Clinical trials: Neonatal
Neonatal Respiratory Distress Syndrome
Impact of Neurophysiological Facilitation of Respiration in Preterm Neonates
Background: Respiratory distress syndrome (RDS) or Neonatal respiratory distress syndrome (NRDS) is characterized by pulmonary insufficiency, in preterm neonates and is the major cause of death in preterm.
- Trial name
- NCT04019886
- Testing
- Neurophysiological Facilitation of Respiration
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Asir John Samuel
Feeding Disorder Neonatal
Effects of PIOMI on Oral Feeding of the Premature Infants
Randomized controlled clinical trial aimed at evaluating the effects of the "Premature infant oral motor intervention" method on the oral feeding skills of the premature infants.
- Trial name
- PIOMI2020 (NCT04290338)
- Testing
- PIOMI
- Volunteers
- 40 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Very Low Birth Weight Infant, Weight Gain
Effect of Milk Warming on the Very Low Birth Weight Infant
This study will compare if using a continuous milk warmer to warm breast milk compared to the standard method of warming breast milk in a hot water bath improves weight gain and feeding tolerance in infants born at 32 weeks…
- Conditions
- Very Low Birth Weight Infant, Weight Gain, Feeding Disorder Neonatal
- Trial name
- VLBW (NCT04282655)
- Testing
- Treatment Guardian Milk Warmer (Medela TM), Control
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Neonatal Infection, Nutritional Anemia
Iron and Infection: Neonatal Nutritional Immunity
The motivation for this study was produced from our preliminary data, which showed that during the first 96 hours of life a full-term neonate will actively reduce the overall serum iron concentration of their blood and the…
- Trial name
- NeoInnate (NCT03353051)
- Testing
- Observational study
- Where
- The Gambia
- Volunteers
- 430 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Neonatal SEPSIS
Intravenous and Oral Fosfomycin in Hospitalised Neonates With Clinical Sepsis
Neonatal sepsis has a high risk of morbidity and mortality. The current WHO and national guidelines recommend antibiotics to which resistance is reported in neonatal populations, although the available data is limited.
- Trial name
- NeoFosfo (NCT03453177)
- Testing
- Standard of Care + Fosfomycin, PK, Analysis of Bacterial Isolates
- Where
- Kenya
- Volunteers
- 120 people
- Sponsor
- Drugs for Neglected Diseases
Neonatal Disorder
Inadvertent Hyperventilation During Intraoperative Care in Neonates
In order to evaluate current anesthetic practice in the care of preterm infants and neonates, the investigators will retrospectively review surgical procedures in infants who are less than 60 weeks post-conceptual age in which an…
- Trial name
- NCT03823716
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Nationwide Children's Hospital
Cardiac Disease, Pediatric Disease
Parametric Mapping in Paediatric Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is increasingly an important tool for diagnosis and management of cardiac diseases in children.
- Conditions
- Cardiac Disease, Pediatric Disease, Cardiomyopathies, Congenital Disorders
- Trial name
- NCT04068987
- Testing
- MRI parametric mapping
- Where
- Hong Kong
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Hong Kong Children's Hospital
Permanent Neonatal Diabetes Mellitus
Long-Term Sulfonylurea Response in ABCC8 Neonatal Diabetes (SuResponsSUR)
The purpose of this study is to investigate long term response of sulfonylurea and glucose control in children with diabetes due to mutations in ABCC8 that have been switched from insulin injections to sulfonylurea tablets.
- Trial name
- SuResponsSUR (NCT02624830)
- Testing
- Sulfonylurea
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Haukeland University Hospital
Jaundice, Neonatal, Hyperbilirubinemia, Neonatal
Stannsoporfin With Light Therapy for Newborn Babies With Jaundice
It is normal for red blood cells to die, even in newborn babies. The waste from that is called bilirubin. The liver clears bilirubin out of the body.
- Trial name
- JASMINE_204 (NCT01887327)
- Testing
- Phototherapy, Stannsoporfin
- Where
- 18 sites in United States
- Volunteers
- 91 people
- Sponsor
- InfaCare Pharmaceuticals Corporation, a Mallinckrodt Company
Nosocomial Infection
New Dosages of Inflammatory Markers for the Early Diagnosis of Nosocomial Bacterial Infections of the Newborn
This study aims to evaluate new dosage of inflammatory markers or new inflammatory markers for the diagnosis of nosocomial bacterial infection.
