Clinical trials: Neonatal Morbidities
Brain Injuries, Congenital Heart Disease
Protecting Brains and Saving Futures - the PBSF Protocol
Background: Multiple neonatal disorders are associated with risks of neurological injury. Thus, management of these infants should involve a coordinated approach to permit early diagnosis with improved clinical care.
- Conditions
- Brain Injuries, Congenital Heart Disease, Newborn Morbidity, Intraventricular Hemorrhage
- Trial name
- PBSF (NCT03786497)
- Where
- 2 sites in Brazil
- Volunteers
- 2,268 people
- Sponsor
- Protecting Brains Saving Futures
Microbial Colonization, Microbial Superinvasion
Metagenomic Analysis of Gut Microbiome in Preterm
This is single center study. The investigators will try to know that relationships between intestinal microbiome and mortality in preterm infants and what relationships is between intestinal microbiome in preterm infants and…
- Conditions
- Microbial Colonization, Microbial Superinvasion, Microbial Substitution, Newborn Morbidity
- Trial name
- MAGMP (NCT03235635)
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Wonju Severance Christian Hospital
Infant Behavior, Infant Conditions
The Effects of Different Music Genres on Heart Rate Variability in Extremely and Very Low Birth Weight Newborns
AIM: to investigate the influence of different music genres on Heart Rate Variability (HRV) of preterm infants. Neonates undergo a daily randomized music listening program.
- Conditions
- Infant Behavior, Infant Conditions, Infant Morbidity
- Trial name
- NCT04049526
- Testing
- The influence of different music genres on Heart Rate Variability (HRV) in preterm infants
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Ospedale di Circolo - Fondazione Macchi
Efficacy/Long-term Effectiveness Endovascular Therapy in PAD
PTA-Registry, a Prospective, Multicenter Study With 24-Month Follow-up
The PTA-Registry (PTA-REG) is a prospective health services research registry to monitor and follow-up patients with peripheral arterial disease undergoing endovascular peripheral intervention.
- Trial name
- PTAReg (NCT03045224)
- Testing
- PTA, balloon angioplasty, stent
- Volunteers
- 1,760 people
- Sponsor
- Vascular Center Berlin
Respiratory Morbidities
Respiratory Morbidities and Outcome in Late Preterm in Neonatal ICU
Aim of the work: To assess the respiratory morbidities \& outcomes in late preterm infants in the neonatal ICU of Assiut university children's Hospital.
- Trial name
- NCT05823064
- Volunteers
- 20 people
- Sponsor
- Assiut University
Pre-eclampsia, Oocyte Donation
PRIOR Study (Pre-eclampsia Risk In Oocyte Recipients)
The aim of this prospective observational cohort study is to investigate the pathophysiological mechanisms behind and risk of pre-eclampsia in women pregnant after fertility treatment with oocyte donation.
- Conditions
- Pre-eclampsia, Oocyte Donation, Pre-Eclampsia; Complicating Pregnancy, Pre-Eclampsia; Mild
- Trial name
- PRIOR (NCT07263490)
- Where
- 6 sites in Denmark
- Volunteers
- 462 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Cardiac Surgery in Neonates
Cardiac Surgery for Babies Less Than 5 kg:Risk Factors for Morbidity and Mortality
Cardiac surgery in babies less than 6 kg of weight is a complex and high-risk procedure. Despite advances in medical technology, mortality and morbidity rates remain high.
- Trial name
- NCT05891405
- Testing
- Cardiac surgery
- Volunteers
- 100 people
- Sponsor
- Sohag University
HIV Infections, HIV/AIDS
Evaluating the Feasibility of Point of Care Birth Testing in Eswatini
This study aims to assess the feasibility and utility of birth testing using point-of-care (POC) testing in maternity settings in Eswatini.
- Conditions
- HIV Infections, HIV/AIDS, Pediatric HIV Infection, Transmission, Perinatal Infection
- Trial name
- NCT04206878
- Testing
- Point-of-care birth test
- Where
- Eswatini
- Volunteers
- 3,316 people
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
Sleep Apnea, Obesity
Sleep Apnea in Pregnancy Screening Study
Obstructive sleep apnea is known to be a significant source of morbidity in the general population. It has been proposed to be associated with the development of preeclampsia and fetal growth restriction.
- Trial name
- SAPSS (NCT01585844)
- Where
- United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
Sickle Cell Disease, Stroke
The Afolabi Stroke Registry for Children and Young Adults With SCD in Northern Nigeria
Sickle Cell Anemia (SCA) occurs in 300,000 newborns per year in the world, with 150,000 affected births in Nigeria, alone. With improvement in survival for children with SCA in both high- and low-resource countries, neurological…
- Conditions
- Sickle Cell Disease, Stroke, Neurologic Manifestations, Neurological Morbidity
- Trial name
- NCT04800809
- Testing
- This study does not entail offering any intervention; all data collected will be based on standard of care.
