Clinical trials: Narcotics
Opioid Dependence
Completion of OST - a Prospective Study
Only limited information on the process of completing long-term opiate substitution treatment (OST) with substances like methadone exist.
- Trial name
- NCT01722435
- Testing
- Opiate Substitution Treatment
- Volunteers
- 78 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Substance Use Disorders, Chronic Pain
IMPOWR-ME Project 1: Trial of Yoga and Physical Therapy Onsite at Opioid Treatment Programs
This is a pragmatic, open label, randomized controlled trial with 1:1:1 allocation to 12 weeks of: (1) onsite yoga at opioid treatment programs (OTPs), (2) onsite physical therapy (PT) at OTPs, or (3) treatment as usual (TAU).
- Conditions
- Substance Use Disorders, Chronic Pain, Opioid Use Disorder, Back Pain Lower Back Chronic
- Trial name
- NCT05492825
- Testing
- Yoga, Physical Therapy, Treatment As Usual
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Albert Einstein College of Medicine
Opioid-Related Disorders
Safety and Tolerability of Buprenorphine/Naloxone Film Strips
This study will evaluate the safety and tolerability on the oral mucosa of buprenorphine/naloxone film strips administered either sublingually or buccally daily for 12 weeks in opioid dependent individuals who are already on a…
- Trial name
- NCT00640835
- Testing
- Buprenorphine/naloxone Film Strip
- Where
- 3 sites in United States
- Volunteers
- 382 people
- Sponsor
- Indivior Inc.
Constipation, Opioid-Induced, Cancer
Electroacupuncture for Opioid-Induced Constipation in Cancer Patients: A Randomized Clinical Trial
The primary objective of this trial is to evaluate the efficacy and safety of electroacupuncture in the management of opioid-induced constipation in patients with cancer.
- Trial name
- NCT06537440
- Testing
- Electroacupuncture
- Where
- China
- Volunteers
- 92 people
- Sponsor
- First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Anesthesia
Is it Possible to Replace Fentanyl in Anesthesia for Minor Procedures?
To compare between fentanyl group and ketamine lidocaine group for induction of anesthesia as regards hemodynamics and smooth intubation.
- Trial name
- NCT03806374
- Testing
- Ketamine, Propofol, Fentanyl
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Opioid Use Disorder
Neurobehavioral Mechanisms of Choice in Opioid Use Disorder
The objective of this protocol is to use probabilistic reinforcement learning choice tasks and magnetic resonance neuroimaging to demonstrate the impact of problematic opioid use and opioid withdrawal on dynamic decision-making…
- Trial name
- NCT03958474
- Testing
- Oxycodone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Joshua A. Lile, Ph.D.
Opioid Abuse, Unspecified
Application of Economics & Social Psychology to Improve Opioid Prescribing Safety Trial 1: EHR Nudges
The opioid epidemic has had a tremendous negative impact on the health of persons in the U.S. The objective of the trial 1 of Application of Economics \& Social psychology to improve Opioid Prescribing Safety (AESOPS-T1), is to…
- Trial name
- AESOPS-T1 (NCT04477304)
- Testing
- Opioid Naive, OR, At-risk for long-term use, OR, Long-term opioid recipient
- Where
- United States
- Volunteers
- 555 people
- Sponsor
- University of Southern California
Postoperative Pain, Cesarean Section
A Comparison of IV Versus PO Acetaminophen Postoperatively for Opioid Consumption After Cesarean Section
This randomized controlled study will compare narcotic consumption between two groups: patients that receive a perioperative dose of IV acetaminophen versus patients that receive a perioperative dose of oral liquid acetaminophen…
- Conditions
- Postoperative Pain, Cesarean Section, Acetaminophen
- Trial name
- NCT04290208
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Main Line Health
Opioid Use Disorder, Cannabis Use
Cannabis Effects on Opioid Self-Administration
The study will enroll participants with opioid use disorder and participants will reside at the University of Kentucky Hospital for this 6-week inpatient trial.
- Trial name
- NCT07668635
- Testing
- Cannabis, Intranasal Opioid Agonist, Oral Opioid Agonist
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Shanna Babalonis, PhD
Opioid Withdrawal (Disorder), Opioid Use Disorder
A Pharmacokinetic, Safety, and Tolerability Study of LUCEMYRA in the Treatment of Opioid Withdrawal Management in Adolescent Subjects
The goal of this clinical study is to evaluate the pharmacokinetic (PK), safety, and tolerability of LUCEMYRA in adolescents age ≥12 to <18 years old abruptly discontinuing opioid use.
