Clinical trials: Neostigmine
Respiratory-Gated Imaging Techniques
Functional Respiratory Imaging After Neostigmine or Sugammadex
The use of neuromuscular blocking agents (NMBAs) is still associated with postoperative pulmonary complications. The investigators rely on acceleromyography (AMG) of a peripheral nerve/muscle to assess the patients' breathing…
- Trial name
- FRINeoS (NCT02284412)
- Testing
- Neostigmine, Sugammadex, Water for injection
- Where
- Belgium
- Volunteers
- 13 people
- Sponsor
- Onze Lieve Vrouw Hospital
Supraglottic Airway Device Insertion
Comparison of the Impacts of Sugammadex With Neostigmine on Patency of Laryngeal Opening (Glottic Aperture Angle)
The aim of this study is to compare the degree of change in the angle of the vocal cords before and after administration of neostigmine or sugammadex.
- Trial name
- NCT04545099
- Testing
- Sugammadex, Neostigmine
- Volunteers
- 84 people
- Sponsor
- Yonsei University
Ileus
A New Approach of Neostigmine in Unavoidable Post Operative Ileus
Postoperative ileus (POI) in the absence of any mechanical obstruction remains a commonly encountered clinical problem.So, this study aimed to show the effective way to decrease the rate of postoperative Ileus (POI).
- Trial name
- NCT00676377
- Testing
- Neostigmine, Saline
- Where
- Iran
- Volunteers
- 3 people
- Sponsor
- Baqiyatallah Medical Sciences University
Neuromuscular Blockade, Anesthesia
Sugammadex Versus Neostigmine for Reversal of Rocuronium Neuromuscular
The aim of this study is to evaluate whether the use of Sugammadex for reversing the neuromuscular blocking effects of rocuronium during neurointerventional procedures can speed recovery of neuromuscular function.
- Trial name
- NCT03322657
- Testing
- Neostigmine, Glycopyrrolate, Sugammadex
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- The Cleveland Clinic
Post-operative Residual Curarization
Different Reversal Agents in Pediatric Day-case Cancer Surgery
The aim of this study was to compare the efficacy of sugammadex and neostigmine on reversing neuromuscular blockers in pediatric patients undergoing outpatient surgical procedures.
- Trial name
- NCT03996655
- Testing
- Sugammadex Injection [Bridion], Neostigmine
- Volunteers
- 80 people
- Sponsor
- National Cancer Institute, Egypt
Post Operative Pain
Ketamine Versus Neostigmine as Adjuvants to Bupivacaine During Ultrasound-guided Serratus Anterior Block
This study is designed to investigate the analgesic efficacy of ketamine compared to neostigmine as adjuvants to LA in ultrasound guided Serratus Anterior Plane Block (SAPB) in patients undergoing Modified Radical Mastectomy.
- Trial name
- NCT05802979
- Testing
- Adjuvants, Anesthesia
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Critically Ill Cirrhotics
To Study the Efficacy of Intravenous Neostigmine in Resolution of Acute GI Paralysis in Critically Ill Cirrhotics
Aim: To determine the efficacy of intravenous neostigmine in the resolution of acute GI paralysis in patients with Critically Ill Cirrhosis (CIC).
- Trial name
- NCT06462872
- Testing
- observational study
- Where
- India
- Volunteers
- 48 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Craniectomy, Sugammadex
Comparison of the Effects of Sugammadex and Neostigmine on Early Extubation, Intensive Care Unit Admission and Length of Stay, and Hospital Costs in Adult Cranial Surgery
The aim of this study was to retrospectively investigate the effects of sugammadex or neostigmine, which are routinely used after the completion of surgery to antagonize (reverse) neuromuscular blockade in adult patients…
- Conditions
- Craniectomy, Sugammadex, Extubation, Recovery After Neuromuscular Block
- Trial name
- NCT06987357
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Postoperative Analgesia
Ultrasound Guided Quadratus Lumborum Block Compared to Caudal Bupivacaine/ Neostigmine in Pediatric Lower Abdominal Surgeries
The aim of this study is to compare the postoperative pain control in children undergoing lower abdominal surgeries receiving QL block with those receiving caudal bupivacaine/ neostigmine.
- Trial name
- NCT04720287
- Testing
- bupivacaine/ neostigmine.
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Recovery Time
Low-dose Neostigmine at TOF Ratio of 0.7 Improves Neuromuscular Recovery
This study is a prospective observational study. A total of 54 patients were included in this study. We observed the time from neostigmine administration to TOF ratio of 1.0.
