Clinical trials: Nephropathy, Diabetic
Diabetic Nephropathy
Assessment of the Effect of Captopril Versus Combination of Captopril and Pentoxifylline on Reducing Proteinuria in Type 2 Diabetic Nephropathy
Diabetic nephropathy is the most common cause of ESRD and has a great impact on mortality and morbidity of diabetic patients. Despite renoprotective effect of ACE inhibitors in diabetic patients they can not hinder the…
- Trial name
- NCT00663949
- Testing
- Captopril, Captopril + Pentoxifylline
- Where
- Iran
- Volunteers
- 70 people
- Sponsor
- Shiraz University of Medical Sciences
Diabetic Kidney Disease
Phase 2 Study of INV-202 in Patients With Diabetic Kidney Disease
The study is designed to assess the efficacy, safety, tolerability, and transformation within the human body of INV-202 investigational drug in the treatment of adult participants with a diagnosis of Diabetic Kidney Disease due…
- Trial name
- NCT05514548
- Testing
- INV-202
- Where
- 72 sites in United States, Canada and 5 more
- Volunteers
- 265 people
- Sponsor
- Inversago Pharma Inc.
Diabetic Nephropathy
SWIDINEP a Swiss Diabetic Nephropathy Cohort
With our SWIDINEP cohort, we propose to explore the relationship between vascular risk markers and renal function decline in CKD stage 1-5.
- Trial name
- SWIDINEP (NCT03407989)
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Diabetic Nephropathy
Study on the Efficacy and Safety of a Novel Tripterygium Wilfordii Preparation in Reducing Proteinuria in Patients With Diabetic Nephropathy
The investigators designed a randomized parallel controlled clinical study, selected 98 cases of diabetic nephropathy patients with urinary protein > 1g, randomly assigned into the Kunxian capsule + irbesartan group or irbesartan…
- Trial name
- NCT04981613
- Testing
- Kunxian capsule
- Where
- China
- Volunteers
- 80 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Diabetes, Hypertension
Real-world Aliskiren Use in Diabetic Patients
The purpose of this study is to evaluate real-world patterns of aliskiren use with a focus of change in renal function following aliskiren initiation as well as to identify "triggering events" that lead to aliskiren initiation.
- Trial name
- NCT01393860
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Novartis
Diabetic Nephropathies
TCF7L2 Gene Polymorphism and AGEs in Diabetic Nephropathy
1. To study genotypic distribution of the TCF7L2 gene polymorphism in Diabetic nephropathy. 2. To assess level of AGEs and Insulin in patients with Diabetic nephropathy. 3.
- Trial name
- NCT04084886
- Volunteers
- 100 people
- Sponsor
- Assiut University
Type 2 Diabetes Mellitus, Diabetic Kidney Disease
Finerenone for the Treatment of Type 2 Diabetes-Related Kidney Disease: Efficacy Observation and Related Factor Analysis
This is a single-center prospective observational clinical study conducted at the First Affiliated Hospital of Chongqing Medical University.
- Trial name
- NCT07717697
- Testing
- Finerenone
- Volunteers
- 425 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Kidney Diseases, Diabetic Nephropathies
A Study of TRPC5 Channel Inhibitor in Patients With Diabetic Nephropathy, Focal Segmental Glomerulosclerosis, and Treatment-Resistant Minimal Change Disease
This is a phase 2a study evaluating the safety and tolerability of multiple ascending doses of GFB-887 in patients with diabetic nephropathy (DN), focal segmental glomerulosclerosis (FSGS), and treatment-resistant minimal change…
- Conditions
- Kidney Diseases, Diabetic Nephropathies, Glomerulosclerosis, Focal Segmental, Nephrosis, Lipoid
- Trial name
- NCT04387448
- Testing
- GFB-887
- Where
- 74 sites in United States
- Volunteers
- 96 people
- Sponsor
- Goldfinch Bio, Inc.
Diabetic Nephropathy, Diabetic Retinopathy
Anti-Nephropathic Effects of Chronic Intermittent Intravenous Insulin Therapy (CIIIT)
Investigators with the goal of optimizing glycemic and blood pressure control saw type 1 diabetic patients weekly. A control group received 3-4 subcutaneous insulin injections per day; an intravenous insulin pulsed infusion group…
- Trial name
- NCT00594152
- Testing
- CIIIT
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Joslin Diabetes Center
Proteinuria
Effect of Oral Supplementation With Curcumin in Patients With Proteinuric Diabetic Kidney Disease
The purpose of this study is to determine if the oral supplementation with curcumin reduces proteinuria, improves the redox and pro-inflammatory state in patients with chronic kidney disease associated to Diabetes mellitus.
