Clinical trials: Nephrolithiasis, open to volunteers
Kidney Stone, Ureteral Stone
Access Sheath and Stent Trial
The study is being completed to compare patient reported outcomes for stent omission vs. placement after using a ureteral access sheath for uncomplicated ureteroscopy.
- Trial name
- ACCENT (NCT07297953)
- Testing
- Surveys
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- University of Michigan
Urolithiasis, Calcium Oxalate, Kidney Stone
A Single-Center Clinical Study on the Efficacy and Safety of VISOR
Goal of this trial: To test a new tool called VISOR in adults (aged 18-80) with 1-3 cm kidney or ureter stones. We want to see: 1. If it's safe and works well 2.
- Trial name
- NCT07071948
- Testing
- Multifunctional Integrated Flexible Ureteroscope
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Rare Kidney Stone Diseases
Monogenic Kidney Stone - Genetic Testing
This study will attempt to identify the specific gene (coded in the DNA) and changes (mutations) within that gene that are the cause of monogenic kidney stone disease.
- Trial name
- NCT03305835
- Where
- United States
- Volunteers
- 6,000 people
- Sponsor
- Mayo Clinic
Kidney Calculi, Urolithiasis
Antibiotic Irrigation and Suction Ureteral Access Sheath in RIRS
Retrograde intrarenal surgery (RIRS) is a widely used treatment for kidney stones; however, postoperative infectious complications remain a significant concern.
- Conditions
- Kidney Calculi, Urolithiasis, Urinary Tract Infections
- Trial name
- NCT07655050
- Testing
- Standard Retrograde Intrarenal Surgery, Gentamicin Irrigation, Suction-Enabled Ureteral Access Sheath
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Hitit University
Renal Calculi, Urinary Calculi
Break Wave(TM) Extracorporeal Lithotripter First-in-Human Study
This is a prospective, open-label, multi-center, single-arm (non-randomized) study to assess the safety and effectiveness of breaking stones in the upper urinary tract using the SonoMotion Break Wave technology.
- Trial name
- NCT03811171
- Testing
- Break Wave extracorporeal lithotripsy
- Where
- 6 sites in United States, Canada
- Volunteers
- 70 people
- Sponsor
- SonoMotion
Nephrolithiasis, Renal Calculi
Comparison of Extracorporeal Shock Wave Lithotripsy Versus Retrograde Intrarenal Surgery in the Management of Renal Calculi
This study is being carried out in patients with kidney stones measuring between 1 and 2 centimeters. Kidney stones are common in Pakistan and can cause severe pain, infection, and repeated hospital visits.
- Trial name
- NCT07261995
- Testing
- Extracorporeal Shock Wave Lithotripsy (ESWL), Retrograde Intrarenal Surgery (RIRS)
- Where
- Pakistan
- Volunteers
- 98 people
- Sponsor
- Ziauddin Hospital
Bariatric Surgery Candidate
Gut Microbiome and Sex as Risk Factors for Kidney Stones After Bariatric Surgery
This is a single-center study that aims to better understand how diet and sex affect the risk of kidney stones in people who have had gastric bypass surgery.
- Trial name
- NCT04590690
- Testing
- Special diet
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Chicago
Nephrolithiasis, Urosepsis
Serum Endotoxin Assay to Predict the Development of Postoperative Infectious Complications and Systemic Inflammatory Response Following Percutaneous Nephrolithotomy.
The aim of the study is to establish an infectious risk stratification system based on pre-and post-operative blood endotoxin profile.
- Trial name
- NCT04669886
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Miami
Renal Stone Disease
Intrarenal Pressure Monitoring During Pediatric Percutaneous Nephrolithotomy, and Its Impact on Post Operative Infectious Complications.
Monitoring of intrarenal pressure during pediatric percutaneous nephrolithotomy and its impact on post operative infectious complications.
- Trial name
- NCT07800546
- Testing
- Intrarenal pressure
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Kidney Stone
Follow-Up of Ureteral Stones ≤4 mm
The goal of this clinical trial is to evaluate the proportion of ureteral stones ≤4 mm that pass spontaneously within 4 and 8 weeks and assess if pain, blood test (S-creatinine), stone size, stone location and hydronephrosis can…
- Trial name
- NCT07176026
- Where
- 2 sites in Sweden
- Volunteers
- 1,600 people
- Sponsor
- Region Skane
Kidney Stones, Nephrolithiasis
Comparison of Different Ventilation Modes for Reducing Kidney Motion During Retrograde Intrarenal Surgery
This randomized clinical trial will compare four ventilation strategies during retrograde intrarenal surgery performed under general anesthesia.
