Clinical trials: Nasal Obstruction
Congestion, Nasal
A Pivotal Study to Assess the Effectiveness of Nasal Dilator (Breathe Right Nasal Strips)
This randomized, double-blind, parallel group, placebo-controlled study assessed subjective measures of nasal airway breathing immediately after application in the morning upon awakening after use of breathe right nasal strips…
- Trial name
- NCT03549130
- Testing
- Breathe Right Tan (small/medium) nasal strips
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- GlaxoSmithKline
Common Cold/Flu, Nasal Congestion
Fixed-dose Combination of 1000 mg Dipyrone Monohydrate + 60 mg Caffeine + 4 mg Chlorpheniramine Maleate in Improving Symptoms of the Common Cold and Flu in Adults
Phase III clinical trial to evaluate the efficacy and safety of a fixed-dose combination of 1000 mg dipyrone monohydrate + 60 mg caffeine + 4 mg chlorpheniramine maleate in improving symptoms of the common cold and flu in adults.
- Conditions
- Common Cold/Flu, Nasal Congestion, Nasal Obstruction
- Trial name
- PANAMA (NCT07626437)
- Testing
- dipyrone monohydrate 1000 mg + chlorpheniramine maleate 4 mg + caffeine 60 mg, dipyrone monohydrate 500 mg + chlorpheniramine maleate 2 mg + caffeine 30 mg
- Where
- 15 sites in Brazil
- Volunteers
- 620 people
- Sponsor
- Brainfarma Industria Química e Farmacêutica S/A
Nasal Congestion
Bioequivalence Between Two Oral Formulations of Diphenhydramine Hydrochloride
The purpose of this study is to determine if two formulations of diphenhydramine hydrochloride are bioequivalent.
- Trial name
- NCT00662337
- Testing
- Diphenhydramine hydrochloride
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Nasal Congestion
Study on Hypertonic Saline Nasal Spray
Phytosun decongestant nasal spray is a class I medical device registered in the European Union for the treatment of nasal congestion. The spray contains hypertonic seawater and essential oils.
- Trial name
- PhytosunDecon (NCT02100605)
- Testing
- Phytosun, decongestant, nasal spray
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Omega Pharma
Nasal Congestion
A User Study of the Soniflow System for Nasal Congestion Relief
The Soniflow System consists of an acoustic vibrational headband paired with a Smartphone App to provide rapid relief of nasal congestion.
- Trial name
- NCT04910139
- Testing
- Soniflow System
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Third Wave Therapeutics
Headache, Migraine
Efficacy and Safety of Tx360® Transnasal Sphenopalatine Ganglion Block in the Treatment of Chronic Migraine
This is a double blind placebo-controlled study which will evaluate the efficacy of bupivacaine compared to saline, delivered by the Tx360® device to the sphenopalatine ganglion (SPG), to treat chronic migraine headache.
- Trial name
- NCT03337620
- Testing
- Tx360
- Where
- 11 sites in United States
- Volunteers
- 174 people
- Sponsor
- Tian Medical Inc.
Seasonal Allergic Rhinitis
POPULAR (Preference Of Patient Using Levocetirizine in Allergic Rhinitis)
Comparative study on clinical efficacy and safety of levocetirizine and desloratadine as measured by the subject's satisfaction/dissatisfaction after one week of treatment
- Trial name
- NCT00160537
- Testing
- Levocetirizine
- Volunteers
- 200 people
- Sponsor
- UCB Pharma
Chronic Sinusitis, Nasal Polyposis
S8 Sinus Implant in Chronic Sinusitis Patients With Recurrent Nasal Polyps
The RESOLVE II Study is a randomized, single-blind, parallel arm, concurrently controlled, multicenter study with 300 chronic sinusitis patients who had prior endoscopic sinus surgery but present with recurrent sinus obstruction.
- Trial name
- RESOLVE_II (NCT02291549)
- Testing
- S8 Sinus Implant, Mometasone furoate nasal spray
- Where
- 40 sites in United States
- Volunteers
- 300 people
- Sponsor
- Intersect ENT
Common Cold, Headache
Efficacy and Safety of Sinutab on Subjects in the Setting of a Common Cold
The purpose of this study is to investigate the efficacy and safety for a marketed sinus allergy product, Sinutab, in the treatment of nasal congestion and headache.
- Conditions
- Common Cold, Headache, Nasal Congestion
- Trial name
- NCT00378144
- Testing
- Pseudoephedrine/Paracetamol
- Where
- Belgium
- Volunteers
- 469 people
- Sponsor
- McNeil AB
Inferior Turbinate Hypertrophy, Nasal Obstruction
Efficacy And Safety of An IRE System For Treatment of Inferior Turbinate Hypertrophy
The purpose of the IRE System is to address the clinical need for reducing the volume of hypertrophic inferior turbinate(s) causing nasal obstruction while minimizing side effects and complications.
- Conditions
- Inferior Turbinate Hypertrophy, Nasal Obstruction, Turbinate; Hypertrophy Mucous Membrane
- Trial name
- NCT06438185
- Testing
- IRE System
- Where
- 4 sites in Israel, Lithuania and 2 more
- Volunteers
- 48 people
- Sponsor
- ENTire Medical Ltd.
