Clinical trials: Nausea and Vomiting
Nausea and Vomiting, Aspiration, Intraoperative
Effects of an Oral Multi-vitamin Carbohydrate Beverage on Intraoperative Nausea and Vomiting
Nausea and vomiting are common and unpleasant symptoms for pregnant women during cesarean section, which can lead to aspiration, a serious complication that can cause pneumonia.
- Trial name
- NCT06333626
- Testing
- multi-vitamin carbohydrate
- Volunteers
- 90 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Chemotherapy-induced Nausea and Vomiting
Feasibility of Olanzapine at REduced doSe in hIGHly Emetogenic chemoTherapy
Olanzapine is frequently used off-label as an adjunct antiemetic in clinical oncology settings. North American oncology guidelines recommend it as salvage therapy and as add-on to the standard triple regimen; some suggest it may…
- Trial name
- FORESIGHT (NCT04075955)
- Testing
- Zyprexa® (OLANZapine 5MG), Emend® (Aprepitant)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- CR-CSSS Champlain-Charles-Le Moyne
Electroacupuncture, Olanzapine-contained Four-drug Antiemetic
Electroacupuncture for the Prevention of Chemotherapy-induced Nausea and Vomiting in Patients With Breast Cancer
This randomized controlled phase III trial aims to evaluate the use of electroacupuncture in combination with olanzapine-containing standard quadruple antiemetic drugs for the treatment of nausea and vomiting induced by highly…
- Conditions
- Electroacupuncture, Olanzapine-contained Four-drug Antiemetic, Nausea and Vomiting
- Trial name
- NCT06200168
- Testing
- Electroacupuncture, Standard antiemetic treatment
- Where
- China
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Jiuda Zhao
Chemotherapy-induced Nausea and Vomiting
Palonosetron, Ondansetron, and Dexamethasone for Delayed Nausea and Vomiting in Autologous Transplant Patients
In this study, patients will receive ondansetron 8mg and dexamethasone 10mg intravenously 30 minutes prior to myeloablative preparative chemotherapy until the last day of chemotherapy.
- Trial name
- NCT01370408
- Testing
- Palonosetron, ondansetron, Dexamethasone
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Northside Hospital, Inc.
Chemotherapy-Induced Nausea and Vomiting
A Safety Study of Intravenous Pro-Netupitant and Palonosetron Combination for the Prevention of Nausea and Vomiting
NEPA-15-18 is a clinical study assessing safety of pro-netupitant and palonosetron, two antiemetic drugs, given with oral dexamethasone.
- Trial name
- NCT02517021
- Testing
- Pro-netupitant/Palonosetron, Netupitant/Palonosetron, Dexamethasone
- Where
- 74 sites in United States, Austria and 10 more
- Volunteers
- 405 people
- Sponsor
- Helsinn Healthcare SA
Chemotherapy-Induced Nausea and Vomiting (CINV)
Efficacy and Safety of Fosaprepitant Dimeglumine in Preventing Chemotherapy-Induced Nausea and Vomiting (MK-0517-031)
This study aims to demonstrate that, when given concomitantly with a 5-hydroxytryptamine 3 (5-HT3) antagonist and a corticosteroid, a single 150 mg intravenous (IV) dose of fosaprepitant given on Day 1 is superior to the control…
- Trial name
- NCT01594749
- Testing
- Fosaprepitant dimeglumine, Dexamethasone, Ondansetron
- Volunteers
- 1,015 people
- Sponsor
- Merck Sharp & Dohme LLC
PONV
Acupoint Stimulation Alleviates Postoperative Nausea and Vomiting
Incidence of postoperative nausea and vomiting (PONV) could be high as 60% after liver surgery. Acupoint stimulation has been proved to decrease PONV.
- Trial name
- NCT05396716
- Testing
- transcutaneous electrical acupoint stimulation
- Volunteers
- 158 people
- Sponsor
- Zhihong LU
Postoperative Nausea and Vomiting
Effect of Intravenous Dextrose on PONV in Patients Undergoing Gynecological Laparoscopy
This study is to explore the relationship between intravenous infusion of dextrose during emergence from anesthesia and the incidence of PONV in patients undergoing gynecology laparoscopy (GL).
- Trial name
- NCT05932160
- Testing
- 5% glucose, lactated ringers
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Weifang Medical University
Functional Gastrointestinal Disorders, Gastroparesis
Validation of a Mental Health Scale for Young People With Chronic Stomach Symptoms
This study aims to validate the Alimetry® Gut-Brain Wellbeing Survey- Youth Version (AGBW-Y), a mental health scale developed for patients aged 12-17 years with chronic stomach symptoms.
- Conditions
- Functional Gastrointestinal Disorders, Gastroparesis, Vomiting; Cyclical, Nausea
- Trial name
- NCT06394154
- Volunteers
- 100 people
- Sponsor
- Greg O'Grady
Emergence Delirium
MELAtonin for Prevention of Postoperative Agitation and Emergence Delirium in Children
Postoperative agitation and emergence delirium describe a spectrum of symptoms of early postoperative negative behavior, in which the child experiences a variety of behavioral disturbances including crying, thrashing, and…
- Trial name
- MELA-PAED (NCT05541276)
- Testing
- Melatonin, Isotonic sodium chloride solution
- Where
- Denmark
- Volunteers
- 676 people
- Sponsor
- Arash Afshari
Postoperative Nausea and Vomiting, Breast Cancer Female
Ramosetron on Late PONV (Postoperative Nausea and Vomiting)
The purpose of this study was to evaluate the effectiveness of additional ramosetron injection for controlling late postoperative nausea and vomiting (PONV) after breast surgery in high risk PONV patients.