- Trial name
- NCT06711640
- Testing
- LUCEMYRA (lofexidine) tablets
- Where
- United States
- Sponsor
- USWM, LLC (dba US WorldMeds)
Opioid Use Disorder
Computerized Anxiety Sensitivity Treatment for Opioid Use Disorders
The primary aim of the current project is to test the acceptability and feasibility of a computerized intervention, titled Computerized Anxiety Sensitivity Treatment (CAST), delivered to Veterans seeking treatment for an opioid…
- Trial name
- CAST-O (NCT03944850)
- Testing
- Computerized Anxiety Sensitivity Treatment
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Southeast Louisiana Veterans Health Care System
Opioid Use Disorder, Opioid Use Disorder, Moderate
Family-Focused Study to Support Medication for Opioid Use Disorder
The purpose of this clinical trial is to develop and test whether a text- and web-based tool called FamilyCHESS - designed for individuals with opioid use disorder (OUD) and a concerned significant other (CSO) - can help the…
- Conditions
- Opioid Use Disorder, Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe
- Trial name
- NCT07451197
- Testing
- FamilyCHESS, Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Pain
Lidocaine For Treatment of Post-operative Pain From Donor Sites Following Burn Injury.
Burn pain is known to be one the most severe forms of acute pain often requiring large amounts of narcotics in addition to other adjuvants.
- Trial name
- LidocaineBurn (NCT02229578)
- Testing
- Lidocaine
- Where
- 2 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Florida
Opioid Use Disorder
Behavioral Pharmacological Examination of a Novel Buprenorphine Induction Method Among Individuals Who Use Fentanyl
The opioid overdose epidemic has persisted for several decades and is now further complicated by the permeation of fentanyl into the illicit opioid supply.
- Trial name
- NBIM (NCT06089707)
- Testing
- Naloxone Nasal Spray
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Maryland, Baltimore
Heroin Dependence, Opioid-Related Disorders
Addiction Treatment in Russia: Oral vs. Naltrexone Implant
Heroin addiction is a growing problem in Russia; individuals who enter heroin addiction treatment often relapse. Therefore, effective heroin addiction treatments are necessary to prevent relapse.
- Trial name
- NCT00218426
- Testing
- naltrexone implant, oral naltrexone
- Where
- 2 sites in United States, Russia
- Volunteers
- 306 people
- Sponsor
- University of Pennsylvania
Opioid Dependence, Opioid Use Disorder (OUD)
VK4-116 Phase I Study With Food-Effect
This first-in-human, randomized, double-blind, placebo-controlled, single ascending dose (SAD), phase I study is designed to assess the safety, tolerability and pharmacokinetics of VK4-116 in healthy volunteers in fasted and fed…
- Trial name
- NCT06808932
- Testing
- VK4-116
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Sleep Apnea, Obstructive
Study to Evaluate Recovery From Postoperative Pain After Sleep Apnea Surgery
The purpose of this study is to assess whether tonsillectomy and UPPP performed using the study device to treat Obstructive Sleep Apnea (OSA) symptoms in adults is associated with less postoperative pain during the 21-day…
- Trial name
- NCT00380458
- Testing
- Coblation (radiofrequency-based device)
- Where
- United States
- Sponsor
- ArthroCare Corporation
Chronic Pain, Opiate Dependence
Developing Brain Stimulation as a Treatment for Chronic Pain in Opiate Dependent
Effective control of chronic pain is a top priority in the United States, as approximately 10% of adults have severe chronic pain - most of which is chronic lower back pain (CLBP).
- Conditions
- Chronic Pain, Opiate Dependence, Lower Back Pain
- Trial name
- NCT03681769
- Testing
- iTBS to the left dlPFC, cTBS to the mPFC
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Medical University of South Carolina
Opioid Use Disorder
Telehealth Treatment for Opioid Use Disorders
This study aims to use an Opioid Use Disorder (OUD) Telehealth Platform to reduce overdose events. This telehealth platform will be pilot tested to evaluate its preliminary efficacy in terms of motivating engagement in…
- Trial name
- NCT05832879
- Testing
- OUD Telehealth Platform
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Yale University
Opioid Abuse, Benzodiazepine Abuse
Opioid/Benzodiazepine Polydrug Abuse: Aim 3
In this study, the investigators will measure affective, neurocognitive and behavioral outcomes related to chronic use of opioids and benzodiazepines (screening phase), and in response to the administration of the opioid…
- Conditions
- Opioid Abuse, Benzodiazepine Abuse, Polysubstance Abuse
- Trial name
- MAP (NCT05006079)
- Testing
- Morphine, Alprazolam
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Wayne State University