Clinical trials: Necrosis, Femur Head
Osteonecrosis, Avascular Necrosis
Effect of HBOT on Femoral Head Avascular Necrosis (AVN)
The primary objective of this study is to determine whether the Hyperbaric Oxygen Therapy (HBOT) conducted under the Marx Protocol improves pain outcomes when combined with core decompression with autologous bone marrow aspirate…
- Trial name
- NCT06931301
- Testing
- Hyperbaric Oxygen Therapy
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Yale University
Avascular Necrosis of Femoral Head
Efficacy of Zoledronic Acid in Preventing Collapse of the Osteonecrotic Femoral Head
The purpose of this study is to test the effect of zoledronic acid over 2 years in preventing early collapse and progression of joint dome depression (≥ 2 mm by X-ray) of the femoral head in patients with large (> 30%: criteria…
- Trial name
- EZAPCOFH (NCT00939900)
- Testing
- zoledronic acid (aclasta)
- Where
- South Korea
- Volunteers
- 110 people
- Sponsor
- Seoul National University Bundang Hospital
Arthritis, Degenerative, Arthritis, Rheumatoid
Excia T Cementless EBRA Study
In this Post Market Clinical Follow-up Study (PMCF Study), the short-term clinical and radiological results of the cementless Excia T® prosthesis in routine clinical use shall be assessed and the migration taking place in the…
- Conditions
- Arthritis, Degenerative, Arthritis, Rheumatoid, Hip Fractures, Femur Head Necrosis
- Trial name
- NCT02799654
- Where
- Germany
- Sponsor
- Aesculap AG
Osteoarthritis, Rheumatoid Arthritis
Project JAY THA Registration Study
This is a prospective, randomized, multicenter clinical study in Chinese subjects to compare the safety and efficacy of the Delta PLUS Femoral Head and SL-TWIN Stem with BIOLOX forte ball head and SL-PLUS Stem in total hip…
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis, Avascular Necrosis
- Trial name
- NCT02347384
- Testing
- Delta PLUS Femoral Head + SL-TWIN Stem, BIOLOX forte ball head + SL-PLUS Stem
- Where
- 4 sites in China
- Volunteers
- 100 people
- Sponsor
- Smith & Nephew Orthopaedics (Beijing) Limited
Necrosis of Femoral Head, Knee Osteoarthritis
Ketamine Prevent POCD
Previous study demonstrated that neuroinflammation induced by surgery is the main cause of the postoperative cognitive dysfunction. As an agonist of NMDA receptor, ketamine is proved to be an anti-inflammation agent.
- Trial name
- KPPOCD (NCT02220400)
- Testing
- Ketamine
- Where
- 3 sites in China
- Volunteers
- 484 people
- Sponsor
- RenJi Hospital
Osteoarthritis, Hip, Femur Head Necrosis
Clinical Outcomes of Primary Cementless Total Hip Arthroplasty Using the Collarless Actis Stem
This study looks at how well a hip replacement using the collarless Actis stem works over five years. Total hip replacement is a common operation for people whose hip joint has been damaged by arthritis, by loss of blood supply…
- Conditions
- Osteoarthritis, Hip, Femur Head Necrosis, Femoral Neck Fractures, Arthritis Rheumatoid
- Trial name
- NCT07828080
- Testing
- Collarless Actis femoral stem
- Where
- South Korea
- Volunteers
- 210 people
- Sponsor
- Seoul National University Bundang Hospital
Hip Replacement, Total, Osteonecrosis of Femoral Head
Ultra-Short Anatomic and Conventional Cementless Stems Cementless Stems in Patients Younger Than Fifty-Five Years Old
As clinical and radiographic performance of an ultra-short anatomic cementless stem have been investigated only two randomized controlled studies, well-designed trials should aim for a thorough comparison of the outcomes of…
- Conditions
- Hip Replacement, Total, Osteonecrosis of Femoral Head, Coxarthrosis
- Trial name
- NCT02338596
- Testing
- Total hip replacement
- Volunteers
- 111 people
- Sponsor
- Ewha Womans University
Osteoarthritis, Avascular Necrosis
Comparison of Hip Resurfacing to Large Femoral Head Total Hip Arthroplasty
This study evaluates femoral head resurfacing versus a large femoral head (Durom®) total hip system. This is a prospective randomized trial.
- Trial name
- NCT00175487
- Testing
- Hip replacement
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- University of British Columbia
Legg Calve Perthes Disease
Multicenter Prospective Cohort Study on Current Treatments of Legg-Calvé-Perthes Disease
Legg-Calvé-Perthes disease is a childhood hip disorder which is common enough to be a significant public health problem (affects 1 in 740 boys between ages 0-14), but uncommon enough to have a sufficient number of patients from a…
- Trial name
- IPSG1 (NCT02040714)
- Testing
- Osteotomy + Long Term Non-Weight Bearing, Osteotomy + Short Term Non-Weight Bearing, Nonoperative Observation
- Where
- 46 sites in United States, Australia and 13 more
- Volunteers
- 1,500 people
- Sponsor
- Texas Scottish Rite Hospital for Children
Hip Replacement Surgery
Efficacy and Safety of Fibrin Sealant Vapor Heated Solvent/Detergent Treated (FS VH S/D) for Hemostasis in Subjects Undergoing Total Hip Replacement
The purpose of the study is to monitor the safety of FS VH S/D and evaluate whether FS VH S/D is superior to standard treatment in reducing blood loss in subjects undergoing total hip replacement with cement-free hip prostheses.