Nasal Airway Obstruction
A Prospective Study Comparing VivAer to Alternative Surgical Procedures to Treat Nasal Airway Obstruction in Patients With Nasal Valve Dysfunction.
The purpose of this study is to compare the clinical outcomes of the VivAer procedure to functional rhinoplasty and septoplasty surgery for the treatment of nasal airway obstruction (NAO) to establish non-inferiority.
- Trial name
- CompAer (NCT06922955)
- Where
- 35 sites in United States
- Volunteers
- 400 people
- Sponsor
- Aerin Medical
Dry Nose, Nose Irritation
Pilot Study to Assess Performance and Safety of SULFEX 13081.22 Nasal Spray in Patients With Dry or Irritated Nose
As the medical device is CE marked, the objective of this study is to provide performance and safety data on SULFEX 13081.22 nasal spray as close as possible to the routine care.
- Trial name
- NCT05499078
- Testing
- SULFEX 13081.22
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- Church & Dwight Company, Inc.
Nasal Obstruction Due to Inferior Turbinate Hypertrophy
Post-Market Clinical Study to Evaluate the Safety and Effectiveness of REFLEX ULTRA 45 for Coblation Inferior Turbinate Reduction in China
The study is a prospective, multi-center, post-market clinical study to evaluate the safety and effectiveness of REFLEX ULTRA 45 for the coblation inferior turbinate reduction in China.
- Trial name
- NCT07025304
- Testing
- REFLEX ULTRA 45
- Where
- 6 sites in China
- Volunteers
- 105 people
- Sponsor
- Smith & Nephew, Inc.
Rhinitis, Allergic, Perennial and Seasonal
A Proof of Concept Study to Assess Effect of Fluticasone Furoate (FF)/Levocabastine Fixed Dose Combination (FDC) Compared With Levocabastine and FF Alone in Subjects With Allergic Rhinitis (AR)
This study will be a randomised, double blind, placebo controlled, 3-way, incomplete block crossover study to evaluate the effect of single and repeat doses of levocabastine, FF, placebo and a FDC of FF/levocabastine…
- Trial name
- NCT01957202
- Testing
- FF/levocabastine, FF, levocabastine
- Where
- Austria
- Volunteers
- 71 people
- Sponsor
- GlaxoSmithKline
Allergic Rhinoconjunctivitis, Chronic Urticaria
Pharmacokinetic Study of Bilastine in Children From 2 to < 12 Years of Age With Either Allergic Rhinoconjunctivitis (AR) or Chronic Urticaria (CU)
The conduct of this clinical trial is aimed at determining the most suitable dose regimen for children in different age groups, and secondarily to assess the safety and tolerability of bilastine in this paediatric population…
- Trial name
- NCT01081574
- Testing
- Bilastine
- Where
- 7 sites in Australia, Germany and 1 more
- Volunteers
- 36 people
- Sponsor
- Faes Farma, S.A.
Acute Agitation
Safety and Tolerability of INP105 (Olanzapine by I231 POD® Device) Nasal Spray in Healthy Volunteers - SNAP 101
The purpose of this study is to evaluate the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of INP105, which is an investigational drug-device combination product comprised of the drug component OLZ administered by a…
- Trial name
- SNAP101 (NCT03624322)
- Testing
- Zyprexa IM, Zydis, INP105
- Where
- Australia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Impel Pharmaceuticals
Nasal Congestion
Bioequivalence of Single Dose Phenylephrine Extended Release Tablets and Phenylephrine HCl Immediate Release Tablets Dosed Every Four Hours (P08340)(COMPLETED)
This study will assess the food-effect bioavailability of an extended release formulation of phenylephrine HCl and its bioequivalence to the marketed immediate release phenylephrine HCl product.
- Trial name
- NCT01354418
- Testing
- Phenylephrine HCl Extended Release, Phenylephrine HCl Immediate Release
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bayer
Nasal Congestion
Sonu Real-World Use Clinical Study to Treat Moderate to Severe Nasal Congestion
Real world utilization of Acoustic Resonance Therapy for symptoms of Nasal Congestion
- Trial name
- NCT06024564
- Testing
- Sonu Acoustic Resonance Therapy
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Third Wave Therapeutics
Seasonal Allergic Rhinitis
Combination Study Of S-555739/Cetirizine HCl In Adult Patients With Seasonal Allergic Rhinitis
The primary objective of the study was to examine the efficacy and safety of S-555739/cetirizine HCl compared with the individual components and placebo.
- Trial name
- NCT01651871
- Testing
- S-555739 Dose 1, S-555739 Dose 2, Cetirizine HCl Dose 1
- Volunteers
- 779 people
- Sponsor
- Shionogi
Nasal Airway Obstruction
InFlux System for Nasal Breathing Improvement
Pilot Study of the Aerin Medical Wand used for Improvement in Nasal Breathing
- Trial name
- NCT01960816
- Testing
- Procedure: thermal coagulation of tissue in the nasal airway
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- Aerin Medical