- Where
- 3 sites in United States, Nigeria
- Volunteers
- 350 people
- Sponsor
- Vanderbilt University Medical Center
Suspected Damage to Fetus From Other Disease in the Mother, Affecting Management of Mother, With Delivery, Patient Death or Serious Disability Associated With A Haemolytic Reaction Due to the Administration of ABO-Incompatible Blood or Blood Products
The Use of Lung Ultrasonography in the Delivery Room in Neonates
Lung ultrasonography has become frequently used in neonatal intensive care units because it is a diagnostic, useful, harmless, radiation-free, bedside, reproducible and practical method.
- Trial name
- LUSIN (NCT06314789)
- Testing
- doing lung ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Acute Renal Failure, Neonatal Morbidity
SafeBoosC-IIIv - Does Cerebral Oximetry Monitoring Affect Renal Outcomes
Cerebral oximetry monitoring allows clinicians to optimize blood flow to the brain and oxygenation using the SafeBoosC treatment guideline. The guideline's interventions aims to stabilize blood pressure and oxygen levels.
- Trial name
- SBIIIvR (NCT06926946)
- Testing
- Intervention Arm- Cerebral Oximetry + Treatment Guideline
- Where
- India
- Volunteers
- 1,000 people
- Sponsor
- St. John's Research Institute
Enterocolitis, Necrotizing, Bacteremia
Antibiotic "Dysbiosis" in Preterm Infants
Prolonged antibiotic use in preterm neonates has significant consequences on the developing intestinal microbiome, metabolome and host response, predisposing the neonate to various major morbidities, including necrotizing…
- Conditions
- Enterocolitis, Necrotizing, Bacteremia, Bronchopulmonary Dysplasia, Intraventricular Hemorrhage
- Trial name
- NCT02784821
- Testing
- Antibiotic, Gastric fluid, Breast milk
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- University of Florida
Newborn, Extreme Prematurity
Improve the Survival Without Morbidity of Extremely Preterm Infants (PREMEX)
The intervention proposed is a new organization of care, based on the EXPRIM (EXtrem PRematurity Innovative Management) protocol, involving early, standardized, and multidisciplinary management of women hospitalized for a risk of…
- Conditions
- Newborn, Extreme Prematurity, Pretrm Infants
- Trial name
- PREMEX (NCT05248477)
- Testing
- Premex Protocol
- Where
- France
- Volunteers
- 2,377 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Newborn Morbidity, Simulation Training
Educational Strategy in Exchange Transfusion
Abstract Background: Exchange transfusion is a highly complex procedure that requires high levels of expertise. Paediatricians trainees do not have adequate training because opportunities to perform this procedure in practice are…
- Conditions
- Newborn Morbidity, Simulation Training, Telemedicine, Assessment, Self
- Trial name
- INTEXUS (NCT04070066)
- Testing
- Digital didactic environment, • Simulated scenario
- Where
- Colombia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universidad de la Sabana
Transient Tachypnea of the Newborn
Dexamethasone in Prevention of Respiratory Morbidity in Elective Caesarean Section in Term Fetus
Introduction: Babies born at term by elective caesarean section (CS) and before onset of labor are more likely to develop respiratory complications than babies born vaginally.
- Trial name
- NCT01772381
- Testing
- Dexamethasone
- Where
- Egypt
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Donor Site, Morbidity
Donor Site Morbidity and Buccinator Muscle Integrity After Buccinator Myomucosal Flap Surgery in Patients With Velopharyngeal Incompetence
The aim of this study is to evaluate donor site morbidity and buccinator muscle integrity following the use of buccinator myomucosa flap in patients with velopharyngeal incompetence.
- Conditions
- Donor Site, Morbidity, Buccinator Muscle, Integrity
- Trial name
- NCT07853872
- Testing
- Bilateral posteriorly based buccinator myomucosal flap surgery
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Sohag University
Genetic Disease, Newborn Morbidity
Newborn Genomics Programme
Genomic methods can significantly contribute to all facets of precision medicine, from diagnosis to prevention, therapeutic intervention, and management of acute and chronic illnesses.
- Trial name
- NCT06081075
- Testing
- Genetic testing
- Where
- New Zealand
- Volunteers
- 500 people
- Sponsor
- Liggins Institute
Morality, Morbidity;Newborn
Comparison of Care Practices, Mortality and Morbidity of Very Preterm Infants Between Two Tertiary Centers in Northwest and South of China
Care practices, mortality and morbidity of very premature infants from two different tertiary centers were collected and compared, in order to discover areas for improvement where these two newborn centers can learn from each…
- Conditions
- Morality, Morbidity;Newborn, Very Preterm Maturity of Infant
- Trial name
- NCT05116670
- Where
- China
- Volunteers
- 807 people
- Sponsor
- Nanjing Medical University
Reproductive, Maternal, Newborn, and Child Health, Integrated, Community-Health Systems
Implementing an Integrated RMNCH Intervention by Community Health Workers in Achham and Dolakha: National Pilot
The investigators will conduct a cluster-controlled, stepped wedge implementation science trial of a bundled reproductive, maternal, neonatal, and child healthcare (RMNCH) delivery intervention within an approximate population of…
- Trial name
- NCT03371186
- Testing
- Community Health Worker, Continuous Surveillance, CB-Integrated Management of Newborn and Childhood Illness
- Where
- 2 sites in Nepal
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Possible