Clinical trials: Nausea and Vomiting, open to volunteers
Spinal Fusion, Nausea and Vomiting, Postoperative
Aprepitant Treatment to Prevent Postoperative Nausea and Vomiting in Children Undergoing Scoliosis Surgery
This research trial will measure how useful Aprepitant is in preventing nausea and vomiting in children having surgery to correct scoliosis (curvature of the spine).
- Conditions
- Spinal Fusion, Nausea and Vomiting, Postoperative, Anesthesia
- Trial name
- NCT06357234
- Testing
- Aprepitant
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- IWK Health Centre
Obese Patients, Bariatric Surgical Pain
Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy
Regional anesthesia is a technique in which a local anesthetic is injected near a nerve or spinal cord to block sensation, motor stimulation, and pain.
- Conditions
- Obese Patients, Bariatric Surgical Pain, Bariatric Surgery (Sleeve Gastrectomy ), Non-Opioid Pain Management
- Trial name
- NCT07084753
- Testing
- Levobupivacaine, Dexamethasone contained in the solution for thoracic paravertebral block, Adrenaline
- Where
- Croatia
- Volunteers
- 36 people
- Sponsor
- IVO JURISIC
Hypotension, Nausea
Granisetron Use, Blood Pressure, and Nausea and Vomiting During Cesarean Delivery Under Spinal Anesthesia
This study will observe 80 adults having a cesarean delivery under spinal anesthesia at Kayseri City Hospital. It will compare patients who receive granisetron as part of routine care to prevent nausea and vomiting with patients…
- Conditions
- Hypotension, Nausea, Vomiting, Cesarean Section
- Trial name
- NCT07861737
- Testing
- Granisetron
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Kayseri City Hospital
Nausea and Vomiting, Nausea
Broadening Antiemetics Research by Comparing the Effectiveness of Fosaprepitant and Metoclopramide
The study team proposes a double-blind, comparative effectiveness, randomized controlled trial (RCT) to address the following goal: to determine the relative efficacy and adverse event profile of fosaprepitant compared to the…
- Conditions
- Nausea and Vomiting, Nausea, Vomiting
- Trial name
- BARF RCT (NCT06740812)
- Testing
- Fosaprepitant for Injection, Metoclopramide Injection
- Where
- United States
- Volunteers
- 212 people
- Sponsor
- Montefiore Medical Center
Postoperative Nausea and Vomiting
Association Between Preoperative Metformin Exposure and Postoperative Nausea and Vomiting in Patients Undergoing General Anesthesia
The aim of this observational study is to investigate the potential effects of metformin on postoperative nausea and vomiting (PONV) in patients undergoing surgery under general anesthesia.
- Trial name
- Met-PONV (NCT07244575)
- Where
- China
- Volunteers
- 909 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Postoperative Pain, Postoperative Nausea and Vomiting (PONV)
Transauricular Vagus Nerve Stimulation Frequencies for Postoperative Pain
The goal of this clinical trial is to learn whether different frequencies of transauricular vagus nerve stimulation (tVNS) can reduce postoperative pain and opioid consumption in adults undergoing abdominal or urologic surgery.
- Conditions
- Postoperative Pain, Postoperative Nausea and Vomiting (PONV), Opioid Consumption, Postoperative
- Trial name
- TVNS-PAIN (NCT07633444)
- Testing
- Transauricular Vagus Nerve Stimulation (tVNS)
- Where
- Brazil
- Volunteers
- 174 people
- Sponsor
- Federal University of Bahia
Germ Cell Cancer
A Simplified Regimen to Prevent Nausea and Vomiting Using Netupitant/Palonosetron in Germ Cell Cancer Patients Receiving Chemotherapy
This is a single-site, open-label, randomized pilot feasibility study conducted at The Ottawa Hospital Cancer Centre. A total of 10 participants will be randomized 1:1 to either the experimental or control arm.
- Trial name
- SPARROW-GC (NCT07662200)
- Testing
- Netupitant/Palonosetron Hydrochloride, Ondansetron (Control), Aprepitant
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Ottawa Hospital Research Institute
Efficacy, Safety
Evaluation of the Efficacy and Safety of Megestrol Acetate in Preventing Nausea and Vomiting Induced by Highly Emetogenic Chemotherapy
To evaluate the efficacy of Megestrol Acetate Oral Suspension in Preventing Nausea and Vomiting Induced by Highly Emetogenic Chemotherapy in Malignant Solid Tumor Patients
- Conditions
- Efficacy, Safety, Megestrol Acetate, Adult Subject
- Trial name
- NCT07130617
- Testing
- Low dose of Megestrol Acetate Oral Suspension combined with standard therapy, Medium dose of Megestrol Acetate Oral Suspension combined with standard therapy, High dose of Megestrol Acetate Oral Suspension combined with standard therapy
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Nausea, Vomiting
Periorbital Massage for Nausea and Vomiting After Laparoscopic Surgery
Laparoscopic cholecystectomy is one of the commonly used surgical treatment methods for gallbladder diseases. However, many patients experience significant nausea and vomiting after laparoscopic cholecystectomy.
- Conditions
- Nausea, Vomiting, Laparoscopic Cholecystectomy
- Trial name
- NCT06954935
- Testing
- periorbital massage
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Atlas University
Gastroparesis, Gastroparesis Nondiabetic
Study of Enhanced Programming Stimulation with the Enterra® Therapy System
The purpose of this research study is to evaluate if an enhanced Enterra device programming strategy will improve symptoms associated with gastroparesis, improve symptoms in a faster amount of time, and improve quality of life…
- Conditions
- Gastroparesis, Gastroparesis Nondiabetic, Gastroparesis Due to Diabetes Mellitus
- Trial name
- EXPEDITE (NCT06560307)
- Testing
- Enterra Therapy System
- Where
- 6 sites in United States
- Volunteers
- 50 people
- Sponsor
- Enterra Medical, Inc.