- Trial name
- RIRS-VENT (NCT07705646)
- Testing
- Standard Ventilation, Hypoventilation, Intermittent Apnea Ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Renal Stones
RETRO Study (RETrograde Renal Access Outcomes)
The goal of this observational study is to learn about the benefit of using RetroPerc® in obtaining renal access for percutaneous nephrolithotomy.
- Trial name
- NCT07071831
- Testing
- RetroPerc®
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Kansas Medical Center
Urolithiasis, Renal Stones
Safety and Effectiveness of Antegrade Flexible Ureteroscopy-Assisted Percutaneous Nephrolithotomy for Staghorn Calculi
Objective This study aims to evaluate the safety and efficacy of antegrade flexible ureteroscopy-assisted PCNL for the treatment of staghorn calculi, compared with standard PCNL.
- Trial name
- NCT07172373
- Testing
- antegrade flexible ureteroscopy-assisted PCNL, single PCNL
- Volunteers
- 420 people
- Sponsor
- Tianjin Medical University Second Hospital
Renal Calculi, Ureteral Calculi
Intraoperative Assessment of of Burst Wave Lithotripsy (BWL)
Burst Wave Lithotripsy (BWL) is a novel method of urinary stone fragmentation that uses multi-cycle bursts of low amplitude ultrasound to induce stone fracture.
- Trial name
- NCT03873259
- Testing
- Burst Wave Lithotripsy
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Washington
Urolithiasis, Renal Stones
Predicting the Success of Flexible Ureterorenoscopy for Kidney and Upper Ureter Stones
This observational study aims to test how well a specific medical scoring tool, called a nomogram, can predict the success of a common minimally invasive surgery for kidney stones.
- Conditions
- Urolithiasis, Renal Stones, Upper Ureteric Stones, Urinary Stone Disease
- Trial name
- NCT07753096
- Volunteers
- 70 people
- Sponsor
- Assiut University
Pediatric Renal Stone
Retrograde Intrarenal Surgery Versus Mini Percutaneous Nephrolithotomy
Pediatric nephrolithiasis accounts for approximately 2-3% of all stone disease cases, with recent reports indicating a rising prevalence of up to 10.6%. This increasing incidence poses a growing public health concern.
- Trial name
- NCT07700251
- Testing
- Retrograde Intrarenal Surgery
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- South Valley University
Kidney Calculi, Prostatic Hyperplasia
An International Multicenter Clinical Study on Application of UroMed AI Doctor Based on Large Language Models
This study evaluates our team's urology-specific AI (UroMed AI Doctor) for its safety, professionalism, knowledge and Q\&A ability, and tests its effectiveness against traditional manual urology care, to confirm if it can be a…
- Conditions
- Kidney Calculi, Prostatic Hyperplasia, Urinary Bladder Neoplasms
- Trial name
- NCT07555756
- Testing
- UroMed AI Doctor-assisted Urological Diagnosis, Treatment and Preoperative Health Education, Physician-led Urological Diagnosis, Treatment & Preoperative Education
- Where
- 5 sites in China, Vietnam
- Volunteers
- 1,080 people
- Sponsor
- First Affiliated Hospital of Guangxi Medical University
Kidney Stones
Dual Approach External Oblique Fascial Plane Block Versus Erector Spinae Plane Block for Post Operative Analgesia in Percutaneous Nephrolithotomy
Here is a patient-friendly, ClinicalTrials.gov-compliant Brief Summary written in plain language, avoiding technical jargon as much as possible while remaining accurate.
- Trial name
- BLOCK-PCNL (NCT07359391)
- Testing
- Erector Spinae Plane Block, Dual External Oblique Fascial Plane Block, General Anesthesia
- Volunteers
- 90 people
- Sponsor
- Zagazig University
Nephrolithiasis
Tract Closure in PCNL
This is a prospective, randomized controlled trial evaluating the effect of a hemostatic agent on tract-related bleeding during percutaneous nephrolithotomy (PCNL).
- Trial name
- NCT07668817
- Testing
- Floseal, Surgicel, Surgiflo
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Renal Stones
Ureteroscopic Lithotripsy for Renal Stones Using a Sheathless Approach or Using a Flexible and Navigable Ureteral Access Sheath (FANS)
The primary aim of the study is to compare stone free rates following ureteroscopic (URS) lithotripsy for renal stones with Thulium Fiber Laser (TFL) using a sheathless approach (low power laser settings) or using a flexible and…
- Trial name
- NCT07741084
- Testing
- Sheathless URS, FANS, low power, FANS, high power
- Where
- Norway
- Volunteers
- 225 people
- Sponsor
- Haukeland University Hospital