Clinical trials: Nephrectomy
Renal Cell Carcinoma (Kidney Cancer)
Virtual Renality: Assessing the Impact of Virtual Reality on Preoperative Planning in Renal Cancer Surgery
Rationale: Preoperative planning for both partial and radical nephrectomies using conventional CT imaging can be challenging due to complex renal anatomy and vascularization.
- Trial name
- NCT06960174
- Testing
- Virtual reality
- Volunteers
- 70 people
- Sponsor
- St. Antonius Hospital
Renal Cell Carcinoma, Metastatic Kidney Cancer
Phase-I Trial of Pembrolizumab and Percutaneous Cryoablation Combination Followed by Nephron-Sparing Surgery or Cytoreductive Nephrectomy in Locally Advanced and Metastatic Renal Cell Carcinomas
Patients will undergo a screening process as per standard of care to identify disease type and severity. Careful history and physical examination will also take place to rule out major heart, lung, or kidney disease and pregnancy…
- Trial name
- NCT03189186
- Testing
- Pembrolizumab Injection [Keytruda], Cryoablation, Nephrectomy
- Where
- United States
- Sponsor
- University of California, Irvine
Renal Cell Carcinoma (Kidney Cancer), Postoperative Pain
QLESP Block for Pain Control in Robotic Partial Nephrectomy
The goal of this clinical trial is to learn if an ultrasound-guided nerve block called QLESP works to reduce pain and the need for strong pain medicines after robotic kidney surgery in adults.
- Conditions
- Renal Cell Carcinoma (Kidney Cancer), Postoperative Pain, Nerve Block
- Trial name
- NCT07704970
- Testing
- ropivacaine (local infiltration), ropivacaine
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Huazhong University of Science and Technology
Kidney Cancer
Sunitinib and Surgery in Treating Patients With Localized or Metastatic Kidney Cancer
RATIONALE: Sunitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- NCT00849186
- Testing
- sunitinib malate, neoadjuvant therapy, therapeutic conventional surgery
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Roswell Park Cancer Institute
Anesthesia, Mechanical Ventilation
The Impact of Lumboscopy Versus Laparoscopy on Ventilatory Mechanics
There are several techniques for performing minimally invasive urological surgeries. Among them, laparoscopic surgery, robotic surgery, and lumboscopy are noteworthy (1).
- Conditions
- Anesthesia, Mechanical Ventilation, Respiratory Physiology
- Trial name
- NCT06776068
- Where
- 2 sites in Chile
- Volunteers
- 40 people
- Sponsor
- University of Chile
Recurrent Renal Cell Cancer
Clamped or Unclamped Surgery in Treating Patients With Kidney Cancer
This randomized pilot trial studies clamped or unclamped surgery in treating patients with kidney cancer. Unclamped surgery for kidney cancer may have fewer side effects
- Trial name
- NCT01547676
- Testing
- robot-assisted laparoscopic surgery
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Southern California
Kidney Neoplasm, Nephrectomy
Evaluation of 'RUS NE' in Robot-Assisted Partial Nephrectomy: Efficacy, Safety, and Stability
This study is a retrospective and prospective comparative study evaluating the efficacy, safety, and stability of the surgical navigation system 'RUS NE' in robot-assisted partial nephrectomy.
- Conditions
- Kidney Neoplasm, Nephrectomy, Surgical Navigation Systems, Renal Mass
- Trial name
- HTK_002 (NCT06945640)
- Testing
- RUS NE
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Hutom Corp
Renal Neoplasms, Localized Kidney Tumors
Effect of Non-Clamping and Sutureless Technique on Postoperative Renal Function in Robot-Assisted Partial Nephrectomy
Partial nephrectomy is an operation that removes a kidney tumor while leaving the rest of the kidney in place. It is used to treat selected patients with small tumors confined to the kidney.
- Trial name
- NCT07888608
- Testing
- Off-Clamp, Sutureless Robot-Assisted Partial Nephrectomy, Conventional Robot-Assisted Partial Nephrectomy With Artery Clamping and Sutured Reconstruction
- Where
- China
- Volunteers
- 304 people
- Sponsor
- Shao Pengfei
Metastatic Renal Cell Carcinoma
Clinical Trial to Assess the Importance of Nephrectomy
The study compare the standard treatment with nephrectomy + sunitinib to treatment with sunitinib alone without nephrectomy. This study will be the first trial on this competitive context
- Trial name
- CARMENA (NCT00930033)
- Testing
- Nephrectomy, Sunitinib alone
- Where
- France
- Volunteers
- 452 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Kidney Cancer
Hydroxyethyl Starch and Renal Function After Laparoscopic Nephrectomy
The purpose of this project is to investigate if hydroxyethyl starch (HES) is potential nephrotoxic and examine the effects on the circulation and kidneys during administration of HES during surgery.