- Trial name
- NOSODIAG (NCT00701948)
- Where
- 2 sites in France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Strasbourg, France
Apnea of Prematurity, Preterm Birth
Hemodynamic Responses to Cardio-respiratory Events in Preterm Infants
Intermittent episodes of hypoxemia and/or bradycardia, also defined as cardio-respiratory events (CRE) are very frequent in preterm infants and may result in transient hypoxia and hypoperfusion of target organs, with possible…
- Conditions
- Apnea of Prematurity, Preterm Birth, Patent Ductus Arteriosus, Hypoxia, Brain
- Trial name
- NCT04184245
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Neonatal Urinary Tract Infection
Suprapubic Aspiration Versus Urinary Catheterization In Neonates.
Urinary tract infection (UTI) is relatively common in infants, with an occurence rate of up to 10%. Analysis of collected urine for the presence of bacteria or fungus is the only way to make a certain UTI diagnosis.
- Trial name
- SPA (NCT01726166)
- Testing
- Suprapubic Aspiration, Urinary Catheterization
- Where
- 2 sites in Canada
- Volunteers
- 49 people
- Sponsor
- Children's Hospital of Eastern Ontario
Hearing Loss, Neonatal
Mode of Delivery on Newborn Hearing Test
Neonatal hearing screening may fail due to some perinatal and neonatal factors. It is well known that false positivity increases cost and maternal anxiety and anxiety in the neonatal hearing screening.
- Trial name
- NCT03881514
- Where
- Turkey (Türkiye)
- Volunteers
- 1,000 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Hypothermia Neonatal
Electricity-free Infant Warmer for Newborn Thermoregulation in Rwanda
Hypothermia contributes to a significant portion of neonatal deaths. Kangaroo mother care (KMC) is a safe and effective method of warming; however, it is not always feasible, and not possible in settings such as resuscitation or…
- Trial name
- NCT03031431
- Testing
- Non-Electric Infant Warmer
- Where
- Rwanda
- Volunteers
- 130 people
- Sponsor
- Boston Children's Hospital
Standardized Training System for Residents, Neonatal Outcomes
Associations of the Grades of Doctor and Neonatal Outcomes
In China, the standardized training system for residents was built last year, and the associations of the grades of doctors and accoucheurs and neonatal outcomes remains unclear.
- Trial name
- NCT03227302
- Testing
- attending obstetrician, associate obstetrician, chief obstetrician
- Where
- China
- Volunteers
- 20,000 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Neonatal Acute Respiratory Distress Syndrome(ARDS)
Epidemiological Study of Neonatal Acute Respiratory Distress Syndrome (ARDS)
Neonatal acute respiratory distress syndrome(ARDS) is a rare but often severe respiratory disorder. The incidence remains unclear and mortality is about 30%-60%.
- Trial name
- NCT03311165
- Testing
- no intervention
- Where
- 2 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Neonatal Meconium Aspiration
Helium Oxygen Mixture in the Treatment of Meconium Aspiration Syndrome
Helium-oxygen mixture(heliox) was suggested to be beneficial in meconium aspiration syndrome in previous studies，but the evidence was limited．The aim of the study was to assess the effectiveness of synchronize intermittent…
- Trial name
- NCT02620891
- Testing
- helium oxygen mixture
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ma Juan
Neonatal Abstinence Syndrome
How to Treat Opiate Withdrawal in Neonates
Three different drugs are used in a randomised, double blind, clinical multi-centre trial with three arms. Major objective is to investigate the duration of drug treatment based on the Finnegan score.
- Trial name
- NCT02810782
- Testing
- Phenobarbital, Chlorpromazine, Morphine
- Volunteers
- 120 people
- Sponsor
- University of Zurich
Neonatal Jaundice, Hyperbilirubinemia
Implementation of a Transcutaneous Bilirubinometer
Neonatal jaundice, caused by hyperbilirubinemia, is frequently seen in healthy newborns. Assessment of the degree of jaundice is usually done visually,and if necessary serum bilirubin is investigated in a blood sample.
- Trial name
- NCT01622699
- Testing
- Transcutaneous Bilirubinometer, visual assessment of neonatal jaundice
- Where
- Netherlands
- Volunteers
- 430 people
- Sponsor
- Princess Amalia Children's Clinic
Neonatal Respiratory Distress Syndrome
Effect of Antenatal Corticosteroids on Neonatal Morbidity.
It will be a randomized controlled trial. There will be two study groups. Study group 1 will be given dexamethasone while study group 2 will be given betamethasone. The control group will be given placebo.
- Trial name
- NCT03446937
- Testing
- Dexamethasone Sodium Phosphate Injection, Betamethasone Sodium Phosphate Injection (Medication), Water for injection
- Where
- Nigeria
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ahmadu Bello University Teaching Hospital