- Trial name
- NCT03019848
- Testing
- Curcumin
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Diabetes Mellitus, Type 2, Kidney Failure, Chronic
Study of the Use of Niaspan for Treatment of Dyslipidemia in Diabetic Nephropathy
The primary purpose of this study is to test the effectiveness and tolerability of Niaspan® to improve the levels of blood fats ("good" and "bad" cholesterol and triglyceride levels) in people who have kidney damage due to…
- Conditions
- Diabetes Mellitus, Type 2, Kidney Failure, Chronic, Hyperlipidemia
- Trial name
- NCT00108485
- Testing
- Extended release niacin
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Miami
Diabetic Nephropathies
Serum Immunoglobulin (G) as a Marker of Diabetic Nephropathy
Diabetes mellitus is a chronic disease that affects 366 million people worldwide ( 6.4 % of the adult population ) and is expected to rise to 522 million by 2030 .
- Trial name
- NCT03212755
- Testing
- serum immunoglobulin G level
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Assiut University
Diabetic Nephropathies
PERL Continuous Glucose Monitoring (CGM) Study
Seven-point capillary profiles have shown that mean glucose correlates with both diabetic retinopathy and nephropathy risk. However, there remains great controversy as to whether the degree of variability around mean glucose may…
- Trial name
- NCT03334318
- Testing
- Mean blood glucose, Blood glucose CV, % time 70-180 mg/dL
- Where
- 19 sites in United States, Canada
- Volunteers
- 175 people
- Sponsor
- Joslin Diabetes Center
Diabetic Nephropathy
Beraprost Sodium and Arterial Stiffness in Patients With Type 2 Diabetic Nephropathy
Diabetic nephropathy, the leading cause of end-stage renal disease in many countries, is characterized by high cardiovascular mortality and morbidity even in the early course of the disease.
- Trial name
- NCT01796418
- Testing
- Beraprost sodium
- Where
- 5 sites in South Korea
- Volunteers
- 102 people
- Sponsor
- Seoul National University Hospital
Proteinuria
Anti-proteinuric Effect of Calcitriol in Non-diabetic Kidney Disease Patients
Proteinuria is not only a marker of chronic kidney disease (CKD) progression, but also a marker of cardiovascular disease and death.
- Trial name
- NCT01512862
- Testing
- Calcitriol
- Where
- 3 sites in South Korea
- Volunteers
- 240 people
- Sponsor
- Seoul National University Hospital
Diabetic Kidney Disease (DKD)
Safety and Efficacy of the Combination Therapy of Fucoidan / Fucoxanthin / L-carnitine in Patients With Diabetic Nephropathy.
The purpose of this open-label, preliminary, proof-of-concept clinical trial is to evaluate the efficacy and safety of The purpose of this open-label, preliminary, proof-of-concept clinical trial is to evaluate the efficacy and…
- Trial name
- NCT07804641
- Testing
- Oligo-fucoidan, Fucoxanthin, L-carnitine Formula, Zinc yeast (FFL)
- Where
- Taiwan
- Volunteers
- 63 people
- Sponsor
- Taipei Medical University WanFang Hospital
Diabetes
Vitamin D and Omega-3 Trial to Prevent and Treat Diabetic Kidney Disease
The VITamin D and OmegA-3 TriaL (VITAL; NCT 01169259) is a randomized clinical trial in 20,000 U.S. men and women investigating whether taking daily dietary supplements of vitamin D3 (2000 IU) or fish oil (1 gram of omega-3 fatty…
- Trial name
- VITAL-DKD (NCT01684722)
- Testing
- Vitamin D, Omega-3 fatty acids (fish oil)
- Where
- United States
- Volunteers
- 1,312 people
- Sponsor
- University of Washington
Type 1 Diabetes Mellitus, Diabetic Ketoacidosis
Biomarkers of Acute Organ Injury in Pediatric Newly Diagnosed Type 1 Diabetes
Diabetic ketoacidosis (DKA) is a severe metabolic complication in children with newly diagnosed type 1 diabetes mellitus (T1DM) and may be associated with early injury of vital organs such as the kidneys and the heart.
- Trial name
- NCT07483879
- Testing
- Biomarker and Echocardiographic Assessment
- Where
- Greece
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Cardiovascular Disease, Diabetic Nephropathy
Effect of a Vitamin D Analogue vs Placebo on p-NT-proBNP in Patients With Type 1 DM and Diabetic Nephropathy
The primary objective is to assess the impact of three months of treatment with an active vitamin D analogue on a risk marker for excess overall mortality and cardiovascular morbidity/mortality in Type 1 diabetic patients with…
- Trial name
- NCT01331317
- Testing
- Paricalcitol
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Peter Rossing