- Trial name
- VONE (NCT01486550)
- Testing
- Voluven (Hydroxyethyl starch 130/0,4), Sodium Chloride 9mg/ml
- Where
- Denmark
- Volunteers
- 14 people
- Sponsor
- Regional Hospital Holstebro
Robotic Surgical Procedures, Prostatectomy
MicroPort® Endoscopic Instrument Control System to Accomplish Robotic-assisted Surgery in Urology
Laparoscopy, now virtually completely, was replaced with robotic surgery in uro-oncological surgery in the world. And given the significant increase in the number of robotic surgeries for prostate, bladder and kidney cancer, it…
- Conditions
- Robotic Surgical Procedures, Prostatectomy, Nephrectomy
- Trial name
- MARS (NCT04404738)
- Testing
- MicroPort® robot-assisted laparoscopic surgery, da Vinci robot-assisted laparoscopic surgery
- Where
- 4 sites in China
- Volunteers
- 104 people
- Sponsor
- Changhai Hospital
Metastatic Renal Cell Carcinoma ( mRCC)
Immediate Versus Deferred Cytoreductive Nephrectomy With Ipilimumab/Nivolumab in mRCC
The goal of this clinical trial is to learn whether the timing of surgery (cytoreductive nephrectomy) improves outcomes when combined with immunotherapy (ipilimumab and nivolumab) in adults with metastatic clear cell renal cell…
- Trial name
- IVE in mRCC (NCT07233668)
- Testing
- Ipilimumab plus Nivolumab, Cytoreductive Nephrectomy
- Volunteers
- 172 people
- Sponsor
- Seoul National University Hospital
Renal Cell Carcinoma
A Comparative Study Between AirSeal, an Integrated Insufflation System, and Conventional Insufflation
Renal cancer has traditionally been treated by surgical removal of the tumor, as the tumors are resistant to chemotherapy and radiation.
- Trial name
- NCT02075658
- Testing
- AirSeal® System-Interventional, Conventional Insufflator and Trocar
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, Irvine
Carcinoma, Renal Cell, Pathology
Prognostic Significance of Preoperative Hemoglobin A1c (HbA1c) in Renal Cell Carcinoma
The effect of preoperative glycemic control measured by HbA1c on renal cell carcinoma (RCC) outcome remains controversial. Thus, the investigators aim to examine the association of preoperative glycemic control with oncologic…
- Conditions
- Carcinoma, Renal Cell, Pathology, Treatment Outcome, Hemoglobin A1c Protein, Human
- Trial name
- NCT02417194
- Where
- South Korea
- Volunteers
- 238 people
- Sponsor
- Seoul National University Hospital
Renal Cell Carcinoma
Advantage of a Fast-recovery Protocol for Minimally Invasive Kidney Surgery
Shorten the time spent in the hospital (hospitalization duration) by optimizing the pre, per and postoperative care is of major medical and economic importance.
- Trial name
- RREIN (NCT04601129)
- Testing
- enhanced recovery after surgery program
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Lille
Postoperative Pain Management
A Comparative Study Between Different Volumes During Erector Spinae Block for Pain Control
Since its first description by Forero et al. there have been many articles and case reports including an increasingly number of indications for the ESP block: chronic and acute pain treatment, rib fractures management in the…
- Trial name
- NCT04371341
- Testing
- erector spinae block by 0.25% bupivacaine
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Renal Cell Carcinoma
Study of Sunitinib in Subjects With High Risk Renal Cell Carcinoma
This study is designed to explore the molecular modulatory effect of Sunitinib when given in a neoadjuvant setting prior to radical or partial nephrectomy.
- Trial name
- NCT01070186
- Testing
- Sunitinib, Tumor biopsy, Nephrectomy
- Sponsor
- Jonsson Comprehensive Cancer Center
Nephrectomy, Prostatectomy
Safety and Performance Assessment of a First Four Arms on Demand Open Robotic Solution for Assisted PN, RN and RP
The purpose of this clinical investigation was to evaluate the safety and performance of the Bitrack System and its corresponding ElectroSurgical Endoscopic (ESE) instruments and Non-ElectroSurgical Endoscopic (NESE) instruments…
- Trial name
- NCT06119568
- Testing
- Robot assisted laparoscopic Radical/simple nephrectomy (RN), Partial nephrectomy (PN) or Radical Prostatectomy (RP).
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Rob Surgical Systems S.L.
Carcinoma, Renal Cell
Pilot Study of Neo-Adjuvant Everolimus to Treat Advanced Renal Cell Carcinoma - Analysis of Biomarkers
This study will gather data on potential biomarkers in the treatment of advanced renal cell carcinoma (kidney cancer) and investigate their use as indicators of disease response.
- Trial name
- NCT01107509
- Testing
- everolimus
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Renal Cell Carcinoma
Effect of Ketorolac and Remote Ischemic Preconditioning on Renal Ischemia-reperfusion Injury in Patients Undergoing Partial Nephrectomy
Partial nephrectomy is a widely accepted alternative to radical nephrectomy in patients with clinically localized, unilateral renal cell carcinoma and a normal contralateral kidney.
- Trial name
- NCT01836406
- Testing
- Ketorolac tromethamine and remote ischemic preconditioning
- Where
- South Korea
- Volunteers
- 16 people
- Sponsor
- Yonsei University