Anesthesia, Analgesia
Genetic Variants and Perioperative Morbidity and Mortality
Prospective association study to analyse perioperative patients' outcome. Outcome comprises intraoperative and postoperative complications e.g.
- Conditions
- Anesthesia, Analgesia, Surgical Procedure, Operative
- Trial name
- NCT02124499
- Where
- Switzerland
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Roux-en-y Anastomosis Site, Marginal Ulcer
Marginal Ulcer Healing With Low-Thermal Argon Plasma Endoscopic Treatment
The objective of the study is to investigate the treatment of marginal ulcers with Low Thermal plasma in an endoscopic setting. By a treatment of the ulcerated areas with argon plasma with low power settings (~ 1 W) we…
- Conditions
- Roux-en-y Anastomosis Site, Marginal Ulcer, Marginal Ulcer (Peptic) or Erosion, Ulcer
- Trial name
- AMULET (NCT06543316)
- Testing
- Low Thermal Plasma (LTP) Treatment, Standard of Care Ulcer Treatment (typically PPI Administration)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Christopher C. Thompson, MD, MSc
Intradialytic Nausea and Vomiting, Chronic Kidney Disease
Manual Acupuncture for Intradialytic Nausea and Vomiting in Patients Undergoing Hemodialysis: A Randomized Controlled Trial
This study aims to evaluate the immediate effects of acupuncture therapy at three specific acupuncture points (PC6, ST36, and KI3) on intradialysis nausea and vomiting in patients with chronic kidney disease undergoing regular…
- Conditions
- Intradialytic Nausea and Vomiting, Chronic Kidney Disease, Acupuncture
- Trial name
- NCT07888777
- Testing
- Acupuncture
- Where
- Indonesia
- Volunteers
- 20 people
- Sponsor
- Universitas Indonesia
Bariatric Surgery Candidate, Pain, Postoperative
Autonomic Neural Blockade in Bariatric Surgery
The purpose of this research is to evaluate if autonomic nerve block (ANB- blocking pain and nausea signals) decreases pain and anti-nausea medication requirements as well as the experience of pain/nausea during the first 72…
- Conditions
- Bariatric Surgery Candidate, Pain, Postoperative, Nausea and Vomiting, Postoperative, Opioid Use
- Trial name
- NCT07104825
- Testing
- Intraoperative autonomic neural blockade (ANB), Laparoscopic Standard of Care Abdominal Wall Block
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Endeavor Health
Nausea Gravidarum, Hyperemesis Gravidarum
Tablet Ginger Versus Tablet Doxylamine Succinate in Control of Nausea and Vomiting in Pregnancy
Nausea and vomiting are common GI symptoms of pregnancy. Multiple managing options have been used for NVP. Doxylamine succinate is used as first line treatment for NVP despite that alternative modalities such as ginger extracts…
- Trial name
- GDNVP (NCT06772974)
- Testing
- Doxylamine Succinate USP, Ginger
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- Nawaz Sharif Medical College
Sedation, Cataract
Dexmedetomidine and Propofol for Sedation in Cataract Surgery.
The goal of this prospective, randomized, single-blinded is to learn if there is an ideal sedation protocol in cataract surgery in adults.
- Conditions
- Sedation, Cataract, Hemodynamic, Hemodynamic Changes
- Trial name
- NCT07556133
- Testing
- Dexmedetomidine (DEX), Propofol (PRO), Fentanyl (FEN)
- Where
- Lebanon
- Volunteers
- 1,000 people
- Sponsor
- Saint-Joseph University
Chemotherapy-induced Nausea and Vomiting, Pediatric Cancer
Effect of Guided Imagery on Chemotherapy-related Nausea and Vomiting
The goal of this randomized controlled study is to assess the effect of guided imagery on chemotherapy-related nausea and vomiting in pediatric oncology patients.
- Trial name
- NCT06120764
- Testing
- guided imagery
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Baskent University
Postoperative Sleep Quality, Postoperative Behaviour
Sleep Quality - Comparing the Effect of Ondansetron or Dexamethasone Given as Routine Prophylaxis Intraoperatively to Prevent Post Operative Nausea and Vomiting (SCORPION)
Nausea and vomiting are common complications after anaesthesia, and anaesthetists routinely give medications to prevent them. Dexamethasone and ondansetron are the two most commonly used agents and have a long safety record.
- Conditions
- Postoperative Sleep Quality, Postoperative Behaviour, Postoperative Recovery in Children, Postoperative Nausea and Vomiting (PONV)
- Trial name
- SCORPION (NCT07777276)
- Testing
- Dexamethasone (IV), Ondansetron iv
- Where
- 3 sites in Australia, Brazil
- Volunteers
- 500 people
- Sponsor
- Telethon Kids Institute
PONV
Amisulpride for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Surgery
This study aims to focus on patients undergoing gynecological laparoscopic surgery and further evaluate the role of amisulpride in preventing postoperative nausea and vomiting in these patients.
- Trial name
- Amisulpride (NCT07554040)
- Testing
- Tropisetron
- Volunteers
- 526 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Gynecological Cancer
Breathing Exercise Application in Patients With Gynecological Cancer.
The aim of this study is to determine the effects of breathing exercises on nausea, vomiting and anxiety levels in patients with gynecological cancer.
- Trial name
- NCT06777225
- Testing
- breathing exercises, scale, scala
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Çankırı Karatekin University