- Trial name
- NCT06745492
- Testing
- Neostigmine + Glycopyrrolate
- Where
- South Korea
- Volunteers
- 59 people
- Sponsor
- Seoul National University Hospital
Emergence Delirium
Effect of Sugammadex vs. Neostigmine/Glycopyrrolate on Pediatric Emergence Delirium in Sevoflurane-rocuronium Anesthesia
The aim of this study is to investigate the effect of sugammadex vs. a conventional acetylcholinesterase inhibitor, neostigmine on emergence delirium (ED) during sevoflurane-rocuronium anesthesia in pediatric patients…
- Trial name
- NCT03229486
- Testing
- Sugammadex Injection [Bridion], Neostigmine+Glycopyrronium
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Pusan National University Yangsan Hospital
Neuromuscular Blocking Agents, Reversal of Neuromuscular Blockade
Recovery Times of Half Dose Sugammadex and Neostigmine for Rocuronium-induced Neuromuscular Blockade
In operating procedure with general anesthesia muscle relaxant is usually used to increase success rate of the operation and to give better outcome.
- Conditions
- Neuromuscular Blocking Agents, Reversal of Neuromuscular Blockade, Recovery Time
- Trial name
- NCT06794450
- Testing
- Sugammadex 1 mg/kg, Neostigmine + Atropine
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Universitas Padjadjaran
Observation of Neuromuscular Block
Appropriate Dose of Neostigmine for Reversal of Rocuronium and Cisatracurium
This study aims to find appropriate dose of neostigmine which is possible to reverse rocuronium or cisatracurium till train of four (TOF) 0.9 within 10 minutes.
- Trial name
- NCT01885715
- Testing
- Injection of neostigmine
- Where
- South Korea
- Volunteers
- 112 people
- Sponsor
- Seoul National University Hospital
Pain, Postoperative
The Effect of Intraperitoneal Bupivacaine Versus Bupivacaine With Neostigmine on Pain in Laparoscopic Cholecystectomy
Injection of intraperitoneal bupivacaine revealed an analgesic effect whether injected alone or in combination with other adjuvants, which increase duration of analgesia and decrease the dose of administered bupivacaine thus…
- Trial name
- RCTcompstud (NCT04244097)
- Testing
- Bupivacaine Hydrochloride, Neostigmine
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Kasr El Aini Hospital
Resolution of Neuromuscular Blockade
Resolution of Neuro-muscular Block in Great Obese Patients: Neostigmine vs Sugammadex
It is a observational prospective study. The aim of this study is to compare neostigmine vs sugammadex in the resolution of neuro-muscular blockade in great obese patients.
- Trial name
- NCT02401841
- Testing
- Two different types of drug for resolution of neuro-muscular blockade
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Policlinico Hospital
Neuromuscular Blockade
Effect of Magnesium Sulphate on Neostigmine
The purpose of this study is to evaluate the effect of magnesium sulphate on neostigmine-induced reversal of neuromuscular block by rocuronium
- Trial name
- NCT03020706
- Testing
- Magnesium Sulfate, Injectable
- Where
- South Korea
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Gachon University Gil Medical Center
Bradycardia, Neostigmine Adverse Reaction
0.6 vs. 1.2 mg Atropine Together With Neostigmine 2.5 mg on Heart Rate in Patient Receiving Muscle Relaxant
Balanced general anesthesia with neuromuscular blocking agents has been widely used for surgery.. At the end of surgery, neostigmine has been given for the reversal of neuromuscular blocking agents with several adverse effects…
- Conditions
- Bradycardia, Neostigmine Adverse Reaction, Adverse Reaction to Belladonna or Atropine
- Trial name
- NCT02186132
- Testing
- Atropine 0.6 mg, Atropine 1.2 mg
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Intestinal Disease
Neuromuscular Blockade Comparison for GI-2 Recovery After Bowel Resection
The purpose of this research study is to see the outcome of Sugammadex versus Neostigmine with Glycopyrrolate in colorectal surgery as it relates to its effects on post-surgical time (in hours) to first bowel movement and…
- Trial name
- NCT06112353
- Testing
- Neostigmine Injectable Solution, Sugammadex injection
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- University of California, Irvine
Residual Neuromuscular Block
Neostigmine Reversal And Neuromuscular Recovery
Patients undergoing surgery often receive paralytic agents (or neuromuscular blocking agents (NMBAs)) to facilitate the procedure. At the end of surgery, the effects NMBAs are reversed with a drug called neostigmine.
- Trial name
- NCT02433808
- Testing
- Neostigmine Group, No Neostigmine group
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Neuromuscular Blockade
Sugammadex vs. Neostigmine for Neuromuscular Blockade Reversal in Thoracic Surgical Patients
This prospective, randomized, double blinded study is intended to enroll a total of 92 patients undergoing thoracic surgery with general endotracheal anesthesia at Parkland Hospital.
- Trial name
- NCT03168308
- Testing
- Sugammadex, Neostigmine w/ Glycopyrrolate
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of Texas Southwestern Medical Center