- Trial name
- NCT00161902
- Testing
- Fibrin Sealant Vapor-Heated Solvent/Detergent-treated
- Where
- 7 sites in Austria, Germany and 1 more
- Sponsor
- Baxter Healthcare Corporation
Sickle Cell Disease, Sickle Cell Anemia
Alendronate for Osteonecrosis in Adults With Sickle Cell Disease
A prospective, single-arm, intervention study of oral alendronate in adults with sickle cell disease and osteonecrosis
- Conditions
- Sickle Cell Disease, Sickle Cell Anemia, Osteonecrosis, Ischemic Necrosis
- Trial name
- NCT06016634
- Testing
- Alendronate Sodium
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Davis
Osteoarthritis, Hip, Osteonecrosis of Femoral Head
Squeaking in Ceramic-on-Ceramic Total Hip Arthroplasty Using Delta TT Cup
This study will evaluate clinical outcome on patients who undergo ceramic on ceramic (CoC) bearing total hip arthroplasty (THA) using Delta TT cup.
- Conditions
- Osteoarthritis, Hip, Osteonecrosis of Femoral Head, Femoral Neck Fractures, Rheumatoid Arthritis of Hip
- Trial name
- NCT04594564
- Testing
- Total hip arthroplasty with Delta TT cup
- Where
- South Korea
- Volunteers
- 270 people
- Sponsor
- Seoul National University Hospital
Necrosis of Femoral Head, Knee Osteoarthritis
MRI Maker of Perioperative Neurocognitive Disorder
Periperative neurocognitive disorder(PND) is consistently associated with increased morbidity and mortality, but its mechanisms remain unclear.
- Conditions
- Necrosis of Femoral Head, Knee Osteoarthritis, Fracture of Lower Limb
- Trial name
- MRIPND (NCT03773627)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Osteonecrosis
Post-COVID-19 Sequelae: Osteonecrosis of Femoral Head
During the most recent pandemy COVID-19, various advises concerning complications following high corticosteroid doses administration were pubblished in 2020.
- Trial name
- Covid-ON (NCT05684588)
- Testing
- Magnetic Resonance
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS
Osteonecrosis of the Femoral Head
RAB001（LLP2A-Ale） in Healthy Subjects
This trial is a single center, randomized, double-blind, placebo-controlled dose escalation study aimed at examining the safety, tolerability, and pharmacokinetics/pharmacodynamics of single and multiple injections of RAB001 in…
- Trial name
- LLP2A-Ale (NCT07545018)
- Testing
- RAB001 400 μg/kg group, RAB001 750 μg/kg group, Normal saline
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- ZhongShan LaiBo RuiChen BioMedicine Co.,Ltd.
Avascular Necrosis of Femur Head
Mesenchymal Stem Cells in Osteonecrosis of the Femoral Head
The present study evaluates the effect of XCEL-MT-OSTEO-ALPHA in osteonecrosis of the femoral head in comparison to the standard treatment of isolated core decompression.
- Trial name
- NCT01605383
- Testing
- XCEL-MT-OSTEO-ALPHA, Standard treatment
- Where
- Spain
- Volunteers
- 23 people
- Sponsor
- Banc de Sang i Teixits
Osteonecrosis of the Femoral Head, Avascular Necrosis of the Femoral Head
Autologous Bone Marrow Aspirate Treatment for Early-Stage Osteonecrosis
Osteonecrosis of the femoral head (ONFH) is a debilitating musculoskeletal disease that is characterized by localized death of bone cells and associated cellular elements within the subchondral bone.
- Trial name
- BATON (NCT06123481)
- Testing
- Core Decompression, Core Decompression Procedure with Autologous Bone Marrow Aspirate Concentrate
- Where
- 10 sites in United States
- Volunteers
- 192 people
- Sponsor
- Johns Hopkins University
Avascular Necrosis of the Femoral Head
Outcome After Avascular Necrosis of the Femoral Head in Young Patients
1. The course of AVN between Initial diagnosis and total hip replacement (THA) is analysed. The impact of early interventions versus conservative therapy in AVN before THA will be evaluated. 2.
- Trial name
- AVN (NCT03753282)
- Testing
- questionnaires for patient reported outcome, questionnaire for course of the disease
- Sponsor
- University Hospital, Basel, Switzerland
Osteoarthritis, Arthritis
A Multi-centre, Prospective Surveillance to Assess Mid-term Performance of the Mpact Cup
This is a multi-centre, prospective post marketing surveillance study to assess mid-term performance of the Mpact cup in subjects requiring primary total hip arthroplasty.
- Conditions
- Osteoarthritis, Arthritis, Avascular Necrosis, Fracture of the Femoral Neck or Head
- Trial name
- NCT02196818
- Testing
- Mpact Acetabular Shell
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Medacta International SA
Osteonecrosis of Femoral Head, Osteonecrosis; Aseptic, Idiopathic
Aspirin in the Prevention of Collapse in Osteonecrosis of the Hip
The purpose of this study is to determine if prolonged administration of low-dose aspirin will prevent the progression of early-stage osteonecrosis of the femoral head and may even reduce the extent of involvement of the femoral…
- Trial name
- NCT03405974
- Testing
- Aspirin
- Where
- Canada
- Volunteers
- 114 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre