Clinical trials: Nasal Disease
Bronchopulmonary Dysplasia, Prematurity
Impact of Extended CPAP on Bronchopulmonary Dysplasia
The purpose of this pilot study is to compare if keeping infants on CPAP (continuous positive airway pressure) support for an extended period of time until they are 32 weeks corrected gestational age or 1250 grams (approximately…
- Trial name
- NCT05547139
- Testing
- Protocolized weaning of respiratory support
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
Interstitial Lung Disease (ILD)
Nasal High-flow Oxygen Therapy During Rehabilitive Exercise Training in ILD
Although uncommon, interstitial lung diseases (ILDs), and particularly idiopathic pulmonary fibrosis (IPF), are progressive, irreversible, and ultimately fatal without treatment.
- Trial name
- PID-OX (NCT07679854)
- Testing
- Pulmonary rehabilitation with NHFO2, Pulmonary rehabiltation with conventional oxygen therapy
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Frédéric Hérengt
Adult B Acute Lymphoblastic Leukemia, Adult Nasal Type Extranodal NK/T-Cell Lymphoma
Veliparib, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed or Refractory Lymphoma, Multiple Myeloma, or Solid Tumors
This phase I/II trial studies the side effects and the best dose of veliparib when given together with bendamustine hydrochloride and rituximab and to see how well they work in treating patients with lymphoma, multiple myeloma…
- Conditions
- Adult B Acute Lymphoblastic Leukemia, Adult Nasal Type Extranodal NK/T-Cell Lymphoma, Adult Solid Neoplasm, Anaplastic Large Cell Lymphoma
- Trial name
- NCT01326702
- Testing
- Bendamustine Hydrochloride, Pharmacological Study, Rituximab
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- National Cancer Institute (NCI)
Respiratory Failure, Hypoxemic Respiratory Failure
Helmet NIV vs. CPAP vs. High-flow Nasal Oxygen in Hypoxemic Respiratory Failure
Multicenter, open label, three-arm randomized trial to assess the effect of helmet noninvasive ventilation vs. helmet continuous positive airway pressure vs.
- Trial name
- HENIVOT2 (NCT05089695)
- Testing
- Noninvasive respiratory support
- Where
- Italy
- Volunteers
- 1,200 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Agitation
Emergence Agitation After Nasal Surgery: a Randomized Controlled Comparison Between Melatonin and Mirtazapine
Emergence agitation (EA) is common after nasal surgery under general anesthesia, which can lead to several problems, such as increased risk of injury to the patient or medical staff, pain, decreased patient satisfaction…
- Trial name
- NCT04908605
- Testing
- Mirtazapine, Melatonin
- Where
- Egypt
- Volunteers
- 165 people
- Sponsor
- Ain Shams University
Olfactory Disorder, COVID-19
Simvastatin Nasal Rinses for the Treatment of COVID-19 Mediated Dysomsia
Olfactory dysfunction (OD) or changes in smell and/or taste is one of the cardinal presenting symptoms of COVID-19. Despite the prevalence of COVID and resultant OD, the pathophysiology of COVID-mediated OD is not fully…
- Trial name
- SimCA (NCT05542095)
- Testing
- Simvastatin
- Volunteers
- healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Chronic Rhinosinusitis Without Nasal Polyps, Asthma
Adherence in Global Airways
There is a strong case for treating diseases of both the upper and lower airways (global airways) simultaneously because they share the same inflammatory mechanisms.
- Conditions
- Chronic Rhinosinusitis Without Nasal Polyps, Asthma, Chronic Rhinosinusitis With Nasal Polyps, Chronic Rhinosinusitis (Diagnosis)
- Trial name
- AIR2022 (NCT05553951)
- Testing
- Controlgroup, Intervention
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- Christiane Haase
Asthma, Allergic
Anakinra as a Rescue Treatment for Allergic Inflammation
Participants with mild asthma who are sensitized to either house dust mite or cat hair allergen will undergo nasal instillation of the allergen to elicit nasal allergy symptoms.
- Trial name
- NCT04035109
- Testing
- Anakinra, House dust mite allergen, Cat hair allergen
- Sponsor
- University of North Carolina, Chapel Hill
Edema, Bruising
Steroids for Rhinoplasty: Pain, Nausea, Edema and Ecchymosis
This study will be a prospective randomized study to evaluate the effect of medrol dosepaks (oral corticosteroids) on postoperative outcomes among patients undergoing rhinoplasty by Facial Plastic Surgeons at Vanderbilt.
- Conditions
- Edema, Bruising, Nasal Obstruction, Postoperative Pain
- Trial name
- NCT06483204
- Testing
- Medrol 4 MG Oral Tablet Includes Medrol Dosepak
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Myeloproliferative Disorders, Leukemia
Umbilical Cord Blood (UCB) Transplant, Fludarabine, Melphalan, and Anti-thymocyte Globulin (ATG) in Treating Patients With Hematologic Cancer
RATIONALE: Giving low doses of chemotherapy before a donor umbilical cord blood transplant helps stop the growth of cancer cells. It may also stop the patient's immune system from rejecting the donor's stem cells.
- Conditions
- Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00827099
- Testing
- anti-thymocyte globulin, fludarabine phosphate, Melphalan
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Northside Hospital, Inc.
Bladder Cancer, Cervical Cancer
Zinc Supplements in Lowering Cadmium Levels in Smokers
RATIONALE: Zinc supplements may lower cadmium levels in smokers and may help prevent DNA damage. PURPOSE: This clinical trial is studying how well zinc supplements work in lowering cadmium levels in smokers.
- Conditions
- Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT00376987
- Testing
- zinc oxide
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Wake Forest University Health Sciences
Prematurity; Extreme
High Flow Nasal Cannula in Preterm Infants
The HIFLO study evaluates the impact of HFNC oxygen therapy on duration of nCPAP therapy, oxygen therapy and hospitalization. The cost of use of CPAP and two HFNC devices are also evaluated.
- Trial name
- HIFLO (NCT03007056)
- Testing
- High flow nasal cannula
- Where
- France
- Volunteers
- 207 people
- Sponsor
- Hôpital de la Croix-Rousse
Rhinitis, Allergic, Perennial
A Study of Mometasone Furoate Nasal Spray in Perennial Allergic Rhinitis (Study P03748)(COMPLETED)
This is a multicenter, randomized, double-blind within the dose level, parallel group comparison of mometasone furoate nasal spray in subjects with perennial allergic rhinitis to examine the minimal effective dose, the…
- Trial name
- NCT00779545
- Testing
- Mometasone furoate
- Volunteers
- 455 people
- Sponsor
- Organon and Co
Ventilator Lung; Newborn, Hemodynamic Instability
Cardiorespiratory Effects of Nasal High Frequency Ventilation in Neonates
The aim of the present work is to study the cardio-respiratory effects of non-invasive ventilation (nasal high-frequency ventilation and nasal CPAP) as an initial therapy of respiratory distress in moderate and late preterm…
- Conditions
- Ventilator Lung; Newborn, Hemodynamic Instability, Echocardiography
- Trial name
- NCT05706428
- Testing
- NHFOV, NCPAP
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Alexandria University
Perennial Allergic Rhinitis
Montelukast in Perennial Allergic Rhinitis - 2001-2002 Study (0476-246)
This study will assess the ability of montelukast to improve the signs and symptoms of perennial allergic rhinitis compared to placebo. Cetirizine is included in the study as an active control.
- Trial name
- NCT00974571
- Testing
- montelukast sodium, Comparator: cetirizine
- Volunteers
- 1,365 people
- Sponsor
- Organon and Co
Birch Pollen Allergy, Healthy Control Subjects
Effect of the Nasal Provocation on the Breathing Style
The purpose of this study is to find out how the provocation of the nose changes breathing style (specifically, frequency and tidal volume changes)
- Trial name
- NCT02146300
- Testing
- 1. session birch pollen nasal exposure 2. session xylometazoline nasal exposure
- Where
- Finland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oulu University Hospital
Rhinitis, Allergic, Rhinoconjunctivitis
Study to Evaluate the Efficacy and Safety of "Allergovac Poliplus" in Polysensitized Patients With Allergic Rhinitis/Rhinoconjunctivitis, With or Without Asthma
This is an observational prospective multicenter clinical study, to evaluate the efficacy and safety of the treatment with Allergovac Poliplus subcutaneous immunotherapy (SCIT) with a mixture of 2 allergenic extracts (pollens or…
- Trial name
- ARES (NCT03821077)
- Testing
- Allergen Immunotherapy (AIT)
- Where
- 10 sites in Spain
- Volunteers
- 122 people
- Sponsor
- Roxall Medicina España S.A
Pulmonary Disease, Chronic Obstructive (COPD), Dyspnea
Asymmetric High-Flow Nasal Cannula During Pulmonary Rehabilitation in COPD
This randomized pilot trial evaluated the feasibility and preliminary effects of using asymmetric high-flow nasal cannula (A-HFNC) during exercise-based pulmonary rehabilitation (PR) in patients with chronic obstructive pulmonary…
- Conditions
- Pulmonary Disease, Chronic Obstructive (COPD), Dyspnea, Exercise Tolerance, Rehabilitation
- Trial name
- A-HFNC-PR (NCT07497230)
- Testing
- Asymmetric High-Flow Nasal Cannula (A-HFNC), Conventional Pulmonary Rehabilitation Program
- Where
- Chile
- Volunteers
- 30 people
- Sponsor
- Universidad de Santiago de Chile
Bronchiolitis
High-flow Nasal Oxygen Therapy in Hospitalized Infant With Moderate-to-severe Bronchiolitis
Over the last decade, high-flow nasal oxygen therapy (HFN) has emerged as a new method to provide respiratory support in children with moderate to severe bronchiolitis.
- Trial name
- BRONCHOPTI (NCT02856165)
- Testing
- High-flow nasal canula oxygen therapy, Low-flow oxygen therapy with standard nasal canula
- Where
- France
- Volunteers
- 268 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Seasonal Allergic Rhinitis, SAR
Study of an Investigational Nasal Aerosol or Placebo Nasal Aerosol in Children (Ages 6-11) With Seasonal Allergies
The purpose of this study is to assess the safety and efficacy of an investigational nasal aerosol at two doses compared with placebo nasal aerosol in the treatment of seasonal allergic rhinitis in children (6-11 years of age).
- Trial name
- NCT01307319
- Testing
- BDP HFA
- Where
- 45 sites in United States
- Volunteers
- 715 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
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