRNA concentration in urine
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Swiss Paraplegic Research, Nottwil