- Trial name
- NCT05326360
- Testing
- Ramosetron Hydrochloride
- Where
- South Korea
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Pusan National University Hospital
Head and Neck Cancer
DOsimetry and Radiation Induced NAusea in Head and Neck Cancers
This is a prospective cohort study for the analysis of correlation between dosimetric parameters and RANV (Radiation Associated Nausea and Vomiting) in patients with head and neck cancer undergoing exclusive radiotherapy (RT).
- Trial name
- DORIAN (NCT06341985)
- Testing
- Exclusive radiotherapy
- Where
- 14 sites in Italy
- Volunteers
- 180 people
- Sponsor
- European Institute of Oncology
Postoperative Pain Management, Postoperative Nausea and Vomiting
LAPOFAR Trial: Opioid-Free vs. Remifentanil Anesthesia in Laparoscopic Cholecystectomy
This study was a single-center, prospective, randomized clinical trial designed to compare the effects of opioid-free anesthesia (OFA) with standard opioid-based anesthesia during elective laparoscopic cholecystectomy.
- Conditions
- Postoperative Pain Management, Postoperative Nausea and Vomiting, Laparoscopic Cholecystectomy, Opioid-free Anesthesia
- Trial name
- LAPOFAR (NCT07307625)
- Testing
- Lidocaine + Dexmedetomidine, Remifentanil
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Postoperative Nausea and Vomiting (PONV), Nausea
Aprepitant Versus Ondansetron in Preoperative Triple-therapy Treatment of Nausea and Vomiting
This study is being done to determine the efficacies of two preventative drug combinations for postoperative nausea and vomiting in patients undergoing neurosurgery.
- Trial name
- NCT01474915
- Testing
- Aprepitant, Ondansetron, Promethazine
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Sergio Bergese
Cancer, Malignancy
Ramosetron, Aprepitant and Dexamethasone Versus Ondansetron, Aprepitant and Dexamethasone
The purpose of this study is to assess the efficacy and safety of Ramosetron, Aprepitant and Dexamethasone therapy versus Ondansetron, Aprepitant and Dexamethasone therapy for preventing of nausea and vomiting in highly…
- Trial name
- ROAD (NCT01536691)
- Testing
- ramosetron, ondansetron
- Where
- South Korea
- Volunteers
- 338 people
- Sponsor
- Hallym University Medical Center
Emesis
The Antiemetic Effects of Increased Splanchnic Perfusion, Induced by the Gut Hormone GIP, in Healthy Individuals
This study investigates whether the gut hormone glucose-dependent insulinotropic polypeptide (GIP) can reduce feelings of nausea.
- Trial name
- GIP EMESIS (NCT07687589)
- Testing
- Glucose-dependent Insulinotropic Polypeptide (GIP), GLP-1 (7-36) amide, Apomorphine Injectable Solution
- Where
- Denmark
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Chemotherapy-Induced Nausea and Vomiting
Aprepitant for the Prevention of Chemotherapy Induced Nausea and Vomiting (CINV)(0869-130)(COMPLETED)
The study will test aprepitant for the prevention of CINV in patients receiving their initial cycle of Moderately Emetogenic Chemotherapy (MEC).
- Trial name
- NCT00337727
- Testing
- aprepitant, Comparator: ondansetron, Comparator: dexamethasone
- Volunteers
- 848 people
- Sponsor
- Merck Sharp & Dohme LLC
Breast Neoplasms, Anesthesia, General
Relationship Between Genetic Polymorphism and Postoperative Nausea and Vomiting in Chinese Han Population
Postoperative nausea and vomiting ( PONV ) is one of the common complications after general anesthesia while genetic factors may play an important role in Postoperative nausea and vomiting.
- Trial name
- NCT03705026
- Volunteers
- 568 people
- Sponsor
- Fujian Medical University Union Hospital
Nausea, Vomiting
A Study to Assess the Anti-Emetic Efficacy of Ginger in Children and Adolescents Receiving Chemotherapy
Ginger root powder is found to be significantly effective,when given as an add-on therapy in reducing chemotherapy induced nausea and vomiting in children and adolescents receiving chemotherapy.
- Trial name
- NCT00940368
- Where
- India
- Volunteers
- 60 people
- Sponsor
- All India Institute of Medical Sciences
Postoperative Complications, Postoperative Nausea and Vomiting
Prophylaxy of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Surgery
Postoperative nausea and vomiting (PONV) is one of the most commonly reported adverse effects of anesthesia. The general incidence of vomiting is approximately 30%, nausea at 50% and the PONV rate can go up to 80% in high-risk…
- Trial name
- NCT03202459
- Testing
- Group A - gabapentin 600 mg, Group B - pregabalin
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Faculdade de Ciências Médicas da Santa Casa de São Paulo
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